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Research Output

2020

Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal

Tait, C., Chinnaiya, K., Manning, E., Murtaza, M., Ashton, J-P., Furley, N., Hill, C. J., Alves, C. H., Wijnholds, J., Erdmann, K. S., Furley, A., Rashbass, P., Das, R. M., Storey, K. G. & Placzek, M., Jan 2020, In : PLoS Biology. 18, 3, p. e3000470

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
29 Downloads (Pure)
2019

CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity

Alves, C. H., Boon, N., Mulder, A. A., Koster, A. J., Jost, C. R. & Wijnholds, J., Apr 2019, In : International Journal of Molecular Sciences. 20, 17

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
57 Downloads (Pure)

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5

Quinn, P. M., Buck, T. M., Mulder, A. A., Ohonin, C., Alves, C. H., Vos, R. M., Bialecka, M., van Herwaarden, T., van Dijk, E. H. C., Talib, M., Freund, C., Mikkers, H. M. M., Hoeben, R. C., Goumans, M-J., Boon, C. J. F., Koster, A. J., Chuva de Sousa Lopes, S. M., Jost, C. R. & Wijnholds, J., 2019, In : Stem Cell Reports. 12, p. 906-919

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
120 Downloads (Pure)

Microglial Cell Dysfunction in CRB1-Associated Retinopathies

Alves, C. H. & Wijnholds, J., 2019, In : Advances in Experimental Medicine and Biology. 1185, p. 159-163 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2018

AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa

Alves, C. H. & Wijnholds, J., 2018, In : Methods in Molecular Biology. 1715, p. 135-151 17 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function

Quinn, P. M., Alves, C. H., Klooster, J. & Wijnholds, J., 2018, In : Human Molecular Genetics. 27, p. 3137-3153

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2015

Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models

Pellissier, L. P., Quinn, P. M., Alves, C. H., Vos, R. M., Klooster, J., Flannery, J. G., Heimel, J. A. & Wijnholds, J., 01 Jun 2015, In : Human Molecular Genetics. 24, 11, p. 3104-18 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
144 Downloads (Pure)
2014

The Crumbs complex in the retina. From animal models to function.

Alves, C. H. F., 19 May 2014

Research output: PhD ThesisPhD thesis