• Netherlands

  • Netherlands

Research Output

2010

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

van Arensbergen, J., Garcia-Hurtado, J., Moran, I., Maestro, M. A., Xu, X., van de Casteele, M., Skoudy, A. L., Palassini, M., Heimberg, H. & Ferrer, J., 2010, In : Genome Research. 20, 6, p. 722-732

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Different flavors of pluripotency, molecular mechanisms, and practical implications

Buecker, C. & Geijsen, N., 2010, In : Cell Stem Cell. 7, 5, p. 559-564

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differential effects of rosiglitazone and metformin on postprandial lipemia in patients with HIV-lipodystrophy

van Wijk, J. P., Hoepelman, A. I., de Koning, E., Dallinga-Thie, G., Rabelink, T. J. & Cabezas, M. C., 2010, In : Artheriosclerosis, Thrombosis and Vascular Biology. 31, 1, p. 228-233

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Disclosure of individual genetic data to research participants: the debate reconsidered

Bredenoord, A. L., Kroes, H. Y., Cuppen, E., Parker, M. & van Delden, J. J. M., 2010, In : Trends in Genetics. 27, 2, p. 41-47

Research output: Contribution to journal/periodicalArticleScientificpeer-review

DNA isolation from rat tail or ear

Cuppen, E., 2010, In : Cold Spring Harbor Protocols. 2010, 5, p. 5434

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Double-strand break repair and G4 DNA stability in Caenorhabditis elegans

Pontier, D. B., 2010

Research output: PhD ThesisPhD thesis

Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles

Mokry, M., Hatzis, P., de Bruijn, E., Koster, J., Versteeg, R., Schuijers, J., van de Wetering, M. L., Guryev, V., Clevers, H. & Cuppen, E., 2010, In : PLoS One. 5, 11, p. 15092

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

Jakobsson, L., Franco, C. A., Bentley, K., Collins, R. T., Ponsioen, B., Aspalter, I. M., Rosewell, I., Busse, M., Thurston, G., Medvinsky, A., Schulte-Merker, S. & Gerhardt, H., 2010, In : Nature Cell Biology. 12, 10, p. 943-953

Research output: Contribution to journal/periodicalArticleScientificpeer-review

ENU mutagenesis to generate genetically modified rat models

van Boxtel, R., Gould, M., Cuppen, E. & Smits, B. M., 2010, In : Methods in Molecular Biology. 597, p. 151-167

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo

Sartori da Silva, M. A., Tee, J. M., Paridaen, J. T. M., Brouwers, A. M., Runtuwene, V. J., Zivkovic, D., Diks, S. H., Guardavaccaro, D. & Peppelenbosch, M. P., 2010, In : PLoS One. 5, 11, p. 14023

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo le of small non-coding RNAs in genome stability and chromatin organization

Sartori da Silva, M. A., Tee, J. M., Paridaen, J. T. M., Brouwers, A. M., Runtuwene, V. J., Zivkovic, D., Diks, S. H., van Wolfswinkel, J. C. & Ketting, R. F., 2010, In : Journal of Cell Science. 5, 11, p. 14023

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Evolutionary flux of canonical microRNAs and mirtrons in Drosophila

Berezikov, E., Liu, N., Flynt, A. S., Hodges, E., Rooks, M., Hannon, G. J. & Lai, E. C., 2010, In : Nature Genetics. 42, 1, p. 6-10

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expression patterns of intronic microRNAs in Caenorhabditis elegans

Isik, M., Korswagen, H. C. & Berezikov, E., 2010, In : Silence. 1, 1, p. 5

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling

Ashton, G. H., Morton, J. P., Myant, K., Phesse, T. J., Ridgway, R. A., Marsh, V., Wilkins, J. A., Athineos, D., Muncan, V., Kemp, R., Neufeld, K., Clevers, H., Brunton, V., Winton, D. J., Wang, X., Sears, R., Clarke, A. R., Frame, M. C. & Sansom, O. J., 2010, In : Developmental Cell. 19, 2, p. 259-269

Research output: Contribution to journal/periodicalArticleScientificpeer-review

FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands

Groen, E. J., van Es, M. A., van Vught, P. W., Spliet, W. G. M., van Engelen-Lee, J., de Visser, M., Wokke, J. H., Schelhaas, H. J., Ophoff, R. A., Fumoto, K., Pasterkamp, R. J., Dooijes, D., Cuppen, E., Veldink, J. H. & van den Berg, L., 2010, In : Archives of Neurology. 67, 2, p. 224-230

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats

Kim, K., Warden, C. H., Griffey, S. M., Vilches-Moure, J. G., Hansen, S., Cuppen, E., Nijman, I. J., Chiu, S. & Stern, J. S., 2010, In : Physiol Genomics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genetic regulation of vascular development - building the Zebrafish Vascular Tree

Herpers, R., 2010

Research output: PhD ThesisPhD thesis

Genome organization influences partner selection for chromosomal rearrangements

Wijchers, P. J. & de Laat, W., 2010, In : Trends in Genetics. 27, 2, p. 63-71

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Growth of the Zebrafish Heart

de Pater, E. M., 2010

Research output: PhD ThesisPhD thesis

Heads and Tails of endoderm development & adult tissue homeostasis in zebrafish

Faro, A., 2010

Research output: PhD ThesisPhD thesis

Hen1 is required for oocyte development and piRNA stability in zebrafish

Kamminga, L. M., Luteijn, M. J., den Broeder, M. J., Redl, S., Kaaij, L. J., Roovers, E. F., Ladurner, P., Berezikov, E. & Ketting, R. F., 2010, In : EMBO Journal. 29, 21, p. 3688-3700

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Hoxb8-Cre mice: A tool for brain-sparing conditional gene deletion

Witschi, R., Johansson, T., Morscher, G., Scheurer, L., Deschamps, J. & Zeilhofer, H. U., 2010, In : Genesis. 48, 10, p. 596-602

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Hox genes and regional patterning of the vertebrate body plan

Mallo, M., Wellik, D. M. & Deschamps, J., 2010, In : Developmental Biology. 344, 1, p. 7-15

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Human CD34+/KDR+ Cells Are Generated From Circulating CD34+ Cells After Immobilization on Activated Platelets

de Boer, H., Hovens, M., van Oeveren, A., Snoep, J., de Koning, E., Tamsma, J., Huisman, M., Rabelink, T. J. & van Zonneveld, A. J., 2010, In : Artheriosclerosis, Thrombosis and Vascular Biology.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats

Homberg, J. R., Nijman, I. J., Kuijpers, S. & Cuppen, E., 2010, In : BMC Genetics. 11, p. 37

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification of hoxb1b downstream genes: hoxb1b as a regulatory factor controlling transcriptional networks and cell movement during zebrafish gastrulation

van den Akker, W. M., Durston, A. J. & Spaink, H. P., 2010, In : International Journal of Developmental Biology. 54, 1, p. 55-62

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development

Kosinski, C., Stange, D. E., Xu, C., Chan, A. S., Ho, C., Yuen, S. T., Mifflin, R. C., Powell, D. W., Clevers, H., Leung, S. Y. & Chen, X. N., 2010, In : Gastroenterology. 139, 3, p. 893-903

Research output: Contribution to journal/periodicalArticleScientificpeer-review

In situ hybridization to identify gut stem cells

Gregorieff, A. & Clevers, H., 2010, In : Current Protocols in Stem Cell Biology. Chapter 2, p. 1

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J. G., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M. M. W., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D. & Clevers, H., 2010, In : Cell. 143, 1, p. 134-144

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

van Es, J. H., de Geest, N., van den Born, M. M. W., Clevers, H. & Hassan, B. A., 2010, In : Nature Communications. 1, 2, p. 1-5

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

Barker, N. & Clevers, H., 2010, In : Gastroenterology. 138, 5, p. 1681-1696

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro

Barker, N., Huch, M., Kujala, P., van de Wetering, M. L., Snippert, H. J. G., van Es, J. H., Sato, T., Stange, D. E., Begthel, H. L., van den Born, M. M. W., Danenberg, E. M., van den Brink, S., Korving, J., Abo, A., Peters, P., Wright, N., Poulsom, R. & Clevers, H., 2010, In : Cell Stem Cell. 6, 1, p. 25-36

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

Snippert, H. J. G., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M. L., van den Born, M. M. W., Begthel, H. L., Vries, R. G. J., Stange, D. E., Toftgard, R. & Clevers, H., 2010, In : Science Magazine. 327, 5971, p. 1385-1389

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Lineage tracing in the intestinal epithelium

Barker, N. & Clevers, H., 2010, In : Current Protocols in Stem Cell Biology. Chapter 5, p. 4

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

Tauriello, D. V., Haegebarth, A., Kuper, I., Edelmann, M. J., Henraat, M., Canninga-van Dijk, M. R., Kessler, B. M., Clevers, H. & Maurice, M. M., 2010, In : Molecular Cell. 37, 5, p. 607-619

Research output: Contribution to journal/periodicalArticleScientificpeer-review

MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway

Ng, S. S., Mahmoudi, T., Li, V. S., Hatzis, P., Boersema, P. J., Mohammed, S., Heck, A. & Clevers, H., 2010, In : Biological Chemistry. 391, 2-3, p. 171-180

Research output: Contribution to journal/periodicalArticleScientificpeer-review

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

da Costa Martins, P. A., Salic, K., Gladka, M. M., Armand, A. S., Leptidis, S., el Azzouzi, H., Hansen, A., Coenen-de Roo, C. J., Bierhuizen, M. F. A., van der Nagel, R., van Kuik, J., de Weger, R., de Bruin, A., Condorelli, G., Arbones, M. L., Eschenhagen, T. & de Windt, L. J., 2010, In : Nature Cell Biology. 12, 12, p. 1220-1227

Research output: Contribution to journal/periodicalArticleScientificpeer-review

MicroRNA-directed siRNA biogenesis in Caenorhabditis elegans

Correa, R. L., Steiner, F. A., Berezikov, E. & Ketting, R. F., 2010, In : PLoS Genetics. 6, 4, p. 1000903

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo

Pedrioli, D. M., Karpanen, T., Dabouras, V., Jurisic, G., van de Hoek, G., Shin, J. W., Marino, D., Kalin, R. E., Leidel, S., Cinelli, P., Schulte-Merker, S., Brandli, A. W. & Detmar, M., 2010, In : Molecular and Cellular Biology. 30, 14, p. 3620-3634

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation

Tournoij, E., Weber, G. J., Akkerman, J. W., de Groot, P. G., Zon, L., Moll, F. L. & Schulte-Merker, S., 2010, In : Journal of Thrombosis and Haemostasis. 8, 3, p. 588-595

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples

Nijman, I. J., Mokry, M., van Boxtel, R., Toonen, P. W., de Bruijn, E. & Cuppen, E., 2010, In : Nature Methods. 7, 11, p. 913-915

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Nano-imaging of membrane topography affects interpretations in cell biology

Jalink, K. & van Rheenen, J., 2010, In : Nature Methods. 7, 7, p. 486

Research output: Contribution to journal/periodicalArticleScientificpeer-review

No link of serotonin 2C receptor editing to serotonin transporter genotype

Lyddon, R., Cuppen, E., Haroutunian, V., Siever, L. J. & Dracheva, S., 2010, In : NeuroReport. 21, 17, p. 1080-1084

Research output: Contribution to journal/periodicalArticleScientificpeer-review

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

Cole, A. M., Ridgway, R. A., Derkits, S. E., Parry, L., Barker, N., Clevers, H., Clarke, A. R. & Sansom, O. J., 2010, In : EMBO Molecular Medicine. 2, 11, p. 472-486

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J. G., Stange, D. E., Vries, R. G. J., van den Born, M. M. W., Barker, N., Shroyer, N. F., van de Wetering, M. L. & Clevers, H., 2010, In : Nature. 469, 7330, p. 415-418

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b

Wansleeben, C., Feitsma, H., Montcouquiol, M., Kroon, C., Cuppen, E. & Meijlink, F., 2010, In : Development. 137, 7, p. 1067-1073

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Platelet Activation in Vascular Disease: from Animal Studies to Clinical Consequences

Tournoij, E., 2010

Research output: PhD ThesisPhD thesis

Rat reverse genetics: generation and characterization of chemically induced rat mutants

van Boxtel, R., 2010

Research output: PhD ThesisPhD thesis

Rat traps: filling the toolbox for manipulating the rat genome

van Boxtel, R. & Cuppen, E., 2010, In : Genome Biology. 11, 9, p. 217

Research output: Contribution to journal/periodicalArticleScientificpeer-review