• Netherlands

  • Netherlands

Research Output

Article

Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish

Huitema, L. F., Apschner, A., Logister, I., Spoorendonk, K. M., Bussmann, J., Hammond, C. L. & Schulte-Merker, S., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 52, p. 21372-21377

Research output: Contribution to journal/periodicalArticleScientificpeer-review

ENU mutagenesis to generate genetically modified rat models

van Boxtel, R., Gould, M., Cuppen, E. & Smits, B. M., 2010, In : Methods in Molecular Biology. 597, p. 151-167

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control

Pannekoek, W. J., van Dijk, J., Chan, O. Y., Huveneers, S., Linnemann, J. R., Spanjaard, E., Brouwer, P. E. M., van der Meer, A. J., Zwartkruis, F. J., Rehmann, H., de Rooij, J. & Bos, J., 2011, In : Cellular Signalling. 23, 12, p. 2056-2064

Research output: Contribution to journal/periodicalArticleScientificpeer-review

EphB/EphrinB receptors and Wnt signaling in colorectal cancer.

Clevers, J. C. & Batlle, E., 2006, In : Cancer Research. 66, p. 2-5

Research output: Contribution to journal/periodicalArticleScientificpeer-review

EphB activity suppresses colorectal cancer progression

Batlle, E., Bacani, J., Begthel, H. L., Jonkheer, S., Gregorieff, A., van den Born, M. M. W., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S. & Clevers, J. C., 2005, In : Nature Genetics. 435, p. 1126-1130

Research output: Contribution to journal/periodicalArticleScientificpeer-review

EphB receptor activity suppresses colorectal cancer progression.

Batlle, E., Bacani, J., Begthel, H., Jonkheer, S., Gregorieff, A., Born, M. V. D., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S. & Clevers, J. C., 2005, In : Nature. 435, p. 1126-1130

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutation

de Esch, C. E. F., Ghazvini, M., Loos, F., Schelling-Kazaryan, N., Widagdo, W., Munshi, S. T., van der Wal, E., Douben, H., Gunhanlar, N., Kushner, S. A., Pijnappel, W. W. M. P., de Vrij, F. M. S., Geijsen, N., Gribnau, J. & Willemsen, R., 14 Oct 2014, In : Stem Cell Reports. 3, 4, p. 548-55 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Epigenetic reprogramming: Prdm14 hits the accelerator

Geijsen, N., 2012, In : EMBO Journal. 31, 10, p. 2247-2248

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Epigenomic annotation of gene regulatory alterations during evolution of the primate brain

Vermunt, M. W., Tan, S. C., Castelijns, B., Geeven, G., Reinink, P., de Bruijn, E., Kondova, I., Persengiev, S., Bontrop, R., Cuppen, E., de Laat, W. & Creyghton, M. P., Mar 2016, In : Nature Neuroscience. 19, 3, p. 494-503 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice

Aden, K., Bartsch, K., Dahl, J., Reijns, M. A. M., Esser, D., Sheibani-Tezerji, R., Sinha, A., Wottawa, F., Ito, G., Mishra, N., Knittler, K., Burkholder, A., Welz, L., van Es, J., Tran, F., Lipinski, S., Kakavand, N., Boeger, C., Lucius, R., von Schoenfels, W. & 11 others, Schafmayer, C., Lenk, L., Chalaris, A., Clevers, H., Röcken, C., Kaleta, C., Rose-John, S., Schreiber, S., Kunkel, T., Rabe, B. & Rosenstiel, P., Jan 2019, In : Gastroenterology. 156, 1, p. 145-159.e19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Erfelijke ouderdomsdiabetes bij jongeren

Translated title of the contribution: Maturity-onset diabetes of the youngvan der Tuin, K., Hannema, S. E., Houdijk, E. C. A. M. M., Losekoot, M., de Koning, E. J. P. & Breuning, M. H., 2015, In : Nederlands Tijdschrift voor Geneeskunde. 159, p. A9247

Research output: Contribution to journal/periodicalArticleScientificpeer-review

ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association

Zacharogianni, M., Kondylis, V., Tang, Y., Farhan, H., Xanthakis, D., Fuchs, F., Boutros, M. & Rabouille, C., 2011, In : EMBO Journal. 30, 18, p. 3684-3700

Research output: Contribution to journal/periodicalArticleScientificpeer-review

eRNAs are required for p53-dependent enhancer activity and gene transcription

Melo, C. A., Drost, J., Wijchers, P. J., van de Werken, H., de Wit, E., Oude Vrielink, J. A., Elkon, R., Melo, S. A., Leveille, N., Kalluri, R., de Laat, W. & Agami, R., 2013, In : Molecular Cell. 49, 3, p. 524-535

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Erratum: Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

Hombrink, P., Helbig, C., Backer, R. A., Piet, B., Oja, A. E., Stark, R., Brasser, G., Jongejan, A., Jonkers, R. E., Nota, B., Basak, O., Clevers, H. C., Moerland, P. D., Amsen, D. & van Lier, R. A. W., 19 Jan 2017, In : Nature Immunology. 18, 2, p. 246

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq

Marks, H., Kerstens, H. H. D., Barakat, T. S., Splinter, E., Dirks, R. A. M., van Mierlo, G., Joshi, O., Wang, S-Y., Babak, T., Albers, C. A., Kalkan, T., Smith, A., Jouneau, A., de Laat, W., Gribnau, J. & Stunnenberg, H. G., 2016, In : Genome Biology. 17, p. 22

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

Heijmans, J., van Lidth de Jeude, J. F., Koo, B. K., Rosekrans, S. L., Wielenga, M. C., van de Wetering, M., Ferrante, M., Lee, A. S., Onderwater, J. J., Paton, J. C., Paton, A. W., Mommaas, A. M., Kodach, L. L., Hardwick, J. C., Hommes, D. W., Clevers, H., Muncan, V. & van den Brink, G. R., 2013, In : Cell Reports. 3, 4, p. 1128-1139

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b

Bergink, S., Theil, A. F., Toussaint, W., De Cuyper, I. M., Kulu, D. I., Clapes, T., van der Linden, R., Demmers, J. A., Mul, E. P., van Alphen, F. P., Marteijn, J. A., van Gent, T., Maas, A., Robin, C., Philipsen, S., Vermeulen, W., Mitchell, J. R. & Gutierrez, L., 2013, In : Molecular and Cellular Biology. 33, 19, p. 3879-3892

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo

Sartori da Silva, M. A., Tee, J. M., Paridaen, J. T. M., Brouwers, A. M., Runtuwene, V. J., Zivkovic, D., Diks, S. H., Guardavaccaro, D. & Peppelenbosch, M. P., 2010, In : PLoS One. 5, 11, p. 14023

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo le of small non-coding RNAs in genome stability and chromatin organization

Sartori da Silva, M. A., Tee, J. M., Paridaen, J. T. M., Brouwers, A. M., Runtuwene, V. J., Zivkovic, D., Diks, S. H., van Wolfswinkel, J. C. & Ketting, R. F., 2010, In : Journal of Cell Science. 5, 11, p. 14023

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

Brembeck, F. H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M. & Birchmeier, W., 2004, In : Genes & Development. 18, 18, p. 2225-2230

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Establishment and characterization of a canine keratinocyte organoid culture system

Wiener, D. J., Basak, O., Asra, P., Boonekamp, K. E., Kretzschmar, K., Papaspyropoulos, A. & Clevers, H., Oct 2018, In : Veterinary Dermatology. 29, 5, p. 375-e126

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology

Lolkema, M. P., Gadellaa-van Hooijdonk, C. G., Bredenoord, A. L., Kapitein, P., Roach, N., Cuppen, E., Knoers, N. V. & Voest, E. E., 2013, In : Journal of Clinical Oncology. 31, 15, p. 1842-1848

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Ets2 determines the inflammatory state of endothelial cells in advanced atherosclerotic lesions

Cheng, C. Y., Tempel, D., den Dekker, W. K., Haasdijk, R., Chrifi, I., Bos, F. L., Wagtmans, K., van de Kamp, E. H., Blonden, L., Biessen, E. A., Moll, F. L., Pasterkamp, G., Serruys, P. W., Schulte-Merker, S. & Duckers, H. J., 2011, In : Circulation Research. 109, 4, p. 382-395

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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670 Downloads (Pure)

European immunologists meet in Amsterdam

Clevers, J. C. & Miedema, F., 1997, In : Immunology Today. 18

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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181 Downloads (Pure)

European stem cell research in legal shackles

Nielen, M. G., de Vries, S. A. & Geijsen, N., 2013, In : EMBO Journal. 32, 24, p. 3107-3111

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Every cell is special: genome-wide studies add a new dimension to single-cell biology

Junker, J. P. & van Oudenaarden, A., 27 Mar 2014, In : Cell. 157, 1, p. 8-11 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Everything has its time: Id2 clocks embryonic specification of Lgr5+ gut stem cells

Kretzschmar, K. & Clevers, H., 03 Apr 2017, In : EMBO Journal. 36, 7, p. 837-839 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Evidence for post-transcriptional regulation of clustered microRNAs in Drosophila

Ryazansky, S. S., Gvozdev, V. A. & Berezikov, E., 2011, In : BMC Genomics. 12, p. 371

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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284 Downloads (Pure)

Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence

van Rooijen, C., Simmini, S., Bialecka, M., Neijts, R., van de Ven, C., Beck, F. & Deschamps, J., 2012, In : Development. 139, 14, p. 2576-2583

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics

van Hooff, J. J., Tromer, E., van Wijk, L. M., Snel, B. & Kops, G. J., Sep 2017, In : EMBO Reports. 18, 9, p. 1559-1571 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Evolutionary flux of canonical microRNAs and mirtrons in Drosophila

Berezikov, E., Liu, N., Flynt, A. S., Hodges, E., Rooks, M., Hannon, G. J. & Lai, E. C., 2010, In : Nature Genetics. 42, 1, p. 6-10

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Evolutionary relationship between the T3 chains of the T cell receptor complex and the immunoglobulin supergene family

Gold, D. P., Clevers, J. C., Alarcon, B., Dunlap, S., Novotny, J., Williams, A. F. & Terhorst, C., 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, p. 7649-7653

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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317 Downloads (Pure)

Evolution of microRNA diversity and regulation in animals

Berezikov, E., 2011, In : Nature Reviews Genetics. 12, 12, p. 846-860

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Exosomal microRNA clusters are important for the therapeutic effect of cardiac progenitor cells

Sluijter, J. P. G. & van Rooij, E., 16 Jan 2015, In : Circulation Research. 116, 2, p. 219-21 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Expanding Impact of Stem Cell Science

Clevers, H., 08 May 2018, In : Stem Cell Reports. 10, 5, p. 1427-1428 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Expanding the spectrum of phenotypes associated with germline PIGA mutations: a child with developmental delay, accelerated linear growth, facial dysmorphisms, elevated alkaline phosphatase, and progressive CNS abnormalities

van der Crabben, S. N., Harakalova, M., Brilstra, E. H., van Berkestijn, F. M. C., Hofstede, F. C., van Vught, A. J., Cuppen, E., Kloosterman, W., Ploos van Amstel, H. K., van Haaften, G. & van Haelst, M. M., Jan 2014, In : American Journal of Medical Genetics A. 164A, 1, p. 29-35 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F. C., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 13 Mar 2018, In : Stem Cell Reports. 10, 3, p. 712-724 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

Wielenga, V. J., Smits, R., Korinek, V., Smit, L., Kielman, M., Fodde, R., Clevers, J. C. & Pals, S. T., 1999, In : American Journal of Pathology. 54, p. 515-523

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesis

Oosterwegel, M. A., Timmerman, J., Leiden, J. & Clevers, J. C., 1992, In : Developmental Immunology. 3, p. 1-11

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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266 Downloads (Pure)

Expression of Tac antigen component of bovine interleukin-2 receptor in different leukocyte populations infected with Theileria parva or Theileria annulata

Dobbelaere, D. A., Prospero, T. D., Roditi, I. J., Kelke, C., Baumann, I., Eichhorn, M., Williams, R. O., Ahmed, J. S., Baldwin, C. L. & Clevers, J. C., 1990, In : Infection and Immunity. 58, p. 3847-3855

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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157 Downloads (Pure)

Expression pattern analysis of microRNAs in Caenorhabditis elegans

Isik, M. & Berezikov, E., 2013, In : Methods in Molecular Biology. 936, p. 129-141

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expression pattern of Wnt signaling components in the adult intestine.

Gregorieff, A., Pinto, D., Begthel, H., Destree, O., Kielman, M. & Clevers, J. C., 2005, In : Gastroenterology. 129, p. 626-638

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expression patterns of intronic microRNAs in Caenorhabditis elegans

Isik, M., Korswagen, H. C. & Berezikov, E., 2010, In : Silence. 1, 1, p. 5

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Extensive alternative splicing and dual promoter usage generates TCF-1 protein isoforms with differential transcription control properties

Wetering, M. V. D., Castrop, J., Korinek, V. & Clevers, J. C., 1996, In : Molecular and Cellular Biology. 16, p. 745-752

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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99 Downloads (Pure)

Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes

van Heesch, S., van Iterson, M., Jacobi, J., Boymans, S., Essers, P. B., de Bruijn, E., Hao, W., MacInnes, A. W., Cuppen, E. & Simonis, M., 2014, In : Genome Biology. 15, 1, p. R6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Extracellular cleavage of E-cadherin promotes epithelial cell extrusion

Grieve, A. G. & Rabouille, C., 01 Aug 2014, In : Journal of Cell Science. 127, Pt 15, p. 3331-46 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

Giobbe, G. G., Crowley, C., Luni, C., Campinoti, S., Khedr, M., Kretzschmar, K., De Santis, M. M., Zambaiti, E., Michielin, F., Meran, L., Hu, Q., van Son, G., Urbani, L., Manfredi, A., Giomo, M., Eaton, S., Cacchiarelli, D., Li, V. S. W., Clevers, H., Bonfanti, P. & 2 others, Elvassore, N. & De Coppi, P., 11 Dec 2019, In : Nature Communications. 10, 1, p. 5658

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans

Luteijn, M. J., van Bergeijk, P., Kaaij, L. J., Almeida, M. V., Roovers, E. F., Berezikov, E. & Ketting, R. F., 2012, In : EMBO Journal. 31, 16, p. 3422-3430

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Eyeing up new Wnt pathway players.

Clevers, H., 2009, In : Cell. 139, 2, p. 227-229

Research output: Contribution to journal/periodicalArticleScientificpeer-review

FANCJ promotes DNA synthesis through G-quadruplex structures

Castillo Bosch, P., Segura-Bayona, S., Koole, W., van Heteren, J. T., Dewar, J. M., Tijsterman, M. & Knipscheer, P., 03 Nov 2014, In : EMBO Journal. 33, 21, p. 2521-33 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review