• Netherlands

  • Netherlands

Research Output

2005

Self-renewal and cancer of the gut: two sides of a coin.

Radtke, F. & Clevers, J. C., 2005, In : Science Magazine. 307, p. 1904-1909

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stem cells, asymmetric division and cancer.

Clevers, J. C., 2005, In : Nature Genetics. 37, p. 1027-1028

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt, stem cells and cancer in the intestine.

Pinto, D. & Clevers, J. C., 2005, In : Biology of the cell / under the auspices of the European Cell Biology Organization. 97, p. 185-196

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt control of stem cells and differentiation in the intestinal epithelium.

Pinto, D. & Clevers, J. C., 2005, In : Experimental Cell Research. 306, p. 357-363

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling in the intestinal epithelium: from endoderm to cancer.

Gregorieff, A. & Clevers, J. C., 2005, In : Genes & Development. 19, p. 877-890

Research output: Contribution to journal/periodicalArticleScientificpeer-review

WNT signalling and haematopoiesis: a WNT-WNT situation.

Staal, F. J. T. & Clevers, J. C., 2005, In : Nature Reviews Immunology. 5, p. 21-30

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signalling induces maturation of Paneth cells in intestinal crypts.

Es, J. H. V., Jay, P., Gregorieff, A., Gijn, M. E. V., Jonkheer, S., Hatzis, P., Thiele, A., Born, M. V. D., Gegthel, H., Brabletz, T., Taketo, M. M. & Clevers, J. C., 2005, In : Nature Cell Biology. 7, p. 381-386

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signalling in stem cells and cancer.

Reya, T. & Clevers, J. C., 2005, In : Nature. 434, p. 843-850

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2004

Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected

Le, N. H., Bent, P. V. D., Huls, G., Wetering, M. V. D., Loghman-Adham, M., Ong, A. C., Calvet, J. P., Clevers, J. C., Breuning, M. H., Dam, H. V. & Peters, D. J., 2004, In : Journal of Biological Chemistry. 279, p. 27472-27481

Research output: Contribution to journal/periodicalArticleScientificpeer-review

At the crossroads of inflammation and cancer

Clevers, J. C., 2004, In : Cell. 17, p. 671-6744

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD

Baas, A. F., Kuipers, J., Wel, N. N. V. D., Batlle, E., Koerten, H. K., Peters, P. J. & Clevers, J. C., 2004, In : Cell. 116, p. 457-466

Research output: Contribution to journal/periodicalArticleScientificpeer-review

CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting

Berezikov, E., Guryev, V., Plasterk, R. & Cuppen, E., 2004, In : Genome Research. 14, 1, p. 170-178

Research output: Contribution to journal/periodicalArticleScientificpeer-review

De novo crypt formation and Juvenile Polyposis upon BMP inhibition

Haramis, A. P., Begthel, H., Born, M. V. D., Es, J. V., Jonkheer, S., Offerhaus, G. J. & Clevers, J. C., 2004, In : Science. 303, p. 1684-1686

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

Brembeck, F. H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M. & Birchmeier, W., 2004, In : Genes & Development. 18, 18, p. 2225-2230

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition.

Rentzsch, F., Bakkers, J., Kramer, C. & Hammerschmidt, M., 2004, In : Developmental Dynamics. 231, 4, p. 750-757

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genetic variation in coding regions between and within commonly used inbred rat strains

Smits, B. M., van Zutphen, B. F., Plasterk, R. & Cuppen, E., 2004, In : Genome Research. 14, 7, p. 1285-1290

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation.

Bakkers, J., Kramer, C., Pothof, J., Quaedvlieg, N. E., Spaink, H. P. & Hammerschmidt, M., 2004, In : Development. 131, 3, p. 525-537

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Hindgut defects and transformation of the gastro-intestinal tract in Tcf4-/-/Tcf1-/- embryos

Gregorieff, A., Grosschedl, R. & Clevers, J. C., 2004, In : EMBO Journal. 23, p. 1825-1833

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identifying polymorphisms in the Rattus norvegicus D3 dopamine receptor gene and regulatory region

Smits, B. M., D'Souza, U. M., Berezikov, E., Cuppen, E. & Sluyter, F., 2004, In : Genes Brain and Behavior. 3, 3, p. 138-148

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

Derksen, P. W., Tjin, E., Meijer, H. P., Klok, M. D., MacGillavry, H. D., Oers, M. H. V., Lokhorst, H. M., Bloem, A. C., Clevers, J. C., Nusse, R., Neut, R. V. D., Spaargaren, M. & Pals, S. T., 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, p. 6122-6127

Research output: Contribution to journal/periodicalArticleScientificpeer-review

LKB1 tumor suppressor protein: PARtaker in cell polarity

Baas, A. F., Smit, L. & Clevers, J. C., 2004, In : Trends in Cell Biology. 14, p. 312-319

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

Sansom, O. J., Reed, K. R., Hayes, A. J., Ireland, H., Brinkmann, H., Newton, I. P., Batlle, E., Simon-Assmann, P., Clevers, J. C., Nathke, I. S., Clarke, A. R. & Winton, D. J., 2004, In : Genes & Development. 18, p. 1385-1390

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Signaling mucins in the (S)limelight

Clevers, J. C., 2004, In : Developmental Cell. 7, p. 150-151

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Signaling Pathways in Intestinal Development and Cancer

Sancho, E., Batlle, E. & Clevers, J. C., 2004, In : Annual Review of Cell and Developmental Biology. 20, p. 695-723

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Single nucleotide polymorphisms associated with rat expressed sequences

Guryev, V., Berezikov, E., Malik, R., Plasterk, R. & Cuppen, E., 2004, In : Genome Research. 14, 7, p. 1438-1443

Research output: Contribution to journal/periodicalArticleScientificpeer-review

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

Blache, P., Wetering, M. V. D., Duluc, I., Domon, C., Berta, P., Freund, J. N., Clevers, J. C. & Jay, P., 2004, In : Journal of Cell Biology. 166, p. 37-47

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Target-selected mutagenesis of the rat

Smits, B. M., Mudde, J. B., Plasterk, R. & Cuppen, E., 2004, In : Genomics. 83, 2, p. 332-334

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint

Boersma-Vreugdenhil, G. R., Kuipers, J., Stralen, E. V., Peeters, T., Michaux, L., Hagemeijer, A., Pearson, P. L., Clevers, J. C. & Bast, B. J., 2004, In : British Journal of Haematology. 26, p. 355-363

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt activates the Tak1/Nlk kinase pathway

Smit, L., Baas, A., Kuipers, J., Korswagen, H., Wetering, M. V. D. & Clevers, J. C., 2004, In : Journal of Biological Chemistry.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling: Ig-norrin the dogma

Clevers, J. C., 2004, In : Current Biology. 14, p. 437

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2003

Activation of the tumor suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R. & Clevers, J. C., 2003, In : EMBO Journal. 22, p. 3062-3072

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

Bienz, M. & Clevers, J. C., 2003, In : Nature Cell Biology. 5, p. 179-182

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., Wetering, M. V. D., Clevers, J. C., Taketo, M. M., Behringer, R. R., Shen, M. M. & Birchmeier, W., 2003, In : Development. 130, p. 6283-6294

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

Pinto, D., Gregorieff, A., Begthel, H. & Clevers, J. C., 2003, In : Genes & Development. 17, p. 1709-1713

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Caught up in a Wnt storm: Wnt signaling in cancer

Giles, R. H., Es, J. H. V. & Clevers, J. C., 2003, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1653, p. 1-24

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment

Verbrugge, A., Ruiter, T. T., Clevers, J. C. & Meyaard, L., 2003, In : International Immunology. 15, p. 1349-1358

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Efficient target-selected mutagenesis in zebrafish

Wienholds, E., van Eeden, F., Kosters, M., Mudde, J. B., Plasterk, R. & Cuppen, E., 2003, In : Genome Research. 13, 12, p. 2700-2707

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C

van der Linden, A. M., Moorman, C., Cuppen, E., Korswagen, H. C. & Plasterk, R., 2003, In : Current Biology. 13, 6, p. 516-521

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Live and let die in the intestinal epithelium

Sancho, E., Batlle, E. & Clevers, J. C., 2003, In : Current Opinion in Cell Biology. 15, p. 763-770

Research output: Contribution to journal/periodicalArticleScientificpeer-review

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localise LKB1 in the cytoplasm

Boudeau, J., Baas, A. F., Deak, M., Morrice, N. A., Kieloch, A., Schutkowski, M., Prescott, A. R., Clevers, J. C. & Alessi, D. R., 2003, In : EMBO Journal. 22, p. 5102-5114

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Notch1 functions as a tumor suppressor in mouse skin

Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., Noort, M. V., Hui, C. C., Clevers, J. C., Dotto, G. P. & Radtke, F., 2003, In : Nature Genetics. 33, p. 416-421

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition

Held, W., Clevers, J. C. & Grosschedl, R., 2003, In : European Journal of Immunology. 33, p. 1393-1398

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

Wetering, M. V. D., Oving, I., Muncan, V., Pon Fong, M. T., Brantjes, H., Leenen, D. V., Holstege, F. C., Brummelkamp, T. R., Agami, R. & Clevers, J. C., 2003, In : EMBO Reports. 4, p. 609-615

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Survivin and molecular pathogenesis of colorectal cancer

Kim, P. J., Plescia, J., Clevers, J. C., Fearon, E. R. & Altieri, D. C., 2003, In : Lancet. 362, p. 205-209

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF4 and groucho-related genes influence pituitary growth and development

Brinkmeier, M. L., Potok, M. A., Cha, K. B., Gridley, T., Stifani, S., Meeldijk, J., Clevers, J. C. & Camper, S. A., 2003, In : Molecular Endocrinology. 17, p. 2152-2161

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The microRNA-producing enzyme Dicer1 is essential for zebrafish development

Wienholds, E., Koudijs, M. J., van Eeden, F., Cuppen, E. & Plasterk, R., 2003, In : Nature Genetics. 35, 3, p. 217-218

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Wnt/beta-catenin pathway regulates cardiac valve formation

Hurlstone, A. F., Haramis, A. P., Wienholds, E., Begthel, H. L., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R. & Clevers, J. C., 2003, In : Nature. 425, 6958, p. 633-637

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Thymocyte development: drama without Brahma

Clevers, J. C., 2003, In : Immunity. 19, p. 157-158

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling in the thymus

Staal, F. J. & Clevers, J. C., 2003, In : Current Opinion in Cell Biology. 15, p. 204-208

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2002

Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

Battle, E., Henderson, J. T., Beghtel, H., Born, M. V. D., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., Wetering, M. V. D., Pawson, T. & Clevers, J. C., 2002, In : Cell. 111, p. 251-263

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access