• Netherlands

  • Netherlands

Research Output

Article

Tcf-1-mediated transcription in T lymphocytes: differential role for GSK3beta in fibroblasts and T cells

Staal, F. J. T., Burgering, B. M. T., Wetering, M. V. D. & Clevers, J. C., 1999, In : International Immunology. 11, p. 317-322

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions

Verzi, M. P., Hatzis, P., Sulahian, R., Philips, J., Schuijers, J., Shin, H. D., Freed, E., Lynch, J. P., Dang, D. T., Brown, M., Clevers, H., Liu, X. S. & Shivdasani, R. A., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 34, p. 15157-15162

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF4 and groucho-related genes influence pituitary growth and development

Brinkmeier, M. L., Potok, M. A., Cha, K. B., Gridley, T., Stifani, S., Meeldijk, J., Clevers, J. C. & Camper, S. A., 2003, In : Molecular Endocrinology. 17, p. 2152-2161

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity

Lee, M., Yoon, J., Song, H., Lee, B., Lam, D. T., Yoon, J., Baek, K., Clevers, H. & Jeong, Y., 01 Apr 2017, In : Developmental Biology. 424, 1, p. 62-76 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF transcription factors, mediators of Wnt-signaling in development and cancer

Noort, M. V. & Clevers, J. C., 2002, In : Developmental Biology. 244, p. 1-8

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF transcription factors: molecular switches in carcinogenesis

Roose, J. & Clevers, J. C., 1999, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1424

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

Huang, H. Y., Houwing, S., Kaaij, L. J., Meppelink, A., Redl, S., Gauci, S., Vos, H., Draper, B. W., Moens, C. B., Burgering, B., Ladurner, P., Krijgsveld, J., Berezikov, E. & Ketting, R. F., 2011, In : EMBO Journal. 30, 16, p. 3298-3308

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification

Roovers, E. F., Kaaij, L. J. T., Redl, S., Bronkhorst, A. W., Wiebrands, K., de Jesus Domingues, A. M., Huang, H-Y., Han, C-T., Riemer, S., Dosch, R., Salvenmoser, W., Grün, D., Butter, F., van Oudenaarden, A. & Ketting, R. F., 06 Aug 2018, In : Developmental Cell. 46, 3, p. 285-301.e9

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Temporal precision of regulated gene expression

Gupta, S., Varennes, J., Korswagen, H. C. & Mugler, A., Jun 2018, In : PLoS Computational Biology. 14, 6, p. e1006201

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

Fessler, E., Drost, J., van Hooff, S. R., Linnekamp, J. F., Wang, X., Jansen, M., De Sousa E Melo, F., Prasetyanti, P. R., IJspeert, J. E., Franitza, M., Nürnberg, P., van Noesel, C. J., Dekker, E., Vermeulen, L., Clevers, H. & Medema, J. P., 2016, In : EMBO Molecular Medicine. 8, 7, p. 745-60 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion

Spinnler, R., Gorski, T., Stolz, K., Schuster, S., Garten, A., Beck-Sickinger, A. G., Engelse, M. A., de Koning, E. J., Korner, A., Kiess, W. & Maedler, K., 2013, In : PLoS One. 8, 1, p. 54106

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.

Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kuhl, M., Schaeffer, H. J., Huelsken, J., Behrens, J., Hammerschmidt, M. & Birchmeier, W., 2002, In : Genes & Development. 16, 16, p. 2073-2084

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation.

Claycomb, J. M., Batista, P. J., Pang, K. M., Gu, W., Vasale, J. J., van Wolfswinkel, J. C., Chaves, D. A., Shirayama, M., Mitani, S., Ketting, R. F., Co nte D, J. R. & Mello, C. C., 2009, In : Cell. 139, 1, p. 123-134

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Atp1a1 gene from inbred Dahl salt sensitive rats does not contain the A1079T missense transversion.

Mokry, M. & Cuppen, E., 2008, In : Hypertension. 51, 4, p. 922-927

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans

Korswagen, H. C., Coudreuse, D. Y., Betist, M. C., Water, S. V. D., Zivkovic, D. & Clevers, J. C., 2002, In : Genes & Development. 16, p. 1291-1302

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The beta catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

Wetering, M. V. D., Sancho, E., Verweij, C., Lau, W. D., Oving, I., Hurlstone, A., Horn, K. V. D., Batlle, E., Coudreuse, D., Haramis, A. P., Tjon-Pon-Fong, M., Moerer, P., Born, M. V. D., Soete, G., Pals, S., Eilers, M., Medema, R. & Clevers, J. C., 2002, In : Cell. 111, p. 241-250

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival

Ioannidis, V., Beermann, F., Clevers, J. C. & Held, W., 2001, In : Nature Immunology. 2, p. 691-697

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis

Sylva, M., Li, V. S., Buffing, A. A., van Es, J. H., van den Born, M. M. W., van der Velden, S., Gunst, Q., Koolstra, J. H., Moorman, A. F., Clevers, H. & van den Hoff, M. J., 2011, In : PLoS One. 6, 8, p. 22616

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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The Caenorhabditis elegans Q neuroblasts: A powerful system to study cell migration at single-cell resolution in vivo

Rella, L., Fernandes Póvoa, E. E. & Korswagen, H. C., Apr 2016, In : Genesis. 54, 4, p. 198-211 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The cancer stem cell: premises, promises and challenges

Clevers, H., 2011, In : Nature Medicine. 17, 3, p. 313-319

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

Barker, N., Hurlstone, A., Musisi, H., Miles, A., Bienz, M. & Clevers, J. C., 2001, In : EMBO Journal. 20, p. 4935-4943

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The complex transcription regulatory landscape of our genome: control in three dimensions

Splinter, E. & de Laat, W., 2011, In : EMBO Journal. 30, 21, p. 4345-4355

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

Hurst, L. D., Ghanbarian, A. T., Forrest, A. R. R. & Huminiecki, L., Dec 2015, In : PLoS Biology. 13, 12, p. e1002315

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

t Hart, L. M., Fritsche, A., Nijpels, G., van Leeuwen, N., Donnelly, L. A., Dekker, J. M., Alssema, M., Fadista, J., Carlotti, F., Gjesing, A. P., Palmer, C. N., van Haeften, T. W., Herzberg-Schafer, S. A., Simonis-Bik, A. M., Houwing-Duistermaat, J. J., Helmer, Q., Deelen, J., Guigas, B., Hansen, T., Machicao, F. & 14 others, Willemsen, G., Heine, R. J., Kramer, M. H., Holst, J. J., de Koning, E. J., Haring, H. U., Pedersen, O., Groop, L., de Geus, E. J., Slagboom, P. E., Boomsma, D. I., Eekhoff, E. M., Pearson, E. R. & Diamant, M., 2013, In : Diabetes. 62, 9, p. 3275-3281

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

Bongers, G., Maussang, D., Muniz, L. R., Noriega, V. M., Fraile-Ramos, A., Barker, N., Marchesi, F., Thirunarayanan, N., Vischer, H. F., Qin, L., Mayer, L., Harpaz, N., Leurs, R., Furtado, G. C., Clevers, H., Tortorella, D., Smit, M. J. & Lira, S. A., 2010, In : Journal of Clinical Investigation. 120, 11, p. 3969-3978

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion

Steller, E. J., Ritsma, L., Raats, D. A., Hoogwater, F. J., Emmink, B. L., Govaert, K. M., Laoukili, J., Rinkes, I. H., van Rheenen, J. & Kranenburg, O., 2011, In : EMBO Reports. 12, 9, p. 931-937

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The different shades of mammalian pluripotent stem cells

Kuijk, E. W., Lopes, S. M., Geijsen, N., Macklon, N. & Roelen, B. A., 2011, In : Human Reproduction Update. 17, 2, p. 254-271

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The diverse functions of microRNAs in animal development and disease.

Kloosterman, W. P. & Plasterk, R. H. A., 2006, In : Developmental Cell. 11, 4, p. 441-450

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium

Giuliani, G., Giuliani, F., Volk, T. & Rabouille, C., Feb 2014, In : Nucleic Acids Research. 42, 3, p. 1970-86 17 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The drug-resistance-related protein LRP is the human major vault protein

Scheffer, G. L., Wijngaard, P. L. J., Flens, M. J., Izquierdo, M. A., Slovak, M. L., Pinedo, H. M., Meijer, C. J. L. M., Clevers, J. C. & Scheper, R. J., 1995, In : Nature Medicine. 1, p. 578-582

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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The Dynamic Architecture of Hox Gene Clusters

Noordermeer, D., Leleu, M., Splinter, E., Rougemont, J., de Laat, W. & Duboule, D., 2012, In : Science Magazine. 334, 6053, p. 222-225 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females

van den Bos, R., Homberg, J. R., Gijsbers, E., den Heijer, E. J. & Cuppen, E., 2009, In : Neuropharmacology. 56, 2, p. 493-498

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Efficacy of Cardiac Anti-miR-208a Therapy Is Stress Dependent

Eding, J. E. C., Demkes, C. J., Lynch, J. M., Seto, A. G., Montgomery, R. L., Semus, H. M., Jackson, A. L., Isabelle, M., Chimenti, S. & van Rooij, E., 01 Mar 2017, In : Molecular Therapy. 25, 3, p. 694-704 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The emerging role of retromer in neuroprotection

McMillan, K. J., Korswagen, H. C. & Cullen, P. J., Aug 2017, In : Current Opinion in Immunology. 47, p. 72-82 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

Gregorieff, A., Stange, D. E., Kujala, P., Begthel, H. L., van den Born, M. M. W., Korving, J., Peters, P. J. & Clevers, H., 2009, In : Gastroenterology. 137, 4, p. 1333-1333

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima

Chipman, A. D., Ferrier, D. E. K., Brena, C., Qu, J., Hughes, D. S. T., Schröder, R., Torres-Oliva, M., Znassi, N., Jiang, H., Almeida, F. C., Alonso, C. R., Apostolou, Z., Aqrawi, P., Arthur, W., Barna, J. C. J., Blankenburg, K. P., Brites, D., Capella-Gutiérrez, S., Coyle, M., Dearden, P. K. & 86 others, Du Pasquier, L., Duncan, E. J., Ebert, D., Eibner, C., Erikson, G., Evans, P. D., Extavour, C. G., Francisco, L., Gabaldón, T., Gillis, W. J., Goodwin-Horn, E. A., Green, J. E., Griffiths-Jones, S., Grimmelikhuijzen, C. J. P., Gubbala, S., Guigó, R., Han, Y., Hauser, F., Havlak, P., Hayden, L., Helbing, S., Holder, M., Hui, J. H. L., Hunn, J. P., Hunnekuhl, V. S., Jackson, L., Javaid, M., Jhangiani, S. N., Jiggins, F. M., Jones, T. E., Kaiser, T. S., Kalra, D., Kenny, N. J., Korchina, V., Kovar, C. L., Kraus, F. B., Lapraz, F., Lee, S. L., Lv, J., Mandapat, C., Manning, G., Mariotti, M., Mata, R., Mathew, T., Neumann, T., Newsham, I., Ngo, D. N., Ninova, M., Okwuonu, G., Ongeri, F., Palmer, W. J., Patil, S., Patraquim, P., Pham, C., Pu, L-L., Putman, N. H., Rabouille, C., Ramos, O. M., Rhodes, A. C., Robertson, H. E., Robertson, H. M., Ronshaugen, M., Rozas, J., Saada, N., Sánchez-Gracia, A., Scherer, S. E., Schurko, A. M., Siggens, K. W., Simmons, D., Stief, A., Stolle, E., Telford, M. J., Tessmar-Raible, K., Thornton, R., van der Zee, M., von Haeseler, A., Williams, J. M., Willis, J. H., Wu, Y., Zou, X., Lawson, D., Muzny, D. M., Worley, K. C., Gibbs, R. A., Akam, M. & Richards, S., Nov 2014, In : PLoS Biology. 12, 11, p. e1002005

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research

Simanov, D., Mellaart-Straver, I., Sormacheva, I. & Berezikov, E., 2012, In : Stem Cells International. 2012, p. 167265

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1

Lau, W. B. M. D., Hurenkamp, J., Berendes, P., Touw, I. P., Clevers, J. C. & Dijk, M. A. V., 1998, In : Oncogene. 17, p. 503-510

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Generation of Organoids for Studying Wnt Signaling

Drost, J., Artegiani, B. & Clevers, H., 2016, In : Methods in Molecular Biology. 1481, p. 141-59 19 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance

Atanur, S. S., Birol, I., Guryev, V., Hirst, M., Hummel, O., Morrissey, C., Behmoaras, J., Fernandez-Suarez, X. M., Johnson, M. D., McLaren, W. M., Patone, G., Petretto, E., Plessy, C., Rockland, K. S., Rockland, C., Saar, K., Zhao, Y., Carninci, P., Flicek, P., Kurtz, T. & 6 others, Cuppen, E., Pravenec, M., Hubner, N., Jones, S., Birney, E. & Aitman, T., 2010, In : Genome Research. 20, 6, p. 791-803

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16

van der Linden, A. M., Simmer, F., Cuppen, E. & Plasterk, R., 2001, In : Genetics. 158, 1, p. 221-235

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system

Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S. & Pachnis, V., 02 Nov 2015, In : Gut Microbes. 6, 6, p. 398-403 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The HB4 monoclonal antibody recognizes a carbohydrate structure on lymphocyte surface proteins, related to HB6, CDw75 and CD76

Lau, W. B. M. D., Kuipers, J., Voshol, H., Clevers, J. C. & Bast, E. J. E. G., 1993, In : Journal of Immunology. 150, p. 4911-4919

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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The Hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano

Demircan, T. & Berezikov, E., 2013, In : Stem Cells and Development. 22, 15, p. 2174-2185

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The HMG box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA

Mayer, K., Wolff, E., Clevers, J. C. & Ballhausen, W. G., 1995, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1263, p. 169-172

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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The Human Cell Atlas

05 Dec 2017, In : eLife. 6, e27041.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The human Tcf-1 gene encodes a nuclear DNA-binding protein, uniquely expressed in normal and neoplastic T lineage lymphocytes

Castrop, J., Wichen, D. V., Koomans-Bitter, M., Wetering, M. V. D., Weger, R. D., Dongen, J. V. & Clevers, J. C., 1995, In : Blood. 86, p. 3050-3059

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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The human TRIDENT/HFH-11/FKHL16 gene: structure, localization and promoter characterization

Korver, W., Roose, J., Heinen, K., Olde Weghuis, D., Bruijn, D. D., Geurts van Kessel, A. & Clevers, J. C., 1997, In : Genomics. 46, p. 435-442

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

Splinter, E., de Wit, E., Nora, E. P., Klous, P., van de Werken, H., Zhu, Y., Kaaij, L. J., van Ijcken, W., Gribnau, J., Heard, E. & de Laat, W., 2011, In : Genes & Development. 25, 13, p. 1371-1383

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.

Markiewicz, E., Tilgner, K., Wetering, M. V. D., Clevers, J. C., Dorobek, M., Haumanowa-Petrusewicz, I., Ramaekers, F. C. S., Broers, J. L. V., Blankesteijn, W. M., Salpingidou, G., Wilson, R. G., Ellis, J. A. & Hutchison, C. J., 2006, In : EMBO Journal. 25, p. 3275-3285

Research output: Contribution to journal/periodicalArticleScientificpeer-review