• Netherlands

  • Netherlands

Research Output

2006

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.

Thijssen, V. L., Postel, R., Brandwijk, R. J., Dings, R. P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L. G., Bakkers, J., Mayo, K. H., Poirier, F. & Griffioen, A. W., 2006, Proceedings of the National Academy of Sciences of the United States of America. p. 15975-15980

Research output: Chapter in book/volumeContribution to conference proceedingsScientific

Gene expression: long-term gene silencing by RNAi.

Vastenhouw, N. L., Brunschwig, K., Okihara, K. L., Muller, F., Tijsterman, M. & Plasterk, R. H. A., 2006, In : Nature. 442, 7105

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis

Smits, B. M., Mudde, J. B., van de Belt, J., Verheul, M., Olivier, J., Homberg, J. R., Guryev, V., Cools, A. R., Ellenbroek, B. A., Plasterk, R. & Cuppen, E., 2006, In : Pharmacogenetics and Genomics. 16, 3, p. 159-169 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genetic variation in the zebrafish

Guryev, V., Koudijs, M. J., Berezikov, E., Johnson, S. L., Plasterk, R., van Eeden, F. & Cuppen, E., 2006, In : Genome Research. 16, 4, p. 491-497

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Haplotype block structure is conserved across mammals

Guryev, V., Smits, B. M., van de Belt, J., Verheul, M., Hubner, N. & Cuppen, E., 2006, In : PLoS Genetics. 2, 7, p. 121

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi.

van Haaften, G. W., Romeijn, R., Pothof, J., Koole, W., Mullenders, L. H., Pastink, A., Plasterk, R. H. A. & Tijsterman, M., 2006, In : Current Biology. 16, 13, p. 1344-1350

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Inter-laboratory comparison of three different real-time PCR assays for the detection of Pneumocystis jiroveci in bronchoalveolar lavage fluid samples.

Linssen, C. F., Jacobs, J. A., Beckers, P., Templeton, K. E., Bakkers, J., Kuijper, E. J., Melchers, W. J., Drent, M. & Vink, C., 2006, In : Journal of Medical Microbiology. 55, Pt 9, p. 1229-1235

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis.

Giles, R. H., Lolkema, M. P., Snijckers, C. M., Belderbos, M., Groep, P. V. D., Mans, D. A., Beest, M. V., Noort, M. V., Goldschmeding, R., Diest, P. J. V., Clevers, J. C. & Voest, E. E., 2006, In : Oncogene. 25, p. 3065-3070

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Knocking out the Argonautes.

Steiner, F. A. & Plasterk, R. H. A., 2006, In : Cell. 127, 4, p. 667-668

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis

Berezikov, E., van Tetering, G., Verheul, M., van de Belt, J., van Laake, L. W., Vos, J., Verloop, R., van de Wetering, M. L., Guryev, V., Takada, S., van Zonneveld, A. J., Mano, H., Plasterk, R. & Cuppen, E., 2006, In : Genome Research. 16, 10, p. 1289-1298 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mapping determinants of gene expression plasticity by genetical genomics in C. elegans.

Li, Y., Alvarez, O. A., Gutteling, E. W., Tijsterman, M., Fu, J., Riksen, J. A., Hazendonk, M. G. A., Prins, P., Plasterk, R. H. A., Jansen, R. C., Breitling, R. & Kammenga, J. E., 2006, In : PLoS Genetics. 2, 12

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Micro RNAs in animal development.

Plasterk, R. H. A., 2006, In : Cell. 124, 5, p. 877-881

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Mining the Wnt pathway for cancer therapeutics.

Barker, N. & Clevers, J. C., 2006, In : Nature Reviews Drug Discovery. 5, p. 997-1014

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mouse microRNA profiles determined with a new and sensitive cloning method

Takada, S., Berezikov, E., Yamashita, Y., Lagos-Quintana, M., Kloosterman, W. P., Enomoto, M., Hatanaka, H., Fujiwara, S., Watanabe, H., Soda, M., Choi, Y. L., Plasterk, R., Cuppen, E. & Mano, H., 2006, In : Nucleic Acids Research. 34, 17, p. 115 1 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis.

Jansen, M., Leng, W. W. J. D., Baas, A. F., Myoshi, H., Mathus-Vliegen, L., Taketo, M. M., Clevers, J. C., Giardiello, F. M. & Offerhaus, G. J. A., 2006, In : Gut. 55, p. 1-5

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Perioperative strategy in colonic surgery; LAparoscopy and/or FAst track multimodal management versus standard care (LAFA trial).

Wind, J., Hofland, J., Preckel, B., Hollman, M. W., Bossuyt, P. M. M., Gouma, D. J., Berge Henegouwen, M. I., Fuhring, J. W., Dejong, C. H. C., Dam, R. M. V., Cuesta, M. A., Noordhuis, A., Jong, D. D., Zalingen, E. V., Engel, A. F., Goei, T. H., Stoppelaar, I. E. D., Tets, W. F. V., Wagensveld, B. A. V., Swart, A. & 8 others, Elsen, M. J. L. J. V. D., Gerhards, M. F., Wit, L. T. D., Siepel, M. A. M., Geloven, A. A. W. V., Juttmann, J-W., Clevers, J. C. & Bemelman, W. A., 2006, In : BMC Surgery. 6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.

Muncan, V., Sansom, O. J., Tertoolen, L., Phesse, T. J., Begthel, H., Sancho, E., Cole, A. M., Gregorieff, A., Alboran, I. M. D., Clevers, J. C. & Clarke, A. R., 2006, In : Molecular and Cellular Biology. 26, p. 8418-8426

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Rat genetics: the next episode

Smits, B. M. & Cuppen, E., 2006, In : Trends in Genetics. 22, 4, p. 232-240

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Rats go genomic

Smits, B. M. & Cuppen, E., 2006, In : Genome Biology. 7, 2, p. 306

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Serotypes, genotypes, and antibiotic susceptibility profiles of group B streptococci causing neonatal sepsis and meningitis before and after introduction of antibiotic prophylaxis.

Trijbels-Smeulders, M. A., Kimpen, J. L., Kollee, L. A., Bakkers, J., Melchers, W. J., Spanjaard, L., Wannet, W. J. & Hoogkamp-Korstanje, M. A., 2006, In : Pediatric Infectious Disease Journal. 25, 10, p. 945-948

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The diverse functions of microRNAs in animal development and disease.

Kloosterman, W. P. & Plasterk, R. H. A., 2006, In : Developmental Cell. 11, 4, p. 441-450

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.

Markiewicz, E., Tilgner, K., Wetering, M. V. D., Clevers, J. C., Dorobek, M., Haumanowa-Petrusewicz, I., Ramaekers, F. C. S., Broers, J. L. V., Blankesteijn, W. M., Salpingidou, G., Wilson, R. G., Ellis, J. A. & Hutchison, C. J., 2006, In : EMBO Journal. 25, p. 3275-3285

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.

Malliri, A., Rygiel, T. P., Kammen, R. A. V. D., Song, J-Y., Engers, R., Hurlstone, A. F. L., Clevers, J. C. & Collard, J. G., 2006, In : The Journal of biological chemistry. 281, p. 543-548

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway.

Huang, Z., Xie, H., Ioannidis, V., Held, W., Clevers, J. C., Sadim, M. S. & Sun, Z., 2006, In : Journal of Immunology. 176, p. 4880-4887

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcription factor target practice.

Hostege, F. C. P. & Clevers, J. C., 2006, In : Cell. 124, p. 21-23

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/beta-catenin signaling in development and disease.

Clevers, J. C., 2006, In : Cell. 127, p. 469-480

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Zebrafish cypher is important for somite formation and heart development.

van der Meer, D. L., Marques, I. J., Leito, J. T., Besser, J., Bakkers, J., Schoonheere, E. & Bagowski, C. P., 2006, In : Developmental Biology. 299, 2, p. 356-372

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2005

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, J. C., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A. & Karsenty, G., 2005, In : Developmental Cell. 8, p. 751-764

Research output: Contribution to journal/periodicalArticleScientificpeer-review

CASCAD: a database of annotated candidate single nucleotide polymorphisms associated with expressed sequences

Guryev, V., Berezikov, E. & Cuppen, E., 2005, In : BMC Genomics. 6, 1, p. 10

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Chlamydia trachomatis and genital human papillomavirus infections in female university students in Honduras.

Tabora, N., Zelaya, A., Bakkers, J., Melchers, W. J. & Ferrera, A., 2005, In : The American Journal of Tropical Medicine and Hygiene. 73, 1, p. 50-53

Research output: Contribution to journal/periodicalArticleScientificpeer-review

CONREAL web server: identification and visualization of conserved transcription factor binding sites

Berezikov, E., Guryev, V. & Cuppen, E., 2005, In : Nucleic Acids Research. 33, Web Server issue, p. 447-450

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection.

Bopegamage, S., Kovacova, J., Vargova, A., Motusova, J., Petrovicova, A., Benkovicova, M., Gomolcak, P., Bakkers, J., van Kuppeveld, F., Melchers, W. J. & Galama, J. M., 2005, In : Journal of General Virology. 86, Pt 12, p. 3271-3280

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.

Sansom, O. J., Reed, K. R., Wetering, M. V. D., Muncan, V., Winston, D., Clevers, J. C. & Clarke, A. R., 2005, In : The Journal of biological chemistry. 280, p. 28463-28467

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo.

Bakkers, J., Camacho-Carvajal, M., Nowak, M., Kramer, C., Danger, B. & Hammerschmidt, M., 2005, In : Cell Cycle. 4, 6, p. 790-800

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.

Riedl, J. A., Brandt, D. T., Batlle, E., Price, L. S., Clevers, J. C. & Bos, J. L., 2005, In : The Biochemical journal. 389, p. 465-469

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates

Smits, B. M., Guryev, V., Zeegers, D., Wedekind, D., Hedrich, H. J. & Cuppen, E., 2005, In : BMC Genomics. 6, p. 170

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

EphB activity suppresses colorectal cancer progression

Batlle, E., Bacani, J., Begthel, H. L., Jonkheer, S., Gregorieff, A., van den Born, M. M. W., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S. & Clevers, J. C., 2005, In : Nature Genetics. 435, p. 1126-1130

Research output: Contribution to journal/periodicalArticleScientificpeer-review

EphB receptor activity suppresses colorectal cancer progression.

Batlle, E., Bacani, J., Begthel, H., Jonkheer, S., Gregorieff, A., Born, M. V. D., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S. & Clevers, J. C., 2005, In : Nature. 435, p. 1126-1130

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expression pattern of Wnt signaling components in the adult intestine.

Gregorieff, A., Pinto, D., Begthel, H., Destree, O., Kielman, M. & Clevers, J. C., 2005, In : Gastroenterology. 129, p. 626-638

Research output: Contribution to journal/periodicalArticleScientificpeer-review

FoxM1 is required for execution of the mitotic programme and chromosome stability.

Laoukili, J., Kooistra, M. R. H., Bras, A., Kauw, J., Kerkhoven, R. M., Morrison, A., Clevers, J. C. & Medema, R. H., 2005, In : Nature Cell Biology. 7, p. 126-136

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

Forcet, C., Etienne-Manneville, S., Gaude, H., Fournier, L., Debilly, S., Salmi, M., Baas, A., Olschwang, S., Clevers, J. C. & Billaud, M., 2005, In : Human Molecular Genetics. 14, p. 1283-1292

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Haplotype-based genetics in mice and rats

Cuppen, E., 2005, In : Trends in Genetics. 21, 6, p. 318-322

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Hoe de Nederlandse wetenschap beter te maken. [Improving the health of scientific research in The netherlands.]

Clevers, J. C., 2005, In : Nederlands Tijdschrift voor Geneeskunde. 149, p. 1608-1611

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics

Smits, B. M., Peters, T. A., Mul, J. D., Croes, H. J., Fransen, J. A., Beynon, A. J., Guryev, V., Plasterk, R. & Cuppen, E., 2005, In : Genetics. 170, 4, p. 1887-1896

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Influenza-associated encephalopathy: no evidence for neuroinvasion by influenza virus nor for reactivation of human herpesvirus 6 or 7.

van Zeijl, J. H., Bakkers, J., Wilbrink, B., Melchers, W. J., Mullaart, R. A. & Galama, J. M., 2005, In : Clinical Infectious Diseases. 40, 3, p. 483-485

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

Es, J. H. V., Gijn, M. E. V., Riccio, O., Born, M. V. D., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winston, D. J., Radtke, F. & Clevers, J. C., 2005, In : Nature. 435, p. 959-963

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease.

Es, J. H. V. & Clevers, J. C., 2005, In : Trends in Molecular Medicine. 11, p. 496-502

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Phylogenetic shadowing and computational identification of human microRNA genes

Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R. & Cuppen, E., 2005, In : Cell. 120, 1, p. 21-24

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity

Pellis-van Berkel, W., Verheijen, M. H., Cuppen, E., Asahina, M., de Rooij, J., Jansen, G., Plasterk, R., Bos, J. L. & Zwartkruis, F. J., 2005, In : Molecular Biology of the Cell. 16, 1, p. 106-116

Research output: Contribution to journal/periodicalArticleScientificpeer-review