• Netherlands

  • Netherlands

Research Output

3C-based technologies to study the shape of the genome

de Laat, W. & Dekker, J., 2012, In : Methods. 58, 3, p. 189-191

Research output: Contribution to journal/periodicalArticleScientificpeer-review

3D chromatin conformation correlates with replication timing and is conserved in resting cells

Moindrot, B., Audit, B., Klous, P., Baker, A., Thermes, C., de Laat, W., Bouvet, P., Mongelard, F. & Arneodo, A., 2012, In : Nucleic Acids Research. 40, 19, p. 9470-9481

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

4C-seq from beginning to end: A detailed protocol for sample preparation and data analysis

Krijger, P. H. L., Geeven, G., Bianchi, V., Hilvering, C. R. E. & de Laat, W., 26 Jul 2019, In : Methods.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

4C technology: protocols and data analysis

van de Werken, H. J., de Vree, P. J., Splinter, E., Holwerda, S. J., Klous, P., de Wit, E. & de Laat, W., 2012, In : Methods in Enzymology. 513, p. 89-112

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A20 controls intestinal homeostasis through cell-specific activities

Vereecke, L., Vieira-Silva, S., Billiet, T., van Es, J. H., Mc Guire, C., Slowicka, K., Sze, M., van den Born, M., De Hertogh, G., Clevers, H., Raes, J., Rutgeerts, P., Vermeire, S., Beyaert, R. & van Loo, G., 2014, In : Nature Communications. 5, p. 5103

Research output: Contribution to journal/periodicalArticleScientificpeer-review

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

Smeland, M. F., McClenaghan, C., Roessler, H. I., Savelberg, S., Hansen, G. Å. M., Hjellnes, H., Arntzen, K. A., Müller, K. I., Dybesland, A. R., Harter, T., Sala-Rabanal, M., Emfinger, C. H., Huang, Y., Singareddy, S. S., Gunn, J., Wozniak, D. F., Kovacs, A., Massink, M., Tessadori, F., Kamel, S. M. & 5 others, Bakkers, J., Remedi, M. S., Van Ghelue, M., Nichols, C. G. & van Haaften, G., 01 Oct 2019, In : Nature Communications. 10, 1, p. 4457

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected

Le, N. H., Bent, P. V. D., Huls, G., Wetering, M. V. D., Loghman-Adham, M., Ong, A. C., Calvet, J. P., Clevers, J. C., Breuning, M. H., Dam, H. V. & Peters, D. J., 2004, In : Journal of Biological Chemistry. 279, p. 27472-27481

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A bone to pick with zebrafish: chemistry and genetics of osteogenesis

Mackay, E., 25 Nov 2014, Utrecht: Utrecht University. 128 p.

Research output: PhD ThesisPhD thesis

Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line

Lau, N. C., Robine, N., Martin, R., Chung, W. J., Niki, Y., Berezikov, E. & Lai, E. C., 2009, In : Genome Research. 19, 10, p. 1776-1785

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility

Engert, C. G., Droste, R., van Oudenaarden, A. & Horvitz, H. R., Apr 2018, In : PLoS Genetics. 14, 4, p. e1007295

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A case of cross-reactivity

Korswagen, H. C., 2011, In : Chemistry & Biology. 18, 4, p. 409-410

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries

Mokry, M., Feitsma, H., Nijman, I. J., de Bruijn, E., van der Zaag, P. J., Guryev, V. & Cuppen, E., 2010, In : Nucleic Acids Research. 38, 10, p. 116

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., Wild, B., Camargo, S. M., Singer, D., Richter, A. P., Kuba, K., Fukamizu, A., Schreiber, S., Clevers, H., Verrey, F., Rosenstiel, P. & 1 others, Penninger, J. M., 2012, In : Nature. 487, 7408, p. 477-481

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

Ciarlo, C., Kaufman, C. K., Kinikoglu, B., Michael, J., Yang, S., D Amato, C., Blokzijl-Franke, S., den Hertog, J., Schlaeger, T. M., Zhou, Y., Liao, E. & Zon, L. I., 23 Aug 2017, In : eLife. 6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A common ancestor of the mammalian transcription factors TCF-1 and TCF-1 alpha/LEF1 expressed in chicken T cells

Castrop, J., Hoevenagel, R. & Clevers, J. C., 1992, In : European Journal of Immunology. 22, p. 1327-1330

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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A common cofilin activity cycle in invasive tumor cells and inflammatory cells

van Rheenen, J., Condeelis, J. & Glogauer, M., 2009, In : Journal of Cell Science. 122, Pt 3, p. 305-311

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A common genetic variant within SCN10A modulates cardiac SCN5A expression

van den Boogaard, M., Smemo, S., Burnicka-Turek, O., Arnolds, D. E., van de Werken, H. J. G., Klous, P., McKean, D., Muehlschlegel, J. D., Moosmann, J., Toka, O., Yang, X. H., Koopmann, T. T., Adriaens, M. E., Bezzina, C. R., de Laat, W., Seidman, C., Seidman, J. G., Christoffels, V. M., Nobrega, M. A., Barnett, P. & 1 others, Moskowitz, I. P., 01 Apr 2014, In : Journal of Clinical Investigation. 124, 4, p. 1844-52 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis

Essers, P. B., Pereboom, T. C., Goos, Y. J., Paridaen, J. T. & Macinnes, A. W., 15 Jan 2014, In : Developmental Biology. 385, 2, p. 304-15 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

Yan, H. H. N., Siu, H. C., Law, S., Ho, S. L., Yue, S. S. K., Tsui, W. Y., Chan, D., Chan, A. S., Ma, S., Lam, K. O., Bartfeld, S., Man, A. H. Y., Lee, B. C. H., Chan, A. S. Y., Wong, J. W. H., Cheng, P. S. W., Chan, A. K. W., Zhang, J., Shi, J., Fan, X. & 5 others, Kwong, D. L. W., Mak, T. W., Yuen, S. T., Clevers, H. & Leung, S. Y., 06 Dec 2018, In : Cell Stem Cell. 23, 6, p. 882-897.e11

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt

Buske, P., Galle, J., Barker, N., Aust, G., Clevers, H. & Loeffler, M., 2011, In : PLoS Computational Biology. 7, 1, p. 1001045

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes

Slavov, N., Airoldi, E. M., van Oudenaarden, A. & Botstein, D., 2012, In : Molecular Biology of the Cell. 23, 10, p. 1986-1997

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal

van Es, J. H., Haegebarth, A., Kujala, P., Itzkovitz, S., Koo, B. K., Boj, S. F., Korving, J., van den Born, M., van Oudenaarden, A., Robine, S. & Clevers, H., 2012, In : Molecular and Cellular Biology. 32, 10, p. 1918-1927

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Morin, P. J., Sparks, A., Korinek, V., Barker, N., Clevers, J. C., Vogelstein, B. & Kinzler, K., 1997, In : Science. 275, p. 1787-1790

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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944 Downloads (Pure)

Activation of the tumor suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R. & Clevers, J. C., 2003, In : EMBO Journal. 22, p. 3062-3072

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Active Wnt signaling in response to cardiac injury

Oerlemans, M. I., Goumans, M. J., van Middelaar, B., Clevers, H., Doevendans, P. A. & Sluijter, J. P., 2010, In : Basic Research in Cardiology. 105, 5, p. 631-641

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth

Samuel, M. S., Lopez, J. I., McGhee, E. J., Croft, D. R., Strachan, D., Timpson, P., Munro, J., Schroder, E., Zhou, J., Brunton, V., Barker, N., Clevers, H., Sansom, O. J., Anderson, K. I., Weaver, V. M. & Olson, M. F., 2011, In : Cancer Cell. 19, 6, p. 776-791

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats

Homberg, J. R., de Boer, S. F., Raaso, H. S., Olivier, J. D. A., Verheul, M., Ronken, E., Cools, A. R., Ellenbroek, B. A., Schoffelmeer, A. N. M., Vanderschuren, L. J. M. J., de Vries, T. J. & Cuppen, E., 2008, In : Psychopharmacology (Berl). 200, p. 367-380

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2 microglobulin knockout mice

Santos, M., Clevers, J. C., Sousa, M. D. & Marx, J. J., 1998, In : Blood. 91, p. 3059-3065

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Additive effects of attention and stimulus contrast in primary visual cortex.

Thiele, A., Pooresmaeili, A., Delicato, L. S., Herrero, J. L. & Roelfsema, P. R., 2009, In : Cerebral Cortex. 19, p. 2970-2981

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A decade of 3C technologies: insights into nuclear organization

de Wit, E. & de Laat, W., 2012, In : Genes & Development. 26, 1, p. 11-24

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A deep sequencing approach to uncover the miRNOME in the human heart

Leptidis, S., el Azzouzi, H., Lok, S. I., de Weger, R., Olieslagers, S., Kisters, N., Silva, G. J., Heymans, S., Cuppen, E., Berezikov, E., de Windt, L. J. & da Costa Martins, P., 2013, In : PLoS One. 8, 2, p. 57800

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.

Haramis, A-PG., Hurlstone, A., Velden, Y. V. D., Begthel, H., Born, M. V. D., Offerhaus, G. J. A. & Clevers, J. C., 2006, In : EMBO Reports. 7, p. 444-449

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder

Tessadori, F., Rehman, A. U., Giltay, J. C., Xia, F., Streff, H., Duran, K., Bakkers, J., Lalani, S. R. & van Haaften, G., 05 Dec 2019, In : European Journal of Human Genetics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Aduld Stem Cells in Mice

Snippert, H. J. G., 2011

Research output: PhD ThesisPhD thesis

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

Schuijers, J. & Clevers, H., 2012, In : EMBO Journal. 31, 12, p. 2685-2696

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.

Colak, D., Mori, T., Brill, M. S., Pfeifer, A., Falk, S., Deng, C., Monteiro, R., Mummery, C. L., Sommer, L. & Gotz, M., 2008, In : Journal of Neuroscience. 28, 2, p. 434-445

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Adult Stem Cell-Derived Kidney Organoids to Model Tissue Physiology and Disease

Schutgens, F., 21 Nov 2017, Utrecht University.

Research output: PhD ThesisPhD thesis

Adult stem cells in the small intestine are intrinsically programmed with their location-specific function

Middendorp, S., Schneeberger, K., Wiegerinck, C. L., Mokry, M., Akkerman, R. D. L., van Wijngaarden, S., Clevers, H. & Nieuwenhuis, E. E. S., May 2014, In : Stem Cells. 32, 5, p. 1083-91 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Advances in single-cell sequencing technologies and applications in cancer

Kester, L., 15 Mar 2018, Utrecht University.

Research output: PhD ThesisPhD thesis

Open Access

Advances in β-cell replacement therapy for the treatment of type 1 diabetes

Vantyghem, M-C., de Koning, E. J. P., Pattou, F. & Rickels, M. R., 05 Oct 2019, In : The Lancet. 394, 10205, p. 1274-1285 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Advance to GO: Regulation of mitotic progression by the spindle checkpoint kinase MPS1

Pachis, S. T., 24 Sep 2019, Utrecht University.

Research output: PhD ThesisPhD thesis

Open Access
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A FERM domain governs apical confinement of PTP-BL in epithelial cells

Cuppen, E., Wijers, M., Schepens, J., Fransen, J. A., Wieringa, B. & Hendriks, W., 1999, In : Journal of Cell Science. 112 ( Pt 1, p. 3299-3308

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Afferent Neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats

Gumbs, M. C. R., Vuuregge, A. H., Eggels, L., Unmehopa, U. A., Lamuadni, K., Mul, J. D. & la Fleur, S. E., 2019, In : Journal of Comparative Neurology. 527, p. 2659-2674

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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A fisheye view on lymphangiogenesis

van Impel, A. & Schulte-Merker, S., 2014, In : Advances in anatomy, embryology, and cell biology. 214, p. 153-65 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A functional CFTR assay using primary cystic fibrosis intestinal organoids

Dekkers, J. F., Wiegerinck, C. L., de Jonge, H. R., Bronsveld, I., Janssens, H. M., de Winter-de Groot, K. M., Brandsma, A. M., de Jong, N. W., Bijvelds, M. J., Scholte, B. J., Nieuwenhuis, E. E., van den Brink, S., Clevers, H., van der Ent, C. K., Middendorp, S. & Beekman, J. M., 2013, In : Nature Medicine. 19, 7, p. 939-945

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A functional screen identifies specific microRNAs capable of inhibiting human melanoma cell viability

Poell, J. B., van Haastert, R. J., de Gunst, T., Schultz, I. J., Gommans, W. M., Verheul, M., Cerisoli, F., van Noort, P. I., Prevost, G. P., Schaapveld, R. Q. & Cuppen, E., 2012, In : PLoS One. 7, 8, p. 43569

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A gene family of HMG box factors with homology to TCF-1

Castrop, J., Norren, K. V. & Clevers, J. C., 1992, In : Nucleic Acids Research. 611

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary

Soh, Y. Q. S., Junker, J. P., Gill, M. E., Mueller, J. L., van Oudenaarden, A. & Page, D. C., Sep 2015, In : PLoS Genetics. 11, 9, p. e1005531

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression

Gupta, R. M., Hadaya, J., Trehan, A., Zekavat, S. M., Roselli, C., Klarin, D., Emdin, C. A., Hilvering, C. R. E., Bianchi, V., Mueller, C., Khera, A. V., Ryan, R. J. H., Engreitz, J. M., Issner, R., Shoresh, N., Epstein, C. B., de Laat, W., Brown, J. D., Schnabel, R. B., Bernstein, B. E. & 1 others, Kathiresan, S., 27 Jul 2017, In : Cell. 170, 3, p. 522-533.e15

Research output: Contribution to journal/periodicalArticleScientificpeer-review