• Netherlands

  • Netherlands

Research Output

Article

Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

Ouahed, J., Spencer, E., Kotlarz, D., Shouval, D. S., Kowalik, M., Peng, K., Field, M., Grushkin-Lerner, L., Pai, S-Y., Bousvaros, A., Cho, J., Argmann, C., Schadt, E., Mcgovern, D. P. B., Mokry, M., Nieuwenhuis, E., Clevers, H., Powrie, F., Uhlig, H., Klein, C. & 3 others, Muise, A., Dubinsky, M. & Snapper, S. B., 03 Dec 2019, In : Inflammatory Bowel Diseases.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

Frentzas, S., Simoneau, E., Bridgeman, V. L., Vermeulen, P. B., Foo, S., Kostaras, E., Nathan, M. R., Wotherspoon, A., Gao, Z-H., Shi, Y., Van den Eynden, G., Daley, F., Peckitt, C., Tan, X., Salman, A., Lazaris, A., Gazinska, P., Berg, T. J., Eltahir, Z., Ritsma, L. & 11 others, van Rheenen, J., Khashper, A., Brown, G., Nyström, H., Sund, M., Van Laere, S., Loyer, E., Dirix, L., Cunningham, D., Metrakos, P. & Reynolds, A. R., Nov 2016, In : Nature Medicine. 22, 11, p. 1294-1302 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling

Huveneers, S., Oldenburg, J., Spanjaard, E., Van Der Krogt, G., Grigoriev, I., Akhmanova, A., Rehmann, H. & de Rooij, J., 2012, In : Journal of Cell Biology. 196, 5, p. 641-652

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation

Twiss, F., le Duc, Q., van der Horst, S., Tabdili, H., Van Der Krogt, G., Wang, N., Rehmann, H., Huveneers, S., Leckband, D. E. & de Rooij, J., 2012, In : Biology Open. 1, 11, p. 1128-1140

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner

le Duc, Q., Shi, Q., Blonk, I., Sonnenberg, A., Wang, N., Leckband, D. & de Rooij, J., 2010, In : Journal of Cell Biology. 189, 7, p. 1107-1115

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies

Ramanan, V., Trehan, K., Ong, M-L., Luna, J. M., Hoffmann, H-H., Espiritu, C., Sheahan, T. P., Chandrasekar, H., Schwartz, R. E., Christine, K. S., Rice, C. M., van Oudenaarden, A. & Bhatia, S. N., Jul 2016, In : Virology. 494, p. 236-47 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Visceral endoderm induces specification of cardiomyocytes in mice

Nijmeijer, R. M., Leeuwis, J. W., DeLisio, A., Mummery, C. L. & Chuva de Sousa Lopes, S. M., 2009, In : Stem Cell Research. 3, 2-3, p. 170-178

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

Farin, H. F., Jordens, I., Mosa, M. H., Basak, O., Korving, J., Tauriello, D. V. F., de Punder, K., Angers, S., Peters, P. J., Maurice, M. M. & Clevers, H., 18 Feb 2016, In : Nature. 530, 7590, p. 340-3 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish

van Rooijen, E., Voest, E. E., Logister, I., Bussmann, J., Korving, J., van Eeden, F. J., Giles, R. H. & Schulte-Merker, S., 2010, In : Disease Models & Mechanisms. 3, 5-6, p. 343-353

Research output: Contribution to journal/periodicalArticleScientificpeer-review

WGA activates human T lymphocytes by stimulation of phosphoinositide hydrolysis

Clevers, J. C., Bresser, A. D., Kleinveld, H., Gmelig-Meyling, F. H. J. & Ballieux, R. E., 1986, In : Journal of Immunology. 136, p. 3180-3183

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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What does the concept of the stem cell niche really mean today?

Lander, A. D., Kimble, J., Clevers, H., Fuchs, E., Montarras, D., Buckingham, M., Calof, A. L., Trumpp, A. & Oskarsson, T., 2012, In : BMC Biology. 10, p. 19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

When noisy neighbors are a blessing: analysis of gene expression noise identifies coregulated genes

Junker, J. P. & van Oudenaarden, A., 2012, In : Molecular Cell. 45, 4, p. 437-438

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding

Drost, J. & Clevers, H., 04 Aug 2016, In : Molecular Cell. 63, 3, p. 352-4 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

Wang, K., Yuen, S. T., Xu, J., Lee, S. P., Yan, H. H. N., Shi, S. T., Siu, H. C., Deng, S., Chu, K. M., Law, S., Chan, K. H., Chan, A. S. Y., Tsui, W. Y., Ho, S. L., Chan, A. K. W., Man, J. L. K., Foglizzo, V., Ng, M. K., Chan, A. S., Ching, Y. P. & 8 others, Cheng, G. H. W., Xie, T., Fernandez, J., Li, V. S. W., Clevers, H., Rejto, P. A., Mao, M. & Leung, S. Y., Jun 2014, In : Nature Genetics. 46, 6, p. 573-82 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Whole-organism clone tracing using single-cell sequencing

Alemany, A., Florescu, M., Baron, C. S., Peterson-Maduro, J. & van Oudenaarden, A., 05 Apr 2018, In : Nature. 556, 7699, p. 108-112 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt, stem cells and cancer in the intestine.

Pinto, D. & Clevers, J. C., 2005, In : Biology of the cell / under the auspices of the European Cell Biology Organization. 97, p. 185-196

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/beta-catenin and MAPK signaling: allies and enemies in different battlefields

Guardavaccaro, D. & Clevers, H., 2012, In : Science Signaling. 5, 219, p. 15

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/beta-catenin signaling and disease

Clevers, H. & Nusse, R., 2012, In : Cell. 149, 6, p. 1192-1205

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/beta-catenin signaling in development and disease.

Clevers, J. C., 2006, In : Cell. 127, p. 469-480

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/beta-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine

Lickert, H., Domon, C., Huls, G., Wehrle, C., Duluc, I., Clevers, J. C., Meyer, B. I., Freund, J. N. & Kemler, R., 2000, In : Development. 127, p. 3805-3813

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Nusse, R. & Clevers, H., 01 Jun 2017, In : Cell. 169, 6, p. 985-999 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Kretzschmar, K. & Clevers, H., 15 Aug 2017, In : Developmental Biology. 428, 2, p. 273-282 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice

Galceran, J., Farinas, I., Depew, M. J., Clevers, J. C. & Grosschedl, R., 1999, In : Genes & Development. 13, p. 709-717

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt activates the Tak1/Nlk kinase pathway

Smit, L., Baas, A., Kuipers, J., Korswagen, H., Wetering, M. V. D. & Clevers, J. C., 2004, In : Journal of Biological Chemistry.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt control of stem cells and differentiation in the intestinal epithelium.

Pinto, D. & Clevers, J. C., 2005, In : Experimental Cell Research. 306, p. 357-363

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF

Schuijers, J., Mokry, M., Hatzis, P., Cuppen, E. & Clevers, H., 13 Jan 2014, In : EMBO Journal. 33, 2, p. 146-56 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnts as self-renewal factors: mammary stem cells and beyond

Verheyen, E. M. & Clevers, H., 2010, In : Cell Stem Cell. 6, 6, p. 494-495

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling, lgr5, and stem cells in the intestine and skin.

Haegebarth, A. & Clevers, H., 2009, In : American Journal of Pathology. 174, 3, p. 715-721

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling, stem cells, and cancer of the gastrointestinal tract

Schepers, A. & Clevers, H., 2012, In : Cold Spring Harbor perspectives in biology. 4, 4, p. 7989

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling: Ig-norrin the dogma

Clevers, J. C., 2004, In : Current Biology. 14, p. 437

Research output: Contribution to journal/periodicalArticleScientificpeer-review

WNT signaling and lymphocyte development

Wetering, M. V. D., Lau, W. D. & Clevers, J. C., 2002, In : Cell. 109

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Wnt signaling controls the phosphorylation status of beta-catenin

Noort, M. V., Meeldijk, J., Zee, R. V. D., Destree, O. & Clevers, J. C., 2002, In : Journal of Biological Chemistry. 277, p. 17901-17905

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling in Alzheimer's disease: up or down, that is the question

Boonen, R. A. C. M., van Tijn, P. & Zivkovic, D., 2009, In : Ageing Research Reviews. 8, 2, p. 71-82

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling in the intestinal epithelium: from endoderm to cancer.

Gregorieff, A. & Clevers, J. C., 2005, In : Genes & Development. 19, p. 877-890

Research output: Contribution to journal/periodicalArticleScientificpeer-review

WNT signaling in the normal intestine and colorectal cancer

Lau, W. D., Barker, N. & Clevers, J. C., 2007, In : Frontiers in Bioscience: a journal and virtual library. 12, p. 471-491

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling in the thymus

Staal, F. J. & Clevers, J. C., 2003, In : Current Opinion in Cell Biology. 15, p. 204-208

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

Staal, F. J. T., Meeldijk, J., Moerer, P., Jay, P., Weerdt, B. C. M. V. D., Vainio, S., Nolan, G. P. & Clevers, J. C., 2001, In : European Journal of Immunology. 31, p. 285-293

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

Verhoeven, M. C., Haase, C., Christoffels, V. M., Weidinger, G. & Bakkers, J., 2011, In : Birth Defects Research Part A: Clinical and Molecular Teratology. 91, 6, p. 435-440

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer

Boon, E. M., Neut, R. V. D., Wetering, M. V. D., Clevers, J. C. & Pals, S. T., 2002, In : Cancer Research. 62, p. 5126-5128

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells.

Yang, P. T., Lorenowicz, M. J., Silhankova, M., Coudreuse, D. Y. M., Betist, M. C. & Korswagen, H. C., 2008, In : Developmental Cell. 14, 1, p. 140-147

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex

Li, V. S., Ng, S. S., Boersema, P. J., Low, T. Y., Karthaus, W. R., Gerlach, J. P., Mohammed, S., Heck, A. J. R., Maurice, M. M., Mahmoudi, T. & Clevers, H., 2012, In : Cell. 149, 6, p. 1245-1256

Research output: Contribution to journal/periodicalArticleScientificpeer-review

WNT signalling and haematopoiesis: a WNT-WNT situation.

Staal, F. J. T. & Clevers, J. C., 2005, In : Nature Reviews Immunology. 5, p. 21-30

Research output: Contribution to journal/periodicalArticleScientificpeer-review

WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer

Driehuis, E. & Clevers, H., Dec 2017, In : British Journal of Pharmacology. 174, 24, p. 4547-4563 17 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Wnt signalling induces maturation of Paneth cells in intestinal crypts.

Es, J. H. V., Jay, P., Gregorieff, A., Gijn, M. E. V., Jonkheer, S., Hatzis, P., Thiele, A., Born, M. V. D., Gegthel, H., Brabletz, T., Taketo, M. M. & Clevers, J. C., 2005, In : Nature Cell Biology. 7, p. 381-386

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signalling in stem cells and cancer.

Reya, T. & Clevers, J. C., 2005, In : Nature. 434, p. 843-850

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells

Silhankova, M., Port, F., Harterink, M., Basler, K. & Korswagen, H. C., 2010, In : EMBO Journal. 29, 24, p. 4094-4105

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signals are transmitted through N-terminally dephosphorylated {beta}-catenin

Staal, F. J., Noort, M. V., Strous, G. J. & Clevers, J. C., 2002, In : EMBO Reports. 3, p. 63-68

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Woekerende kanker groeit uit stamcel

Clevers, H. & van Santen, H., 02 Aug 2012, In : NRC Handelsblad. Wetenschapsbijlage, p. 13-13 1 p.

Research output: Contribution to journal/periodicalArticlePopularizing

Xenograft and organoid model systems in cancer research

Bleijs, M., van de Wetering, M., Clevers, H. & Drost, J., 01 Aug 2019, In : EMBO Journal. 38, 15, p. e101654

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Xenopus egg extract: A powerful tool to study genome maintenance mechanisms

Hoogenboom, W. S., Klein Douwel, D. & Knipscheer, P., 15 Aug 2017, In : Developmental Biology. 428, 2, p. 300-309 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review