• Netherlands

  • Netherlands

Research Output

Article

The intestinal crypt, a prototype stem cell compartment

Clevers, H., 2013, In : Cell. 154, 2, p. 274-284

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The intestinal stem cell.

Barker, N., van de Wetering, M. L. & Clevers, H., 2008, In : Genes & Development. 22, 14, p. 1856-1864

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

Merlos-Suarez, A., Barriga, F. M., Jung, P., Iglesias, M., Cespedes, M. V., Rossell, D., Sevillano, M., Hernando-Momblona, X., da Silva-Diz, V., Munoz, P., Clevers, H., Sancho, E., Mangues, R. & Batlle, E., 2011, In : Cell Stem Cell. 8, 5, p. 511-524

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Intestinal Wnt/TCF Signature

Flier, L. G. V. D., Sabates-Bellver, J., Oving, I., Haegebarth, A., Palo, M. D., Anti, M., Gijn, M. E. V., Suijkerbuijk, S., Wetering, M. V. D., Marra, G. & Clevers, J. C., 2007, In : Gastroenterology. 132, p. 628-632

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The kinase TNIK is an essential activator of Wnt target genes.

Mahmoudi, T., Li, V. S., Ng, S. S., Taouatas, N., Vries, R. G. J., Mohammed, S., Heck, A. J. R. & Clevers, H., 2009, In : EMBO Journal. 28, 21, p. 3329-3340

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis

Mahmoudi, T., Boj, S. F., Hatzis, P., Li, V. S., Taouatas, N., Vries, R. G. J., Teunissen, H., Begthel, H. L., Korving, J., Mohammed, S., Heck, A. & Clevers, H., 2010, In : PLoS Biology. 8, 11, p. 1000539

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

Munoz, J., Stange, D. E., Schepers, A. G., van de Wetering, M., Koo, B. K., Itzkovitz, S., Volckmann, R., Kung, K. S., Koster, J., Radulescu, S., Myant, K., Versteeg, R., Sansom, O. J., van Es, J. H., Barker, N., van Oudenaarden, A., Mohammed, S., Heck, A. J. R. & Clevers, H., 2012, In : EMBO Journal. 31, 14, p. 3079-3091

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Majority of CD45 Ter119 CD31 Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors

Boulais, P. E., Mizoguchi, T., Zimmerman, S., Nakahara, F., Vivié, J., Mar, J. C., van Oudenaarden, A. & Frenette, P. S., 16 Oct 2018, In : Immunity. 49, 4, p. 627-639.e6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The many faces of RNAi

Ketting, R. F., 2011, In : Developmental Cell. 20, 2, p. 148-161

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The many faces of the tumor suppressor gene APC

Es, J. H. V., Giles, R. H. & Clevers, J. C., 2001, In : Experimental Cell Research. 264, p. 126-134

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The ME491 melanoma-associated glycoprotein family. Antigenic identity of the ME491, NKI/C-3, NGA and CD61 proteins

Demetrick, D., Herlyn, D., Tretiak, M., Creasey, D., Clevers, J. C., Vennegoor, C. J. G. M., Dixon, W. T. & Jerry, L. M., 1992, In : Journal of the National Cancer Institute. 84, p. 422-429

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury

van Golen, R. F., Reiniers, M. J., Vrisekoop, N., Zuurbier, C. J., Olthof, P. B., van Rheenen, J., van Gulik, T. M., Parsons, B. J. & Heger, M., 01 Sep 2014, In : Antioxidants and Redox Signaling. 21, 7, p. 1098-118 21 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The microRNA-producing enzyme Dicer1 is essential for zebrafish development

Wienholds, E., Koudijs, M. J., van Eeden, F., Cuppen, E. & Plasterk, R., 2003, In : Nature Genetics. 35, 3, p. 217-218

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The molecular basis of monopolin recruitment to the kinetochore

Plowman, R., Singh, N., Tromer, E. C., Payan, A., Duro, E., Spanos, C., Rappsilber, J., Snel, B., Kops, G. J. P. L., Corbett, K. D. & Marston, A. L., Sep 2019, In : Chromosoma. 128, 3, p. 331-354 24 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The multiple facets of the Golgi reassembly stacking proteins

Vinke, F. P., Grieve, A. & Rabouille, C., 2011, In : Biochemical Journal. 433, 3, p. 423-433

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
330 Downloads (Pure)

The murine Sox-4 protein is encoded on a single exon

Schilham, M. W., Eijk, M. V., Wetering, M. V. D. & Clevers, J. C., 1993, In : Nucleic Acids Research. 21, p. 2009-2009

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
195 Downloads (Pure)

The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1.

Weiss, H., Arndt, T., Jorns, A., Lenzen, S., Cuppen, E., Hedrich, H. J., Tiedge, M. & Wedekind, D., 2008, In : Mammalian Genome. 19, 4, p. 292-297

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Myofibroblasts' War on Drugs

Puschhof, J. & Clevers, H., 24 Sep 2018, In : Developmental Cell. 46, 6, p. 669-670 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The neuronal nitric oxide synthase PDZ motif binds to -G(D,E)XV* carboxyterminal sequences

Schepens, J., Cuppen, E., Wieringa, B. & Hendriks, W., 1997, In : FEBS Letters. 409, 1, p. 53-56

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The next step in tissue culture

Clevers, H., 2010, In : Utrecht Medical Sciences.

Research output: Contribution to journal/periodicalArticleScientific

The nuclear effector of wnt-signaling, tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas

Tiemessen, M. M., Baert, M. R., Schonewille, T., Brugman, M. H., Famili, F., Salvatori, D. C., Meijerink, J. P., Ozbek, U., Clevers, H., van Dongen, J. J. & Staal, F. J., 2012, In : PLoS Biology. 10, 11, p. 1001430

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish

Paridaen, J. T. M., Janson, E., Utami, K. H., Pereboom, T. C., Essers, P., van Rooijen, C. R., Zivkovic, D. & MacInnes, A. W., 2011, In : Developmental Biology. 355, 2, p. 286-301

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Paneth cell, caloric restriction, and intestinal integrity

Clevers, H., 2012, In : New England Journal of Medicine. 367, 16, p. 1560-1561

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The planar cell polarity pathway in vertebrate development

Wansleeben, C. & Meijlink, F., 2011, In : Developmental Dynamics. 240, 3, p. 616-626

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism

Mentink, R. A., Rella, L., Radaszkiewicz, T. W., Gybel, T., Betist, M. C., Bryja, V. & Korswagen, H. C., Dec 2018, In : PLoS Genetics. 14, 12, p. e1007840

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The pluripotent genome in three dimensions is shaped around pluripotency factors

de Wit, E., Bouwman, B. A. M., Zhu, Y., Klous, P., Splinter, E., Verstegen, M. J., Krijger, P. H., Festuccia, N., Nora, E. P., Welling, M., Heard, E., Geijsen, N., Poot, R. A., Chambers, I. & de Laat, W., 2013, In : Nature. 501, 7466, p. 227-231

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies

Busslinger, G. A., Lissendorp, F., Franken, I. A., van Hillegersberg, R., Ruurda, J. P., Clevers, H. & de Maat, M. F. G., Apr 2020, In : Open Biology. 10, 4, p. 190274

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.

Malliri, A., Rygiel, T. P., Kammen, R. A. V. D., Song, J-Y., Engers, R., Hurlstone, A. F. L., Clevers, J. C. & Collard, J. G., 2006, In : The Journal of biological chemistry. 281, p. 543-548

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish development

Rodriguez Proserpi, F., Vacaru, A., Overvoorde, J. & den Hertog, J., 2008, In : Developmental Biology. 324, p. 122-130

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint

Boersma-Vreugdenhil, G. R., Kuipers, J., Stralen, E. V., Peeters, T., Michaux, L., Hagemeijer, A., Pearson, P. L., Clevers, J. C. & Bast, B. J., 2004, In : British Journal of Haematology. 26, p. 355-363

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.

Wassmer, T., Attar, N., Harterink, M., van Weering, J. R., Traer, C. J., Oakley, J., Goud, B., Stephens, D. J., Verkade, P., Korswagen, H. C. & Cullen, P. J., 2009, In : Developmental Cell. 17, 1, p. 110-122

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors)

Lips, D. J., Barker, N., Clevers, H. & Hennipman, A., 2009, In : European Journal of Surgical Oncology. 35, 1, p. 3-10

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair

S Hoogenboom, W., A C M Boonen, R. & Knipscheer, P., 2019, In : Nucleic Acids Research.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The role of small non-coding RNAs in genome stability and chromatin organization

van Wolfswinkel, J. C. & Ketting, R. F., 2010, In : Journal of Cell Science. 123, Pt 11, p. 1825-1839

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model: Dis Model Mech

Homberg, J. R., Olivier, J. D., VandenBroeke, M., Youn, J., Ellenbroek, A. K., Karel, P., Shan, L., van Boxtel, R., Ooms, S., Balemans, M., Langedijk, J., Muller, M., Vriend, G., Cools, A. R., Cuppen, E. & Ellenbroek, B. A., 05 Oct 2016, In : Disease Models & Mechanisms. 9, 10, p. 1147-1158 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos

Kuijk, E. W., van Tol, L. T., te Velde, H., Wubbolts, R., Welling, M., Geijsen, N. & Roelen, B. A., 2012, In : Development. 139, 5, p. 871-882

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

de Lau, W., Peng, W. C., Gros, P. & Clevers, H., 15 Feb 2014, In : Genes & Development. 28, 4, p. 305-16 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The R-spondin protein family

de Lau, W. B. M., Snel, B. & Clevers, H. C., 2012, In : Genome Biology. 13, 3, p. 242

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Schizosaccharomyces pombe mating-type gene mat-MC encodes a sequence-specific DNA-binding HMG box protein

Dooijes, D., Wetering, M. V. D., Knippels, L. & Clevers, J. C., 1993, In : Journal of Biological Chemistry. 268, p. 24813-24817

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
216 Downloads (Pure)

The second decade of 3C technologies: detailed insights into nuclear organization

Denker, A. & de Laat, W., 15 Jun 2016, In : Genes & Development. 30, 12, p. 1357-82 26 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The sequence-specific HMG box of TCF-1 adopts a predominantly alpha-helical conformation in solution

Houte, L. V., Oers, A. M. V., Wetering, M. V. D., Dooijes, D., Kaptein, R. & Clevers, J. C., 1993, In : Journal of Biological Chemistry. 268, p. 18083-18087

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
262 Downloads (Pure)

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish

Velden, Y. U., Wang, L., Zevenhoven, J., van Rooijen, E., van Lohuizen, M., Giles, R. H., Clevers, H. & Haramis, A. P., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 11, p. 4358-4363

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
464 Downloads (Pure)

The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats

Chan, J. Y., Snoeren, E., Cuppen, E., Waldinger, M., Olivier, B. & Oosting, R., 2011, In : Journal of Sexual Medicine. 8, 1, p. 97-108

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Sox-13 gene: structure, promoter characterization, and chromosomal localization

Roose, J., Korver, W., Boer, R. D., Kuipers, J., Hurenkamp, J. & Clevers, J. C., 1999, In : Genomics. 57, p. 301-305

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer

Medina, P. P., Castillo, S. D., Blanco, S., Sanz-Garcia, M., Largo, C., Alvarez, S., Yokota, J., Gonzalez-Neira, A., Benitez, J., Clevers, H., Cigudosa, J. C., Lazo, P. A. & Sanchez-Cespedes, M., 2009, In : Human Molecular Genetics. 18, 7, p. 1343-1352

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The statistical geometry of transcriptome divergence in cell-type evolution and cancer

Liang, C., Forrest, A. R. R. & Wagner, G. P., 2015, In : Nature Communications. 6, p. 6066

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, J. C., Shibuya, H. & Matsumoto, K., 1999, In : Nature. 399, p. 798-802

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The T cell Receptor/CD3 complex: A dynamic protein ensemble

Clevers, J. C., Alarcon, B., Wileman, T. & Terhorst, C., 1988, In : Annual Review of Immunology. 6, p. 629-662

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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294 Downloads (Pure)

The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders

Northrup, E., Zschemisch, N. H., Eisenblatter, R., Glage, S., Wedekind, D., Cuppen, E., Dorsch, M. & Hedrich, H. J., 2012, In : PLoS One. 7, 5, p. 38001

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts

Middelkoop, T. C., Williams, L., Yang, P. T., Luchtenberg, J., Betist, M. C., Ji, N., van Oudenaarden, A., Kenyon, C. & Korswagen, H. C., 2012, In : Developmental Biology. 361, 2, p. 338-348

Research output: Contribution to journal/periodicalArticleScientificpeer-review