• Netherlands

  • Netherlands

Research Output

2018

A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility

Engert, C. G., Droste, R., van Oudenaarden, A. & Horvitz, H. R., Apr 2018, In : PLoS Genetics. 14, 4, p. e1007295

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

Yan, H. H. N., Siu, H. C., Law, S., Ho, S. L., Yue, S. S. K., Tsui, W. Y., Chan, D., Chan, A. S., Ma, S., Lam, K. O., Bartfeld, S., Man, A. H. Y., Lee, B. C. H., Chan, A. S. Y., Wong, J. W. H., Cheng, P. S. W., Chan, A. K. W., Zhang, J., Shi, J., Fan, X. & 5 others, Kwong, D. L. W., Mak, T. W., Yuen, S. T., Clevers, H. & Leung, S. Y., 06 Dec 2018, In : Cell Stem Cell. 23, 6, p. 882-897.e11

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Advances in single-cell sequencing technologies and applications in cancer

Kester, L., 15 Mar 2018, Utrecht University.

Research output: PhD ThesisPhD thesis

Open Access

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Sachs, N., de Ligt, J., Kopper, O., Gogola, E., Bounova, G., Weeber, F., Balgobind, A. V., Wind, K., Gracanin, A., Begthel, H., Korving, J., van Boxtel, R., Duarte, A. A., Lelieveld, D., van Hoeck, A., Ernst, R. F., Blokzijl, F., Nijman, I. J., Hoogstraat, M., van der Ven, M. & 11 others, Egan, D. A., Zinzalla, V., Moll, J., Boj, S. F., Voest, E. E., Wessels, L., van Diest, P. J., Rottenberg, S., Vries, R. G. J., Cuppen, E. & Clevers, H., 2018, In : Cell.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Archaeal DNA on the histone merry-go-round

Bhattacharyya, S., Mattiroli, F. & Luger, K., Sep 2018, In : FEBS Journal. 285, 17, p. 3168-3174 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Artificial Pancreas or Novel Beta-Cell Replacement Therapies: a Race for Optimal Glycemic Control?

Nijhoff, M. F. & de Koning, E. J. P., 24 Sep 2018, In : Current Diabetes Reports. 18, 11, p. 110

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Associations of Abdominal Subcutaneous and Visceral Fat with Insulin Resistance and Secretion Differ Between Men and Women: The Netherlands Epidemiology of Obesity Study

de Mutsert, R., Gast, K., Widya, R., de Koning, E., Jazet, I., Lamb, H., le Cessie, S., de Roos, A., Smit, J., Rosendaal, F. & den Heijer, M., Feb 2018, In : Metabolic Syndrome and Related Disorders. 16, 1, p. 54-63 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Automated brightfield morphometry of 3D organoid populations by OrganoSeg

Borten, M. A., Bajikar, S. S., Sasaki, N., Clevers, H. & Janes, K. A., 28 Mar 2018, In : Scientific Reports. 8, 1, p. 5319

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A Zinc Finger Transcription Factor, , Required for the Specification of a Dopamine Neuron-Producing Lineage

Doitsidou, M., Minevich, G., Kroll, J. R., Soete, G., Gowtham, S., Korswagen, H. C., Sebastiaan van Zon, J. & Hobert, O., 04 Jan 2018, In : G3 (Bethesda, Md.). 8, 1, p. 17-26 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Bioengineered bile ducts recapitulate key cholangiocyte functions

Chen, C., Jochems, P. G. M., Salz, L., Schneeberger, K., Penning, L. C., van de Graaf, S. F. J., Beuers, U., Clevers, H., Geijsen, N., Masereeuw, R. & Spee, B., 12 Jun 2018, In : Biofabrication. 10, 3, p. 034103

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Bioluminescent reporter assay for monitoring ER stress in human beta cells

Kracht, M. J. L., de Koning, E. J. P., Hoeben, R. C., Roep, B. O. & Zaldumbide, A., 10 Dec 2018, In : Scientific Reports. 8, 1, p. 17738

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Blastocyst-like structures generated solely from stem cells

Rivron, N. C., Frias-Aldeguer, J., Vrij, E. J., Boisset, J-C., Korving, J., Vivié, J., Truckenmüller, R. K., van Oudenaarden, A., van Blitterswijk, C. A. & Geijsen, N., May 2018, In : Nature. 557, 7703, p. 106-111 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model

Braham, M. V. J., Minnema, M. C., Aarts, T., Sebestyen, Z., Straetemans, T., Vyborova, A., Kuball, J., Öner, F. C., Robin, C. & Alblas, J., 2018, In : OncoImmunology. 7, 6, p. e1434465

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

Oosterhof, N., Kuil, L. E., van der Linde, H. C., Burm, S. M., Berdowski, W., van IJcken, W. F. J., van Swieten, J. C., Hol, E. M., Verheijen, M. H. G. & van Ham, T. J., Jun 2018, In : Cell Reports. 24, 5, p. 1203-1217.e6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
134 Downloads (Pure)

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

Linnekamp, J. F., Hooff, S. R. V., Prasetyanti, P. R., Kandimalla, R., Buikhuisen, J. Y., Fessler, E., Ramesh, P., Lee, K. A. S. T., Bochove, G. G. W., de Jong, J. H., Cameron, K., Leersum, R. V., Rodermond, H. M., Franitza, M., Nürnberg, P., Mangiapane, L. R., Wang, X., Clevers, H., Vermeulen, L., Stassi, G. & 1 others, Medema, J. P., Mar 2018, In : Cell Death and Differentiation. 25, 3, p. 616-633 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Controlled Release of RNAi Molecules by Tunable Supramolecular Hydrogel Carriers

Bakker, M. H., van Rooij, E. & Dankers, P. Y. W., 16 Nov 2018, In : Chemistry - An Asian Journal. 13, 22, p. 3501-3508 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-"

Muncan, V., Sansom, O. J., Tertoolen, L., Phesse, T. J., Begthel, H., Sancho, E., Cole, A. M., Gregorieff, A., Moreno de Alboran, I., Clevers, H. & Clarke, A. R., 15 Dec 2018, In : Molecular and Cellular Biology. 38, 24

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining Adult Stem Cells by Function, not by Phenotype

Clevers, H. & Watt, F. M., 20 Jun 2018, In : Annual Review of Biochemistry. 87, p. 1015-1027 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining outcomes for beta cell replacement therapy: a work in progress

Piemonti, L., de Koning, E. J. P., Berney, T., Odorico, J. S., Markmann, J. F., Stock, P. G. & Rickels, M. R., Jun 2018, In : Diabetologia. 61, 6, p. 1273-1276 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Defining outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop

Rickels, M. R., Stock, P. G., de Koning, E. J. P., Piemonti, L., Pratschke, J., Alejandro, R., Bellin, M. D., Berney, T., Choudhary, P., Johnson, P. R., Kandaswamy, R., Kay, T. W. H., Keymeulen, B., Kudva, Y. C., Latres, E., Langer, R. M., Lehmann, R., Ludwig, B., Markmann, J. F., Marinac, M. & 6 others, Odorico, J. S., Pattou, F., Senior, P. A., Shaw, J. A. M., Vantyghem, M-C. & White, S., Apr 2018, In : Transplant international : official journal of the European Society for Organ Transplantation. 31, 4, p. 343-352 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop

Rickels, M. R., Stock, P. G., de Koning, E. J. P., Piemonti, L., Pratschke, J., Alejandro, R., Bellin, M. D., Berney, T., Choudhary, P., Johnson, P. R., Kandaswamy, R., Kay, T. W. H., Keymeulen, B., Kudva, Y. C., Latres, E., Langer, R. M., Lehmann, R., Ludwig, B., Markmann, J. F., Marinac, M. & 6 others, Odorico, J. S., Pattou, F., Senior, P. A., Shaw, J. A. M., Vantyghem, M-C. & White, S., Sep 2018, In : Transplantation. 102, 9, p. 1479-1486 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Detection of mRNA and Associated Molecules by ISH-IEM on Frozen Sections

Rabouille, C., 2018, In : Methods in Molecular Biology. 1649, p. 177-186 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Zhou, J., Li, C., Sachs, N., Chiu, M. C., Wong, B. H-Y., Chu, H., Poon, V. K-M., Wang, D., Zhao, X., Wen, L., Song, W., Yuan, S., Wong, K. K-Y., Chan, J. F-W., To, K. K-W., Chen, H., Clevers, H. & Yuen, K-Y., 26 Jun 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. 6822-6827 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

Sacristan, C., Ahmad, M. U. D., Keller, J., Fermie, J., Groenewold, V., Tromer, E., Fish, A., Melero, R., Carazo, J. M., Klumperman, J., Musacchio, A., Perrakis, A. & Kops, G. J., Jul 2018, In : Nature Cell Biology. 20, 7, p. 800-810 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

Tessadori, F., Roessler, H. I., Savelberg, S. M. C., Chocron, S., Kamel, S. M., Duran, K. J., van Haelst, M. M., van Haaften, G. & Bakkers, J., 18 Oct 2018, In : Disease Models & Mechanisms. 11, 10

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish

Ferrero, G., Mahony, C. B., Dupuis, E., Yvernogeau, L., Di Ruggiero, E., Miserocchi, M., Caron, M., Robin, C., Traver, D., Bertrand, J. Y. & Wittamer, V., 03 Jul 2018, In : Cell Reports. 24, 1, p. 130-141 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma

Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Öner, F. C., Robin, C., Lode, A., Gelinsky, M. & Alblas, J., May 2018, In : Tissue Engineering - Part C: Methods. 24, 5, p. 300-312 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Enhancer hubs and loop collisions identified from single-allele topologies

Allahyar, A., Vermeulen, C., Bouwman, B. A. M., Krijger, P. H. L., Verstegen, M. J. A. M., Geeven, G., van Kranenburg, M., Pieterse, M., Straver, R., Haarhuis, J. H. I., Jalink, K., Teunissen, H., Renkens, I. J., Kloosterman, W. P., Rowland, B. D., de Wit, E., de Ridder, J. & de Laat, W., Aug 2018, In : Nature Genetics. 50, 8, p. 1151-1160 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

Beumer, J., Artegiani, B., Post, Y., Reimann, F., Gribble, F., Nguyen, T. N., Zeng, H., Van den Born, M., Van Es, J. H. & Clevers, H., Aug 2018, In : Nature Cell Biology. 20, 8, p. 909-916 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant

van der Sanden, S. M. G., Sachs, N., Koekkoek, S. M., Koen, G., Pajkrt, D., Clevers, H. & Wolthers, K. C., 09 May 2018, In : Emerging Microbes & Infections . 7, 1, p. 84

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Establishment and characterization of a canine keratinocyte organoid culture system

Wiener, D. J., Basak, O., Asra, P., Boonekamp, K. E., Kretzschmar, K., Papaspyropoulos, A. & Clevers, H., Oct 2018, In : Veterinary Dermatology. 29, 5, p. 375-e126

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expanding Impact of Stem Cell Science

Clevers, H., 08 May 2018, In : Stem Cell Reports. 10, 5, p. 1427-1428 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F. C., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 13 Mar 2018, In : Stem Cell Reports. 10, 3, p. 712-724 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Factors involved in cardiac physiological and pathological remodeling

Demkes, C. J., 17 Apr 2018, Utrecht University.

Research output: PhD ThesisPhD thesis

FRET-based Stoichiometry Measurements of Protein Complexes

Mattiroli, F., Gu, Y. & Luger, K., 05 Feb 2018, In : Bio-Protocol. 7, 3

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

Dijkstra, K. K., Cattaneo, C. M., Weeber, F., Chalabi, M., van de Haar, J., Fanchi, L. F., Slagter, M., van der Velden, D. L., Kaing, S., Kelderman, S., van Rooij, N., van Leerdam, M. E., Depla, A., Smit, E. F., Hartemink, K. J., de Groot, R., Wolkers, M. C., Sachs, N., Snaebjornsson, P., Monkhorst, K. & 4 others, Haanen, J., Clevers, H., Schumacher, T. N. & Voest, E. E., 06 Sep 2018, In : Cell. 174, 6, p. 1586-1598.e12

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genome editing by natural and engineered CRISPR-associated nucleases

Wu, W. Y., Lebbink, J. H. G., Kanaar, R., Geijsen, N. & van der Oost, J., Jul 2018, In : Nature Chemical Biology. 14, 7, p. 642-651 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis

Mur, P., De Voer, R. M., Olivera-Salguero, R., Rodríguez-Perales, S., Pons, T., Setién, F., Aiza, G., Valdés-Mas, R., Bertini, A., Pineda, M., Vreede, L., Navarro, M., Iglesias, S., González, S., Brunet, J., Valencia, A., Esteller, M., Lázaro, C., Kops, G. J. P. L., Urioste, M. & 3 others, Puente, X. S., Capellá, G. & Valle, L., 15 Feb 2018, In : Molecular Cancer. 17, 1, p. 23

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

Rumping, L., Tessadori, F., Pouwels, P. J., Vringer, E., Wijnen, J. P., Bhogal, A. A., Savelberg, S. M., Duran, K. J., Bakkers, M. J., Ramos, R. J., Schellekens, P. A., Kroes, H. Y., Klomp, D. W., Black, G. C., Taylor, R. L., Bakkers, J. P., Prinsen, H. C., Knaap, M. S., Dansen, T. B., Rehmann, H. & 6 others, Zwartkruis, F. J., Houwen, R. H., Haaften, G., Verhoeven-Duif, N. M., Jans, J. J. & Hasselt, P. M., 2018, In : Human Molecular Genetics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

Grinenko, T., Eugster, A., Thielecke, L., Ramasz, B., Krüger, A., Dietz, S., Glauche, I., Gerbaulet, A., von Bonin, M., Basak, O., Clevers, H., Chavakis, T. & Wielockx, B., 15 May 2018, In : Nature Communications. 9, 1, p. 1898

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Hepatic and Biliary Differentiation of Somatic Cells

Chen, C., 2018, Utrecht University.

Research output: PhD ThesisPhD thesis

Open Access

Hepatocyte-like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers

Chen, C., Pla-Palacín, I., Baptista, P. M., Shang, P., Oosterhoff, L. A., van Wolferen, M. E., Penning, L. C., Geijsen, N. & Spee, B., Nov 2018, In : Biotechnology and Bioengineering. 115, 11, p. 2807-2816 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Heterozygous missense mutations in NFATC1 are associated with atrioventricular septal defect

Ferese, R., Bonetti, M., Consoli, F., Guida, V., Sarkozy, A., Lepri, F. R., Versacci, P., Gambardella, S., Calcagni, G., Margiotti, K., Piceci Sparascio, F., Hozhabri, H., Mazza, T., Digilio, M. C., Dallapiccola, B., Tartaglia, M., Marino, B., Hertog, J. D. & De Luca, A., Oct 2018, In : Human Mutation. 39, 10, p. 1428-1441 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Hypothermic Oxygenated Machine Perfusion of the Human Donor Pancreas

Leemkuil, M., Lier, G., Engelse, M. A., Ploeg, R. J., de Koning, E. J. P., 't Hart, N. A., Krikke, C. & Leuvenink, H. G. D., Oct 2018, In : Transplantation Direct. 4, 10, p. e388

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Imaging organoids: a bright future ahead

Rios, A. C. & Clevers, H., 03 Jan 2018, In : Nature Methods. 15, 1, p. 24-26 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Imaging Translation Dynamics of Single mRNA Molecules in Live Cells

Ruijtenberg, S., Hoek, T. A., Yan, X. & Tanenbaum, M. E., 2018, In : Methods in Molecular Biology. 1649, p. 385-404 20 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Implementation of a Structured Diabetes Consultation Model to Facilitate a Person-Centered Approach: Results From a Nationwide Dutch Study

Rutten, G. E. H. M., van Vugt, H. A., de Weerdt, I. & de Koning, E., Apr 2018, In : Diabetes Care. 41, 4, p. 688-695 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1

Magliozzi, R., Carrero, Z. I., Low, T. Y., Yuniati, L., Valdes-Quezada, C., Kruiswijk, F., van Wijk, K., Heck, A. J. R., Jackson, C. L. & Guardavaccaro, D., 12 Jun 2018, In : Cell Reports. 23, 11, p. 3381-3391.e4

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis

Laarman, M. D., Vermunt, M. W. & Ruigrok, Y. M., Feb 2018, In : Stroke. 49, 2, p. 447-453 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
155 Downloads (Pure)

Intra-tumour diversification in colorectal cancer at the single-cell level

Roerink, S. F., Sasaki, N., Lee-Six, H., Young, M. D., Alexandrov, L. B., Behjati, S., Mitchell, T. J., Grossmann, S., Lightfoot, H., Egan, D. A., Pronk, A., Smakman, N., van Gorp, J., Anderson, E., Gamble, S. J., Alder, C., van de Wetering, M., Campbell, P. J., Stratton, M. R. & Clevers, H., Apr 2018, In : Nature. 556, 7702, p. 457-462 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review