• Netherlands

  • Netherlands

Research Output

1999

Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1

Held, W., Kunz, B., Lowin-Kropf, B., Wetering, M. V. D. & Clevers, J. C., 1999, In : Immunity. 11, p. 433-442

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

Wielenga, V. J., Smits, R., Korinek, V., Smit, L., Kielman, M., Fodde, R., Clevers, J. C. & Pals, S. T., 1999, In : American Journal of Pathology. 54, p. 515-523

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines

Kuipers, J., Vaandrager, J. W., Weghuis, D. O., Pearson, P. L., Scheres, J., Lokhorst, H. M., Clevers, J. C. & Bast, B. J., 1999, In : Cancer Genetics and Cytogenetics. 109, p. 99-107

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification and molecular characterization of BP75, a novel bromodomain-containing protein

Cuppen, E., van Ham, M., Pepers, B., Wieringa, B. & Hendriks, W., 1999, In : FEBS Letters. 459, 3, p. 291-298

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor

Es, J. H. V., Kirkpatrick, C., Wetering, M. V. D., Molenaar, M., Miles, A., Kuiper, J., Destree, O. & Clevers, J. C., 1999, In : Current Biology. 9, p. 105-108

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Leukocyte-Associated Ig-Like Receptor-1 Functions as an Inhibitory Receptor on Cytotoxic T Cells

Meyaard, L., Hurenkamp, J., Clevers, J. C., Lanier, L. L. & Phillips, J. H., 1999, In : Journal of Immunology. 162, p. 5800-5804

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling

Vuurst de Vries, A. R. V. D., Clevers, J. C., Logtenberg, T. & Meyaard, L., 1999, In : European Journal of Immunology. 29, p. 3160-3167

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium

Barker, N., Huls, G., Korinek, V. & Clevers, J. C., 1999, In : American Journal of Pathology. 154, p. 29-35

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1

Roose, J., Huls, G., Beest, M. V., Moerer, P., Horn, K. V. D., Goldschmeding, R., Logtenberg, T. & Clevers, J. C., 1999, In : Science. 285, p. 1923-1926

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tcf-1-mediated transcription in T lymphocytes: differential role for GSK3beta in fibroblasts and T cells

Staal, F. J. T., Burgering, B. M. T., Wetering, M. V. D. & Clevers, J. C., 1999, In : International Immunology. 11, p. 317-322

Research output: Contribution to journal/periodicalArticleScientificpeer-review

TCF transcription factors: molecular switches in carcinogenesis

Roose, J. & Clevers, J. C., 1999, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1424

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Sox-13 gene: structure, promoter characterization, and chromosomal localization

Roose, J., Korver, W., Boer, R. D., Kuipers, J., Hurenkamp, J. & Clevers, J. C., 1999, In : Genomics. 57, p. 301-305

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, J. C., Shibuya, H. & Matsumoto, K., 1999, In : Nature. 399, p. 798-802

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice

Galceran, J., Farinas, I., Depew, M. J., Clevers, J. C. & Grosschedl, R., 1999, In : Genes & Development. 13, p. 709-717

Research output: Contribution to journal/periodicalArticleScientificpeer-review

1998

Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2 microglobulin knockout mice

Santos, M., Clevers, J. C., Sousa, M. D. & Marx, J. J., 1998, In : Blood. 91, p. 3059-3065

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Critical involvement of Tcf-1 in expansion of thymocytes

Schilham, M. W., Wilson, A., Moerer, P., Benaissa-Trouw, B. J., Cumano, A. & Clevers, J. C., 1998, In : Journal of Immunology. 161, p. 3984-3991

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf 4

Korinek, V., Barker, N., Moerer, P., Donselaar, E. V., Huls, G., Peters, P. J. & Clevers, J. C., 1998, In : Nature Genetics. 19, p. 379-383

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Destabilization of beta-Catenin by Presenilin-1 Mutations Increases Neuronal Vulnerability to Apoptosis

Zhang, Z., Hartmann, H., Minh Do, V., Abramowski, D., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., Wetering, M. V. D., Clevers, J. C., Saftig, P., Strooper, B. D., He, X. & Yankner, B. A., 1998, In : Nature. 395, p. 698-702

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differential expression of the HMG box transcription factors XTcf 3 and Xlef 1 during early Xenopus development

Molenaar, M., Roose, J., Peterson, J., Venanzi, S., Clevers, J. C. & Destree, O., 1998, In : Mechanisms of Development. 75, p. 163-166

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Drosophila RpS3a, a novel Minute gene situated between the segment polarity genescubitus interruptus and dTCF

Beest, M. V., Mortin, M. & Clevers, J. C., 1998, In : Nucleic Acids Research. 26, p. 4471-4475

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

Cavallo, R. A., Cox, R. T., Moline, M. M., Roose, J., Polevoy, G. A., Clevers, J. C., Peifer, M. & Bejsovec, A., 1998, In : Nature. 395, p. 604-608

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genomic organization of the segment polarity gene pan in Drosophila melanogaster

Dooijes, D., Beest, M. V., Wetering, M. V. D., Boulanger, G., Jones, T., Clevers, J. C. & Mortin, M. A., 1998, In : Molecular Genetics and Genomics. 258, p. 45-52

Research output: Contribution to journal/periodicalArticleScientificpeer-review

High expression of the HMG box factor sox-13 in arterial walls during embryonic development

Roose, J., Korver, W., Oving, E., Wilson, A., Wagenaar, G., Markman, M., Lamers, W. & Clevers, J. C., 1998, In : Nucleic Acids Research. 26, p. 469-476

Research output: Contribution to journal/periodicalArticleScientificpeer-review

HMG box containing transcription factors in lymphocyte differentiation

Schilham, M. W. & Clevers, J. C., 1998, In : Immunology. 10, p. 127-132

Research output: Contribution to journal/periodicalArticleScientificpeer-review

PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL

Cuppen, E., Gerrits, H., Pepers, B., Wieringa, B. & Hendriks, W., 1998, In : Molecular Biology of the Cell. 9, 3, p. 671-683 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Putative myeloma precursor cells expressing 2,6 sialic acid modified antigens actually belong to the erythroid lineage

Lau, W. B. D., Kuipers, J., Peters, P. J., Lokhorst, H. M., Clevers, J. C. & Bast, B. J., 1998, In : Leuk Res. 22, p. 163-173

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1

Okamura, R. M., Sigvardsson, M., Galceran, J., Verbeek, S., Clevers, J. C. & Grosschedl, R., 1998, In : Immunity. 8, p. 11-20

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Sox4-deficiency syndrome in mice is an animal model for common trunk

Ya, J., Schilham, M. W., Boer, P. A. D., Moorman, A. F., Clevers, J. C. & Lamers, W. H., 1998, In : Circulation Research. 83, p. 986-994

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1

Lau, W. B. M. D., Hurenkamp, J., Berendes, P., Touw, I. P., Clevers, J. C. & Dijk, M. A. V., 1998, In : Oncogene. 17, p. 503-510

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., Wetering, M. V. D., Destree, O. & Clevers, J. C., 1998, In : Nature. 395, p. 608-612

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptional control during T cell development

Clevers, J. C. & Ferrier, P., 1998, In : Current Opinion in Cell Biology. 10, p. 166-171

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse

Korinek, V., Barker, N., Willert, K., Molenaar, M., Roose, J., Wagenaar, G., Markman, M., Lamers, W., Destree, O. & Clevers, J. C., 1998, In : Molecular and Cellular Biology. 18, p. 1248-1256

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident

Korver, W., Schilham, M. W., Moerer, P., Hoff, M. J. V. D., Dam, K., Lamers, W. H., Medema, R. H. & Clevers, J. C., 1998, In : Current Biology. 8, p. 1327-1330

Research output: Contribution to journal/periodicalArticleScientificpeer-review

1997

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Morin, P. J., Sparks, A., Korinek, V., Barker, N., Clevers, J. C., Vogelstein, B. & Kinzler, K., 1997, In : Science. 275, p. 1787-1790

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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979 Downloads (Pure)

Animal models of congenital defects in the ventriculoarterial connection of the heart

Ya, J., Schilham, M. W., Clevers, J. C., Moorman, A. F. & Lamers, W. H., 1997, In : Journal of Molecular Medicine. 75, p. 551-566

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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277 Downloads (Pure)

Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF

Wetering, M. V. D., Cavallo, R., Dooijes, D., Beest, M. V., Es, J. V., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M. & Clevers, J. C., 1997, In : Cell. 88, p. 789-799

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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589 Downloads (Pure)

Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites

Kjaerulff, S., Dooijes, D., Clevers, J. C. & Nielsen, O., 1997, In : EMBO Journal. 16, p. 4021-4033

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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233 Downloads (Pure)

Constitutive Transcriptional Activation by a beta-catenin-Tcf complex in APC-/- Colon Carcinoma

Korinek, V., Barker, N., Morin, P. J., Wichen, D. V., Weger, R. D., Kinzler, K. W., Vogelstein, B. & Clevers, J. C., 1997, In : Science. 275, p. 1784-1787

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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800 Downloads (Pure)

Control of gene expression during lymphoid development: targeted gene disruption provides new clues

Dooijes, D. & Clevers, J. C., 1997, In : APMIS. 105, p. 337-344

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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259 Downloads (Pure)

Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells

Mayer, K., Hieronymus, T., Castrop, J., Clevers, J. C. & Ballhausen, W. G., 1997, In : International Journal of Cancer. 72, p. 625-630

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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523 Downloads (Pure)

European immunologists meet in Amsterdam

Clevers, J. C. & Miedema, F., 1997, In : Immunology Today. 18

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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181 Downloads (Pure)

In vivo mucosal uptake, mucosal transfer and retention of iron in mice

Santos, M., Wienk, K. J., Schilham, M. W., Clevers, J. C., Sousa, M. D. & Marx, J. J., 1997, In : Laboratory Animals. 31, p. 264-270

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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263 Downloads (Pure)

Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan Theileria parva

Daubenberger, C., Heussler, V., Gobright, E., Wijngaard, P., Clevers, J. C., Wells, C., Tsuji, N., Musoke, A. & McKeever, D., 1997, In : Molecular and Biochemical Parasitology. 85, p. 265-269

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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422 Downloads (Pure)

Mutations of the hereditary hemochromatosis candidate gene HLA-H in porphyria cutanea tarda

Santos, M., Clevers, J. C. & Marx, J. J., 1997, In : New England Journal of Medicine. 336, p. 1327-1328

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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48 Downloads (Pure)

No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like Fas-associated phosphatase-1 in Fas-mediated apoptosis

Cuppen, E., Nagata, S., Wieringa, B. & Hendriks, W., 1997, In : Journal of Biological Chemistry. 272, 48, p. 30215-30220 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Sox-4 facilitates thymocyte differentiation

Schilham, M. W., Moerer, P., Cuomo, A. & Clevers, J. C., 1997, In : European Journal of Immunology. 27, p. 1292-1295

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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306 Downloads (Pure)

TCF/LEF factors earn their wings

Clevers, J. C. & Wetering, M. V. D., 1997, In : Trends in Genetics. 13, p. 485-489

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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302 Downloads (Pure)

The human TRIDENT/HFH-11/FKHL16 gene: structure, localization and promoter characterization

Korver, W., Roose, J., Heinen, K., Olde Weghuis, D., Bruijn, D. D., Geurts van Kessel, A. & Clevers, J. C., 1997, In : Genomics. 46, p. 435-442

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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583 Downloads (Pure)

The neuronal nitric oxide synthase PDZ motif binds to -G(D,E)XV* carboxyterminal sequences

Schepens, J., Cuppen, E., Wieringa, B. & Hendriks, W., 1997, In : FEBS Letters. 409, 1, p. 53-56

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes

Korver, W., Roose, J., Wilson, A. & Clevers, J. C., 1997, In : Immunobiology. 198, p. 157-161

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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250 Downloads (Pure)