• Netherlands

  • Netherlands

Research Output

Article

Critical involvement of Tcf-1 in expansion of thymocytes

Schilham, M. W., Wilson, A., Moerer, P., Benaissa-Trouw, B. J., Cumano, A. & Clevers, J. C., 1998, In : Journal of Immunology. 161, p. 3984-3991

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Crypt base columnar stem cells in small intestines of mice are radioresistant

Hua, G., Thin, T. H., Feldman, R., Haimovitz-Friedman, A., Clevers, H., Fuks, Z. & Kolesnick, R., 2012, In : Gastroenterology. 143, 5, p. 1266-1276

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Crypt stem cells as the cells-of-origin of intestinal cancer.

Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M. L., Begthel, H. L., van den Born, M. M. W., Danenberg, E. M., Clarke, A. R., Sansom, O. J. & Clevers, H., 2009, In : Nature. 457, 7229, p. 608-611

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

Wang, J., Wang, Z., Yu, T., Yang, H., Virshup, D. M., Kops, G. J. P. L., Lee, S. H., Zhou, W., Li, X., Xu, W. & Rao, Z., Jul 2016, In : Protein & cell. 7, 7, p. 516-26 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

CTCF: the protein, the binding partners, the binding sites and their chromatin loops

Holwerda, S. J. & de Laat, W., 2013, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 368, 1620, p. 20120369

Research output: Contribution to journal/periodicalArticleScientificpeer-review

CTCF Binding Polarity Determines Chromatin Looping

de Wit, E., Vos, E. S. M., Holwerda, S. J. B., Valdes-Quezada, C., Verstegen, M. J. A. M., Teunissen, H., Splinter, E., Wijchers, P. J., Krijger, P. H. L. & de Laat, W., 27 Oct 2015, In : Molecular Cell.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

Broutier, L., Andersson-Rolf, A., Hindley, C. J., Boj, S. F., Clevers, H., Koo, B-K. & Huch, M., Sep 2016, In : Nature Protocols. 11, 9, p. 1724-43 20 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.

Sansom, O. J., Reed, K. R., Wetering, M. V. D., Muncan, V., Winston, D., Clevers, J. C. & Clarke, A. R., 2005, In : The Journal of biological chemistry. 280, p. 28463-28467

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss

Cole, A. M., Myant, K., Reed, K. R., Ridgway, R. A., Athineos, D., van den Brink, G. R., Muncan, V., Clevers, H., Clarke, A. R., Sicinski, P. & Sansom, O. J., 2010, In : Cancer Research. 70, 20, p. 8149-8158

Research output: Contribution to journal/periodicalArticleScientificpeer-review

DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

Redolfi, J., Zhan, Y., Valdes-Quezada, C., Kryzhanovska, M., Guerreiro, I., Iesmantavicius, V., Pollex, T., Grand, R. S., Mulugeta, E., Kind, J., Tiana, G., Smallwood, S. A., de Laat, W. & Giorgetti, L., Jun 2019, In : Nature Structural & Molecular Biology. 26, 6, p. 471-480 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dampening of expression oscillations by synchronous regulation of a microRNA and its target

Kim, D., Grun, D. & van Oudenaarden, A., 2013, In : Nature Genetics. 45, 11, p. 1337-1344

Research output: Contribution to journal/periodicalArticleScientificpeer-review

DAMP production by human islets under low oxygen and nutrients in the presence or absence of an immunoisolating-capsule and necrostatin-1

Paredes-Juarez, G. A., Sahasrabudhe, N. M., Tjoelker, R. S., de Haan, B. J., Engelse, M. A., de Koning, E. J. P., Faas, M. M. & de Vos, P., 2015, In : Scientific Reports. 5, p. 14623

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

d-Asb11 is an essential mediator of canonical Delta-Notch signalling.

Diks, S. H., Sartori da Silva, M. A., Hillebrands, J-L., Bink, R. J., Versteeg, H. H., van Rooijen, C., Brouwers, A. M., Chitnis, A. B., Peppelenbosch, M. P. & Zivkovic, D., 2008, In : Nature Cell Biology. 10, 10, p. 1190-1198

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Datasets from an interaction proteomics screen for substrates of the SCF(βTrCP) ubiquitin ligase

Magliozzi, R., Peng, M., Mohammed, S., Guardavaccaro, D., Heck, A. J. R. & Low, T. Y., Sep 2015, In : Data in Brief. 4, p. 229-34 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells

Chen, H-H., Welling, M., Bloch, D. B., Muñoz, J., Mientjes, E., Chen, X., Tramp, C., Wu, J., Yabuuchi, A., Chou, Y-F., Buecker, C., Krainer, A., Willemsen, R., Heck, A. J. & Geijsen, N., 11 Nov 2014, In : Stem Cell Reports. 3, 5, p. 892-904 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

DAZL regulates Tet1 translation in murine embryonic stem cells

Welling, M., Chen, H-H., Muñoz, J., Musheev, M. U., Kester, L., Junker, J. P., Mischerikow, N., Arbab, M., Kuijk, E., Silberstein, L., Kharchenko, P. V., Geens, M., Niehrs, C., van de Velde, H., van Oudenaarden, A., Heck, A. J. & Geijsen, N., Jul 2015, In : EMBO Reports. 16, 7, p. 791-802 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Dcr1 tracked down

Kaaij, L. J. & Ketting, R. F., 2010, In : Developmental Cell. 18, 1, p. 6-7

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Decapentaplegic is a direct target of dTcf repression in the Drosophila visceral mesoderm

Yang, X., Beest, M. V., Clevers, J. C., Jones, T., Hursh, D. A. & Mortin, M. A., 2000, In : Development. 127, p. 3695-3702

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Deconvolving the roles of Wnt ligands and receptors in sensing and amplification

Tan, R. Z., Ji, N., Mentink, R. A., Korswagen, H. C. & van Oudenaarden, A., 2013, In : Molecular Systems Biology. 9, p. 631

Research output: Contribution to journal/periodicalArticleScientificpeer-review

De darmen gered, de dogma's gesneuveld

Becker, S., 10 Aug 2011, In : Trouw. p. 2-3 2 p.

Research output: Contribution to journal/periodicalArticlePopularizing

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence

Berezikov, E., Robine, N., Samsonova, A., Westholm, J. O., Naqvi, A., Hung, J. H., Okamura, K., Dai, Q., Bortolamiol-Becet, D., Martin, R., Zhao, Y., Zamore, P. D., Hannon, G. J., Marra, M. A., Weng, Z., Perrimon, N. & Lai, E. C., 2011, In : Genome Research. 21, 2, p. 203-215

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man

Santos, M., Schilham, M. W., Rademakers, L. H., Marx, J. J. M., Sousa, M. D. & Clevers, J. C., 1996, In : Journal of Experimental Medicine. 184, p. 1975-1985

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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264 Downloads (Pure)

Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos

Kanwal, Z., Zakrzewska, A., den Hertog, J., Spaink, H. P., Schaaf, M. J. & Meijer, A. H., 2013, In : Journal of Immunology. 190, 4, p. 1631-1645

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats

Chen, X., Walther, F. J., van Boxtel, R., Laghmani, E. H., Sengers, R. M. A., Folkerts, G., DeRuiter, M. C., Cuppen, E. & Wagenaar, G. T. M., 23 Oct 2015, In : Acta Physiologica (Oxford, England).

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis

Post, Y. & Clevers, H., 01 Aug 2019, In : Cell Stem Cell. 25, 2, p. 174-183 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining Adult Stem Cells by Function, not by Phenotype

Clevers, H. & Watt, F. M., 20 Jun 2018, In : Annual Review of Biochemistry. 87, p. 1015-1027 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining outcomes for beta cell replacement therapy: a work in progress

Piemonti, L., de Koning, E. J. P., Berney, T., Odorico, J. S., Markmann, J. F., Stock, P. G. & Rickels, M. R., Jun 2018, In : Diabetologia. 61, 6, p. 1273-1276 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Defining outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop

Rickels, M. R., Stock, P. G., de Koning, E. J. P., Piemonti, L., Pratschke, J., Alejandro, R., Bellin, M. D., Berney, T., Choudhary, P., Johnson, P. R., Kandaswamy, R., Kay, T. W. H., Keymeulen, B., Kudva, Y. C., Latres, E., Langer, R. M., Lehmann, R., Ludwig, B., Markmann, J. F., Marinac, M. & 6 others, Odorico, J. S., Pattou, F., Senior, P. A., Shaw, J. A. M., Vantyghem, M-C. & White, S., Apr 2018, In : Transplant international : official journal of the European Society for Organ Transplantation. 31, 4, p. 343-352 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop

Rickels, M. R., Stock, P. G., de Koning, E. J. P., Piemonti, L., Pratschke, J., Alejandro, R., Bellin, M. D., Berney, T., Choudhary, P., Johnson, P. R., Kandaswamy, R., Kay, T. W. H., Keymeulen, B., Kudva, Y. C., Latres, E., Langer, R. M., Lehmann, R., Ludwig, B., Markmann, J. F., Marinac, M. & 6 others, Odorico, J. S., Pattou, F., Senior, P. A., Shaw, J. A. M., Vantyghem, M-C. & White, S., Sep 2018, In : Transplantation. 102, 9, p. 1479-1486 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells

Han, S., Fink, J., Jörg, D. J., Lee, E., Yum, M. K., Chatzeli, L., Merker, S. R., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, J-H., Sasaki, N., Mort, R. L., Basak, O., Clevers, H., Stange, D. E., Philpott, A. & 3 others, Kim, J. K., Simons, B. D. & Koo, B-K., 05 Sep 2019, In : Cell Stem Cell. 25, 3, p. 342-356.e7

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling

Magliozzi, R., Kim, J., Low, T. Y., Heck, A. J. R. & Guardavaccaro, D., 03 Oct 2014, In : The Journal of biological chemistry. 289, 40, p. 27400-9 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Degree and site of chromosomal instability define its oncogenic potential

Hoevenaar, W. H. M., Janssen, A., Quirindongo, A. I., Ma, H., Klaasen, S. J., Teixeira, A., van Gerwen, B., Lansu, N., Morsink, F. H. M., Offerhaus, G. J. A., Medema, R. H., Kops, G. J. P. L. & Jelluma, N., 20 Mar 2020, In : Nature Communications. 11, 1, p. 1501

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

"De keuze van Hans Clevers"

Clevers, H., 2009, In : Academische Boekengids.

Research output: Contribution to journal/periodicalArticlePopularizing

Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration

Matondo, R. B., Punt, C., Homberg, J. R., Toussaint, M. J., Kisjes, R., Korporaal, S. J., Akkerman, J. W., Cuppen, E. & de Bruin, A., 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 4, p. 963-968

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dendra2 photoswitching through the Mammary Imaging Window

Gligorijevic, B., Kedrin, D., Segall, J. E., Condeelis, J. & van Rheenen, J., 2009, In : Journal of Visualized Experiments. 28

Research output: Contribution to journal/periodicalArticleScientificpeer-review

De novo crypt formation and Juvenile Polyposis upon BMP inhibition

Haramis, A. P., Begthel, H., Born, M. V. D., Es, J. V., Jonkheer, S., Offerhaus, G. J. & Clevers, J. C., 2004, In : Science. 303, p. 1684-1686

Research output: Contribution to journal/periodicalArticleScientificpeer-review

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

Grün, D., Muraro, M. J., Boisset, J-C., Wiebrands, K., Lyubimova, A., Dharmadhikari, G., van den Born, M., van Es, J., Jansen, E., Clevers, H., de Koning, E. J. P. & van Oudenaarden, A., 21 Jun 2016, In : Cell Stem Cell.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphism.

Karatas, A., Hegner, B., de Windt, L. J., Luft, F. C., Schubert, C., Gross, V., Akashi, Y. J., Gurgen, D., Kintscher, U., da Costa Goncalves, A. C., Regitz-Zagrosek, V. & Dragun, D., 2008, In : Hypertension. 51, 4, p. 1177-1183

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf 4

Korinek, V., Barker, N., Moerer, P., Donselaar, E. V., Huls, G., Peters, P. J. & Clevers, J. C., 1998, In : Nature Genetics. 19, p. 379-383

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

van Arensbergen, J., Garcia-Hurtado, J., Moran, I., Maestro, M. A., Xu, X., van de Casteele, M., Skoudy, A. L., Palassini, M., Heimberg, H. & Ferrer, J., 2010, In : Genome Research. 20, 6, p. 722-732

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Deriving cell lines from zebrafish embryos and tumors

Choorapoikayil, S., Overvoorde, J. & den Hertog, J., 2013, In : Zebrafish. 10, 3, p. 316-325

Research output: Contribution to journal/periodicalArticleScientificpeer-review

De rol van transcriptiefactoren in de differentiatie van beenmergstamcellen naar immuuncompetente T lymfocyten

Clevers, J. C., 1993, In : Mediator.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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75 Downloads (Pure)

Design and Analysis of Single-Cell Sequencing Experiments

Grün, D. & van Oudenaarden, A., 05 Nov 2015, In : Cell. 163, 4, p. 799-810 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Designer matrices for intestinal stem cell and organoid culture

Gjorevski, N., Sachs, N., Manfrin, A., Giger, S., Bragina, M. E., Ordóñez-Morán, P., Clevers, H. & Lutolf, M. P., 16 Nov 2016, In : Nature. 539, 7630, p. 560-564 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Destabilization of beta-Catenin by Presenilin-1 Mutations Increases Neuronal Vulnerability to Apoptosis

Zhang, Z., Hartmann, H., Minh Do, V., Abramowski, D., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., Wetering, M. V. D., Clevers, J. C., Saftig, P., Strooper, B. D., He, X. & Yankner, B. A., 1998, In : Nature. 395, p. 698-702

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo.

Bakkers, J., Camacho-Carvajal, M., Nowak, M., Kramer, C., Danger, B. & Hammerschmidt, M., 2005, In : Cell Cycle. 4, 6, p. 790-800

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Detailed imaging and genetic analysis reveal a secondary BRAF(L) (505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

Hoogstraat, M., Gadellaa-van Hooijdonk, C. G., Ubink, I., Besselink, N. J. M., Pieterse, M., Veldhuis, W., van Stralen, M., Meijer, E. F. J., Willems, S. M., Hadders, M. A., Kuilman, T., Krijgsman, O., Peeper, D. S., Koudijs, M. J., Cuppen, E., Voest, E. E. & Lolkema, M. P., May 2015, In : Pigment Cell & Melanoma Research. 28, 3, p. 318-23 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

Busse, N., Paroni, F., Richardson, S. J., Laiho, J. E., Oikarinen, M., Frisk, G., Hyöty, H., de Koning, E., Morgan, N. G. & Maedler, K., 21 Feb 2017, In : Oncotarget. 8, 8, p. 12620-12636 17 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Detection of mRNA and Associated Molecules by ISH-IEM on Frozen Sections

Rabouille, C., 2018, In : Methods in Molecular Biology. 1649, p. 177-186 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation

Splinter, E., de Wit, E., van de Werken, H. J., Klous, P. & de Laat, W., 2012, In : Methods. 58, 3, p. 221-230

Research output: Contribution to journal/periodicalArticleScientificpeer-review