• Netherlands

  • Netherlands

Research Output

Article

Cdx2 contributes to the expansion of the early primordial germ cell population in the mouse

Bialecka, M., Young, T., Chuva de Sousa Lopes, S. M., ten Berge, D., Sanders, A., Beck, F. & Deschamps, J., 2012, In : Developmental Biology. 371, 2, p. 227-234

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cdx2 determines the fate of postnatal intestinal endoderm

Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N., Freund, J. N., Deschamps, J. & Beck, F., 2012, In : Development. 139, 3, p. 465-474

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Open Access
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Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

Young, T., Rowland, J. E., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., van Nes, J., de Graaff, W. G. A. J., Duluc, I., Freund, J. N., Beck, F., Mallo, M. & Deschamps, J., 2009, In : Developmental Cell. 17, 4, p. 516-526

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche

Amin, S., Neijts, R., Simmini, S., van Rooijen, C., Tan, S. C., Kester, L., van Oudenaarden, A., Creyghton, M. P. & Deschamps, J., 20 Dec 2016, In : Cell Reports. 17, 12, p. 3165-3177 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology

Neijts, R., Amin, S., van Rooijen, C. & Deschamps, J., 29 Dec 2016, In : Developmental Biology.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cdx mutant axial progenitor cells are rescued by grafting to a wild type environment

Bialecka, M., Wilson, V. & Deschamps, J., 2010, In : Developmental Biology. 347, 1, p. 228-234

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Celebrating 100 years of Developmental Biology at the Hubrecht Institute

den Hertog, J. & van Oudenaarden, A., 2017, In : Developmental Biology. 428, 2, p. 259-260

Research output: Contribution to journal/periodicalArticlePopularizing

Cell adaptation upon stress: the emerging role of membrane-less compartments

Rabouille, C. & Alberti, S., Aug 2017, In : Current Opinion in Immunology. 47, p. 34-42 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue

Nadra, K., Medard, J. J., Mul, J. D., Han, G. S., Gres, S., Pende, M., Metzger, D., Chambon, P., Cuppen, E., Saulnier-Blache, J. S., Carman, G. M., Desvergne, B. & Chrast, R., 2012, In : Molecular and Cellular Biology. 32, 23, p. 4794-4810

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cell biology. The unusual case of Porcupine

Lum, L. & Clevers, H., 2012, In : Science Magazine. 337, 6097, p. 922-923

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites

Kjaerulff, S., Dooijes, D., Clevers, J. C. & Nielsen, O., 1997, In : EMBO Journal. 16, p. 4021-4033

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Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans

Mentink, R. A., Middelkoop, T. C., Rella, L., Ji, N., Tang, C. Y., Betist, M. C., van Oudenaarden, A. & Korswagen, H. C., 27 Oct 2014, In : Developmental Cell. 31, 2, p. 188-201 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation

Teklenburg, G., Weimar, C. H., Fauser, B. C., Macklon, N., Geijsen, N., Heijnen, C. J., Lopes, S. M. & Kuijk, E. W., 2012, In : PLoS One. 7, 3, p. 32701

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming

Krijger, P. H. L., Di Stefano, B., de Wit, E., Limone, F., van Oevelen, C., de Laat, W. & Graf, T., 05 May 2016, In : Cell Stem Cell. 18, 5, p. 597-610 14 p.

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Open Access

Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression

van Zon, J. S., Kienle, S., Huelsz-Prince, G., Barkoulas, M. & van Oudenaarden, A., 2015, In : Nature Communications. 6, p. 7053

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cell Type Purification by Single-Cell Transcriptome-Trained Sorting

Baron, C. S., Barve, A., Muraro, M. J., van der Linden, R., Dharmadhikari, G., Lyubimova, A., de Koning, E. J. P. & van Oudenaarden, A., 03 Oct 2019, In : Cell. 179, 2, p. 527-542.e19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model

Braham, M. V. J., Minnema, M. C., Aarts, T., Sebestyen, Z., Straetemans, T., Vyborova, A., Kuball, J., Öner, F. C., Robin, C. & Alblas, J., 2018, In : OncoImmunology. 7, 6, p. e1434465

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cellular protection mechanisms that minimise accumulation of mutations in intestinal tissue

van Rheenen, J. & Bruens, L., 09 Nov 2017, In : Schweizerische Medizinische Wochenschrift. 147, p. w14539

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cellular stress leads to the formation of membraneless stress assemblies in eukaryotic cells

van Leeuwen, W. & Rabouille, C., Sep 2019, In : Traffic. 20, 9, p. 623-638 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells

Arner, E., Forrest, A. R. R., Ehrlund, A., Mejhert, N., Itoh, M., Kawaji, H., Lassmann, T., Laurencikiene, J., Rydén, M. & Arner, P., 2014, In : PLoS One. 9, 3, p. e80274

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

Beqqali, A., Monshouwer-Kloots, J., Monteiro, R., Welling, M., Bakkers, J., Ehler, E., Verkleij, A. J., Mummery, C. L. & Passier, R., 2010, In : Journal of Cell Science. 123, Pt 7, p. 1141-1150

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Characterization and dynamics of pericentromere-associated domains in mice

Wijchers, P. J., Geeven, G., Eyres, M., Bergsma, A. J., Janssen, M., Verstegen, M., Zhu, Y., Schell, Y., Vermeulen, C., de Wit, E. & de Laat, W., 16 Apr 2015, In : Genome Research.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Characterization and expression of the murine CD3-epsilon gene

Clevers, J. C., Dunlap, S., Saito, H., Georgopoulos, K., Wileman, T. & Terhorst, C., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, p. 8623-8627

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria-parva

Toye, P. G., Metzelaar, M. J., Wijngaard, P. L. J., Nene, V., Iams, K., Roose, J., Nyanjui, J. K., Gobright, E., Musoke, A. J. & Clevers, J. C., 1995, In : Journal of Immunology. 155, p. 1370-1381

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

Dekkers, J. F., Berkers, G., Kruisselbrink, E., Vonk, A., de Jonge, H. R., Janssens, H. M., Bronsveld, I., van de Graaf, E. A., Nieuwenhuis, E. E. S., Houwen, R. H. J., Vleggaar, F. P., Escher, J. C., de Rijke, Y. B., Majoor, C. J., Heijerman, H. G. M., de Winter-de Groot, K. M., Clevers, H., van der Ent, C. K. & Beekman, J. M., 22 Jun 2016, In : Science Translational Medicine. 8, 344, p. 344ra84

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells

Xu, X. Q., Graichen, R., Soo, S. Y., Balakrishnan, T., Bte Rahmat, S. N., Sieh, S., Tham, S. C., Freund, C. M. A. H., Moore, J., Mummery, C. L., Colman, A., Zweigerdt, R. & Davidson, B. P., 2008, In : Differentiation. 76, p. 958-970

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis

Qiu, W., Wang, X., Leibowitz, B., Liu, H., Barker, N., Okada, H., Oue, N., Yasui, W., Clevers, H., Schoen, R. E., Yu, J. & Zhang, L., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 46, p. 20027-20032

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chimeren helpen stamcelonderzoekers

Geijsen, N., 06 Dec 2013, In : Noorderlicht Online.

Research output: Contribution to journal/periodicalArticlePopularizing

Chlamydia trachomatis and genital human papillomavirus infections in female university students in Honduras.

Tabora, N., Zelaya, A., Bakkers, J., Melchers, W. J. & Ferrera, A., 2005, In : The American Journal of Tropical Medicine and Hygiene. 73, 1, p. 50-53

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes

07 May 2019, In : Journal of the American Heart Association. 8, 9, p. e011201

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Chromatin loops, gene positioning, and gene expression

Holwerda, S. & de Laat, W., 2012, In : Frontiers in Genetics. 3, p. 217

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline

Kloosterman, W. P., Guryev, V., van Roosmalen, M., Duran, K. J., de Bruijn, E., Bakker, S., Letteboer, T., van Nesselrooij, B., Hochstenbach, R., Poot, M. & Cuppen, E., 2011, In : Human Molecular Genetics. 20, 10, p. 1916-1924

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Open Access
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Chromothripsis in congenital disorders and cancer: similarities and differences

Kloosterman, W. P. & Cuppen, E., 2013, In : Current Opinion in Cell Biology. 25, 3, p. 341-348

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chromothripsis in healthy individuals affects multiple protein-coding genes and can result in severe congenital abnormalities in offspring

de Pagter, M. S., van Roosmalen, M. J., Baas, A. F., Renkens, I., Duran, K. J., van Binsbergen, E., Tavakoli-Yaraki, M., Hochstenbach, R., van der Veken, L. T., Cuppen, E. & Kloosterman, W. P., 02 Apr 2015, In : American Journal of Human Genetics. 96, 4, p. 651-6 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

Kloosterman, W. P., Hoogstraat, M., Paling, O., Tavakoli-Yaraki, M., Renkens, I., Vermaat, J. E., van Roosmalen, M., van Lieshout, S., Nijman, I. J., Roessingh, W., Van't Slot, R., van de Belt, J., Guryev, V., Koudijs, M. J., Voest, E. E. & Cuppen, E., 2011, In : Genome Biology. 12, 10, p. 103

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Open Access
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Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat

Mul, J. D., la Fleur, S. E., Toonen, P. W., Afrasiab-Middelman, A., Binnekade, R., Schetters, D., Verheij, M. M., Sears, R., Homberg, J. R., Schoffelmeer, A. N. M., Adan, R. A., DiLeone, R. J., Vries, T. & Cuppen, E., 2011, In : PLoS One. 6, 5, p. 19600

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Open Access
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Circadian clocks: from stem cells to tissue homeostasis and regeneration

Dierickx, P., Van Laake, L. W. & Geijsen, N., 19 Dec 2017, In : EMBO Reports.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Circadian networks in human embryonic stem cell-derived cardiomyocytes

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., Geijsen, N. & Van Laake, L. W., Jul 2017, In : EMBO Reports. 18, 7, p. 1199-1212 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Circumvention of tolerance for the nuclear T cell protein Tcf-1 by immunization of Tcf-1 knock-out mice

Castrop, J., Verbeek, S., Hofhuis, F. & Clevers, J. C., 1995, In : Immunobiology. 193, p. 281-287

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Clinical evidence for an association between familial adenomatous polyposis and type II diabetes

Nieuwenhuis, M. H., Douma, K. F., Bleiker, E. M., Aaronson, N. K., Clevers, H. & Vasen, H. F., 2012, In : International Journal of Cancer. 131, 6, p. 1488-1489

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1

Held, W., Kunz, B., Lowin-Kropf, B., Wetering, M. V. D. & Clevers, J. C., 1999, In : Immunity. 11, p. 433-442

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein

Hurlstone, A. F., Olave, I. A., Barker, N., Noort, M. V. & Clevers, J. C., 2002, In : Biochemical Journal. 364, p. 255-264

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cloning and expression of new microRNAs from zebrafish

Kloosterman, W. P., Steiner, F. A., Berezikov, E., de Bruijn, E. S., van de Belt, J., Verheul, M., Cuppen, E. & Plasterk, R., 2006, In : Nucleic Acids Research. 34, 9, p. 2558-2569

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cloning-free CRISPR

Arbab, M., Srinivasan, S., Hashimoto, T., Geijsen, N. & Sherwood, R. I., 27 Oct 2015, In : Stem Cell Reports.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cloning of the murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and TCR-alpha enhancers

Oosterwegel, M., Wetering, M. V. D., Dooijes, D., Klomp, L., Winoto, A., Georgopoulos, K., Meijlink, F. & Clevers, J. C., 1991, In : Journal of Experimental Medicine. 173, p. 1133-1142

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Close linkage of the mouse and human CD3-g and d genes suggests a control of their transcription by common regulatory elements

Saito, H., Koyama, T., Georgopoulos, K., Clevers, J. C., Haser, W. G., LeBien, T., Tonegawa, S. & Terhorst, C., 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, p. 9131-9134

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Clustering of monoclonal-antibodies recognizing different members of the WC1 gene family

MacHugh, N. D., Wijngaard, P. L. J., Clevers, J. C. & Davis, W. C., 1993, In : Veterinary Immunology and Immunopathology. 39, p. 155-160

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c-Myb is required for progenitor cell homeostasis in colonic crypts

Malaterre, J., Carpinelli, M., Ernst, M., Alexander, W., Cooke, M., Sutton, S., Dworkin, S., Heakth, J. K., Frampton, J., McArthur, G., Clevers, J. C., Hilton, D., Mantamadiotis, T. & Ramsay, R. G., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, p. 3829-3834

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Coculturing Human Islets with Proangiogenic Support Cells to Improve Islet Revascularization at the Subcutaneous Transplantation Site

Buitinga, M., Janeczek Portalska, K., Cornelissen, D-J., Plass, J., Hanegraaf, M., Carlotti, F., de Koning, E., Engelse, M., van Blitterswijk, C., Karperien, M., van Apeldoorn, A. & de Boer, J., Feb 2016, In : Tissue engineering. Part A. 22, 3-4, p. 375-85 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Coexistence of quiescent and active adult stem cells in mammals

Li, L. & Clevers, H., 2010, In : Science Magazine. 327, 5965, p. 542-545

Research output: Contribution to journal/periodicalArticleScientificpeer-review