Research output per year
Research output per year
- 22 results
Search results
-
2019
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells
Han, S., Fink, J., Jörg, D. J., Lee, E., Yum, M. K., Chatzeli, L., Merker, S. R., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, J-H., Sasaki, N., Mort, R. L., Basak, O., Clevers, H., Stange, D. E., Philpott, A., & 3 others, 05 Sept 2019, In: Cell Stem Cell. 25, 3, p. 342-356.e7Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access70 Citations (Scopus) -
2018
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., Simons, B. D. & Clevers, H., 23 Jan 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E610-E619Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access94 Citations (Scopus) -
2015
Frizzled7 functions as a wnt receptor in intestinal epithelial lgr5(+) stem cells
Flanagan, D. J., Phesse, T. J., Barker, N., Schwab, R. H. M., Amin, N., Malaterre, J., Stange, D. E., Nowell, C. J., Currie, S. A., Saw, J. T. S., Beuchert, E., Ramsay, R. G., Sansom, O. J., Ernst, M., Clevers, H. & Vincan, E., 12 May 2015, In: Stem Cell Reports. 4, 5, p. 759-67 9 p.Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access90 Citations (Scopus) -
2013
Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors
Stange, D. E. & Clevers, H., 2013, In: Stem Cells. 31, 11, p. 2287-2295Research output: Contribution to journal/periodical › Article › Scientific › peer-review
27 Citations (Scopus) -
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
Stange, D. E., Koo, B. K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Koster, J., Geahlen, J. H., Peters, P. J., van Es, J. H., van de Wetering, M., Mills, J. C. & Clevers, H., 2013, In: Cell. 155, 2, p. 357-368Research output: Contribution to journal/periodical › Article › Scientific › peer-review
362 Citations (Scopus) -
2012
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
Schepers, A. G., Snippert, H. J. G., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M. & Clevers, H., 2012, In: Science Magazine. 337, 6095, p. 730-735Research output: Contribution to journal/periodical › Article › Scientific › peer-review
843 Citations (Scopus) -
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
Wong, V. M., Stange, D. E., Page, M. E., Buczacki, S., Wabik, A., Itami, S., van de Wetering, M., Poulsom, R., Wright, N. A., Trotter, M. W., Watt, F. M., Winton, D. J., Clevers, H. & Jensen, K. B., 2012, In: Nature Cell Biology. 14, 4, p. 401-408Research output: Contribution to journal/periodical › Article › Scientific › peer-review
315 Citations (Scopus) -
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers
Munoz, J., Stange, D. E., Schepers, A. G., van de Wetering, M., Koo, B. K., Itzkovitz, S., Volckmann, R., Kung, K. S., Koster, J., Radulescu, S., Myant, K., Versteeg, R., Sansom, O. J., van Es, J. H., Barker, N., van Oudenaarden, A., Mohammed, S., Heck, A. J. R. & Clevers, H., 2012, In: EMBO Journal. 31, 14, p. 3079-3091Research output: Contribution to journal/periodical › Article › Scientific › peer-review
540 Citations (Scopus) -
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
Koo, B. K., Spit, M., Jordens, I., Low, T. Y., Stange, D. E., van de Wetering, M., van Es, J. H., Mohammed, S., Heck, A. J. R., Maurice, M. M. & Clevers, H., 2012, In: Nature. 488, 7413, p. 665-669Research output: Contribution to journal/periodical › Article › Scientific › peer-review
640 Citations (Scopus) -
2011
Controlled gene expression in primary Lgr5 organoid cultures
Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., van Es, J. H. & Clevers, H., 2011, In: Nature Methods. 9, 1, p. 81-83Research output: Contribution to journal/periodical › Article › Scientific › peer-review
226 Citations (Scopus) -
Highly sensitive proteome analysis of FACS-sorted adult colon stem cells
Di Palma, S., Stange, D. E., van de Wetering, M. L., Clevers, H., Heck, A. & Mohammed, S., 2011, In: Journal of Proteome Research. 10, 8, p. 3814-3819Research output: Contribution to journal/periodical › Article › Scientific › peer-review
54 Citations (Scopus)3 Downloads (Pure) -
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
de Lau, W. B. M., Barker, N., Low, T. Y., Koo, B. K., Li, V. S., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P., van de Wetering, M. L., Stange, D. E., van Es, J. H., Guardavaccaro, D., Schasfoort, R. B., Mohri, Y., Nishimori, K., Mohammed, S., Heck, A. & Clevers, H., 2011, In: Nature. 476, 7360, p. 293-297Research output: Contribution to journal/periodical › Article › Scientific › peer-review
937 Citations (Scopus) -
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D. & Clevers, H., 2011, In: Gastroenterology. 141, 5, p. 1762-1772Research output: Contribution to journal/periodical › Article › Scientific › peer-review
2134 Citations (Scopus) -
2010
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development
Kosinski, C., Stange, D. E., Xu, C., Chan, A. S., Ho, C., Yuen, S. T., Mifflin, R. C., Powell, D. W., Clevers, H., Leung, S. Y. & Chen, X. N., 2010, In: Gastroenterology. 139, 3, p. 893-903Research output: Contribution to journal/periodical › Article › Scientific › peer-review
102 Citations (Scopus) -
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
Barker, N., Huch, M., Kujala, P., van de Wetering, M. L., Snippert, H. J. G., van Es, J. H., Sato, T., Stange, D. E., Begthel, H. L., van den Born, M. M. W., Danenberg, E. M., van den Brink, S., Korving, J., Abo, A., Peters, P., Wright, N., Poulsom, R. & Clevers, H., 2010, In: Cell Stem Cell. 6, 1, p. 25-36Research output: Contribution to journal/periodical › Article › Scientific › peer-review
1124 Citations (Scopus) -
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
Snippert, H. J. G., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M. L., van den Born, M. M. W., Begthel, H. L., Vries, R. G. J., Stange, D. E., Toftgard, R. & Clevers, H., 2010, In: Science Magazine. 327, 5971, p. 1385-1389Research output: Contribution to journal/periodical › Article › Scientific › peer-review
583 Citations (Scopus) -
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J. G., Stange, D. E., Vries, R. G. J., van den Born, M. M. W., Barker, N., Shroyer, N. F., van de Wetering, M. L. & Clevers, H., 2010, In: Nature. 469, 7330, p. 415-418Research output: Contribution to journal/periodical › Article › Scientific › peer-review
1742 Citations (Scopus) -
2009
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.
van der Flier, L. G., Haegebarth, A., Stange, D. E., van de Wetering, M. L. & Clevers, H., 2009, In: Gastroenterology. 137, 1, p. 15-17Research output: Contribution to journal/periodical › Article › Scientific › peer-review
370 Citations (Scopus) -
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.
Snippert, H. J. G., van Es, J. H., van den Born, M. M. W., Begthel, H. L., Stange, D. E., Barker, N. & Clevers, H., 2009, In: Gastroenterology. 136, 7, p. 2181-2187Research output: Contribution to journal/periodical › Article › Scientific › peer-review
184 Citations (Scopus) -
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Sato, T., Vries, R. G. J., Snippert, H. J. G., van de Wetering, M. L., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J. & Clevers, H., 2009, In: Nature. 459, 7244, p. 262-265Research output: Contribution to journal/periodical › Article › Scientific › peer-review
4179 Citations (Scopus) -
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.
Gregorieff, A., Stange, D. E., Kujala, P., Begthel, H. L., van den Born, M. M. W., Korving, J., Peters, P. J. & Clevers, H., 2009, In: Gastroenterology. 137, 4, p. 1333-1333Research output: Contribution to journal/periodical › Article › Scientific › peer-review
175 Citations (Scopus) -
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
van der Flier, L. G., van Gijn, M. E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D. E., Begthel, H. L., van den Born, M. M. W., Guryev, V., Oving, I. M., van Es, J. H., Barker, N., Peters, P. J., van de Wetering, M. L. & Clevers, H., 2009, In: Cell. 136, 5, p. 903-912Research output: Contribution to journal/periodical › Article › Scientific › peer-review
551 Citations (Scopus)