• Netherlands

  • Netherlands

Research Output

1985

Calcium ionophore A23187 induces Il2 reactivity in human T cells

Clevers, J. C., Hoeksema, M., Gmelig-Meyling, F. & Ballieux, R. E., 1985, In : Scandinavian Journal of Immunology. 22, p. 633-638

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
111 Downloads (Pure)

Ligands of surface Ig raise cytoplasmic free Ca++ in human B cells

Clevers, J. C., Bloem, A. C., Gmelig-Meyling, F. & Ballieux, R. E., 1985, In : Scandinavian Journal of Immunology. 22, p. 557-562

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
236 Downloads (Pure)

Synergistic action of A23187 and phorbol ester on human B cell activation

Clevers, J. C., Versteegen, J. M. T., Logtenberg, T., Gmelig-Meyling, F. H. J. & Ballieux, R. E., 1985, In : Journal of Immunology. 135, p. 3827-3830

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
113 Downloads (Pure)
1986

Synergistic action of A23187 and PMA on B cells in CLL

Clevers, J. C., Versteegen, J. M. T., Gmelig-Meyling, F. H. J. & Ballieux, R. E., 1986, Elsevier B.V.

Research output: Book/ReportBookScientific

File
56 Downloads (Pure)

T cells in B cell chronic lymphocytic leukaemia

Bloem, A. C., Clevers, J. C., Bast, E. J. E. G. & Ballieux, R. E., 1986, In : Clinical & Experimental Immunology. 63, p. 188-193

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
53 Downloads (Pure)

WGA activates human T lymphocytes by stimulation of phosphoinositide hydrolysis

Clevers, J. C., Bresser, A. D., Kleinveld, H., Gmelig-Meyling, F. H. J. & Ballieux, R. E., 1986, In : Journal of Immunology. 136, p. 3180-3183

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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123 Downloads (Pure)
1987

CD3: Structural and genetic aspects of a cell surface glycoprotein complex

Hall, C., Alarcon, B., Berkhout, B., Clevers, J. C., Georgopoulos, K., Gold, D., Pettey, C., Elsen, P. V. D., Wileman, T. & Terhorst, C., 1987, Oxford: Oxford University Press.

Research output: Book/ReportBookScientific

Close linkage of the mouse and human CD3-g and d genes suggests a control of their transcription by common regulatory elements

Saito, H., Koyama, T., Georgopoulos, K., Clevers, J. C., Haser, W. G., LeBien, T., Tonegawa, S. & Terhorst, C., 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, p. 9131-9134

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
41 Downloads (Pure)

Evolutionary relationship between the T3 chains of the T cell receptor complex and the immunoglobulin supergene family

Gold, D. P., Clevers, J. C., Alarcon, B., Dunlap, S., Novotny, J., Williams, A. F. & Terhorst, C., 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, p. 7649-7653

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
308 Downloads (Pure)
1988

Characterization and expression of the murine CD3-epsilon gene

Clevers, J. C., Dunlap, S., Saito, H., Georgopoulos, K., Wileman, T. & Terhorst, C., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, p. 8623-8627

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
205 Downloads (Pure)

Human CD3-epsilon gene contains 3 miniexons and is transcribed from a non-TATA promoter

Clevers, J. C., Dunlap, S., Wileman, T. & Terhorst, C., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, p. 8156-8160

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
103 Downloads (Pure)

The T cell Receptor/CD3 complex: A dynamic protein ensemble

Clevers, J. C., Alarcon, B., Wileman, T. & Terhorst, C., 1988, In : Annual Review of Immunology. 6, p. 629-662

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
280 Downloads (Pure)

The transmembrane orientation of the epsilon chain of the TCR/CD3 complex

Clevers, J. C., Dunlap, S. & Terhorst, C., 1988, In : European Journal of Immunology. 18, p. 705-710

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
314 Downloads (Pure)
1989

An enhancer located in a CpG-island 3' of the TCR/CD3-e gene confers T lymphocyte-specificity to its promoter

Clevers, J. C., Lonberg, N., Dunlap, S., Lacy, E. & Terhorst, C., 1989, In : EMBO Journal. 8, p. 2527-2535

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes

Peters, P., Geuze, H. J., Donk, H. A. V. D., Slot, J. W., Griffith, J. M., Stam, N. J., Clevers, J. C. & Borst, J., 1989, In : European Journal of Immunology. 19, p. 1469-1475

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
520 Downloads (Pure)
1990

Expression of Tac antigen component of bovine interleukin-2 receptor in different leukocyte populations infected with Theileria parva or Theileria annulata

Dobbelaere, D. A., Prospero, T. D., Roditi, I. J., Kelke, C., Baumann, I., Eichhorn, M., Williams, R. O., Ahmed, J. S., Baldwin, C. L. & Clevers, J. C., 1990, In : Infection and Immunity. 58, p. 3847-3855

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
134 Downloads (Pure)

Identification of a bovine surface antigen uniquely expressed on CD4/CD8 negative TCR-gamma/delta positive T lymphocytes

Clevers, J. C., MacHugh, N. D., Bensaid, A., Dunlap, S., Baldwin, C. L., Kaushal, A., Iams, K., Howard, C. J. & Morrisson, W. I., 1990, In : European Journal of Immunology. 20, p. 809-817

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
347 Downloads (Pure)
1991

A method for cDNA cloning in COS cells irrespective of subcellular site of expression

Horst, E., Wijngaard, P. L. J., Metzelaar, M., Bast, E. J. E. G. & Clevers, J. C., 1991, In : Nucleic Acids Research. 19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
205 Downloads (Pure)

A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells

Metzelaar, M., Wijngaard, P., Peters, P., Nieuwenhuis, K., Sixma, J. & Clevers, J. C., 1991, In : Journal of Biological Chemistry. 266, p. 3239-3245

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
104 Downloads (Pure)

Cloning of the murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and TCR-alpha enhancers

Oosterwegel, M., Wetering, M. V. D., Dooijes, D., Klomp, L., Winoto, A., Georgopoulos, K., Meijlink, F. & Clevers, J. C., 1991, In : Journal of Experimental Medicine. 173, p. 1133-1142

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
339 Downloads (Pure)

Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box

Wetering, M. V. D., Oosterwegel, M., Dooijes, D. & Clevers, J. C., 1991, In : EMBO Journal. 10, p. 123-132

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
340 Downloads (Pure)

Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage

Bensaid, A., Kaushal, A., Baldwin, C. L., Clevers, J. C., Young, J. R., Kemp, S. J., MacHugh, N. D., Toye, P. G. & Teale, A. J., 1991, In : Immunogenetics. 33, p. 247-254

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
260 Downloads (Pure)

TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers

Oosterwegel, M. A., Wetering, M. L. V. D., Holstege, F. C. P., Prosser, H. M., Owen, M. J. & Clevers, J. C., 1991, In : International Immunology. 3, p. 1189-1192

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
84 Downloads (Pure)

Towards a molecular understanding of T cell differentiation

Clevers, J. C. & Owen, M., 1991, In : Immunology Today. 12, p. 86-92

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
276 Downloads (Pure)
1992

A common ancestor of the mammalian transcription factors TCF-1 and TCF-1 alpha/LEF1 expressed in chicken T cells

Castrop, J., Hoevenagel, R. & Clevers, J. C., 1992, In : European Journal of Immunology. 22, p. 1327-1330

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
97 Downloads (Pure)

A gene family of HMG box factors with homology to TCF-1

Castrop, J., Norren, K. V. & Clevers, J. C., 1992, In : Nucleic Acids Research. 611

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
63 Downloads (Pure)

Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesis

Oosterwegel, M. A., Timmerman, J., Leiden, J. & Clevers, J. C., 1992, In : Developmental Immunology. 3, p. 1-11

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
255 Downloads (Pure)

Heterodimeric complex formation with CD8 and TCR by bispecific antibody sustains paracrine IL-2-dependent growth of CD3+ CD8+ T cells

Lau, W. B. M. D., Boom, S. E., Heije, K., Griffioen, A. W., Braakman, E., Bolhuis, R. L. H., Tax, W. J. M., Clevers, J. C. & Bast, E. J. E. G., 1992, In : Journal of Immunology. 149, p. 1840-1846

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
137 Downloads (Pure)

Lysosomal membrane glycoproteins in platelets

Metzelaar, M. J. & Clevers, J. C., 1992, In : Thrombosis and Haemostasis. 68, p. 378-382

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
483 Downloads (Pure)

Molecular characterisation of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T-lymphocytes

Wijngaard, P. L. J., Metzelaar, M., MacHugh, N. D., Morrison, W. I. & Clevers, J. C., 1992, In : Journal of Immunology. 149, p. 3273-3277

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
163 Downloads (Pure)

Sequence-specific interaction of the HMG-box factor TCF-1 occurs within the minor groove of a Watson-Crick double helix

Wetering, M. V. D. & Clevers, J. C., 1992, In : EMBO Journal. 11, p. 3039-3044

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
315 Downloads (Pure)

Structure and mapping of the human TCF-1 gene; Characterization of its promoter

Wetering, M. V. D., Oosterwegel, M., Holstege, F., Suykerbuyk, R., Geurts van Kessel, A. & Clevers, J. C., 1992, In : Journal of Biological Chemistry. 267, p. 8530-8536

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
326 Downloads (Pure)

The ME491 melanoma-associated glycoprotein family. Antigenic identity of the ME491, NKI/C-3, NGA and CD61 proteins

Demetrick, D., Herlyn, D., Tretiak, M., Creasey, D., Clevers, J. C., Vennegoor, C. J. G. M., Dixon, W. T. & Jerry, L. M., 1992, In : Journal of the National Cancer Institute. 84, p. 422-429

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
82 Downloads (Pure)
1993

Ancestry and diversity of the HMG box superfamily

Laudet, V., Stehelin, D. & Clevers, J. C., 1993, In : Nucleic Acids Research. 21, p. 2493-2501

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
430 Downloads (Pure)

Clustering of monoclonal-antibodies recognizing different members of the WC1 gene family

MacHugh, N. D., Wijngaard, P. L. J., Clevers, J. C. & Davis, W. C., 1993, In : Veterinary Immunology and Immunopathology. 39, p. 155-160

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
209 Downloads (Pure)

De rol van transcriptiefactoren in de differentiatie van beenmergstamcellen naar immuuncompetente T lymfocyten

Clevers, J. C., 1993, In : Mediator.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
75 Downloads (Pure)

Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis

Oosterwegel, M., Wetering, M. V. D., Timmerman, J., Kruisbeek, A., Destree, O., Meijlink, F. & Clevers, J. C., 1993, In : Development. 118, p. 439-448

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
218 Downloads (Pure)

HMG box proteins in early T cell differentiation

Oosterwegel, M., Wetering, M. V. D. & Clevers, J. C., 1993, In : Thymus. 22, p. 67-81

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
45 Downloads (Pure)

Sox 15, a novel member of the murine Sox family of HMG box transcription factors

Wetering, M. V. D. & Clevers, J. C., 1993, In : Nucleic Acids Research. 21, p. 1669-1669

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
184 Downloads (Pure)

SOX-4, an SRY-like HMG box protein, is a transcriptional activator in lymphocytes

Wetering, M. V. D., Oosterwegel, M., Norren, K. V. & Clevers, J. C., 1993, In : EMBO Journal. 12, p. 3847-3854

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
233 Downloads (Pure)

The HB4 monoclonal antibody recognizes a carbohydrate structure on lymphocyte surface proteins, related to HB6, CDw75 and CD76

Lau, W. B. M. D., Kuipers, J., Voshol, H., Clevers, J. C. & Bast, E. J. E. G., 1993, In : Journal of Immunology. 150, p. 4911-4919

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
311 Downloads (Pure)

The murine Sox-4 protein is encoded on a single exon

Schilham, M. W., Eijk, M. V., Wetering, M. V. D. & Clevers, J. C., 1993, In : Nucleic Acids Research. 21, p. 2009-2009

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
185 Downloads (Pure)

The Schizosaccharomyces pombe mating-type gene mat-MC encodes a sequence-specific DNA-binding HMG box protein

Dooijes, D., Wetering, M. V. D., Knippels, L. & Clevers, J. C., 1993, In : Journal of Biological Chemistry. 268, p. 24813-24817

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
215 Downloads (Pure)

The sequence-specific HMG box of TCF-1 adopts a predominantly alpha-helical conformation in solution

Houte, L. V., Oers, A. M. V., Wetering, M. V. D., Dooijes, D., Kaptein, R. & Clevers, J. C., 1993, In : Journal of Biological Chemistry. 268, p. 18083-18087

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
261 Downloads (Pure)

Thoughts on thymus and T-lymphocyte repertoire. Relevance to the tolerance of the immune response

Schuurman, H. J., Hu, H., Weger, R. A. D. & Clevers, J. C., 1993, In : Netherlands Journal of Medicine. 43, p. 38-54

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcription factors in early T cell development

Clevers, J. C., Oosterwegel, M. A. & Georgopoulos, K., 1993, In : Immunology Today. 14, p. 591-596

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
258 Downloads (Pure)
1994

A novel multi-gene family of sheep gamma delta T cells

Walker, I. D., Glew, M. D., O'Keeffe, M. A., Metcalfe, S. A., Clevers, J. C., Wijngaard, P. L., Adams, T. E. & Hein, W. R., 1994, In : Immunology. 83, p. 517-523

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
107 Downloads (Pure)

Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy

Fournier, B., Saudubray, J. M., Benichou, B., Lyonnet, S., Munnich, A., Clevers, J. C. & Poll-The, B. T., 1994, In : Journal of Clinical Investigation. 94, p. 526-531

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
207 Downloads (Pure)

Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T-lymphocytes

Wijngaard, P. L. J., MacHugh, N. D., Metzelaar, M. J., Romberg, S., Bensaid, A., Pepin, L., Davis, W. C. & Clevers, J. C., 1994, In : Journal of Immunology. 152, p. 3476-3482

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
141 Downloads (Pure)
1995

Analysis of CD2 and TCR-beta gene expression in Jurkat cell mutants suggests a cis regulation of gene expression

Kamoun, M., Woods, J. S. & Clevers, J. C., 1995, In : Journal of Immunology. 155, p. 3929-3937

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
123 Downloads (Pure)