• Netherlands

  • Netherlands

Research Output

Article

Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

Clevers, H., Loh, K. M. & Nusse, R., 03 Oct 2014, In : Science Magazine. 346, 6205, p. 1248012

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem Cells in Repair of Gastrointestinal Epithelia

Andersson-Rolf, A., Zilbauer, M., Koo, B-K. & Clevers, H., Jul 2017, In : Physiology (Bethesda, Md.). 32, 4, p. 278-289 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cells marked by the R-spondin receptor LGR5

Koo, B-K. & Clevers, H., Aug 2014, In : Gastroenterology. 147, 2, p. 289-302 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia

Smink, A. M., Li, S., Swart, D. H., Hertsig, D. T., de Haan, B. J., Kamps, J. A. A. M., Schwab, L., van Apeldoorn, A., de Koning, E., Faas, M. M., Lakey, J. R. T. & de Vos, P., Sep 2017, In : Journal of Biomedical Materials Research - Part A. 105, 9, p. 2533-2542 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Stochastic cytokine expression induces mixed T helper cell States

Fang, M., Xie, H., Dougan, S. K., Ploegh, H. & van Oudenaarden, A., 2013, In : PLoS Biology. 11, 7, p. 1001618

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Strategies for homeostatic stem cell self-renewal in adult tissues

Simons, B. D. & Clevers, H., 2011, In : Cell. 145, 6, p. 851-862

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function

de Winter-de Groot, K. M., Janssens, H. M., van Uum, R. T., Dekkers, J. F., Berkers, G., Vonk, A., Kruisselbrink, E., Oppelaar, H., Vries, R., Clevers, H., Houwen, R. H. J., Escher, J. C., Elias, S. G., de Jonge, H. R., de Rijke, Y. B., Tiddens, H. A. W. M., van der Ent, C. K. & Beekman, J. M., Sep 2018, In : European Respiratory Journal. 52, 3

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats.

Olivier, J., Cools, A. R., Olivier, B., Homberg, J. R., Cuppen, E. & Ellenbroek, B. A., 2008, In : European Journal of Pharmacology. 590, 1-3, p. 190-197

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stressing the importance of choice - validity of a preclinical free-choice high-caloric diet paradigm to model behavioral, physiological, and molecular adaptations during human diet-induced obesity and metabolic dysfunction

Slomp, M., Belegri, E., Blancas-Velazquez, A. S., Diepenbroek, C., Eggels, L., Gumbs, M. C. R., Joshi, A., Koekkoek, L. L., Lamuadni, K., Ugur, M., Unmehopa, U. A., la Fleur, S. E. & Mul, J. D., 2019, In : Journal of Neuroendocrinology. 31, p. e12718

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Structure and mapping of the human TCF-1 gene; Characterization of its promoter

Wetering, M. V. D., Oosterwegel, M., Holstege, F., Suykerbuyk, R., Geurts van Kessel, A. & Clevers, J. C., 1992, In : Journal of Biological Chemistry. 267, p. 8530-8536

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Structure-guided design of selective Epac1 and Epac2 agonists

Schwede, F., Bertinetti, D., Langerijs, C. N., Hadders, M. A., Wienk, H., Ellenbroek, J. H., de Koning, E. J. P., Bos, J. L., Herberg, F. W., Genieser, H-G., Janssen, R. A. J. & Rehmann, H., Jan 2015, In : PLoS Biology. 13, 1, p. e1002038

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

Peng, W. C., De Lau, W., Forneris, F., Granneman, J. C., Huch, M., Clevers, H. & Gros, P., 2013, In : Cell Reports. 3, 6, p. 1885-1892

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

Peng, W. C., De Lau, W., Madoori, P. K., Forneris, F., Granneman, J. C., Clevers, H. & Gros, P., 2013, In : PLoS One. 8, 12, p. 83110

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology

Sasaki, N. & Clevers, H., Oct 2018, In : Current Opinion in Genetics & Development. 52, p. 117-122 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Studying extracellular vesicle transfer by a Cre-loxP method

Zomer, A., Steenbeek, S. C., Maynard, C. & van Rheenen, J., Jan 2016, In : Nature Protocols. 11, 1, p. 87-101 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying Kinetochore Kinases

Saurin, A. T. & Kops, G. J. P. L., 2016, In : Methods in Molecular Biology. 1413, p. 333-47 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying Lineage Decision-Making In Vitro: Emerging Concepts and Novel Tools

Semrau, S. & van Oudenaarden, A., 13 Nov 2015, In : Annual Review of Cell and Developmental Biology. 31, p. 317-45 29 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C).

Louwers, M., Splinter, E., van Driel, R., de Laat, W. & Stam, M., 2009, In : Nature Protocols. 4, 8, p. 1216-1229

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying Protein-Tyrosine Phosphatases in Zebrafish

Hale, A. J. & den Hertog, J., 2016, In : Methods in Molecular Biology. 1447, p. 351-72 22 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

SUGAR-DIP trial: oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial

de Wit, L., Rademaker, D., Voormolen, D. N., Akerboom, B. M. C., Kiewiet-Kemper, R. M., Soeters, M. R., Verwij-Didden, M. A. L., Assouiki, F., Schippers, D. H., Vermeulen, M. A. R., Kuppens, S. M. I., Oosterwerff, M. M., Zwart, J. J., Diekman, M. J. M., Vogelvang, T. E., Gallas, P. R. J., Galjaard, S., Visser, W., Horree, N., Klooker, T. K. & 46 others, Laan, R., Heijligenberg, R., Huisjes, A. J. M., van Bemmel, T., van Meir, C. A., van den Beld, A. W., Hermes, W., Vidarsdottir, S., Veldhuis-Vlug, A. G., Dullemond, R. C., Jansen, H. J., Sueters, M., de Koning, E. J. P., van Laar, J. O. E. H., Wouters-van Poppel, P., Sanson-van Praag, M. E., van den Akker, E. S., Brouwer, C. B., Hermsen, B. B., Potter van Loon, B. J., van der Heijden, O. W. H., de Galan, B. E., van Leeuwen, M., Wijbenga, J. A. M., de Boer, K., van Bon, A. C., van der Made, F. W., Eskes, S. A., Zandstra, M., van Houtum, W. H., Braams-Lisman, B. A. M., Daemen-Gubbels, C. R. G. M., Wouters, M. G. A. J., IJzerman, R. G., Mensing van Charante, N. A., Zwertbroek, R., Bosmans, J. E., Evers, I. M., Mol, B. W., de Valk, H. W., Groenendaal, F., Naaktgeboren, C. A., Painter, R. C., deVries, J. H., Franx, A. & van Rijn, B. B., 18 Aug 2019, In : BMJ Open. 9, 8, p. e029808

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice

Demarque, M. D., Nacerddine, K., Neyret-Kahn, H., Andrieux, A., Danenberg, E. M., Jouvion, G., Bomme, P., Hamard, G., Romagnolo, B., Terris, B., Cumano, A., Barker, N., Clevers, H. & Dejean, A., 2010, In : Gastroenterology. 140, 1, p. 286-296

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Suppressive lateral interactions at parafoveal representations in primary visual cortex.

Pooresmaeili, A., Herrero, J. L., Self, M. W., Roelfsema, P. R. & Thiele, A., 2010, In : Journal of Neuroscience. 30, p. 12745-12758

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Surgical implantation of an abdominal imaging window for intravital microscopy

Ritsma, L., Steller, E. J., Ellenbroek, S. I., Kranenburg, O., Rinkes, I. H. & van Rheenen, J., 2013, In : Nature Protocols. 8, 3, p. 583-594

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Janda, C. Y., Dang, L. T., You, C., Chang, J., de Lau, W., Zhong, Z. A., Yan, K. S., Marecic, O., Siepe, D., Li, X., Moody, J. D., Williams, B. O., Clevers, H., Piehler, J., Baker, D., Kuo, C. J. & Garcia, K. C., 11 May 2017, In : Nature. 545, 7653, p. 234-237 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Survivin and molecular pathogenesis of colorectal cancer

Kim, P. J., Plescia, J., Clevers, J. C., Fearon, E. R. & Altieri, D. C., 2003, In : Lancet. 362, p. 205-209

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Swim-training changes the spatio-temporal dynamics of skeletogenesis in zebrafish larvae (Danio rerio)

Fiaz, A. W., Leon-Kloosterziel, K. M., Gort, G., Schulte-Merker, S., van Leeuwen, J. L. & Kranenbarg, S., 2012, In : PLoS One. 7, 4, p. 34072

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

Ren, Z., van Andel, H., de Lau, W., Hartholt, R. B., Maurice, M. M., Clevers, H., Kersten, M. J., Spaargaren, M. & Pals, S. T., 06 Dec 2017, In : Blood.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1

Roose, J., Huls, G., Beest, M. V., Moerer, P., Horn, K. V. D., Goldschmeding, R., Logtenberg, T. & Clevers, J. C., 1999, In : Science. 285, p. 1923-1926

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Synergistic action of A23187 and phorbol ester on human B cell activation

Clevers, J. C., Versteegen, J. M. T., Logtenberg, T., Gmelig-Meyling, F. H. J. & Ballieux, R. E., 1985, In : Journal of Immunology. 135, p. 3827-3830

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Systematic biases in DNA copy number originate from isolation procedures

van Heesch, S., Mokry, M., Boskova, V., Junker, W., Mehon, R., Toonen, P., de Bruijn, E., Shull, J. D., Aitman, T. J., Cuppen, E. & Guryev, V., 2013, In : Genome Biology. 14, 4, p. 33

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Systematic generation of in vivo G protein-coupled receptor mutants in the rat

van Boxtel, R., Vroling, B., Toonen, P. W., Nijman, I. J., van Roekel, H., Verheul, M., Baakman, C., Guryev, V., Vriend, G. & Cuppen, E., 2010, In : Pharmacogenomics Journal. 11, 5, p. 326-336

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Systematic identification of signal-activated stochastic gene regulation

Neuert, G., Munsky, B., Tan, R. Z., Teytelman, L., Khammash, M. & van Oudenaarden, A., 2013, In : Science Magazine. 339, 6119, p. 584-587

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma

Babae, N., Bourajjaj, M., Liu, Y., Van Beijnum, J. R., Cerisoli, F., Scaria, P. V., Verheul, M., Van Berkel, M. P., Pieters, E. H. E., Van Haastert, R. J., Yousefi, A., Mastrobattista, E., Storm, G., Berezikov, E., Cuppen, E., Woodle, M., Schaapveld, R. Q. J., Prevost, G. P., Griffioen, A. W., Van Noort, P. I. & 1 others, Schiffelers, R. M., 30 Aug 2014, In : Oncotarget. 5, 16, p. 6687-700 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tacrolimus-Induced BMP/SMAD Signaling Associates with Metabolic Stress-Activated FOXO1 to Trigger β-Cell Failure

Triñanes, J., Dijke, P. T., Groen, N., Hanegraaf, M., Porrini, E., Rodriguez-Rodriguez, A. E., Drachenberg, C., Rabelink, T. J., de Koning, E., Carlotti, F. & de Vries, A. P. J., 15 Nov 2019, In : Diabetes.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tailored Hox gene transcription and the making of the thumb.

Deschamps, J., 2008, In : Genes & Development. 22, 3, p. 293-296

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tales from the crypt: new insights into intestinal stem cells

Gehart, H. & Clevers, H., Jan 2019, In : Nature Reviews Gastroenterology and Hepatology. 16, 1, p. 19-34 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tales of the unexpected: tcf1 functions as a tumor suppressor for leukemias

Staal, F. J. & Clevers, H., 2012, In : Immunity. 37, 5, p. 761-763

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Targeted next-generation sequencing: a novel diagnostic tool for primary immunodeficiencies

Nijman, I. J., van Montfrans, J. M., Hoogstraat, M., Boes, M. L., van de Corput, L., Renner, E. D., van Zon, P., van Lieshout, S., Elferink, M. G., van der Burg, M., Vermont, C. L., van der Zwaag, B., Janson, E., Cuppen, E., Ploos van Amstel, J. K. & van Gijn, M. E., Feb 2014, In : Journal of Allergy and Clinical Immunology. 133, 2, p. 529-34 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping

de Vree, P. J. P., de Wit, E., Yilmaz, M., van de Heijning, M., Klous, P., Verstegen, M. J. A. M., Wan, Y., Teunissen, H., Krijger, P. H. L., Geeven, G., Eijk, P. P., Sie, D., Ylstra, B., Hulsman, L. O. M., van Dooren, M. F., van Zutven, L. J. C. M., van den Ouweland, A., Verbeek, S., van Dijk, K. W., Cornelissen, M. & 19 others, Das, A. T., Berkhout, B., Sikkema-Raddatz, B., van den Berg, E., van der Vlies, P., Weening, D., den Dunnen, J. T., Matusiak, M., Lamkanfi, M., Ligtenberg, M. J. L., ter Brugge, P., Jonkers, J., Foekens, J. A., Martens, J. W., van der Luijt, R., van Amstel, H. K. P., van Min, M., Splinter, E. & de Laat, W., Oct 2014, In : Nature Biotechnology. 32, 10, p. 1019-25 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Targeting development of incretin-producing cells increases insulin secretion

Petersen, N., Reimann, F., van Es, J. H., van den Berg, B. M., Kroone, C., Pais, R., Jansen, E., Clevers, H., Gribble, F. M. & de Koning, E. J. P., Jan 2015, In : Journal of Clinical Investigation. 125, 1, p. 379-85 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Verissimo, C. S., Overmeer, R. M., Ponsioen, B., Drost, J., Mertens, S., Verlaan-Klink, I., Gerwen, B. V., van der Ven, M., Wetering, M. V. D., Egan, D. A., Bernards, R., Clevers, H., Bos, J. L. & Snippert, H. J., 15 Nov 2016, In : eLife. 5

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Target-selected mutagenesis of the rat

Smits, B. M., Mudde, J. B., Plasterk, R. & Cuppen, E., 2004, In : Genomics. 83, 2, p. 332-334

Research output: Contribution to journal/periodicalArticleScientificpeer-review

T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis.

Faro, A., Boj, S. F., Ambrosio, R., van den Broek, O., Korving, J. & Clevers, H., 2009, In : Zebrafish. 6, 1, p. 59-68

Research output: Contribution to journal/periodicalArticleScientificpeer-review

T-cell factors: turn-ons and turn-offs

Hurlstone, A. & Clevers, J. C., 2002, In : EMBO Journal. 21, p. 2303-2311

Research output: Contribution to journal/periodicalArticleScientificpeer-review

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

Fu, Y-Y., Egorova, A., Sobieski, C., Kuttiyara, J., Calafiore, M., Takashima, S., Clevers, H. & Hanash, A. M., 16 Jul 2019, In : Immunity. 51, 1, p. 90-103.e3

Research output: Contribution to journal/periodicalArticleScientificpeer-review

T cells in B cell chronic lymphocytic leukaemia

Bloem, A. C., Clevers, J. C., Bast, E. J. E. G. & Ballieux, R. E., 1986, In : Clinical & Experimental Immunology. 63, p. 188-193

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling

Brantjes, H., Barker, N., Es, J. V. & Clevers, J. C., 2002, In : Biological Chemistry. 383, p. 255-261

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF/LEF factors earn their wings

Clevers, J. C. & Wetering, M. V. D., 1997, In : Trends in Genetics. 13, p. 485-489

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Tcf/Lef transcription factors during T-cell development: unique and overlapping functions

Staal, F. J. T. & Clevers, J. C., 2001, In : The Hematology Journal. 1, p. 3-6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers

Oosterwegel, M. A., Wetering, M. L. V. D., Holstege, F. C. P., Prosser, H. M., Owen, M. J. & Clevers, J. C., 1991, In : International Immunology. 3, p. 1189-1192

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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