• Netherlands

  • Netherlands

Research Output

Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis

Oosterwegel, M., Wetering, M. V. D., Timmerman, J., Kruisbeek, A., Destree, O., Meijlink, F. & Clevers, J. C., 1993, In : Development. 118, p. 439-448

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Differential expression of the HMG box transcription factors XTcf 3 and Xlef 1 during early Xenopus development

Molenaar, M., Roose, J., Peterson, J., Venanzi, S., Clevers, J. C. & Destree, O., 1998, In : Mechanisms of Development. 75, p. 163-166

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans

Kamminga, L. M., van Wolfswinkel, J. C., Luteijn, M. J., Kaaij, L. J., Bagijn, M. P., Sapetschnig, A., Miska, E. A., Berezikov, E. & Ketting, R. F., 2012, In : PLoS Genetics. 8, 7, p. 1002702

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration

Wu, Z-W., Hale, A. J., Lemeer, S. & den Hertog, J., 16 Aug 2017, In : Scientific Reports. 7, 1, p. 8460

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Differential requirement for pten lipid and protein phosphatase activity during zebrafish embryonic development

Stumpf, M. & Den Hertog, J., 01 Feb 2016, In : PLoS One. 11, 2, e0148508.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

Morikawa, H., Ohkura, N., Vandenbon, A., Itoh, M., Nagao-Sato, S., Kawaji, H., Lassmann, T., Carninci, P., Hayashizaki, Y., Forrest, A. R. R., Standley, D. M., Date, H. & Sakaguchi, S., 08 Apr 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 14, p. 5289-94 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differential Stoichiometry among Core Ribosomal Proteins

Slavov, N., Semrau, S., Airoldi, E., Budnik, B. & van Oudenaarden, A., 03 Nov 2015, In : Cell Reports. 13, 5, p. 865-73 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Zhou, J., Li, C., Sachs, N., Chiu, M. C., Wong, B. H-Y., Chu, H., Poon, V. K-M., Wang, D., Zhao, X., Wen, L., Song, W., Yuan, S., Wong, K. K-Y., Chan, J. F-W., To, K. K-W., Chen, H., Clevers, H. & Yuen, K-Y., 26 Jun 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. 6822-6827 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan

Emmink, B. L., Houdt, W. J., Vries, R. G. J., Hoogwater, F. J., Govaert, K. M., Verheem, A., Nijkamp, M. W., Steller, E. J., Jimenez, C. R., Clevers, H., Rinkes, I. H. & Kranenburg, O., 2011, In : Gastroenterology. 141, 1, p. 269-278

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium

Stange, D. E., Koo, B. K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Koster, J., Geahlen, J. H., Peters, P. J., van Es, J. H., van de Wetering, M., Mills, J. C. & Clevers, H., 2013, In : Cell. 155, 2, p. 357-368

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Disclosure of individual genetic data to research participants: the debate reconsidered

Bredenoord, A. L., Kroes, H. Y., Cuppen, E., Parker, M. & van Delden, J. J. M., 2010, In : Trends in Genetics. 27, 2, p. 41-47

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

Wang, X., Tucker, N. R., Rizki, G., Mills, R., Krijger, P. H., de Wit, E., Subramanian, V., Bartell, E., Nguyen, X-X., Ye, J., Leyton-Mange, J., Dolmatova, E. V., van der Harst, P., de Laat, W., Ellinor, P. T., Newton-Cheh, C., Milan, D. J., Kellis, M. & Boyer, L. A., 2016, In : eLife. 5

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Discovery of molecular markers to discriminate corneal endothelial cells in the human body

Yoshihara, M., Ohmiya, H., Hara, S., Kawasaki, S., Hayashizaki, Y., Itoh, M., Kawaji, H., Tsujikawa, M. & Nishida, K., 2015, In : PLoS One. 10, 3, p. e0117581

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Discovery of variants unmasked by hemizygous deletions

Hochstenbach, R., Poot, M., Nijman, I. J., Renkens, I., Duran, K. J., Van't Slot, R., van Binsbergen, E., van der Zwaag, B., Vogel, M. J., Terhal, P. A., Ploos van Amstel, H. K., Kloosterman, W. P. & Cuppen, E., 2012, In : European Journal of Human Genetics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., de Bruin, A., Rothuizen, J., Penning, L. C. & Schotanus, B. A., 06 Oct 2015, In : Stem Cell Reports.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

Dutta, D., Heo, I. & Clevers, H., May 2017, In : Trends in Molecular Medicine. 23, 5, p. 393-410 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

Jaitin, D. A., Weiner, A., Yofe, I., Lara-Astiaso, D., Keren-Shaul, H., David, E., Salame, T. M., Tanay, A., van Oudenaarden, A. & Amit, I., 15 Dec 2016, In : Cell. 167, 7, p. 1883-1896.e15

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins

Harterink, M. & Korswagen, H. C., 2012, In : Acta Physiologica (Oxford, England). 204, 1, p. 8-16

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected beta cells

Schulte, B. M., Kers-Rebel, E. D., Bottino, R., Piganelli, J. D., Galama, J. M., Engelse, M. A., de Koning, E. J. & Adema, G. J., Jun 2016, In : Clinical & Experimental Immunology. 184, 3, p. 293-307 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct and overlapping functions of ptpn11 genes in Zebrafish development

Bonetti, M., Rodriguez-Martinez, V., Paardekooper Overman, J., Overvoorde, J., van Eekelen, M., Jopling, C. & Hertog, J. D., 2014, In : PLoS One. 9, 4, p. e94884

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

Gerbe, F., van Es, J. H., Makrini, L., Brulin, B., Mellitzer, G., Robine, S., Romagnolo, B., Shroyer, N. F., Bourgaux, J. F., Pignodel, C., Clevers, H. & Jay, P., 2011, In : Journal of Cell Biology. 192, 5, p. 767-780

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct beta-catenins mediate adhesion and signalling functions in C. elegans

Korswagen, R., Herman, M. & Clevers, J. C., 2000, In : Nature. 406, p. 527-532

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes

Karmouch, J., Zhou, Q. Q., Miyake, C. Y., Lombardi, R., Kretzschmar, K., Bannier-Hélaouët, M., Clevers, H., Wehrens, X. H. T., Willerson, J. T. & Marian, A. J., 08 Dec 2017, In : Circulation Research. 121, 12, p. 1346-1359 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila

Bhambhani, C., Ravindranath, A. J., Mentink, R. A., Chang, M. V., Betist, M. C., Yang, Y. X., Koushika, S. P., Korswagen, H. C. & Cadigan, K. M., Feb 2014, In : PLoS Genetics. 10, 2, p. e1004133

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

Krens, S. F. G., He, S., Lamers, G. E. M., Meijer, A. H., Bakkers, J., Schmidt, T., Spaink, H. P. & Snaar-Jagalska, B. E., 2008, In : Developmental Biology. 319, 2, p. 370-383

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines

Hollestelle, A., Nagel, J. H., Smid, M., Lam, S., Elstrodt, F., Wasielewski, M., Ng, S. S., French, P. J., Peeters, J. K., Rozendaal, M. J., Riaz, M., Koopman, D. G., Ten Hagen, T. L., De Leeuw, B. H., Zwarthoff, E. C., Teunisse, A., Van der Spek, P. J., Klijn, J. G., Dinjens, W. N., Ethier, S. P. & 6 others, Clevers, H., Jochemsen, A. G., Den Bakker, M. A., Foekens, J. A., Martens, J. W. & Schutte, M., 2009, In : Breast Cancer Research and Treatment.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart.

de Pater, E. M., Clijsters, L., Marques, S. R., Lin, Y. F., Garavito-Aguilar, Z. V., Yelon, D. & Bakkers, J., 2009, In : Development. 136, 10, p. 1633-1641

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., Chio, I. I. C., Hwang, C-I., Tiriac, H., Baker, L. A., Engle, D. D., Feig, C., Kultti, A., Egeblad, M., Fearon, D. T., Crawford, J. M. & 3 others, Clevers, H., Park, Y. & Tuveson, D. A., 06 Mar 2017, In : Journal of Experimental Medicine. 214, 3, p. 579-596 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Distribution and functional impact of DNA copy number variation in the rat.

Guryev, V., Saar, K., Adamovic, T., Verheul, M., van Heesch, S., Cook, S., Pravenec, M., Aitman, T., Jacob, H., Shull, J. D., Hubner, N. & Cuppen, E., 2008, In : Nature Genetics. 40, 5, p. 538-545

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Divergence of zebrafish and mouse lymphatic cell fate specification pathways

van Impel, A., Zhao, Z., Hermkens, D. M. A., Roukens, M. G., Fischer, J. C., Peterson-Maduro, J., Duckers, H., Ober, E. A., Ingham, P. W. & Schulte-Merker, S., Mar 2014, In : Development. 141, 6, p. 1228-38 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements

Hakim, O., Sung, M. H., Voss, T. C., Splinter, E., John, S., Sabo, P. J., Thurman, R. E., Stamatoyannopoulos, J. A., de Laat, W. & Hager, G. L., 2011, In : Genome Research. 21, 5, p. 697-706

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Diversity of microRNAs in human and chimpanzee brain

Cuppen, E., 2006, In : Nature Genetics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

van Es, J. H., Sato, T., van de Wetering, M., Lyubimova, A., Nee, A. N., Gregorieff, A., Sasaki, N., Zeinstra, L., van den Born, M., Korving, J., Martens, A. C., Barker, N., van Oudenaarden, A. & Clevers, H., 2012, In : Nature Cell Biology. 14, 10, p. 1099-1104

Research output: Contribution to journal/periodicalArticleScientificpeer-review

DNA isolation from rat tail or ear

Cuppen, E., 2010, In : Cold Spring Harbor Protocols. 2010, 5, p. 5434

Research output: Contribution to journal/periodicalArticleScientificpeer-review

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

Roost, M. S., Slieker, R. C., Bialecka, M., van Iperen, L., Gomes Fernandes, M. M., He, N., Suchiman, H. E. D., Szuhai, K., Carlotti, F., de Koning, E. J. P., Mummery, C. L., Heijmans, B. T. & Chuva de Sousa Lopes, S. M., 13 Oct 2017, In : Nature Communications. 8, 1, p. 908

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

Kaaij, L. T., van de Wetering, M., Fang, F., Decato, B., Molaro, A., van de Werken, H. J., van Es, J. H., Schuijers, J., de Wit, E., de Laat, W., Hannon, G. J., Clevers, H. C., Smith, A. D. & Ketting, R. F., 2013, In : Genome Biology. 14, 5, p. 50

Research output: Contribution to journal/periodicalArticleScientificpeer-review

DNA Methylation Landscapes of Human Fetal Development

Slieker, R. C., Roost, M. S., van Iperen, L., Suchiman, H. E. D., Tobi, E. W., Carlotti, F., de Koning, E. J. P., Slagboom, P. E., Heijmans, B. T. & Chuva de Sousa Lopes, S. M., Oct 2015, In : PLoS Genetics. 11, 10, p. e1005583

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

DNA mismatch repair, genome instability and cancer in zebrafish

Feitsma, H., 2008, Amsterdam: F&N Boekservice. 142 p.

Research output: PhD ThesisPhD thesis

DNA repair mechanisms in C. elegans

Brouwer, K., 2009, Utrecht: Universiteit Utrecht.

Research output: PhD ThesisPhD thesis

Dominant missense mutations in ABCC9 cause Cantu syndrome

Harakalova, M., van Harssel, J. J., Terhal, P. A., van Lieshout, S., Duran, K., Renkens, I., Amor, D. J., Wilson, L. C., Kirk, E. P., Turner, C. L., Shears, D., Garcia-Minaur, S., Lees, M. M., Ross, A., Venselaar, H., Vriend, G., Takanari, H., Rook, M. B., van der Heyden, M. A., Asselbergs, F. W. & 11 others, Breur, H. M., Swinkels, M. E., Scurr, I. J., Smithson, S. F., Knoers, N. V., van der Smagt, J. J., Nijman, I. J., Kloosterman, W. P., van Haelst, M. M., van Haaften, G. & Cuppen, E., 2012, In : Nature Genetics. 44, 7, p. 793-796

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dominant-negative ALK2 allele associates with congenital heart defects.

Smith, K., Joziasse, I. C., Chocron, S., van Dinther, M., Guryev, V., Verhoeven, M. C., Rehmann, H., van der Smagt, J. J., Doevendans, P. A., Cuppen, E., Mulder, B. J. M., ten Dijke, P. & Bakkers, J., 2009, In : Circulation. 119, 24, p. 3062-3069

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Double-strand break repair and G4 DNA stability in Caenorhabditis elegans

Pontier, D. B., 2010

Research output: PhD ThesisPhD thesis

Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.

Riedl, J. A., Brandt, D. T., Batlle, E., Price, L. S., Clevers, J. C. & Bos, J. L., 2005, In : The Biochemical journal. 389, p. 465-469

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Drosophila patterning is established by differential association of mRNAs with P bodies

Weil, T. T., Parton, R. M., Herpers, B., Soetaert, J., Veenendaal, T., Xanthakis, D., Dobbie, I. M., Halstead, J. M., Hayashi, R., Rabouille, C. & Davis, I., 2012, In : Nature Cell Biology. 14, 12, p. 1305-1315

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Drosophila RpS3a, a novel Minute gene situated between the segment polarity genescubitus interruptus and dTCF

Beest, M. V., Mortin, M. & Clevers, J. C., 1998, In : Nucleic Acids Research. 26, p. 4471-4475

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

Cavallo, R. A., Cox, R. T., Moline, M. M., Roose, J., Polevoy, G. A., Clevers, J. C., Peifer, M. & Bejsovec, A., 1998, In : Nature. 395, p. 604-608

Research output: Contribution to journal/periodicalArticleScientificpeer-review

dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila

Lawrence, N., Dearden, P., Hartley, D., Roose, J., Clevers, J. C. & Arias, A. M., 2000, In : International Journal of Developmental Biology. 44, p. 749-756

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dual origins of dairy cattle farming--evidence from a comprehensive survey of European Y-chromosomal variation

Edwards, C. J., Ginja, C., Kantanen, J., Perez-Pardal, L., Tresset, A., Stock, F., Gama, L. T., Penedo, M. C., Bradley, D. G., Lenstra, J. A. & Nijman, I. J., 2011, In : PLoS One. 6, 1, p. 15922

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., He, X., Wang, J., Lu, C., Wu, L. N., Weng, Q., Mao, M., Li, J., van Es, J. H., Xin, M., Parry, L., Goldman, S. A., Clevers, H. & Lu, Q. R., 2016, In : Nature Communications. 7, p. 10883

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

Sacristan, C., Ahmad, M. U. D., Keller, J., Fermie, J., Groenewold, V., Tromer, E., Fish, A., Melero, R., Carazo, J. M., Klumperman, J., Musacchio, A., Perrakis, A. & Kops, G. J., Jul 2018, In : Nature Cell Biology. 20, 7, p. 800-810 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review