• Netherlands

  • Netherlands

Research Output

2017

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

Cristobal, A., van den Toorn, H. W. P., van de Wetering, M., Clevers, H., Heck, A. J. R. & Mohammed, S., 03 Jan 2017, In : Cell Reports. 18, 1, p. 263-274 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

Aguilera-Gomez, A., Zacharogianni, M., van Oorschot, M. M., Genau, H., Grond, R., Veenendaal, T., Sinsimer, K. S., Gavis, E. R., Behrends, C. & Rabouille, C., 25 Jul 2017, In : Cell Reports. 20, 4, p. 935-948 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Postnatal Cardiac Gene Editing Using CRISPR/Cas9 With AAV9-Mediated Delivery of Short Guide RNAs Results in Mosaic Gene Disruption

Johansen, A. K., Molenaar, B., Versteeg, D., Leitoguinho, A. R., Demkes, C., Spanjaard, B., de Ruiter, H., Akbari Moqadam, F., Kooijman, L., Zentilin, L., Giacca, M. & van Rooij, E., 27 Oct 2017, In : Circulation Research. 121, 10, p. 1168-1181 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

Alieva, M., Margarido, A. S., Wieles, T., Abels, E. R., Colak, B., Boquetale, C., Jan Noordmans, H., Snijders, T. J., Broekman, M. L. D. & van Rheenen, J., 08 Aug 2017, In : Scientific Reports. 7, 1, p. 7529

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience

De Sousa, P. A., Steeg, R., Wachter, E., Bruce, K., King, J., Hoeve, M., Khadun, S., McConnachie, G., Holder, J., Kurtz, A., Seltmann, S., Dewender, J., Reimann, S., Stacey, G., O'Shea, O., Chapman, C., Healy, L., Zimmermann, H., Bolton, B., Rawat, T. & 48 others, Atkin, I., Veiga, A., Kuebler, B., Serano, B. M., Saric, T., Hescheler, J., Brüstle, O., Peitz, M., Thiele, C., Geijsen, N., Holst, B., Clausen, C., Lako, M., Armstrong, L., Gupta, S. K., Kvist, A. J., Hicks, R., Jonebring, A., Brolén, G., Ebneth, A., Cabrera-Socorro, A., Foerch, P., Geraerts, M., Stummann, T. C., Harmon, S., George, C., Streeter, I., Clarke, L., Parkinson, H., Harrison, P. W., Faulconbridge, A., Cherubin, L., Burdett, T., Trigueros, C., Patel, M. J., Lucas, C., Hardy, B., Predan, R., Dokler, J., Brajnik, M., Keminer, O., Pless, O., Gribbon, P., Claussen, C., Ringwald, A., Kreisel, B., Courtney, A. & Allsopp, T. E., Apr 2017, In : Stem Cell Research. 20, p. 105-114 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease

Hale, A. J., Ter Steege, E. & den Hertog, J., 15 Aug 2017, In : Developmental Biology. 428, 2, p. 283-292 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Recruitment and positioning determine the specific role of the XPF-ERCC1 endonuclease in interstrand crosslink repair

Klein Douwel, D., Hoogenboom, W. S., Boonen, R. A. & Knipscheer, P., 14 Jul 2017, In : EMBO Journal. 36, 14, p. 2034-2046 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Restricted intra-embryonic origin of bona fide hematopoietic stem cells in the chicken

Yvernogeau, L. & Robin, C., 01 Jul 2017, In : Development (Cambridge). 144, 13, p. 2352-2363 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Retriever fetches integrins from endosomes

Rabouille, C., 29 Sep 2017, In : Nature Cell Biology. 19, 10, p. 1144-1146 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells

Morcos, M. N. F., Schoedel, K. B., Hoppe, A., Behrendt, R., Basak, O., Clevers, H. C., Roers, A. & Gerbaulet, A., 06 Jun 2017, In : Stem Cell Reports. 8, 6, p. 1472-1478 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Science Forum: The Human Cell Atlas

Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P. J., Carninci, P., Clatworthy, M., Clevers, H., Deplancke, B., Dunham, I., Eberwine, J., Eils, R., Enard, W., Farmer, A. D., Fugger, L., Göttgens, B., Hacohen, N. & 30 others, Haniffa, M., Hemberg, M., Kim, S. K., Klenerman, P., Kriegstein, A., Lein, E., Linnarsson, S., Lundberg, E., Lundeberg, J., Majumder, P., Marioni, J. C., Merad, M., Mhlanga, M., Nawijn, M., Netea, M. G., Nolan, G., Pe'er, D., Phillipakis, A., Ponting, C. P., Quake, S. R., Reik, W., Rozenblatt-Rosen, O., Sanes, J. R., Satija, R., Schumacher, T. N., Shalek, A. K., Shapiro, E., Sharma, P., Shin, J. W. & van Oudenaarden, A., 05 Dec 2017, In : eLife. 6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping

Vermeulen, C., Geeven, G., de Wit, E., Verstegen, M. J. A. M., Jansen, R. P. M., van Kranenburg, M., de Bruijn, E., Pulit, S. L., Kruisselbrink, E., Shahsavari, Z., Omrani, D., Zeinali, F., Najmabadi, H., Katsila, T., Vrettou, C., Patrinos, G. P., Traeger-Synodinos, J., Splinter, E., Beekman, J. M., Kheradmand Kia, S. & 3 others, Te Meerman, G. J., Ploos van Amstel, H. K. & de Laat, W., 07 Sep 2017, In : American Journal of Human Genetics. 101, 3, p. 326-339 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Shp2-MAPK signalling drives proliferation during zebrafish embryo caudal fin-fold regeneration

Hale, A. J. & den Hertog, J., 04 Dec 2017, In : Molecular and Cellular Biology.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

Dharmadhikari, G., Stolz, K., Hauke, M., Morgan, N. G., Varki, A., de Koning, E., Kelm, S. & Maedler, K., 05 Apr 2017, In : Scientific Reports. 7, p. 45319

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

van den Brink, S. C., Sage, F., Vértesy, Á., Spanjaard, B., Peterson-Maduro, J., Baron, C. S., Robin, C. & van Oudenaarden, A., 29 Sep 2017, In : Nature Methods. 14, 10, p. 935-936 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Small chromosomal regions position themselves autonomously according to their chromatin class

van de Werken, H. J. G., Haan, J. C., Feodorova, Y., Bijos, D., Weuts, A., Theunis, K., Holwerda, S. J. B., Meuleman, W., Pagie, L., Thanisch, K., Kumar, P., Leonhardt, H., Marynen, P., van Steensel, B., Voet, T., de Laat, W., Solovei, I. & Joffe, B., Jun 2017, In : Genome Research. 27, 6, p. 922-933 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Stem cell-derived organoids and their application for medical research and patient treatment

Bartfeld, S. & Clevers, H., Jul 2017, In : Journal of Molecular Medicine. 95, 7, p. 729-738 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Stem Cells in Repair of Gastrointestinal Epithelia

Andersson-Rolf, A., Zilbauer, M., Koo, B-K. & Clevers, H., Jul 2017, In : Physiology (Bethesda, Md.). 32, 4, p. 278-289 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia

Smink, A. M., Li, S., Swart, D. H., Hertsig, D. T., de Haan, B. J., Kamps, J. A. A. M., Schwab, L., van Apeldoorn, A., de Koning, E., Faas, M. M., Lakey, J. R. T. & de Vos, P., Sep 2017, In : Journal of Biomedical Materials Research - Part A. 105, 9, p. 2533-2542 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Janda, C. Y., Dang, L. T., You, C., Chang, J., de Lau, W., Zhong, Z. A., Yan, K. S., Marecic, O., Siepe, D., Li, X., Moody, J. D., Williams, B. O., Clevers, H., Piehler, J., Baker, D., Kuo, C. J. & Garcia, K. C., 11 May 2017, In : Nature. 545, 7653, p. 234-237 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Survival lessons from stress assemblies

Aguilera-Gomez, A., 13 Apr 2017, utrecht : University of Utrecht.

Research output: PhD ThesisPhD thesis

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

Ren, Z., van Andel, H., de Lau, W., Hartholt, R. B., Maurice, M. M., Clevers, H., Kersten, M. J., Spaargaren, M. & Pals, S. T., 06 Dec 2017, In : Blood.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity

Lee, M., Yoon, J., Song, H., Lee, B., Lam, D. T., Yoon, J., Baek, K., Clevers, H. & Jeong, Y., 01 Apr 2017, In : Developmental Biology. 424, 1, p. 62-76 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Efficacy of Cardiac Anti-miR-208a Therapy Is Stress Dependent

Eding, J. E. C., Demkes, C. J., Lynch, J. M., Seto, A. G., Montgomery, R. L., Semus, H. M., Jackson, A. L., Isabelle, M., Chimenti, S. & van Rooij, E., 01 Mar 2017, In : Molecular Therapy. 25, 3, p. 694-704 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The emerging role of retromer in neuroprotection

McMillan, K. J., Korswagen, H. C. & Cullen, P. J., Aug 2017, In : Current Opinion in Immunology. 47, p. 72-82 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The Human Cell Atlas

05 Dec 2017, In : eLife. 6, e27041.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

De Angelis, J. E., Lagendijk, A. K., Chen, H., Tromp, A., Bower, N. I., Tunny, K. A., Brooks, A. J., Bakkers, J., Francois, M., Yap, A. S., Simons, C., Wicking, C., Hogan, B. M. & Smith, K. A., 23 Jan 2017, In : Developmental Cell. 40, 2, p. 123-136 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

De Angelis, J. E., Lagendijk, A. K., Chen, H., Tromp, A., Bower, N. I., Tunny, K. A., Brooks, A. J., Bakkers, J., Francois, M., Yap, A. S., Simons, C., Wicking, C., Hogan, B. M. & Smith, K. A., 27 Feb 2017, In : Developmental Cell. 40, 4, p. 421

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury

Lacraz, G. P. A., Junker, J. P., Gladka, M. M., Molenaar, B., Scholman, K. T., Vigil-Garcia, M., Versteeg, D., de Ruiter, H., Vermunt, M. W., Creyghton, M. P., Huibers, M. M. H., de Jonge, N., van Oudenaarden, A. & van Rooij, E., 10 Oct 2017, In : Circulation. 136, 15, p. 1396-1409 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

Yang, X. H., Nadadur, R. D., Hilvering, C. R., Bianchi, V., Werner, M., Mazurek, S. R., Gadek, M., Shen, K. M., Goldman, J. A., Tyan, L., Bekeny, J., Hall, J. M., Lee, N., Perez-Cervantes, C., Burnicka-Turek, O., Poss, K. D., Weber, C. R., de Laat, W., Ruthenburg, A. J. & Moskowitz, I. P., 27 Dec 2017, In : eLife. 6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Translational applications of adult stem cell-derived organoids

Drost, J. & Clevers, H., 15 Mar 2017, In : Development (Cambridge). 144, 6, p. 968-975 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney

Schutgens, F., Rookmaaker, M. B., Blokzijl, F., van Boxtel, R., Vries, R. R. G., Cuppen, E., Verhaar, M. C. & Clevers, H., 26 Dec 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11190-E11198

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Twists and turns

Noël, E. S. & Bakkers, J., 28 Nov 2017, In : eLife. 6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Two paths to let the replisome go

D'Angiolella, V. & Guardavaccaro, D., Jul 2017, In : Cell Death and Differentiation. 24, 7, p. 1140-1141 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Unique Phylogenetic Distributions of the Ska and Dam1 Complexes Support Functional Analogy and Suggest Multiple Parallel Displacements of Ska by Dam1

van Hooff, J. J. E., Snel, B. & Kops, G. J. P. L., 01 May 2017, In : Genome Biology and Evolution. 9, 5, p. 1295-1303 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., Nik-Zainal, S., Kuiper, R. P., Cuppen, E. & Clevers, H., 13 Oct 2017, In : Science. 358, 6360, p. 234-238 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Vasohibins encode tubulin detyrosinating activity

Nieuwenhuis, J., Adamopoulos, A., Bleijerveld, O. B., Mazouzi, A., Stickel, E., Celie, P., Altelaar, M., Knipscheer, P., Perrakis, A., Blomen, V. A. & Brummelkamp, T. R., 15 Dec 2017, In : Science. 358, 6369, p. 1453-1456 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Nusse, R. & Clevers, H., 01 Jun 2017, In : Cell. 169, 6, p. 985-999 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Kretzschmar, K. & Clevers, H., 15 Aug 2017, In : Developmental Biology. 428, 2, p. 273-282 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer

Driehuis, E. & Clevers, H., Dec 2017, In : British Journal of Pharmacology. 174, 24, p. 4547-4563 17 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Xenopus egg extract: A powerful tool to study genome maintenance mechanisms

Hoogenboom, W. S., Klein Douwel, D. & Knipscheer, P., 15 Aug 2017, In : Developmental Biology. 428, 2, p. 300-309 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2016

Analysis of neural crest-derived clones reveals novel aspects of facial development

Kaucka, M., Ivashkin, E., Gyllborg, D., Zikmund, T., Tesarova, M., Kaiser, J., Xie, M., Petersen, J., Pachnis, V., Nicolis, S. K., Yu, T., Sharpe, P., Arenas, E., Brismar, H., Blom, H., Clevers, H., Suter, U., Chagin, A. S., Fried, K., Hellander, A. & 1 others, Adameyko, I., Aug 2016, In : Journal of Dairy Science. 2, 8, p. e1600060

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets

Smink, A. M., Hertsig, D. T., Schwab, L., van Apeldoorn, A. A., de Koning, E., Faas, M. M., de Haan, B. J. & de Vos, P., 15 Jul 2016, In : Journal of refractive surgery (Thorofare, N.J. : 1995).

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A Single-Cell Transcriptome Atlas of the Human Pancreas

Muraro, M. J., Dharmadhikari, G., Grün, D., Groen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M. A., Carlotti, F., de Koning, E. J. P. & van Oudenaarden, A., 26 Oct 2016, In : Cell Systems. 3, 4, p. 385-394.e3

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Attachment issues: kinetochore transformations and spindle checkpoint silencing

Etemad, B. & Kops, G. J., Apr 2016, In : Current Opinion in Cell Biology. 39, p. 101-8 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation

van Heesbeen, R. G. H. P., Raaijmakers, J. A., Tanenbaum, M. E., Halim, V. A., Lelieveld, D., Lieftink, C., Heck, A. J. R., Egan, D. A. & Medema, R. H., 29 Jun 2016, In : Chromosoma.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

Vecchione, L., Gambino, V., Raaijmakers, J., Schlicker, A., Fumagalli, A., Russo, M., Villanueva, A., Beerling, E., Bartolini, A., Mollevi, D. G., El-Murr, N., Chiron, M., Calvet, L., Nicolazzi, C., Combeau, C., Henry, C., Simon, I. M., Tian, S., In 't Veld, S., D'ario, G. & 14 others, Mainardi, S., Beijersbergen, R. L., Lieftink, C., Linn, S., Rumpf-Kienzl, C., Delorenzi, M., Wessels, L., Salazar, R., Di Nicolantonio, F., Bardelli, A., van Rheenen, J., Medema, R. H., Tejpar, S. & Bernards, R., 07 Apr 2016, In : Cell. 165, 2, p. 317-30 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals its Specific Role in Laterality Organ Function

Noël, E. S., Momenah, T. S., Al-Dagriri, K., Al-Suwaid, A., Al-Shahrani, S., Jiang, H., Willekers, S., Oostveen, Y. Y., Chocron, S., Postma, A. V., Bhuiyan, Z. A. & Bakkers, J., Feb 2016, In : Human Mutation.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Birth and upgrowth of the Hox topological domains during evolution

Deschamps, J., Mar 2016, In : Nature Genetics. 48, 3, p. 227-8 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cardiac Repair after Myocardial Infarction

van Rooij, E., 07 Jan 2016, In : The New England Journal of Medicine. 374, 1, p. 85-7 3 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review