• Netherlands

  • Netherlands

Research Output

2009

Repertoire and evolution of miRNA genes in four divergent nematode species.

de Wit, E., Linsen, S. E. V., Cuppen, E. & Berezikov, E., 2009, In : Genome Research. 19, 11, p. 2064-2074

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Role of Cdx and Hox genes in posterior axial extension in the mouse

Young, T., 2009, Universiteit Utrecht. 126 p.

Research output: PhD ThesisPhD thesis

Sailing with the Wnt: charting the Wnt processing and secretion route

Lorenowicz, M. J. & Korswagen, H. C., 2009, In : Experimental Cell Research. 315, 16, p. 2683-2689

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Searching for adult stem cells in the intestine

Clevers, H., 2009, In : EMBO Molecular Medicine. 1, 5, p. 255-259

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Semiconserved regulation of mesendoderm differentiation by microRNAs.

Ketting, R. F., 2009, In : Developmental Cell. 16, 4, p. 487-488

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis.

Bakkers, J., Verhoeven, M. C. & Abdelilah-Seyfried, S., 2009, In : Developmental Biology. 330, 2, p. 213-220

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

Sato, T., Vries, R. G. J., Snippert, H. J. G., van de Wetering, M. L., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J. & Clevers, H., 2009, In : Nature. 459, 7244, p. 262-265

Research output: Contribution to journal/periodicalArticleScientificpeer-review

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

Chen, G., Korfhagen, T. R., Xu, Y., Kitzmiller, J., Wert, S. E., Maeda, Y., Gregorieff, A., Clevers, H. & Whitsett, J. A., 2009, In : Journal of Clinical Investigation. 119, 10, p. 2914-2924

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Special Issue

Korswagen, H. C. (ed.), 2009, Utrecht: Universiteit Utrecht.

Research output: Book/ReportBookScientific

Stem cells, self-renewal, and differentiation in the intestinal epithelium.

van der Flier, L. G. & Clevers, H., 2009, In : Annual Review of Physiology. 71, p. 241-260

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C).

Louwers, M., Splinter, E., van Driel, R., de Laat, W. & Stam, M., 2009, In : Nature Protocols. 4, 8, p. 1216-1229

Research output: Contribution to journal/periodicalArticleScientificpeer-review

T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis.

Faro, A., Boj, S. F., Ambrosio, R., van den Broek, O., Korving, J. & Clevers, H., 2009, In : Zebrafish. 6, 1, p. 59-68

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation.

Claycomb, J. M., Batista, P. J., Pang, K. M., Gu, W., Vasale, J. J., van Wolfswinkel, J. C., Chaves, D. A., Shirayama, M., Mitani, S., Ketting, R. F., Co nte D, J. R. & Mello, C. C., 2009, In : Cell. 139, 1, p. 123-134

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females

van den Bos, R., Homberg, J. R., Gijsbers, E., den Heijer, E. J. & Cuppen, E., 2009, In : Neuropharmacology. 56, 2, p. 493-498

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

Gregorieff, A., Stange, D. E., Kujala, P., Begthel, H. L., van den Born, M. M. W., Korving, J., Peters, P. J. & Clevers, H., 2009, In : Gastroenterology. 137, 4, p. 1333-1333

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The kinase TNIK is an essential activator of Wnt target genes.

Mahmoudi, T., Li, V. S., Ng, S. S., Taouatas, N., Vries, R. G. J., Mohammed, S., Heck, A. J. R. & Clevers, H., 2009, In : EMBO Journal. 28, 21, p. 3329-3340

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.

Wassmer, T., Attar, N., Harterink, M., van Weering, J. R., Traer, C. J., Oakley, J., Goud, B., Stephens, D. J., Verkade, P., Korswagen, H. C. & Cullen, P. J., 2009, In : Developmental Cell. 17, 1, p. 110-122

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors)

Lips, D. J., Barker, N., Clevers, H. & Hennipman, A., 2009, In : European Journal of Surgical Oncology. 35, 1, p. 3-10

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer

Medina, P. P., Castillo, S. D., Blanco, S., Sanz-Garcia, M., Largo, C., Alvarez, S., Yokota, J., Gonzalez-Neira, A., Benitez, J., Clevers, H., Cigudosa, J. C., Lazo, P. A. & Sanchez-Cespedes, M., 2009, In : Human Molecular Genetics. 18, 7, p. 1343-1352

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

Schwamborn, J. C., Berezikov, E. & Knoblich, J. A., 2009, In : Cell. 136, 5, p. 913-925

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue- and expression level-specific chromatin looping at maize b1 epialleles.

Louwers, M., Bader, R., Haring, M., van Driel, R., de Laat, W. & Stam, M., 2009, In : Plant Cell. 21, 3, p. 832-842

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tracing the history of goat pastoralism: new clues from mitochondrial and Y chromosome DNA in North Africa

Pereira, F., Queiros, S., Gusmao, L., Nijman, I. J., Cuppen, E., Lenstra, J. A., Consortium, E., Davis, S. J., Nejmeddine, F. & Amorim, A., 2009, In : Molecular Biology and Evolution. 26, 12, p. 2765-2773

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

van der Flier, L. G., van Gijn, M. E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D. E., Begthel, H. L., van den Born, M. M. W., Guryev, V., Oving, I. M., van Es, J. H., Barker, N., Peters, P. J., van de Wetering, M. L. & Clevers, H., 2009, In : Cell. 136, 5, p. 903-912

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling.

Hammond, C. L. & Schulte-Merker, S., 2009, In : Development. 136, 23, p. 3991-4000

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering.

Leyman, S., Sidani, M., Ritsma, L., Waterschoot, D., Eddy, R., Dewitte, D., Debeir, O., Decaestecker, C., Vandekerckhove, J., van Rheenen, J., Ampe, C., Condeelis, J. & Van Troys, M., 2009, In : Molecular Biology of the Cell. 20, 21, p. 4509-4523

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.

Hogan, B. M., Herpers, R., de Witte, M., Helotera, H., Alitalo, K., Duckers, H. J. & Schulte-Merker, S., 2009, In : Development. 136, 23, p. 4001-4009

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Visceral endoderm induces specification of cardiomyocytes in mice

Nijmeijer, R. M., Leeuwis, J. W., DeLisio, A., Mummery, C. L. & Chuva de Sousa Lopes, S. M., 2009, In : Stem Cell Research. 3, 2-3, p. 170-178

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling, lgr5, and stem cells in the intestine and skin.

Haegebarth, A. & Clevers, H., 2009, In : American Journal of Pathology. 174, 3, p. 715-721

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling in Alzheimer's disease: up or down, that is the question

Boonen, R. A. C. M., van Tijn, P. & Zivkovic, D., 2009, In : Ageing Research Reviews. 8, 2, p. 71-82

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt target gene analysis in colorectal cancer and intestinal stem cells

van der Flier, L. G., 2009, Universiteit Utrecht. 136 p.

Research output: PhD ThesisPhD thesis

Zebrafish and phosphatase function

den Hertog, J., 2009, Handbook of Cell Signaling Chapter 101. Bradshaw, R. & Dennis, E. (eds.).

Research output: Chapter in book/volumeChapterScientific

Zebrafish development and regeneration: new tools for biomedical research

Brittijn, S. A., Duivesteijn, S. J., Belmamoune, M., Bertens, L. F., Bitter, W., de Bruijn, J. D., Champagne, D. L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C. M., Janssen, R. A., De Jong, I. M., De Kloet, E. R., Kros, A., Meijer, A. H., Metz, J. R., Van der Sar, A. M., Schaaf, M. J., Schulte-Merker, S., Spaink, H. P. & 7 others, Tak, P. P., Verbeek, F. J., Vervoordeldonk, M. J., Vonk, F. J., Witte, F., Yuan, H. & Richardson, M. K., 2009, In : International Journal of Developmental Biology. 53, 5-6, p. 835-850

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

van Rooijen, E., Voest, E. E., Logister, I., Korving, J., Schwerte, T., Schulte-Merker, S., Giles, R. H. & van Eeden, F. J., 2009, In : Blood. 113, 25, p. 6449-6460

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2008

Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats

Homberg, J. R., de Boer, S. F., Raaso, H. S., Olivier, J. D. A., Verheul, M., Ronken, E., Cools, A. R., Ellenbroek, B. A., Schoffelmeer, A. N. M., Vanderschuren, L. J. M. J., de Vries, T. J. & Cuppen, E., 2008, In : Psychopharmacology (Berl). 200, p. 367-380

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.

Colak, D., Mori, T., Brill, M. S., Pfeifer, A., Falk, S., Deng, C., Monteiro, R., Mummery, C. L., Sommer, L. & Gotz, M., 2008, In : Journal of Neuroscience. 28, 2, p. 434-445

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A genome-wide SNP panel for mapping and association studies in the rat.

Nijman, I. J., Kuipers, S., Verheul, M., Guryev, V. & Cuppen, E., 2008, In : BMC Genomics. 9

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos.

Feitsma, H., Akay, A. & Cuppen, E., 2008, In : Nucleic Acids Research. 36, 12, p. 4047-4056

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.

Goessling, W., North, T. E., Lord, A. M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A. P., Puder, M., Clevers, H., Moon, R. T. & Zon, L. I., 2008, In : Developmental Biology. 320, 1, p. 161-174

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A practical guide for the identification of membrane and plasma membrane proteins in human embryonic stem cells and human embryonal carcinoma cells.

Dormeyer, W., van Hoof, D., Mummery, C. L., Krijgsveld, J. & Heck, A., 2008, In : Proteomics. 8, 19, p. 4036-4053

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.

Cid, V. J., Rodriguez-Escudero, I., Andres-Pons, A., Roma-Mateo, C., Gil, A., den Hertog, J., Molina, M. & Pulido, R., 2008, In : Oncogene. 27, 41, p. 5431-5442

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders.

Olivier, J., Van Der Hart, M. G. C., Van Swelm, R. P. L., Dederen, P. J., Homberg, J. R., Cremers, T., Deen, P. M. T., Cuppen, E., Cools, A. R. & Ellenbroek, B. A., 2008, In : Neuroscience. 152, 3, p. 573-584

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Ataxia with loss of Purkinje cells in a mouse model for Refsum disease.

Ferdinandusse, S., Zomer, A. W. M., Komen, J. C., van den Brink, C., Thanos, M., Hamers, F. P. T., Wanders, R. J. A. T., van der Saag, P. T., Poll-The, B. T. & Brites, P., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 46, p. 17712-17717

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A transgenic mouse model for "lipid hang-up", or why pathologists need to be involved in genetically engineered mouse modelling

Offerhaus, G. J. A., Milne, A. N. A., Oving, I. M., van Gijn, M. E., Hruban, R. H. & Clevers, H., 2008, In : Gut. 57, p. 1739-1740 1739 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W., Plasterk, R. H. A. & Nollen, E. A. A., 2008, In : PLoS Genetics. 4, p. 100027

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cardiac recovery by stem and progenitor cells

van Laake, L. W., 2008, 248 p.

Research output: PhD ThesisPhD thesis

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish.

Hogan, B. M., Bussmann, J., Wolburg, H. & Schulte-Merker, S., 2008, In : Human Molecular Genetics. 17, 16, p. 2424-2432

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells

Xu, X. Q., Graichen, R., Soo, S. Y., Balakrishnan, T., Bte Rahmat, S. N., Sieh, S., Tham, S. C., Freund, C. M. A. H., Moore, J., Mummery, C. L., Colman, A., Zweigerdt, R. & Davidson, B. P., 2008, In : Differentiation. 76, p. 958-970

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Comparative functional analysis provides evidence for a crucial role for the homeobox gene Nkx2.1/Titf-1 in forebrain evolution.

van den Akker, W. M. R., Brox, A., Puelles, L., Durston, A. J. & Medina, L., 2008, In : Journal of Comparative Neurology. 506, 2, p. 211-223

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos.

Lemeer, S., Jopling, C., Gouw, J., Mohammed, S., Heck, A., Slijper, M. & den Hertog, J., 2008, In : Molecular and Cellular Proteomics. 7, 11, p. 2176-2187

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Completion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1.

Leal, M. C., Feitsma, H., Cuppen, E., Franca, L. R. & Schulz, R. W., 2008, In : Cell and Tissue Research. 332, 1, p. 133-139

Research output: Contribution to journal/periodicalArticleScientificpeer-review