• Netherlands

  • Netherlands

Research Output

1997

The winged-helix transcription factor Trident is expressed in cycling cells

Korver, W., Roose, J. & Clevers, J. C., 1997, In : Nucleic Acids Research. 25, p. 1715-1719

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
470 Downloads (Pure)
1996

Allogeneic bone marrow transplantation can restore CD4+ T-lymphocyte count and immune function in idiopathic CD4+ T-lymphocytepenia

Petersen, E. J., Rozenberg-Arska, M., Dekker, A. W., Clevers, J. C. & Verdonck, L. F., 1996, In : Bone Marrow Transplantation. 18, p. 813-815

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
119 Downloads (Pure)

Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man

Santos, M., Schilham, M. W., Rademakers, L. H., Marx, J. J. M., Sousa, M. D. & Clevers, J. C., 1996, In : Journal of Experimental Medicine. 184, p. 1975-1985

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
264 Downloads (Pure)

Extensive alternative splicing and dual promoter usage generates TCF-1 protein isoforms with differential transcription control properties

Wetering, M. V. D., Castrop, J., Korinek, V. & Clevers, J. C., 1996, In : Molecular and Cellular Biology. 16, p. 745-752

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
99 Downloads (Pure)

Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice

Ohteki, T., Wilson, A., Verbeek, S., MacDonald, H. R. & Clevers, J. C., 1996, In : European Journal of Immunology. 26, p. 351-355

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
128 Downloads (Pure)

Sox-4 gene is required for cardiac outflow tract formation and pro-B lymphocyte expansion

Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, N. V., Boer, P. D., Wetering, M. V. D., Verbeek, S., Lamers, W., Kruisbeek, A., Cumano, A. & Clevers, J. C., 1996, In : Nature. 380, p. 711-714

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
138 Downloads (Pure)

Transcriptional control of lymphoid development. Lessons from gene targeting

Clevers, J. C. & Grosschedl, R., 1996, In : Immunology Today. 17, p. 336-343

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
728 Downloads (Pure)

Xtcf-3 Transcription factor mediates beta-catenin-induced axis formation in xenopus embryos

Molenaar, M., Wetering, M. V. D., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destré, O. & Clevers, J. C., 1996, In : Cell. 86, p. 391-399

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
571 Downloads (Pure)
1995

Analysis of CD2 and TCR-beta gene expression in Jurkat cell mutants suggests a cis regulation of gene expression

Kamoun, M., Woods, J. S. & Clevers, J. C., 1995, In : Journal of Immunology. 155, p. 3929-3937

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
125 Downloads (Pure)

An assay for the identification of antigens recognized by cytotoxic T-cells, based on transient transfection of COS cells

Toye, P., Wijngaard, P., MacHugh, N. & Clevers, J. C., 1995, In : Journal of Immunological Methods. 187, p. 95-101

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
483 Downloads (Pure)

An HMG box containing T-cell factor required for thymocyte differentiation

Verbeek, J. S., Ison, D., Hofhuis, F., Robanus-Maandag, E., Riele, H. T., Wetering, M. V. D., Oosterwegel, M., Wilson, A., MacDonald, H. R. & Clevers, J. C., 1995, In : Nature. 374, p. 70-74

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
645 Downloads (Pure)

Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria-parva

Toye, P. G., Metzelaar, M. J., Wijngaard, P. L. J., Nene, V., Iams, K., Roose, J., Nyanjui, J. K., Gobright, E., Musoke, A. J. & Clevers, J. C., 1995, In : Journal of Immunology. 155, p. 1370-1381

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
77 Downloads (Pure)

Circumvention of tolerance for the nuclear T cell protein Tcf-1 by immunization of Tcf-1 knock-out mice

Castrop, J., Verbeek, S., Hofhuis, F. & Clevers, J. C., 1995, In : Immunobiology. 193, p. 281-287

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
193 Downloads (Pure)

Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator SOX-4

Houte, L. P. A. V., Chuprina, V. P., Wetering, M. V. D., Boelens, R., Kaptein, R. & Clevers, J. C., 1995, In : Journal of Biological Chemistry. 270, p. 30516-30524

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
429 Downloads (Pure)

The drug-resistance-related protein LRP is the human major vault protein

Scheffer, G. L., Wijngaard, P. L. J., Flens, M. J., Izquierdo, M. A., Slovak, M. L., Pinedo, H. M., Meijer, C. J. L. M., Clevers, J. C. & Scheper, R. J., 1995, In : Nature Medicine. 1, p. 578-582

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
745 Downloads (Pure)

The HMG box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA

Mayer, K., Wolff, E., Clevers, J. C. & Ballhausen, W. G., 1995, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1263, p. 169-172

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
236 Downloads (Pure)

The human Tcf-1 gene encodes a nuclear DNA-binding protein, uniquely expressed in normal and neoplastic T lineage lymphocytes

Castrop, J., Wichen, D. V., Koomans-Bitter, M., Wetering, M. V. D., Weger, R. D., Dongen, J. V. & Clevers, J. C., 1995, In : Blood. 86, p. 3050-3059

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
358 Downloads (Pure)
1994

A novel multi-gene family of sheep gamma delta T cells

Walker, I. D., Glew, M. D., O'Keeffe, M. A., Metcalfe, S. A., Clevers, J. C., Wijngaard, P. L., Adams, T. E. & Hein, W. R., 1994, In : Immunology. 83, p. 517-523

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
108 Downloads (Pure)

Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy

Fournier, B., Saudubray, J. M., Benichou, B., Lyonnet, S., Munnich, A., Clevers, J. C. & Poll-The, B. T., 1994, In : Journal of Clinical Investigation. 94, p. 526-531

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
215 Downloads (Pure)

Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T-lymphocytes

Wijngaard, P. L. J., MacHugh, N. D., Metzelaar, M. J., Romberg, S., Bensaid, A., Pepin, L., Davis, W. C. & Clevers, J. C., 1994, In : Journal of Immunology. 152, p. 3476-3482

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
141 Downloads (Pure)
1993

Ancestry and diversity of the HMG box superfamily

Laudet, V., Stehelin, D. & Clevers, J. C., 1993, In : Nucleic Acids Research. 21, p. 2493-2501

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
435 Downloads (Pure)

Clustering of monoclonal-antibodies recognizing different members of the WC1 gene family

MacHugh, N. D., Wijngaard, P. L. J., Clevers, J. C. & Davis, W. C., 1993, In : Veterinary Immunology and Immunopathology. 39, p. 155-160

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
218 Downloads (Pure)

De rol van transcriptiefactoren in de differentiatie van beenmergstamcellen naar immuuncompetente T lymfocyten

Clevers, J. C., 1993, In : Mediator.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
78 Downloads (Pure)

Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis

Oosterwegel, M., Wetering, M. V. D., Timmerman, J., Kruisbeek, A., Destree, O., Meijlink, F. & Clevers, J. C., 1993, In : Development. 118, p. 439-448

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
219 Downloads (Pure)

HMG box proteins in early T cell differentiation

Oosterwegel, M., Wetering, M. V. D. & Clevers, J. C., 1993, In : Thymus. 22, p. 67-81

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
46 Downloads (Pure)

Sox 15, a novel member of the murine Sox family of HMG box transcription factors

Wetering, M. V. D. & Clevers, J. C., 1993, In : Nucleic Acids Research. 21, p. 1669-1669

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
191 Downloads (Pure)

SOX-4, an SRY-like HMG box protein, is a transcriptional activator in lymphocytes

Wetering, M. V. D., Oosterwegel, M., Norren, K. V. & Clevers, J. C., 1993, In : EMBO Journal. 12, p. 3847-3854

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
245 Downloads (Pure)

The HB4 monoclonal antibody recognizes a carbohydrate structure on lymphocyte surface proteins, related to HB6, CDw75 and CD76

Lau, W. B. M. D., Kuipers, J., Voshol, H., Clevers, J. C. & Bast, E. J. E. G., 1993, In : Journal of Immunology. 150, p. 4911-4919

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
311 Downloads (Pure)

The murine Sox-4 protein is encoded on a single exon

Schilham, M. W., Eijk, M. V., Wetering, M. V. D. & Clevers, J. C., 1993, In : Nucleic Acids Research. 21, p. 2009-2009

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
191 Downloads (Pure)

The Schizosaccharomyces pombe mating-type gene mat-MC encodes a sequence-specific DNA-binding HMG box protein

Dooijes, D., Wetering, M. V. D., Knippels, L. & Clevers, J. C., 1993, In : Journal of Biological Chemistry. 268, p. 24813-24817

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
216 Downloads (Pure)

The sequence-specific HMG box of TCF-1 adopts a predominantly alpha-helical conformation in solution

Houte, L. V., Oers, A. M. V., Wetering, M. V. D., Dooijes, D., Kaptein, R. & Clevers, J. C., 1993, In : Journal of Biological Chemistry. 268, p. 18083-18087

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
261 Downloads (Pure)

Thoughts on thymus and T-lymphocyte repertoire. Relevance to the tolerance of the immune response

Schuurman, H. J., Hu, H., Weger, R. A. D. & Clevers, J. C., 1993, In : Netherlands Journal of Medicine. 43, p. 38-54

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcription factors in early T cell development

Clevers, J. C., Oosterwegel, M. A. & Georgopoulos, K., 1993, In : Immunology Today. 14, p. 591-596

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
264 Downloads (Pure)
1992

A common ancestor of the mammalian transcription factors TCF-1 and TCF-1 alpha/LEF1 expressed in chicken T cells

Castrop, J., Hoevenagel, R. & Clevers, J. C., 1992, In : European Journal of Immunology. 22, p. 1327-1330

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
97 Downloads (Pure)

A gene family of HMG box factors with homology to TCF-1

Castrop, J., Norren, K. V. & Clevers, J. C., 1992, In : Nucleic Acids Research. 611

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
63 Downloads (Pure)

Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesis

Oosterwegel, M. A., Timmerman, J., Leiden, J. & Clevers, J. C., 1992, In : Developmental Immunology. 3, p. 1-11

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
266 Downloads (Pure)

Heterodimeric complex formation with CD8 and TCR by bispecific antibody sustains paracrine IL-2-dependent growth of CD3+ CD8+ T cells

Lau, W. B. M. D., Boom, S. E., Heije, K., Griffioen, A. W., Braakman, E., Bolhuis, R. L. H., Tax, W. J. M., Clevers, J. C. & Bast, E. J. E. G., 1992, In : Journal of Immunology. 149, p. 1840-1846

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
137 Downloads (Pure)

Lysosomal membrane glycoproteins in platelets

Metzelaar, M. J. & Clevers, J. C., 1992, In : Thrombosis and Haemostasis. 68, p. 378-382

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
492 Downloads (Pure)

Molecular characterisation of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T-lymphocytes

Wijngaard, P. L. J., Metzelaar, M., MacHugh, N. D., Morrison, W. I. & Clevers, J. C., 1992, In : Journal of Immunology. 149, p. 3273-3277

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
169 Downloads (Pure)

Sequence-specific interaction of the HMG-box factor TCF-1 occurs within the minor groove of a Watson-Crick double helix

Wetering, M. V. D. & Clevers, J. C., 1992, In : EMBO Journal. 11, p. 3039-3044

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
316 Downloads (Pure)

Structure and mapping of the human TCF-1 gene; Characterization of its promoter

Wetering, M. V. D., Oosterwegel, M., Holstege, F., Suykerbuyk, R., Geurts van Kessel, A. & Clevers, J. C., 1992, In : Journal of Biological Chemistry. 267, p. 8530-8536

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
326 Downloads (Pure)

The ME491 melanoma-associated glycoprotein family. Antigenic identity of the ME491, NKI/C-3, NGA and CD61 proteins

Demetrick, D., Herlyn, D., Tretiak, M., Creasey, D., Clevers, J. C., Vennegoor, C. J. G. M., Dixon, W. T. & Jerry, L. M., 1992, In : Journal of the National Cancer Institute. 84, p. 422-429

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
82 Downloads (Pure)
1991

A method for cDNA cloning in COS cells irrespective of subcellular site of expression

Horst, E., Wijngaard, P. L. J., Metzelaar, M., Bast, E. J. E. G. & Clevers, J. C., 1991, In : Nucleic Acids Research. 19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
212 Downloads (Pure)

A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells

Metzelaar, M., Wijngaard, P., Peters, P., Nieuwenhuis, K., Sixma, J. & Clevers, J. C., 1991, In : Journal of Biological Chemistry. 266, p. 3239-3245

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
107 Downloads (Pure)

Cloning of the murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and TCR-alpha enhancers

Oosterwegel, M., Wetering, M. V. D., Dooijes, D., Klomp, L., Winoto, A., Georgopoulos, K., Meijlink, F. & Clevers, J. C., 1991, In : Journal of Experimental Medicine. 173, p. 1133-1142

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
340 Downloads (Pure)

Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box

Wetering, M. V. D., Oosterwegel, M., Dooijes, D. & Clevers, J. C., 1991, In : EMBO Journal. 10, p. 123-132

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
340 Downloads (Pure)

Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage

Bensaid, A., Kaushal, A., Baldwin, C. L., Clevers, J. C., Young, J. R., Kemp, S. J., MacHugh, N. D., Toye, P. G. & Teale, A. J., 1991, In : Immunogenetics. 33, p. 247-254

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
270 Downloads (Pure)

TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers

Oosterwegel, M. A., Wetering, M. L. V. D., Holstege, F. C. P., Prosser, H. M., Owen, M. J. & Clevers, J. C., 1991, In : International Immunology. 3, p. 1189-1192

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
84 Downloads (Pure)

Towards a molecular understanding of T cell differentiation

Clevers, J. C. & Owen, M., 1991, In : Immunology Today. 12, p. 86-92

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
292 Downloads (Pure)
1990

Expression of Tac antigen component of bovine interleukin-2 receptor in different leukocyte populations infected with Theileria parva or Theileria annulata

Dobbelaere, D. A., Prospero, T. D., Roditi, I. J., Kelke, C., Baumann, I., Eichhorn, M., Williams, R. O., Ahmed, J. S., Baldwin, C. L. & Clevers, J. C., 1990, In : Infection and Immunity. 58, p. 3847-3855

Research output: Contribution to journal/periodicalArticleScientificpeer-review

File
157 Downloads (Pure)