• Netherlands

  • Netherlands

Research Output

2020

Degree and site of chromosomal instability define its oncogenic potential

Hoevenaar, W. H. M., Janssen, A., Quirindongo, A. I., Ma, H., Klaasen, S. J., Teixeira, A., van Gerwen, B., Lansu, N., Morsink, F. H. M., Offerhaus, G. J. A., Medema, R. H., Kops, G. J. P. L. & Jelluma, N., 20 Mar 2020, In : Nature Communications. 11, 1, p. 1501

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing

Artegiani, B., Hendriks, D., Beumer, J., Kok, R., Zheng, X., Joore, I., Chuva de Sousa Lopes, S., van Zon, J., Tans, S. & Clevers, H., Mar 2020, In : Nature Cell Biology. 22, 3, p. 321-331 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

Ringel, T., Frey, N., Ringnalda, F., Janjuha, S., Cherkaoui, S., Butz, S., Srivatsa, S., Pirkl, M., Russo, G., Villiger, L., Rogler, G., Clevers, H., Beerenwinkel, N., Zamboni, N., Baubec, T. & Schwank, G., 05 Mar 2020, In : Cell Stem Cell. 26, 3, p. 431-440.e8

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link

Hanswijk, S. I., Spoelder, M., Shan, L., Verheij, M. M. M., Muilwijk, O. G., Li, W., Liu, C., Kolk, S. M. & Homberg, J. R., 2020, In : International Journal of Molecular Sciences. 21, 16, E5850.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

Castelijns, B., Baak, M. L., Timpanaro, I. S., Wiggers, C. R. M., Vermunt, M. W., Shang, P., Kondova, I., Geeven, G., Bianchi, V., de Laat, W., Geijsen, N. & Creyghton, M. P., 16 Jan 2020, In : Nature Communications. 11, 1, p. 301

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair

Sato, K., Brandsma, I., van Rossum-Fikkert, S. E., Verkaik, N., Oostra, A. B., Dorsman, J. C., van Gent, D. C., Knipscheer, P., Kanaar, R. & Zelensky, A. N., 18 Mar 2020, In : Nucleic Acids Research. 48, 5, p. 2442-2456 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Lund, M. L., Sorrentino, G., Egerod, K. L., Kroone, C., Mortensen, B., Knop, F. K., Reimann, F., Gribble, F. M., Drucker, D. J., de Koning, E. J. P., Schoonjans, K., Bäckhed, F., Schwartz, T. W. & Petersen, N., Apr 2020, In : Diabetes. 69, 4, p. 614-623 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors

Wang, D., Wang, J., Bai, L., Pan, H., Feng, H., Clevers, H. & Zeng, Y. A., 19 Mar 2020, In : Cell. 180, 6, p. 1198-1211.e19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Multi-contact 4C: long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies

Vermeulen, C., Allahyar, A., Bouwman, B. A. M., Krijger, P. H. L., Verstegen, M. J. A. M., Geeven, G., Valdes-Quezada, C., Renkens, I., Straver, R., Kloosterman, W. P., de Ridder, J. & de Laat, W., Feb 2020, In : Nature Protocols. 15, 2, p. 364-397 34 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Rosenbluth, J. M., Schackmann, R. C. J., Gray, G. K., Selfors, L. M., Li, C. M-C., Boedicker, M., Kuiken, H. J., Richardson, A., Brock, J., Garber, J., Dillon, D., Sachs, N., Clevers, H. & Brugge, J. S., 06 Apr 2020, In : Nature Communications. 11, 1, p. 1711

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Quantification of mRNA translation in live cells using single-molecule imaging

Khuperkar, D., Hoek, T. A., Sonneveld, S., Verhagen, B. M. P., Boersma, S. & Tanenbaum, M. E., Apr 2020, In : Nature Protocols. 15, 4, p. 1371-1398 28 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Rewiring E2 enzymes

Sato, K. & Knipscheer, P., Mar 2020, In : Nature Chemical Biology. 16, 3, p. 227-229 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies

Battich, N., Beumer, J., de Barbanson, B., Krenning, L., Baron, C. S., Tanenbaum, M. E., Clevers, H. & van Oudenaarden, A., 06 Mar 2020, In : Science. 367, 6482, p. 1151-1156 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Snake Venom Gland Organoids

Post, Y., Puschhof, J., Beumer, J., Kerkkamp, H. M., de Bakker, M. A. G., Slagboom, J., de Barbanson, B., Wevers, N. R., Spijkers, X. M., Olivier, T., Kazandjian, T. D., Ainsworth, S., Iglesias, C. L., van de Wetering, W. J., Heinz, M. C., van Ineveld, R. L., van Kleef, R. G. D. M., Begthel, H., Korving, J., Bar-Ephraim, Y. E. & 11 others, Getreuer, W., Rios, A. C., Westerink, R. H. S., Snippert, H. J. G., van Oudenaarden, A., Peters, P. J., Vonk, F. J., Kool, J., Richardson, M. K., Casewell, N. R. & Clevers, H., 23 Jan 2020, In : Cell. 180, 2, p. 233-247.e21

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies

Busslinger, G. A., Lissendorp, F., Franken, I. A., van Hillegersberg, R., Ruurda, J. P., Clevers, H. & de Maat, M. F. G., Apr 2020, In : Open Biology. 10, 4, p. 190274

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

Thomaidou, S., Kracht, M. J. L., van der Slik, A., Laban, S., de Koning, E. J., Carlotti, F., Hoeben, R. C., Roep, B. O. & Zaldumbide, A., Apr 2020, In : Diabetes. 69, 4, p. 670-680 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review