• Netherlands

  • Netherlands

Research Output

2018

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., Simons, B. D. & Clevers, H., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E610-E619

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Unconventional protein secretion: Diversity and consensus

Nickel, W. & Rabouille, C., Nov 2018, In : Seminars in Cell & Developmental Biology. 83, p. 1-2 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Use and application of 3D-organoid technology

Artegiani, B. & Clevers, H., 01 Aug 2018, In : Human Molecular Genetics. 27, R2, p. R99-R107

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome

Kievit, A., Tessadori, F., Douben, H., Jordens, I., Maurice, M., Hoogeboom, J., Hennekam, R., Nampoothiri, S., Kayserili, H., Castori, M., Whiteford, M., Motter, C., Melver, C., Cunningham, M., Hing, A., Kokitsu-Nakata, N. M., Vendramini-Pittoli, S., Richieri-Costa, A., Baas, A. F., Breugem, C. C. & 17 others, Duran, K., Massink, M., Derksen, P. W. B., van IJcken, W. F. J., van Unen, L., Santos-Simarro, F., Lapunzina, P., Gil-da Silva Lopes, V. L., Lustosa-Mendes, E., Krall, M., Slavotinek, A., Martinez-Glez, V., Bakkers, J., van Gassen, K. L. I., de Klein, A., van den Boogaard, M-J. H. & van Haaften, G., Feb 2018, In : European Journal of Human Genetics. 26, 2, p. 210-219 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation

Staels, W., Verdonck, Y., Heremans, Y., Leuckx, G., De Groef, S., Heirman, C., de Koning, E., Gysemans, C., Thielemans, K., Baeyens, L., Heimberg, H. & De Leu, N., Aug 2018, In : Diabetologia. 61, 8, p. 1804-1810 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Whole-organism clone tracing using single-cell sequencing

Alemany, A., Florescu, M., Baron, C. S., Peterson-Maduro, J. & van Oudenaarden, A., 05 Apr 2018, In : Nature. 556, 7699, p. 108-112 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling

Harris, A., Siggers, P., Corrochano, S., Warr, N., Sagar, D., Grimes, D. T., Suzuki, M., Burdine, R. D., Cong, F., Koo, B-K., Clevers, H., Stévant, I., Nef, S., Wells, S., Brauner, R., Ben Rhouma, B., Belguith, N., Eozenou, C., Bignon-Topalovic, J., Bashamboo, A. & 2 others, McElreavey, K. & Greenfield, A., 22 May 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 21, p. 5474-5479 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

Mavrommati, I., Faedda, R., Galasso, G., Li, J., Burdova, K., Fischer, R., Kessler, B. M., Carrero, Z. I., Guardavaccaro, D., Pagano, M. & D'Angiolella, V., 25 Sep 2018, In : Cell Reports. 24, 13, p. 3404-3412 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2017

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

Ciarlo, C., Kaufman, C. K., Kinikoglu, B., Michael, J., Yang, S., D Amato, C., Blokzijl-Franke, S., den Hertog, J., Schlaeger, T. M., Zhou, Y., Liao, E. & Zon, L. I., 23 Aug 2017, In : eLife. 6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Adult Stem Cell-Derived Kidney Organoids to Model Tissue Physiology and Disease

Schutgens, F., 21 Nov 2017, Utrecht University.

Research output: PhD ThesisPhD thesis

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression

Gupta, R. M., Hadaya, J., Trehan, A., Zekavat, S. M., Roselli, C., Klarin, D., Emdin, C. A., Hilvering, C. R. E., Bianchi, V., Mueller, C., Khera, A. V., Ryan, R. J. H., Engreitz, J. M., Issner, R., Shoresh, N., Epstein, C. B., de Laat, W., Brown, J. D., Schnabel, R. B., Bernstein, B. E. & 1 others, Kathiresan, S., 27 Jul 2017, In : Cell. 170, 3, p. 522-533.e15

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

Artegiani, B., Lyubimova, A., Muraro, M. J., van Es, J. H., van Oudenaarden, A. & Clevers, H., 12 Dec 2017, In : Cell Reports. 21, 11, p. 3271-3284 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Association of fasting triglyceride concentration and postprandial triglyceride response with the carotid intima-media thickness in the middle aged: The Netherlands Epidemiology of Obesity study

Christen, T., de Mutsert, R., Gast, K. B., Rensen, P. C. N., de Koning, E., Rosendaal, F. R., Trompet, S. & Jukema, J. W., 16 May 2017, In : Journal of Clinical Lipidology. 11, 2, p. 377-385.e1

Research output: Contribution to journal/periodicalArticleScientificpeer-review

At the base of colinear Hox gene expression: cis-features and trans-factors orchestrating the initial phase of Hox cluster activation

Neijts, R. & Deschamps, J., 15 Aug 2017, In : Developmental Biology. 428, 2, p. 293-299 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A Unifying Theory of Branching Morphogenesis

Hannezo, E., Scheele, C. L. G. J., Moad, M., Drogo, N., Heer, R., Sampogna, R. V., van Rheenen, J. & Simons, B. D., 21 Sep 2017, In : Cell. 171, 1, p. 242-255.e27

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

Kracht, M. J. L., van Lummel, M., Nikolic, T., Joosten, A. M., Laban, S., van der Slik, A. R., van Veelen, P. A., Carlotti, F., de Koning, E. J. P., Hoeben, R. C., Zaldumbide, A. & Roep, B. O., Apr 2017, In : Nature Medicine. 23, 4, p. 501-507 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Beyond growth signaling: Paneth cells metabolically support ISCs

Dayton, T. L. & Clevers, H., Jul 2017, In : Cell Research. 27, 7, p. 851-852 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

Yost, S., de Wolf, B., Hanks, S., Zachariou, A., Marcozzi, C., Clarke, M., de Voer, R. M., Etemad, B., Uijttewaal, E., Ramsay, E., Wylie, H., Elliott, A., Picton, S., Smith, A., Smithson, S., Seal, S., Ruark, E., Houge, G., Pines, J., Kops, G. J. P. L. & 1 others, Rahman, N., Jul 2017, In : Nature Genetics. 49, 7, p. 1148-1151 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

Duarte, A. V., Gogola, E., Sachs, N., Barazas, M., Annunziato, S., R de Ruiter, J., Velds, A., Blatter, S., Houthuijzen, J. M., van der Ven, M., Clevers, H., Borst, P., Jonkers, J. & Rottenberg, S., 11 Dec 2017, In : Nature Methods.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cancer stem cells revisited

Batlle, E. & Clevers, H., 06 Oct 2017, In : Nature Medicine. 23, 10, p. 1124-1134 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Can We Just Say: Transcription Second?

Krijger, P. H. L. & de Laat, W., 06 Apr 2017, In : Cell. 169, 2, p. 184-185 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Celebrating 100 years of Developmental Biology at the Hubrecht Institute

den Hertog, J. (Guest ed.) & van Oudenaarden, A. (Guest ed.), 15 Aug 2017, In : Developmental Biology. 428, 2

Research output: Contribution to journal/periodicalSpecial issue (editorship)Scientific

Celebrating 100 years of Developmental Biology at the Hubrecht Institute

den Hertog, J. & van Oudenaarden, A., 2017, In : Developmental Biology. 428, 2, p. 259-260

Research output: Contribution to journal/periodicalArticlePopularizing

Cell adaptation upon stress: the emerging role of membrane-less compartments

Rabouille, C. & Alberti, S., Aug 2017, In : Current Opinion in Immunology. 47, p. 34-42 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cellular protection mechanisms that minimise accumulation of mutations in intestinal tissue

van Rheenen, J. & Bruens, L., 09 Nov 2017, In : Schweizerische Medizinische Wochenschrift. 147, p. w14539

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Characterization of islet cells during development and after transplantation

van Gurp, L., 17 Mar 2017, Utrecht University.

Research output: PhD ThesisPhD thesis

Circadian clocks: from stem cells to tissue homeostasis and regeneration

Dierickx, P., Van Laake, L. W. & Geijsen, N., 19 Dec 2017, In : EMBO Reports.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Circadian networks in human embryonic stem cell-derived cardiomyocytes

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., Geijsen, N. & Van Laake, L. W., Jul 2017, In : EMBO Reports. 18, 7, p. 1199-1212 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Circadian networks in stem cells and their cardiac derivatives

Dierickx, P., 23 Feb 2017

Research output: PhD ThesisPhD thesis

Cis-regulatory elements in the primate brain: from functional specialization to neurodegeneration

Vermunt, M. W., 23 Feb 2017

Research output: PhD ThesisPhD thesis

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Jost, M., Chen, Y., Gilbert, L. A., Horlbeck, M. A., Krenning, L., Menchon, G., Rai, A., Cho, M. Y., Stern, J. J., Prota, A. E., Kampmann, M., Akhmanova, A., Steinmetz, M. O., Tanenbaum, M. E. & Weissman, J. S., 05 Oct 2017, In : Molecular Cell. 68, 1, p. 210-223.e6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?

Schneeberger, K., Spee, B., Costa, P., Sachs, N., Clevers, H. & Malda, J., 06 Mar 2017, In : Biofabrication. 9, 1, p. 013001

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Correction: The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

Mahmoudi, T., Boj, S. F., Hatzis, P., Li, V. S. W., Taouatas, N., Vries, R. G. J., Teunissen, H., Begthel, H., Korving, J., Mohammed, S., Heck, A. J. R. & Clevers, H., Feb 2017, In : PLoS Biology. 15, 2, p. e1002596

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Steinhart, Z., Pavlovic, Z., Chandrashekhar, M., Hart, T., Wang, X., Zhang, X., Robitaille, M., Brown, K. R., Jaksani, S., Overmeer, R. M., Boj, S. F., Adams, J., Pan, J., Clevers, H., Sidhu, S., Moffat, J. & Angers, S., 07 Nov 2017, In : Nature Medicine. 23, 11, p. 1384

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

CRISPR/Cas 9 genome editing and its applications in organoids

Driehuis, E. & Clevers, H., 01 Mar 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 3, p. G257-G265

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

Busse, N., Paroni, F., Richardson, S. J., Laiho, J. E., Oikarinen, M., Frisk, G., Hyöty, H., de Koning, E., Morgan, N. G. & Maedler, K., 21 Feb 2017, In : Oncotarget. 8, 8, p. 12620-12636 17 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration

Wu, Z-W., Hale, A. J., Lemeer, S. & den Hertog, J., 16 Aug 2017, In : Scientific Reports. 7, 1, p. 8460

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

Dutta, D., Heo, I. & Clevers, H., May 2017, In : Trends in Molecular Medicine. 23, 5, p. 393-410 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes

Karmouch, J., Zhou, Q. Q., Miyake, C. Y., Lombardi, R., Kretzschmar, K., Bannier-Hélaouët, M., Clevers, H., Wehrens, X. H. T., Willerson, J. T. & Marian, A. J., 08 Dec 2017, In : Circulation Research. 121, 12, p. 1346-1359 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., Chio, I. I. C., Hwang, C-I., Tiriac, H., Baker, L. A., Engle, D. D., Feig, C., Kultti, A., Egeblad, M., Fearon, D. T., Crawford, J. M. & 3 others, Clevers, H., Park, Y. & Tuveson, D. A., 06 Mar 2017, In : Journal of Experimental Medicine. 214, 3, p. 579-596 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

Roost, M. S., Slieker, R. C., Bialecka, M., van Iperen, L., Gomes Fernandes, M. M., He, N., Suchiman, H. E. D., Szuhai, K., Carlotti, F., de Koning, E. J. P., Mummery, C. L., Heijmans, B. T. & Chuva de Sousa Lopes, S. M., 13 Oct 2017, In : Nature Communications. 8, 1, p. 908

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells

Semrau, S., Goldmann, J. E., Soumillon, M., Mikkelsen, T. S., Jaenisch, R. & van Oudenaarden, A., 23 Oct 2017, In : Nature Communications. 8, 1, p. 1096

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Editorial overview: Cell organelles

Rabouille, C. & Antonny, B., Aug 2017, In : Current Opinion in Immunology. 47, p. iv-vi

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Embryonic hematopoiesis under microscopic observation

Klaus, A. & Robin, C., 15 Aug 2017, In : Developmental Biology. 428, 2, p. 318-327 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

Deschamps, J. & Duboule, D., 15 Jul 2017, In : Genes and Development. 31, 14, p. 1406-1416 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer

Dreijerink, K. M. A., Groner, A. C., Vos, E. S. M., Font-Tello, A., Gu, L., Chi, D., Reyes, J., Cook, J., Lim, E., Lin, C. Y., de Laat, W., Rao, P. K., Long, H. W. & Brown, M., 07 Mar 2017, In : Cell Reports. 18, 10, p. 2359-2372 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Erratum: Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

Hombrink, P., Helbig, C., Backer, R. A., Piet, B., Oja, A. E., Stark, R., Brasser, G., Jongejan, A., Jonkers, R. E., Nota, B., Basak, O., Clevers, H. C., Moerland, P. D., Amsen, D. & van Lier, R. A. W., 19 Jan 2017, In : Nature Immunology. 18, 2, p. 246

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Everything has its time: Id2 clocks embryonic specification of Lgr5+ gut stem cells

Kretzschmar, K. & Clevers, H., 03 Apr 2017, In : EMBO Journal. 36, 7, p. 837-839 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics

van Hooff, J. J., Tromer, E., van Wijk, L. M., Snel, B. & Kops, G. J., Sep 2017, In : EMBO Reports. 18, 9, p. 1559-1571 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Evolution of the Kinetochore Network in Eukaryotes

Tromer, E., 12 Dec 2017, Utrecht University.

Research output: PhD ThesisPhD thesis

Open Access