• Netherlands

  • Netherlands

Research Output

Article

The time is right: proteome biology of stem cells.

Whetton, A. D., Williamson, A. J. K., Krijgsveld, J., Lee, B. H., Lemischka, I., Oh, S., Pera, M., Mummery, C. L. & Heck, A. J. R., 2008, In : Cell Stem Cell. 2, 3, p. 215-217

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The transmembrane orientation of the epsilon chain of the TCR/CD3 complex

Clevers, J. C., Dunlap, S. & Terhorst, C., 1988, In : European Journal of Immunology. 18, p. 705-710

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
317 Downloads (Pure)

The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

Schwamborn, J. C., Berezikov, E. & Knoblich, J. A., 2009, In : Cell. 136, 5, p. 913-925

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2alpha.

Gort, E. H., van Haaften, G., Verlaan, I., Groot, A. J., Plasterk, R., Shvarts, A., Suijkerbuijk, K. P. M., van Laar, T., van der Wall, E., Raman, V., van Diest, P. J., Tijsterman, M. & Vooijs, M., 2008, In : Oncogene. 27, 11, p. 1501-1510

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan

Rabouille, C., 18 Apr 2019, In : Molecular Cell. 74, 2, p. 225-226 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2

Essers, P. B., Klasson, T. D., Pereboom, T. C., Mans, D. A., Nicastro, M., Boldt, K., Giles, R. H. & MacInnes, A. W., 05 Feb 2015, In : Oncogene. 34, 6, p. 771-9 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes

Korver, W., Roose, J., Wilson, A. & Clevers, J. C., 1997, In : Immunobiology. 198, p. 157-161

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
261 Downloads (Pure)

The winged-helix transcription factor Trident is expressed in cycling cells

Korver, W., Roose, J. & Clevers, J. C., 1997, In : Nucleic Acids Research. 25, p. 1715-1719

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
475 Downloads (Pure)

The Wnt/beta-catenin pathway regulates cardiac valve formation

Hurlstone, A. F., Haramis, A. P., Wienholds, E., Begthel, H. L., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R. & Clevers, J. C., 2003, In : Nature. 425, 6958, p. 633-637

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., Wetering, M. V. D., Destree, O. & Clevers, J. C., 1998, In : Nature. 395, p. 608-612

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Yin-Yang of TCF/b-Catenin Signaling

Barker, N., Morin, P. J. & Clevers, J. C., 2000, In : Advances in Cancer Research. 77, p. 1-24

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment

Helker, C. S., Schuermann, A., Karpanen, T., Zeuschner, D., Belting, H. G., Affolter, M., Schulte-Merker, S. & Herzog, W., 2013, In : Development. 140, 13, p. 2776-2786

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The zebrafish reference genome sequence and its relationship to the human genome.

Howe, K., Clark, M. D., Torroja, C. F., Torrance, J., Berthelot, C., Muffato, M., Collins, J. E., Humphray, S., McLaren, K., Matthews, L., McLaren, S., Sealy, I., Caccamo, M., Churcher, C., Scott, C., Barrett, J. C., Koch, R., Rauch, G. J., White, S., Chow, W. & 157 others, Kilian, B., Quintais, L. T., Guerra-Assuncao, J. A., Zhou, Y., Gu, Y., Yen, J., Vogel, J. H., Eyre, T., Redmond, S., Banerjee, R., Chi, J., Fu, B., Langley, E., Maguire, S. F., Laird, G. K., Lloyd, D., Kenyon, E., Donaldson, S., Sehra, H., Almeida-King, J., Loveland, J., Trevanion, S., Jones, M., Quail, M., Willey, D., Hunt, A., Burton, J., Sims, S., McLay, K., Plumb, B., Davis, J., Clee, C., Oliver, K., Clark, R., Riddle, C., Elliot, D., Threadgold, G., Harden, G., Ware, D., Mortimore, B., Kerry, G., Heath, P., Phillimore, B., Tracey, A., Corby, N., Dunn, M., Johnson, C., Wood, J., Clark, S., Pelan, S., Griffiths, G., Smith, M., Glithero, R., Howden, P., Barker, N., Stevens, C., Harley, J., Holt, K., Panagiotidis, G., Lovell, J., Beasley, H., Henderson, C., Gordon, D., Auger, K., Wright, D., Collins, J., Raisen, C., Dyer, L., Leung, K., Robertson, L., Ambridge, K., Leongamornlert, D., McGuire, S., Gilderthorp, R., Griffiths, C., Manthravadi, D., Nichol, S., Barker, G., Whitehead, S., Kay, M., Brown, J., Murnane, C., Gray, E., Humphries, M., Sycamore, N., Barker, D., Saunders, D., Wallis, J., Babbage, A., Hammond, S., Mashreghi-Mohammadi, M., Barr, L., Martin, S., Wray, P., Ellington, A., Matthews, N., Ellwood, M., Woodmansey, R., Clark, G., Cooper, J., Tromans, A., Grafham, D., Skuce, C., Pandian, R., Andrews, R., Harrison, E., Kimberley, A., Garnett, J., Fosker, N., Hall, R., Garner, P., Kelly, D., Bird, C., Palmer, S., Gehring, I., Berger, A., Dooley, C. M., Ersan-Urun, Z., Eser, C., Geiger, H., Geisler, M., Karotki, L., Kirn, A., Konantz, J., Konantz, M., Oberlander, M., Rudolph-Geiger, S., Teucke, M., Osoegawa, K., Zhu, B., rapp, A., Widaa, S., Langford, C., Yang, F., Carter, N. P., Harrow, J., Ning, Z., Herrero, J., Searle, S. M., Enright, A., Geisler, R., Plasterk, R. H. A., Lee, C., Westerfield, M., de Jong, P. J., Zon, L. I., Postlethwait, J. H., Nusslein-Volhard, C., Hubbard, T. J., Roest Crollius, H., Rogers, J., Stemple, D. L., Begum, S., Lloyd, C., Lanz, C., Raddatz, G. & Schuster, S. C., 2013, In : Nature. 496, 7446, p. 498-503

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL

Cuppen, E., Wansink, D. G., de Leeuw, A., Wieringa, B., Hendriks, W. & van der Ham, M., 2000, In : European Journal of Cell Biology. 79, 4, p. 283-293

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Thirty Years of Pancreas Transplantation at Leiden University Medical Center: Long-Term Follow-Up in a Large Eurotransplant Center

Kopp, W. H., Verhagen, M. J. J., Blok, J. J., Huurman, V. A. L., de Fijter, J. W., de Koning, E. J., Putter, H., Baranski, A. G., Schaapherder, A. F. M., Braat, A. E. & Ringers, J., 20 Feb 2015, In : Cell Transplantation.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Thoughts on thymus and T-lymphocyte repertoire. Relevance to the tolerance of the immune response

Schuurman, H. J., Hu, H., Weger, R. A. D. & Clevers, J. C., 1993, In : Netherlands Journal of Medicine. 43, p. 38-54

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Thymocyte development: drama without Brahma

Clevers, J. C., 2003, In : Immunity. 19, p. 157-158

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue- and expression level-specific chromatin looping at maize b1 epialleles.

Louwers, M., Bader, R., Haring, M., van Driel, R., de Laat, W. & Stam, M., 2009, In : Plant Cell. 21, 3, p. 832-842

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

Cabeza-Cabrerizo, M., van Blijswijk, J., Wienert, S., Heim, D., Jenkins, R. P., Chakravarty, P., Rogers, N., Frederico, B., Acton, S., Beerling, E., van Rheenen, J., Clevers, H., Schraml, B. U., Bajénoff, M., Gerner, M., Germain, R. N., Sahai, E., Klauschen, F. & Reis E Sousa, C., 01 Mar 2019, In : Science immunology. 4, 33

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue-Engineering the Intestine: The Trials before the Trials

Clevers, H., Conder, R. K., Li, V. S. W., Lutolf, M. P., Vallier, L., Chan, S., Grikscheit, T. C., Jensen, K. B. & De Coppi, P., 06 Jun 2019, In : Cell Stem Cell. 24, 6, p. 855-859 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue-resident adult stem cell populations of rapidly self-renewing organs

Barker, N., Bartfeld, S. & Clevers, H., 2010, In : Cell Stem Cell. 7, 6, p. 656-670

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

Ariotti, S., Beltman, J. B., Chodaczek, G., Hoekstra, M. E., van Beek, A. E., Gomez-Eerland, R., Ritsma, L., van Rheenen, J., Maree, A. F., Zal, T., de Boer, R. J., Haanen, J. B. & Schumacher, T. N., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19739-19744

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue-specific designs of stem cell hierarchies

Visvader, J. E. & Clevers, H., Apr 2016, In : Nature Cell Biology. 18, 4, p. 349-55 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., Nijman, I. J., Martincorena, I., Mokry, M., Wiegerinck, C. L., Middendorp, S., Sato, T., Schwank, G., Nieuwenhuis, E. E. S., Verstegen, M. M. A., van der Laan, L. J. W. & 8 others, de Jonge, J., IJzermans, J. N. M., Vries, R. G., van de Wetering, M., Stratton, M. R., Clevers, H., Cuppen, E. & van Boxtel, R., 13 Oct 2016, In : Nature. 538, 7624, p. 260-264 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

De Angelis, J. E., Lagendijk, A. K., Chen, H., Tromp, A., Bower, N. I., Tunny, K. A., Brooks, A. J., Bakkers, J., Francois, M., Yap, A. S., Simons, C., Wicking, C., Hogan, B. M. & Smith, K. A., 23 Jan 2017, In : Developmental Cell. 40, 2, p. 123-136 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

De Angelis, J. E., Lagendijk, A. K., Chen, H., Tromp, A., Bower, N. I., Tunny, K. A., Brooks, A. J., Bakkers, J., Francois, M., Yap, A. S., Simons, C., Wicking, C., Hogan, B. M. & Smith, K. A., 27 Feb 2017, In : Developmental Cell. 40, 4, p. 421

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

TMEM59 potentiates Wnt signaling by promoting signalosome formation

Gerlach, J. P., Jordens, I., Tauriello, D. V. F., van 't Land-Kuper, I., Bugter, J. M., Noordstra, I., van der Kooij, J., Low, T. Y., Pimentel-Muiños, F. X., Xanthakis, D., Fenderico, N., Rabouille, C., Heck, A. J. R., Egan, D. A. & Maurice, M. M., 24 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 17, p. E3996-E4005

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Toepassingen van levende biobank zijn grenzeloos

Bedaf, M. & Clevers, H., 2012, In : Oncology News International. 5, 6, p. 1-3 3 p.

Research output: Contribution to journal/periodicalArticlePopularizing

Tomo-seq: A method to obtain genome-wide expression data with spatial resolution

Kruse, F., Junker, J. P., van Oudenaarden, A. & Bakkers, J., 2016, In : Methods in Cell Biology. 135, p. 299-307 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury

Lacraz, G. P. A., Junker, J. P., Gladka, M. M., Molenaar, B., Scholman, K. T., Vigil-Garcia, M., Versteeg, D., de Ruiter, H., Vermunt, M. W., Creyghton, M. P., Huibers, M. M. H., de Jonge, N., van Oudenaarden, A. & van Rooij, E., 10 Oct 2017, In : Circulation. 136, 15, p. 1396-1409 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Topologically heterogeneous beta cell adaptation in response to high-fat diet in mice

Ellenbroek, J. H., Tons, H. A., de Graaf, N., Loomans, C. J., Engelse, M. A., Vrolijk, H., Voshol, P. J., Rabelink, T. J., Carlotti, F. & de Koning, E. J., 2013, In : PLoS One. 8, 2, p. 56922

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Topology of mammalian developmental enhancers and their regulatory landscapes

de Laat, W. & Duboule, D., 2013, In : Nature. 502, 7472, p. 499-506

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules

Jevtov, I., Zacharogianni, M., van Oorschot, M. M., van Zadelhoff, G., Aguilera-Gomez, A., Vuillez, I., Braakman, I., Hafen, E., Stocker, H. & Rabouille, C., 15 Jul 2015, In : Journal of Cell Science. 128, 14, p. 2497-508 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Toward effective software solutions for big biology

Prins, P., de Ligt, J., Tarasov, A., Jansen, R. C., Cuppen, E. & Bourne, P. E., Jul 2015, In : Nature Biotechnology. 33, 7, p. 686-7 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Towards a molecular understanding of T cell differentiation

Clevers, J. C. & Owen, M., 1991, In : Immunology Today. 12, p. 86-92

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
295 Downloads (Pure)

Towards personalized therapy in pediatric acute lymphoblastic leukemia: RAS mutations and prednisolone resistance

Ariës, I. M., van den Dungen, R. E., Koudijs, M. J., Cuppen, E., Voest, E., Molenaar, J. J., Caron, H. N., Pieters, R. & den Boer, M. L., Apr 2015, In : Haematologica. 100, 4, p. e132-6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Tracing the evolution of tissue identity with microRNAs

De Mulder, K. & Berezikov, E., 2010, In : Genome Biology. 11, 3, p. 111

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tracing the history of goat pastoralism: new clues from mitochondrial and Y chromosome DNA in North Africa

Pereira, F., Queiros, S., Gusmao, L., Nijman, I. J., Cuppen, E., Lenstra, J. A., Consortium, E., Davis, S. J., Nejmeddine, F. & Amorim, A., 2009, In : Molecular Biology and Evolution. 26, 12, p. 2765-2773

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tracking adult stem cells

Snippert, H. J. G. & Clevers, H., 2011, In : EMBO Reports. 12, 2, p. 113-122

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptional control during T cell development

Clevers, J. C. & Ferrier, P., 1998, In : Current Opinion in Cell Biology. 10, p. 166-171

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptional control of lymphoid development. Lessons from gene targeting

Clevers, J. C. & Grosschedl, R., 1996, In : Immunology Today. 17, p. 336-343

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
731 Downloads (Pure)

Transcriptional Control of T Lymphocyte Differentiation

Staal, F. J. T., Weerkamp, F., Langerak, A. W., Hendriks, R. W. & Clevers, J. C., 2001, In : Stem Cells. 19, p. 165-179

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration

Vermunt, M. W. & Creyghton, M. P., 2016, In : Current Neurology and Neuroscience Reports. 16, 10, p. 94

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Transcriptional profiling of cells sorted by RNA abundance

Klemm, S., Semrau, S., Wiebrands, K., Mooijman, D., Faddah, D. A., Jaenisch, R. & van Oudenaarden, A., May 2014, In : Nature Methods. 11, 5, p. 549-51 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway.

Huang, Z., Xie, H., Ioannidis, V., Held, W., Clevers, J. C., Sadim, M. S. & Sun, Z., 2006, In : Journal of Immunology. 176, p. 4880-4887

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

Liu, X., Chen, X., Zhong, B., Wang, A., Wang, X., Chu, F., Nurieva, R. I., Yan, X., Chen, P., van der Flier, L. G., Nakatsukasa, H., Neelapu, S. S., Chen, W., Clevers, H., Tian, Q., Qi, H., Wei, L. & Dong, C., 27 Mar 2014, In : Nature. 507, 7493, p. 513-8 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

van der Flier, L. G., van Gijn, M. E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D. E., Begthel, H. L., van den Born, M. M. W., Guryev, V., Oving, I. M., van Es, J. H., Barker, N., Peters, P. J., van de Wetering, M. L. & Clevers, H., 2009, In : Cell. 136, 5, p. 903-912

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

Yang, X. H., Nadadur, R. D., Hilvering, C. R., Bianchi, V., Werner, M., Mazurek, S. R., Gadek, M., Shen, K. M., Goldman, J. A., Tyan, L., Bekeny, J., Hall, J. M., Lee, N., Perez-Cervantes, C., Burnicka-Turek, O., Poss, K. D., Weber, C. R., de Laat, W., Ruthenburg, A. J. & Moskowitz, I. P., 27 Dec 2017, In : eLife. 6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Transcription factors in early T cell development

Clevers, J. C., Oosterwegel, M. A. & Georgopoulos, K., 1993, In : Immunology Today. 14, p. 591-596

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
269 Downloads (Pure)

Transcription factor target practice.

Hostege, F. C. P. & Clevers, J. C., 2006, In : Cell. 124, p. 21-23

Research output: Contribution to journal/periodicalArticleScientificpeer-review