• Netherlands

  • Netherlands

Research Output

2002

beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds

Cheon, S. S., Cheah, A. Y., Turley, S., Nadesan, P., Poon, R., Clevers, J. C. & Alman, B. A., 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, p. 6973-6978

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein

Hurlstone, A. F., Olave, I. A., Barker, N., Noort, M. V. & Clevers, J. C., 2002, In : Biochemical Journal. 364, p. 255-264

Research output: Contribution to journal/periodicalArticleScientificpeer-review

GENOTRACE: cDNA-based local GENOme assembly from TRACE archives

Berezikov, E., Plasterk, R. & Cuppen, E., 2002, In : Bioinformatics. 18, 10, p. 1396-1397

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification of two novel regulated serines in the N terminus of beta-catenin

Noort, M. V., Wetering, M. V. D. & Clevers, J. C., 2002, In : Experimental Cell Research. 276, p. 264-272

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency

Gallagher, R. C., Hay, T., Meniel, V., Naughton, C., Anderson, T. J., Shibata, H., Ito, M., Clevers, J. C., Noda, T., Sansom, O. J., Mason, J. O. & Clarke, A. R., 2002, In : Oncogene. 21, p. 6446-6457

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Inflating cell numbers by Wnt.

Clevers, J. C., 2002, In : Molecular Cell. 10, p. 260-261

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Molecular causes of colon cancer

Oving, I. M. & Clevers, J. C., 2002, In : European Journal of Clinical Investigation. 32, p. 448-457

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Negative feedback loop of Wnt ignaling through upregulation of conductin/axin2 in colorectal and liver tumors

Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., Wetering, M. V. D., Clevers, J. C., Schlag, P. M., Birchmeier, W. & Behrens, J., 2002, In : Molecular and Cellular Biology. 22, p. 1184-1193

Research output: Contribution to journal/periodicalArticleScientificpeer-review

T-cell factors: turn-ons and turn-offs

Hurlstone, A. & Clevers, J. C., 2002, In : EMBO Journal. 21, p. 2303-2311

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling

Brantjes, H., Barker, N., Es, J. V. & Clevers, J. C., 2002, In : Biological Chemistry. 383, p. 255-261

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF transcription factors, mediators of Wnt-signaling in development and cancer

Noort, M. V. & Clevers, J. C., 2002, In : Developmental Biology. 244, p. 1-8

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.

Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kuhl, M., Schaeffer, H. J., Huelsken, J., Behrens, J., Hammerschmidt, M. & Birchmeier, W., 2002, In : Genes & Development. 16, 16, p. 2073-2084

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans

Korswagen, H. C., Coudreuse, D. Y., Betist, M. C., Water, S. V. D., Zivkovic, D. & Clevers, J. C., 2002, In : Genes & Development. 16, p. 1291-1302

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The beta catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

Wetering, M. V. D., Sancho, E., Verweij, C., Lau, W. D., Oving, I., Hurlstone, A., Horn, K. V. D., Batlle, E., Coudreuse, D., Haramis, A. P., Tjon-Pon-Fong, M., Moerer, P., Born, M. V. D., Soete, G., Pals, S., Eilers, M., Medema, R. & Clevers, J. C., 2002, In : Cell. 111, p. 241-250

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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WNT signaling and lymphocyte development

Wetering, M. V. D., Lau, W. D. & Clevers, J. C., 2002, In : Cell. 109

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Wnt signaling controls the phosphorylation status of beta-catenin

Noort, M. V., Meeldijk, J., Zee, R. V. D., Destree, O. & Clevers, J. C., 2002, In : Journal of Biological Chemistry. 277, p. 17901-17905

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer

Boon, E. M., Neut, R. V. D., Wetering, M. V. D., Clevers, J. C. & Pals, S. T., 2002, In : Cancer Research. 62, p. 5126-5128

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signals are transmitted through N-terminally dephosphorylated {beta}-catenin

Staal, F. J., Noort, M. V., Strous, G. J. & Clevers, J. C., 2002, In : EMBO Reports. 3, p. 63-68

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm.

Bakkers, J., Hild, M., Kramer, C., Furutani-Seiki, M. & Hammerschmidt, M., 2002, In : Developmental Cell. 2, 5, p. 617-627

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2001

All Tcf HMG box transcription factors interact with Groucho-related co-repressors

Brantjes, H., Roose, J., Wetering, M. V. D. & Clevers, J. C., 2001, In : Nucleic Acids Research. 29, p. 1410-1419

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant

Water, S. V. D., Wetering, M. V. D., Joore, J., Esseling, J., Bink, R., Clevers, J. C. & Zivkovic, D., 2001, In : Development. 128, p. 3877-3888

Research output: Contribution to journal/periodicalArticleScientificpeer-review

LEF1 turns over a new leaf

Lau, W. D. & Clevers, J. C., 2001, In : Nature Genetics. 28, p. 3-4

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling

Wetering, M. V. D., Barker, N., Harkes, I. C., Heyden, M. V. D., Dijk, N. J., Hollestelle, A., Klijn, J. G., Clevers, J. C. & Schutte, M., 2001, In : Cancer Research. 61, p. 278-284

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mutations in the APC tumor suppressor gene cause chromosomal instability in colorectal cancer

Fodde, R., Kuipers, J., Rosenberg, C., Smits, R., Kielman, M., Gaspar, C., Es, J. H. V., Breukel, C., Wiegant, J., Giles, R. H. & Clevers, J. C., 2001, In : Nature Cell Biology. 3, p. 433-438

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells

Chan, M. F., van Amerongen, R., Nijjar, T., Cuppen, E., Jones, P. A. & Laird, P. W., 2001, In : Molecular and Cellular Biology. 21, 22, p. 7587-7600 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Regulation of lineage commitment during lymphocyte development

Staal, F. J. & Clevers, J. C., 2001, In : International Reviews of Immunology. 20, p. 45-64

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tcf/Lef transcription factors during T-cell development: unique and overlapping functions

Staal, F. J. T. & Clevers, J. C., 2001, In : The Hematology Journal. 1, p. 3-6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival

Ioannidis, V., Beermann, F., Clevers, J. C. & Held, W., 2001, In : Nature Immunology. 2, p. 691-697

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

Barker, N., Hurlstone, A., Musisi, H., Miles, A., Bienz, M. & Clevers, J. C., 2001, In : EMBO Journal. 20, p. 4935-4943

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16

van der Linden, A. M., Simmer, F., Cuppen, E. & Plasterk, R., 2001, In : Genetics. 158, 1, p. 221-235

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The many faces of the tumor suppressor gene APC

Es, J. H. V., Giles, R. H. & Clevers, J. C., 2001, In : Experimental Cell Research. 264, p. 126-134

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptional Control of T Lymphocyte Differentiation

Staal, F. J. T., Weerkamp, F., Langerak, A. W., Hendriks, R. W. & Clevers, J. C., 2001, In : Stem Cells. 19, p. 165-179

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tumor environment: a potent driving force in colorectal cancer?

Barker, N. & Clevers, J. C., 2001, In : Trends in Molecular Medicine. 7, p. 535-537

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

Staal, F. J. T., Meeldijk, J., Moerer, P., Jay, P., Weerdt, B. C. M. V. D., Vainio, S., Nolan, G. P. & Clevers, J. C., 2001, In : European Journal of Immunology. 31, p. 285-293

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2000

Armadillo takes the APC shuttle

Clevers, J. C., 2000, In : Nature Cell Biology. 2, p. 177-178

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Axin and hepatocellular carcinomas

Clevers, J. C., 2000, In : Nature Genetics. 24, p. 206-208

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Catenins, Wnt signaling and cancer

Barker, N. & Clevers, J. C., 2000, In : BioEssays. 22, p. 961-965

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Decapentaplegic is a direct target of dTcf repression in the Drosophila visceral mesoderm

Yang, X., Beest, M. V., Clevers, J. C., Jones, T., Hursh, D. A. & Mortin, M. A., 2000, In : Development. 127, p. 3695-3702

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis

Molenaar, M., Brian, E., Roose, J., Clevers, J. C. & Destree, O., 2000, In : Mechanisms of Development. 91, p. 311-315

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct beta-catenins mediate adhesion and signalling functions in C. elegans

Korswagen, R., Herman, M. & Clevers, J. C., 2000, In : Nature. 406, p. 527-532

Research output: Contribution to journal/periodicalArticleScientificpeer-review

dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila

Lawrence, N., Dearden, P., Hartley, D., Roose, J., Clevers, J. C. & Arias, A. M., 2000, In : International Journal of Developmental Biology. 44, p. 749-756

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag 1

Santos, M. M., Sousa, M. D., Rademakers, L. H., Clevers, J. C., Marx, J. J. & Schilham, M. W., 2000, In : American Journal of Pathology. 157, p. 1883-1892

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Linking colorectal cancer to Wnt signaling

Bienz, M. & Clevers, J. C., 2000, In : Cell. 103, p. 311-320

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Roles of Sox4 in central nervous system development

Cheung, M., Abu-Elmagd, M., Clevers, J. C. & Scotting, P. J., 2000, In : Molecular Brain Research. 79, p. 180-191

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Separate beta-catenins mediate Wnt signaling and cadherin adhesion in C. elegans

Korswagen, R., Herman, M. & Clevers, J. C., 2000, In : Nature. 406, p. 527-532

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs

Beest, M. V., Dooijes, D., Wetering, M. V. D., Kjearulff, S., Bonvin, A., Nielsen, O. & Clevers, J. C., 2000, In : Journal of Biological Chemistry. 275, p. 27266-27273

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Yin-Yang of TCF/b-Catenin Signaling

Barker, N., Morin, P. J. & Clevers, J. C., 2000, In : Advances in Cancer Research. 77, p. 1-24

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL

Cuppen, E., Wansink, D. G., de Leeuw, A., Wieringa, B., Hendriks, W. & van der Ham, M., 2000, In : European Journal of Cell Biology. 79, 4, p. 283-293

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/beta-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine

Lickert, H., Domon, C., Huls, G., Wehrle, C., Duluc, I., Clevers, J. C., Meyer, B. I., Freund, J. N. & Kemler, R., 2000, In : Development. 127, p. 3805-3813

Research output: Contribution to journal/periodicalArticleScientificpeer-review

1999

A FERM domain governs apical confinement of PTP-BL in epithelial cells

Cuppen, E., Wijers, M., Schepens, J., Fransen, J. A., Wieringa, B. & Hendriks, W., 1999, In : Journal of Cell Science. 112 ( Pt 1, p. 3299-3308

Research output: Contribution to journal/periodicalArticleScientificpeer-review