• Netherlands

  • Netherlands

Research Output

Spdef null mice lack conjunctival goblet cells and provide a model of dry eye

Marko, C. K., Menon, B. B., Chen, G., Whitsett, J. A., Clevers, H. & Gipson, I. K., 2013, In : American Journal of Pathology. 183, 1, p. 35-48

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Special Issue

Korswagen, H. C. (ed.), 2009, Utrecht: Universiteit Utrecht.

Research output: Book/ReportBookScientific

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

Wetering, M. V. D., Oving, I., Muncan, V., Pon Fong, M. T., Brantjes, H., Leenen, D. V., Holstege, F. C., Brummelkamp, T. R., Agami, R. & Clevers, J. C., 2003, In : EMBO Reports. 4, p. 609-615

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy

Etemad, B., Vertesy, A., Kuijt, T. E. F., Sacristan, C., van Oudenaarden, A. & Kops, G. J. P. L., 17 Jun 2019, In : Journal of Cell Science. 132, 12

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue

Quyn, A. J., Appleton, P. L., Carey, F. A., Steele, R. J., Barker, N., Clevers, H., Ridgway, R. A., Sansom, O. J. & Nathke, I. S., 2010, In : Cell Stem Cell. 6, 2, p. 175-181

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Spin-off uit vouwend DNA

de Laat, W., 2010, In : Onderzoekers verbreden de Horizon.

Research output: Contribution to journal/periodicalArticleScientific

Stamceltherapie maakt eerste beloften waar

Clevers, H., 2010, Gezondgids.

Research output: Chapter in book/volumeChapterScientific

Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons

Bellouze, S., Baillat, G., Buttigieg, D., de la Grange, P., Rabouille, C. & Haase, G., 2016, In : Molecular Neurodegeneration. 11, 1, p. 43

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Stem-cell-based therapy and lessons from the heart.

Passier, R., van Laake, L. W. & Mummery, C. L., 2008, In : Nature. 453, 7193, p. 322-329

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling

Zeilstra, J., Joosten, S. P. J., van Andel, H., Tolg, C., Berns, A., Snoek, M., van de Wetering, M., Spaargaren, M., Clevers, H. & Pals, S. T., 30 Jan 2014, In : Oncogene. 33, 5, p. 665-70 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cell-derived organoids and their application for medical research and patient treatment

Bartfeld, S. & Clevers, H., Jul 2017, In : Journal of Molecular Medicine. 95, 7, p. 729-738 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Stem cell reprogramming: blood, neurons, and beyond

Robin, C., Jaffredo, T. & Zaehres, H., Dec 2019, In : FEBS Letters. 593, 23, p. 3241-3243 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Stem cells, asymmetric division and cancer.

Clevers, J. C., 2005, In : Nature Genetics. 37, p. 1027-1028

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cells, self-renewal, and differentiation in the intestinal epithelium.

van der Flier, L. G. & Clevers, H., 2009, In : Annual Review of Physiology. 71, p. 241-260

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem Cells: A unifying theory for the crypt

Clevers, H., 2013, In : Nature. 495, 7439, p. 53-54

Research output: Contribution to journal/periodicalArticleScientificpeer-review

STEM CELLS. What is an adult stem cell?

Clevers, H., 11 Dec 2015, In : Science Magazine. 350, 6266, p. 1319-20 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cells and cancer of the stomach and intestine

Vries, R. G. J., Huch, M. & Clevers, H., 2010, In : Molecular Oncology. 4, 5, p. 373-384

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Stem cell self-renewal in intestinal crypt

Simons, B. D. & Clevers, H., 2011, In : Experimental Cell Research. 317, 19, p. 2719-2724

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

Clevers, H., Loh, K. M. & Nusse, R., 03 Oct 2014, In : Science Magazine. 346, 6205, p. 1248012

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem Cells in Repair of Gastrointestinal Epithelia

Andersson-Rolf, A., Zilbauer, M., Koo, B-K. & Clevers, H., Jul 2017, In : Physiology (Bethesda, Md.). 32, 4, p. 278-289 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cells marked by the R-spondin receptor LGR5

Koo, B-K. & Clevers, H., Aug 2014, In : Gastroenterology. 147, 2, p. 289-302 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia

Smink, A. M., Li, S., Swart, D. H., Hertsig, D. T., de Haan, B. J., Kamps, J. A. A. M., Schwab, L., van Apeldoorn, A., de Koning, E., Faas, M. M., Lakey, J. R. T. & de Vos, P., Sep 2017, In : Journal of Biomedical Materials Research - Part A. 105, 9, p. 2533-2542 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Stochastic cytokine expression induces mixed T helper cell States

Fang, M., Xie, H., Dougan, S. K., Ploegh, H. & van Oudenaarden, A., 2013, In : PLoS Biology. 11, 7, p. 1001618

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Strategies for homeostatic stem cell self-renewal in adult tissues

Simons, B. D. & Clevers, H., 2011, In : Cell. 145, 6, p. 851-862

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function

de Winter-de Groot, K. M., Janssens, H. M., van Uum, R. T., Dekkers, J. F., Berkers, G., Vonk, A., Kruisselbrink, E., Oppelaar, H., Vries, R., Clevers, H., Houwen, R. H. J., Escher, J. C., Elias, S. G., de Jonge, H. R., de Rijke, Y. B., Tiddens, H. A. W. M., van der Ent, C. K. & Beekman, J. M., Sep 2018, In : European Respiratory Journal. 52, 3

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats.

Olivier, J., Cools, A. R., Olivier, B., Homberg, J. R., Cuppen, E. & Ellenbroek, B. A., 2008, In : European Journal of Pharmacology. 590, 1-3, p. 190-197

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stressing the importance of choice - validity of a preclinical free-choice high-caloric diet paradigm to model behavioral, physiological, and molecular adaptations during human diet-induced obesity and metabolic dysfunction

Slomp, M., Belegri, E., Blancas-Velazquez, A. S., Diepenbroek, C., Eggels, L., Gumbs, M. C. R., Joshi, A., Koekkoek, L. L., Lamuadni, K., Ugur, M., Unmehopa, U. A., la Fleur, S. E. & Mul, J. D., 2019, In : Journal of Neuroendocrinology. 31, p. e12718

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Structure and mapping of the human TCF-1 gene; Characterization of its promoter

Wetering, M. V. D., Oosterwegel, M., Holstege, F., Suykerbuyk, R., Geurts van Kessel, A. & Clevers, J. C., 1992, In : Journal of Biological Chemistry. 267, p. 8530-8536

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
326 Downloads (Pure)

Structure-guided design of selective Epac1 and Epac2 agonists

Schwede, F., Bertinetti, D., Langerijs, C. N., Hadders, M. A., Wienk, H., Ellenbroek, J. H., de Koning, E. J. P., Bos, J. L., Herberg, F. W., Genieser, H-G., Janssen, R. A. J. & Rehmann, H., Jan 2015, In : PLoS Biology. 13, 1, p. e1002038

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

Peng, W. C., De Lau, W., Forneris, F., Granneman, J. C., Huch, M., Clevers, H. & Gros, P., 2013, In : Cell Reports. 3, 6, p. 1885-1892

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

Peng, W. C., De Lau, W., Madoori, P. K., Forneris, F., Granneman, J. C., Clevers, H. & Gros, P., 2013, In : PLoS One. 8, 12, p. 83110

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology

Sasaki, N. & Clevers, H., Oct 2018, In : Current Opinion in Genetics & Development. 52, p. 117-122 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Studying extracellular vesicle transfer by a Cre-loxP method

Zomer, A., Steenbeek, S. C., Maynard, C. & van Rheenen, J., Jan 2016, In : Nature Protocols. 11, 1, p. 87-101 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying Kinetochore Kinases

Saurin, A. T. & Kops, G. J. P. L., 2016, In : Methods in Molecular Biology. 1413, p. 333-47 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying Lineage Decision-Making In Vitro: Emerging Concepts and Novel Tools

Semrau, S. & van Oudenaarden, A., 13 Nov 2015, In : Annual Review of Cell and Developmental Biology. 31, p. 317-45 29 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C).

Louwers, M., Splinter, E., van Driel, R., de Laat, W. & Stam, M., 2009, In : Nature Protocols. 4, 8, p. 1216-1229

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Studying Protein-Tyrosine Phosphatases in Zebrafish

Hale, A. J. & den Hertog, J., 2016, In : Methods in Molecular Biology. 1447, p. 351-72 22 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

SUGAR-DIP trial: oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial

de Wit, L., Rademaker, D., Voormolen, D. N., Akerboom, B. M. C., Kiewiet-Kemper, R. M., Soeters, M. R., Verwij-Didden, M. A. L., Assouiki, F., Schippers, D. H., Vermeulen, M. A. R., Kuppens, S. M. I., Oosterwerff, M. M., Zwart, J. J., Diekman, M. J. M., Vogelvang, T. E., Gallas, P. R. J., Galjaard, S., Visser, W., Horree, N., Klooker, T. K. & 46 others, Laan, R., Heijligenberg, R., Huisjes, A. J. M., van Bemmel, T., van Meir, C. A., van den Beld, A. W., Hermes, W., Vidarsdottir, S., Veldhuis-Vlug, A. G., Dullemond, R. C., Jansen, H. J., Sueters, M., de Koning, E. J. P., van Laar, J. O. E. H., Wouters-van Poppel, P., Sanson-van Praag, M. E., van den Akker, E. S., Brouwer, C. B., Hermsen, B. B., Potter van Loon, B. J., van der Heijden, O. W. H., de Galan, B. E., van Leeuwen, M., Wijbenga, J. A. M., de Boer, K., van Bon, A. C., van der Made, F. W., Eskes, S. A., Zandstra, M., van Houtum, W. H., Braams-Lisman, B. A. M., Daemen-Gubbels, C. R. G. M., Wouters, M. G. A. J., IJzerman, R. G., Mensing van Charante, N. A., Zwertbroek, R., Bosmans, J. E., Evers, I. M., Mol, B. W., de Valk, H. W., Groenendaal, F., Naaktgeboren, C. A., Painter, R. C., deVries, J. H., Franx, A. & van Rijn, B. B., 18 Aug 2019, In : BMJ Open. 9, 8, p. e029808

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice

Demarque, M. D., Nacerddine, K., Neyret-Kahn, H., Andrieux, A., Danenberg, E. M., Jouvion, G., Bomme, P., Hamard, G., Romagnolo, B., Terris, B., Cumano, A., Barker, N., Clevers, H. & Dejean, A., 2010, In : Gastroenterology. 140, 1, p. 286-296

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Suppressive lateral interactions at parafoveal representations in primary visual cortex.

Pooresmaeili, A., Herrero, J. L., Self, M. W., Roelfsema, P. R. & Thiele, A., 2010, In : Journal of Neuroscience. 30, p. 12745-12758

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Surgical implantation of an abdominal imaging window for intravital microscopy

Ritsma, L., Steller, E. J., Ellenbroek, S. I., Kranenburg, O., Rinkes, I. H. & van Rheenen, J., 2013, In : Nature Protocols. 8, 3, p. 583-594

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Janda, C. Y., Dang, L. T., You, C., Chang, J., de Lau, W., Zhong, Z. A., Yan, K. S., Marecic, O., Siepe, D., Li, X., Moody, J. D., Williams, B. O., Clevers, H., Piehler, J., Baker, D., Kuo, C. J. & Garcia, K. C., 11 May 2017, In : Nature. 545, 7653, p. 234-237 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Survival lessons from stress assemblies

Aguilera-Gomez, A., 13 Apr 2017, utrecht : University of Utrecht.

Research output: PhD ThesisPhD thesis

Survivin and molecular pathogenesis of colorectal cancer

Kim, P. J., Plescia, J., Clevers, J. C., Fearon, E. R. & Altieri, D. C., 2003, In : Lancet. 362, p. 205-209

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Swim-training changes the spatio-temporal dynamics of skeletogenesis in zebrafish larvae (Danio rerio)

Fiaz, A. W., Leon-Kloosterziel, K. M., Gort, G., Schulte-Merker, S., van Leeuwen, J. L. & Kranenbarg, S., 2012, In : PLoS One. 7, 4, p. 34072

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

Ren, Z., van Andel, H., de Lau, W., Hartholt, R. B., Maurice, M. M., Clevers, H., Kersten, M. J., Spaargaren, M. & Pals, S. T., 06 Dec 2017, In : Blood.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1

Roose, J., Huls, G., Beest, M. V., Moerer, P., Horn, K. V. D., Goldschmeding, R., Logtenberg, T. & Clevers, J. C., 1999, In : Science. 285, p. 1923-1926

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Synergistic action of A23187 and phorbol ester on human B cell activation

Clevers, J. C., Versteegen, J. M. T., Logtenberg, T., Gmelig-Meyling, F. H. J. & Ballieux, R. E., 1985, In : Journal of Immunology. 135, p. 3827-3830

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Synergistic action of A23187 and PMA on B cells in CLL

Clevers, J. C., Versteegen, J. M. T., Gmelig-Meyling, F. H. J. & Ballieux, R. E., 1986, Elsevier B.V.

Research output: Book/ReportBookScientific

File
56 Downloads (Pure)

Systematic biases in DNA copy number originate from isolation procedures

van Heesch, S., Mokry, M., Boskova, V., Junker, W., Mehon, R., Toonen, P., de Bruijn, E., Shull, J. D., Aitman, T. J., Cuppen, E. & Guryev, V., 2013, In : Genome Biology. 14, 4, p. 33

Research output: Contribution to journal/periodicalArticleScientificpeer-review