• Netherlands

  • Netherlands

Research Output

2011

Single-cell dissection of transcriptional heterogeneity in human colon tumors

Dalerba, P., Kalisky, T., Sahoo, D., Rajendran, P. S., Rothenberg, M. E., Leyrat, A. A., Sim, S., Okamoto, J., Johnston, D. M., Qian, D., Zabala, M., Bueno, J., Neff, N. F., Wang, J. J., Shelton, A. A., Visser, B., Hisamori, S., Shimono, Y., van de Wetering, M. L., Clevers, H. & 2 others, Clarke, M. F. & Quake, S. R., 2011, In : Nature Biotechnology. 29, 12, p. 1120-1127

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish

Clark, M. D., Guryev, V., de Bruijn, E., Nijman, I. J., Tada, M., Wilson, C., Deloukas, P., Postlethwait, J. H., Cuppen, E. & Stemple, D. L., 2011, In : Methods in Cell Biology. 104, p. 219-235

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment

Snippert, H. J. G., Schepers, A. G., Delconte, G., Siersema, P. D. & Clevers, H., 2011, In : Nature Protocols. 6, 8, p. 1221-1228

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice

Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R., Sengupta, S., Seandel, M., Geijsen, N. & Hochedlinger, K., 2011, In : Cell Stem Cell. 9, 4, p. 317-329

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43

Boogerd, C. J., Wong, L. Y., van den Boogaard, M., Bakker, M. A. J., Tessadori, F., Bakkers, J., 't Hoen, P. A. C., Moorman, A. F., Christoffels, V. M. & Barnett, P., 2011, In : Cellular and Molecular Life Sciences. 68, 23, p. 3949-3961

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Sox9 marks adult organ progenitors

Huch, M. & Clevers, H., 2011, In : Nature Genetics. 43, 1, p. 9-10

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cell self-renewal in intestinal crypt

Simons, B. D. & Clevers, H., 2011, In : Experimental Cell Research. 317, 19, p. 2719-2724

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Strategies for homeostatic stem cell self-renewal in adult tissues

Simons, B. D. & Clevers, H., 2011, In : Cell. 145, 6, p. 851-862

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

Huang, H. Y., Houwing, S., Kaaij, L. J., Meppelink, A., Redl, S., Gauci, S., Vos, H., Draper, B. W., Moens, C. B., Burgering, B., Ladurner, P., Krijgsveld, J., Berezikov, E. & Ketting, R. F., 2011, In : EMBO Journal. 30, 16, p. 3298-3308

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis

Sylva, M., Li, V. S., Buffing, A. A., van Es, J. H., van den Born, M. M. W., van der Velden, S., Gunst, Q., Koolstra, J. H., Moorman, A. F., Clevers, H. & van den Hoff, M. J., 2011, In : PLoS One. 6, 8, p. 22616

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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589 Downloads (Pure)

The cancer stem cell: premises, promises and challenges

Clevers, H., 2011, In : Nature Medicine. 17, 3, p. 313-319

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The complex transcription regulatory landscape of our genome: control in three dimensions

Splinter, E. & de Laat, W., 2011, In : EMBO Journal. 30, 21, p. 4345-4355

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion

Steller, E. J., Ritsma, L., Raats, D. A., Hoogwater, F. J., Emmink, B. L., Govaert, K. M., Laoukili, J., Rinkes, I. H., van Rheenen, J. & Kranenburg, O., 2011, In : EMBO Reports. 12, 9, p. 931-937

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The different shades of mammalian pluripotent stem cells

Kuijk, E. W., Lopes, S. M., Geijsen, N., Macklon, N. & Roelen, B. A., 2011, In : Human Reproduction Update. 17, 2, p. 254-271

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

Splinter, E., de Wit, E., Nora, E. P., Klous, P., van de Werken, H., Zhu, Y., Kaaij, L. J., van Ijcken, W., Gribnau, J., Heard, E. & de Laat, W., 2011, In : Genes & Development. 25, 13, p. 1371-1383

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

Merlos-Suarez, A., Barriga, F. M., Jung, P., Iglesias, M., Cespedes, M. V., Rossell, D., Sevillano, M., Hernando-Momblona, X., da Silva-Diz, V., Munoz, P., Clevers, H., Sancho, E., Mangues, R. & Batlle, E., 2011, In : Cell Stem Cell. 8, 5, p. 511-524

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The many faces of RNAi

Ketting, R. F., 2011, In : Developmental Cell. 20, 2, p. 148-161

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The multiple facets of the Golgi reassembly stacking proteins

Vinke, F. P., Grieve, A. & Rabouille, C., 2011, In : Biochemical Journal. 433, 3, p. 423-433

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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330 Downloads (Pure)

The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish

Paridaen, J. T. M., Janson, E., Utami, K. H., Pereboom, T. C., Essers, P., van Rooijen, C. R., Zivkovic, D. & MacInnes, A. W., 2011, In : Developmental Biology. 355, 2, p. 286-301

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The planar cell polarity pathway in vertebrate development

Wansleeben, C. & Meijlink, F., 2011, In : Developmental Dynamics. 240, 3, p. 616-626

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish

Velden, Y. U., Wang, L., Zevenhoven, J., van Rooijen, E., van Lohuizen, M., Giles, R. H., Clevers, H. & Haramis, A. P., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 11, p. 4358-4363

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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464 Downloads (Pure)

The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats

Chan, J. Y., Snoeren, E., Cuppen, E., Waldinger, M., Olivier, B. & Oosting, R., 2011, In : Journal of Sexual Medicine. 8, 1, p. 97-108

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tracking adult stem cells

Snippert, H. J. G. & Clevers, H., 2011, In : EMBO Reports. 12, 2, p. 113-122

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development

Smith, K., Lagendijk, A. K., Courtney, A. D., Chen, H., Paterson, S., Hogan, B. M., Wicking, C. & Bakkers, J., 2011, In : Development. 138, 19, p. 4193-4198

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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343 Downloads (Pure)

Trpv5/6 is vital for epithelial calcium uptake and bone formation

Vanoevelen, J., Janssens, A. C., Huitema, L. F., Hammond, C. J., Metz, J. R., Flik, G., Voets, T. & Schulte-Merker, S., 2011, In : FASEB Journal. 25, 9, p. 3197-3207

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Unconventional secretion: a stress on GRASP

Giuliani, F., Grieve, A. & Rabouille, C., 2011, In : Current Opinion in Cell Biology. 23, 4, p. 498-504

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2 Downloads (Pure)

Unraveling the Wnt secretion pathway

Harterink, M., 2011, 160 p.

Research output: PhD ThesisPhD thesis

Valve morphogenesis; Directing cardiac form and function

Lagendijk, A. K., 2011

Research output: PhD ThesisPhD thesis

Variegated gene expression caused by cell-specific long-range DNA interactions

Noordermeer, D., de Wit, E., Klous, P., van de Werken, H., Simonis, M., Lopez-Jones, M., Eussen, B., Klein, A. M., Singer, R. H. & de Laat, W., 2011, In : Nature Cell Biology. 13, 8, p. 944-951

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

Verhoeven, M. C., Haase, C., Christoffels, V. M., Weidinger, G. & Bakkers, J., 2011, In : Birth Defects Research Part A: Clinical and Molecular Teratology. 91, 6, p. 435-440

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Zebrafish as a model to study cardiac development and human cardiac disease

Bakkers, J., 2011, In : Cardiovascular Research. 91, 2, p. 279-288

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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448 Downloads (Pure)

Zebrafish provides a novel model for lymphatic vascular research

Karpanen, T. & Schulte-Merker, S., 2011, In : Methods in Cell Biology. 105, p. 223-238

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Zebrafish prox1b Mutants Develop a Lymphatic Vasculature, and prox1b Does Not Specifically Mark Lymphatic Endothelial Cells

Tao, S., de Witte, M., Bryson-Richardson, R. J., Currie, P. D., Hogan, B. M. & Schulte-Merker, S., 2011, In : PLoS One. 6, 12, p. 28934

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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371 Downloads (Pure)

Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity

Gjini, E., Hekking, L. H., Kuchler, A., Saharinen, P., Wienholds, E., Post, J., Alitalo, K. & Schulte-Merker, S., 2011, In : Disease Models & Mechanisms. 4, 1, p. 57-66

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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657 Downloads (Pure)
2010

Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries

Mokry, M., Feitsma, H., Nijman, I. J., de Bruijn, E., van der Zaag, P. J., Guryev, V. & Cuppen, E., 2010, In : Nucleic Acids Research. 38, 10, p. 116

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Active Wnt signaling in response to cardiac injury

Oerlemans, M. I., Goumans, M. J., van Middelaar, B., Clevers, H., Doevendans, P. A. & Sluijter, J. P., 2010, In : Basic Research in Cardiology. 105, 5, p. 631-641

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

Sleigh, J. N., Buckingham, S. D., Esmaeili, B., Viswanathan, M., Cuppen, E., Westlund, B. M. & Sattelle, D. B., 2010, In : Human Molecular Genetics. 20, 2, p. 245-260

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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323 Downloads (Pure)

A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction

Wansleeben, C., Feitsma, H., Tertoolen, L. G. J., Kroon, C., Guryev, V., Cuppen, E. & Meijlink, F., 2010, In : International Journal of Developmental Biology. 54, 10, p. 1465-1471

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk

Bussmann, J., Bos, F. L., Urasaki, A., Kawakami, K., Duckers, H. J. & Schulte-Merker, S., 2010, In : Development. 137, 16, p. 2653-2657

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cdx mutant axial progenitor cells are rescued by grafting to a wild type environment

Bialecka, M., Wilson, V. & Deschamps, J., 2010, In : Developmental Biology. 347, 1, p. 228-234

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cell Fate Determination in Zebrafish Embryonic and Adult Muscle Development

Tee, J. M., 2010

Research output: PhD ThesisPhD thesis

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

Beqqali, A., Monshouwer-Kloots, J., Monteiro, R., Welling, M., Bakkers, J., Ehler, E., Verkleij, A. J., Mummery, C. L. & Passier, R., 2010, In : Journal of Cell Science. 123, Pt 7, p. 1141-1150

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis

Qiu, W., Wang, X., Leibowitz, B., Liu, H., Barker, N., Okada, H., Oue, N., Yasui, W., Clevers, H., Schoen, R. E., Yu, J. & Zhang, L., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 46, p. 20027-20032

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Coexistence of quiescent and active adult stem cells in mammals

Li, L. & Clevers, H., 2010, In : Science Magazine. 327, 5965, p. 542-545

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq

Johannes, F., Wardenaar, R., Colome-Tatche, M., Mousson, F., de Graaf, P., Mokry, M., Guryev, V., Timmers, H. T., Cuppen, E. & Jansen, R., 2010, In : Bioinformatics. 26, 8, p. 1000-1006

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Control of endothelial sprouting by a Tel-CtBP complex

Roukens, M. G., Alloul-Ramdhani, M., Baan, B., Kobayashi, K., Peterson-Maduro, J., van Dam, H. J., Schulte-Merker, S. & Baker, D. A., 2010, In : Nature Cell Biology. 12, 10, p. 933-942

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition

Menke, V., van Es, J. H., de Lau, W. B. M., van den Born, M. M. W., Kuipers, E. J., Siersema, P. D., de Bruin, R. W., Kusters, J. G. & Clevers, H., 2010, In : Disease Models & Mechanisms. 3, 1-2, p. 104-110

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss

Cole, A. M., Myant, K., Reed, K. R., Ridgway, R. A., Athineos, D., van den Brink, G. R., Muncan, V., Clevers, H., Clarke, A. R., Sicinski, P. & Sansom, O. J., 2010, In : Cancer Research. 70, 20, p. 8149-8158

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dcr1 tracked down

Kaaij, L. J. & Ketting, R. F., 2010, In : Developmental Cell. 18, 1, p. 6-7

Research output: Contribution to journal/periodicalArticleScientificpeer-review