Hans Clevers

Research output

Research output per year 1985 2009 2010 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2023 2024

• 795 Article
• 16 Book/Film/Article review
• 2 Book
• 1 Chapter
• 1 More
  • 1 Patent

Research output per year

Research output per year

Search results

• 2024

  A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine

  Willemsen, S., Yengej, F. A. Y., Puschhof, J., Rookmaaker, M. B., Verhaar, M. C., van Es, J., Beumer, J. & Clevers, H., 05 Nov 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 45, p. e2411189121

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Behav3d: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response

  Alieva, M., Barrera Román, M., de Blank, S., Petcu, D., Zeeman, A. L., Dautzenberg, N. M. M., Cornel, A. M., van de Ven, C., Pieters, R., den Boer, M. L., Nierkens, S., Calkoen, F. G. J., Clevers, H., Kuball, J., Sebestyén, Z., Wehrens, E. J., Dekkers, J. F. & Rios, A. C., Jul 2024, In: Nature Protocols. 19, 7, p. 2052-2084 33 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review
  1 Citation (Scopus)

• Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase

  Darmasaputra, G. S., Geerlings, C. C., Chuva de Sousa Lopes, S. M., Clevers, H. & Galli, M., 05 Aug 2024, In: Journal of Cell Biology. 223, 8

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  1 Citation (Scopus)

• Cell division-dependent dissemination following E-cadherin loss underlies initiation of diffuse-type gastric cancer

  Monster, J. L., Kemp, L. J., Busslinger, G. A., Vliem, M. J., Derks, L. L., Staes, A. A., Bisseling, T. M., Clevers, H., van der Post, R. S. & Gloerich, M., Jun 2024, In: Journal of Pathology. 263, 2, p. 226-241 16 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  2 Citations (Scopus)

• Chromatin Remodeling in Patient-Derived Colorectal Cancer Models

  Xiang, K., Wang, E., Mantyh, J., Rupprecht, G., Negrete, M., Sanati, G., Hsu, C., Randon, P., Dohlman, A., Kretzschmar, K., Bose, S., Giroux, N., Ding, S., Wang, L., Balcazar, J. P., Huang, Q., Sundaramoorthy, P., Xi, R., McCall, S. J., Wang, Z., & 9 othersJiang, C., Kang, Y., Kopetz, S., Crawford, G. E., Lipkin, S. M., Wang, X-F., Clevers, H., Hsu, D. & Shen, X., Apr 2024, In: Advanced Science. 11, 16, p. e2303379

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Decoding endocrine cell differentiation: insights from high-throughput CRISPR screening in human gut organoids

  Lin, L. & Clevers, H., Jan 2024, In: Clinical and translational medicine. 14, 1, p. e1526

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Derivation of functional thymic epithelial organoid lines from adult murine thymus

  Lim, S., J F van Son, G., Wisma Eka Yanti, N. L., Andersson-Rolf, A., Willemsen, S., Korving, J., Lee, H-G., Begthel, H. & Clevers, H., 23 Apr 2024, In: Cell Reports. 43, 4, p. 114019

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  5 Citations (Scopus)

• Description and functional validation of human enteroendocrine cell sensors

  Beumer, J., Geurts, M. H., Geurts, V., Andersson-Rolf, A., Akkerman, N., Völlmy, F., Krueger, D., Busslinger, G. A., Martínez-Silgado, A., Boot, C., Yousef Yengej, F. A., Puschhof, J., Van de Wetering, W. J., Knoops, K., López-Iglesias, C., Peters, P. J., Vivié, J. A., Mooijman, D., van Es, J. H. & Clevers, H., 18 Oct 2024, In: Science. 386, 6719, p. 341-348 8 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer

  Haughton, P. D., Haakma, W., Chalkiadakis, T., Breimer, G. E., Driehuis, E., Clevers, H., Willems, S., Prekovic, S. & Derksen, P. W. B., Aug 2024, In: Oncogene. 43, 32, p. 2463-2474 12 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  1 Citation (Scopus)

• Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids

  Kluiver, T. A., Lu, Y., Schubert, S. A., Kraaier, L. J., Ringnalda, F., Lijnzaad, P., DeMartino, J., Megchelenbrink, W. L., Amo-Addae, V., Eising, S., de Faria, F. W., Münter, D., van de Wetering, M., Kerl, K., Duiker, E., van den Heuvel, M. C., de Meijer, V. E., de Kleine, R. H., Molenaar, J. J., Margaritis, T., & 5 othersStunnenberg, H. G., de Krijger, R. R., Zsiros, J., Clevers, H. & Peng, W. C., 20 Nov 2024, In: Nature Communications. 15, 1, p. 8576

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  1 Citation (Scopus)

• Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells

  Hernández-López, P., van Diest, E., Brazda, P., Heijhuurs, S., Meringa, A., Hoorens van Heyningen, L., Riillo, C., Schwenzel, C., Zintchenko, M., Johanna, I., Nicolasen, M. J. T., Cleven, A., Kluiver, T. A., Millen, R., Zheng, J., Karaiskaki, F., Straetemans, T., Clevers, H., de Bree, R., Stunnenberg, H. G., & 6 othersPeng, W. C., Roodhart, J., Minguet, S., Sebestyén, Z., Beringer, D. X. & Kuball, J., Jan 2024, In: Nature Immunology. 25, 1, p. 88-101 14 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review
  4 Citations (Scopus)

• Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7

  Boretto, M., Geurts, M. H., Gandhi, S., Ma, Z., Staliarova, N., Celotti, M., Lim, S., He, G-W., Millen, R., Driehuis, E., Begthel, H., Smabers, L., Roodhart, J., van Es, J., Wu, W. & Clevers, H., 19 Mar 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 12, p. e2309902121

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  5 Citations (Scopus)

• Human conjunctiva organoids to study ocular surface homeostasis and disease

  Bannier-Hélaouët, M., Korving, J., Ma, Z., Begthel, H., Giladi, A., Lamers, M. M., van de Wetering, W. J., Yawata, N., Yawata, M., LaPointe, V. L. S., Dickman, M. M., Kalmann, R., Imhoff, S. M., van Es, J. H., López-Iglesias, C., Peters, P. J., Haagmans, B. L., Wu, W. & Clevers, H., 01 Feb 2024, In: Cell Stem Cell. 31, 2, p. 227-243.e12

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  9 Citations (Scopus)

• Human fetal brain self-organizes into long-term expanding organoids

  Hendriks, D., Pagliaro, A., Andreatta, F., Ma, Z., van Giessen, J., Massalini, S., López-Iglesias, C., van Son, G. J. F., DeMartino, J., Damen, J. M. A., Zoutendijk, I., Staliarova, N., Bredenoord, A. L., Holstege, F. C. P., Peters, P. J., Margaritis, T., Chuva de Sousa Lopes, S., Wu, W., Clevers, H. & Artegiani, B., 01 Feb 2024, In: Cell. 187, 3, p. 712-732.e38

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  27 Citations (Scopus)

• Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer

  Rosendahl Huber, A., Pleguezuelos-Manzano, C., Puschhof, J., Ubels, J., Boot, C., Saftien, A., Verheul, M., Trabut, L. T., Groenen, N., van Roosmalen, M., Ouyang, K. S., Wood, H., Quirke, P., Meijer, G., Cuppen, E., Clevers, H. & van Boxtel, R., 11 Mar 2024, In: Cancer Cell. 42, 3, p. 487-496.e6

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  13 Citations (Scopus)

• Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages

  Andersson-Rolf, A., Groot, K., Korving, J., Begthel, H., Hanegraaf, M. A. J., VanInsberghe, M., Salmén, F., van den Brink, S., Lopez-Iglesias, C., Peters, P. J., Krueger, D., Beumer, J., Geurts, M. H., Alemany, A., Gehart, H., Carlotti, F., de Koning, E. J. P., Chuva de Sousa Lopes, S. M., van Oudenaarden, A., van Es, J. H., & 1 othersClevers, H., 26 Dec 2024, In: Cell. 187, 26, p. 7394-7413.e22

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth

  Hendriks, D., Artegiani, B., Margaritis, T., Zoutendijk, I., Chuva de Sousa Lopes, S. & Clevers, H., 13 May 2024, In: Nature Communications. 15, 1, p. 4034

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  1 Citation (Scopus)

• Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms

  Alcala, N., Voegele, C., Mangiante, L., Sexton-Oates, A., Clevers, H., Fernandez-Cuesta, L., Dayton, T. L. & Foll, M., 02 Jan 2024, In: GigaScience. 13

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  1 Citation (Scopus)

• Polyketide synthase positive Escherichia coli one-time measurement in stool is not informative of colorectal cancer risk in a screening setting

  de Klaver, W., de Wit, M., Bolijn, A., Tijssen, M., Delis-van Diemen, P., Lemmens, M., Spaander, M. C., Dekker, E., van Leerdam, M. E., Coupé, V. M., van Boxtel, R., Clevers, H., Carvalho, B. & Meijer, G. A., Jun 2024, In: Journal of Pathology. 263, 2, p. 217-225 9 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools

  Celotti, M., Derks, L. L. M., van Es, J., van Boxtel, R., Clevers, H. & Geurts, M. H., 20 Sept 2024, In: STAR protocols. 5, 3, p. 103189

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  2 Citations (Scopus)

• RANK drives structured intestinal epithelial expansion during pregnancy

  Onji, M., Sigl, V., Lendl, T., Novatchkova, M., Ullate-Agote, A., Andersson-Rolf, A., Kozieradzki, I., Koglgruber, R., Pai, T-P., Lichtscheidl, D., Nayak, K., Zilbauer, M., Carranza García, N. A., Sievers, L. K., Falk-Paulsen, M., Cronin, S. J. F., Hagelkruys, A., Sawa, S., Osborne, L. C., Rosenstiel, P., & 6 othersPasparakis, M., Ruland, J., Takayanagi, H., Clevers, H., Koo, B-K. & Penninger, J. M., Dec 2024, In: Nature. 637, 8044, p. 156-166 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids

  Mizutani, T., Boretto, M., Lim, S., Drost, J., González, D. M., Oka, R., Geurts, M. H., Begthel, H., Korving, J., van Es, J. H., van Boxtel, R. & Clevers, H., Dec 2024, In: Nature cancer. 5, 12, p. 1852-1867 16 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease

  Yousef Yengej, F. A., Pou Casellas, C., Ammerlaan, C. M. E., Olde Hanhof, C. J. A., Dilmen, E., Beumer, J., Begthel, H., Meeder, E. M. G., Hoenderop, J. G., Rookmaaker, M. B., Verhaar, M. C. & Clevers, H., 23 Jan 2024, In: Cell Reports. 43, 1, p. 113614

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  1 Citation (Scopus)

• Tuft cells act as regenerative stem cells in the human intestine

  Huang, L., Bernink, J. H., Giladi, A., Krueger, D., van Son, G. J. F., Geurts, M. H., Busslinger, G., Lin, L., Begthel, H., Zandvliet, M., Buskens, C. J., Bemelman, W. A., López-Iglesias, C., Peters, P. J. & Clevers, H., Oct 2024, In: Nature. 634, 8035, p. 929-935 7 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access
  5 Citations (Scopus)
• 2023

  A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology

  Xu, X., Kumari, R., Zhou, J., Chen, J., Mao, B., Wang, J., Zheng, M., Tu, X., An, X., Chen, X., Zhang, L., Tian, X., Wang, H., Dong, X., Bao, Z., Guo, S., Ouyang, X., Shang, L., Wang, F., Yan, X., & 4 othersZhang, R., Vries, R. G. J., Clevers, H. & Li, Q-X., 2023, In: PLoS ONE. 18, 1, p. e0279821

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids 100%
  • Heterografts 68%
  • Pharmacology 50%
  • Neoplasms 24%
  • Investigational Therapies 15%
  10 Citations (Scopus)

• A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury

  Calafiore, M., Fu, Y-Y., Vinci, P., Arnhold, V., Chang, W. Y., Jansen, S. A., Egorova, A., Takashima, S., Kuttiyara, J., Ito, T., Serody, J., Nakae, S., Turnquist, H., van Es, J., Clevers, H., Lindemans, C. A., Blazar, B. R. & Hanash, A. M., 05 Sept 2023, In: Nature Communications. 14, 1, p. 5411

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • interleukins 100%
  • stem cells 82%
  • Interleukin-33 81%
  • regeneration 66%
  • Epidermal Growth Factor 58%
  10 Citations (Scopus)

• Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities

  Paassen, I., Williams, J., Ríos Arceo, C., Ringnalda, F., Mercer, K. S., Buhl, J. L., Moreno, N., Federico, A., Franke, N. E., Kranendonk, M., Upadhyaya, S. A., Kerl, K., van de Wetering, M., Clevers, H., Kool, M., Hoving, E. W., Roussel, M. F. & Drost, J., May 2023, In: Oncogene. 42, 20, p. 1661-1671 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Typical Teratoid Rhabdoid Tumor 100%
  • Atypical Teratoid Tumor 99%
  • Pharmaceutical Preparations 25%
  • Brain Neoplasms 9%
  • Epigenomics 9%
  9 Citations (Scopus)

• Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk

  Li, Y., Chaurasia, B., Rahman, M. M., Kaddai, V., Maschek, J. A., Berg, J. A., Wilkerson, J. L., Mahmassani, Z. S., Cox, J., Wei, P., Meikle, P. J., Atkinson, D., Wang, L., Poss, A. M., Playdon, M. C., Tippetts, T. S., Mousa, E. M., Nittayaboon, K., Anandh Babu, P. V., Drummond, M. J., & 7 othersClevers, H., Shayman, J. A., Hirabayashi, Y., Holland, W. L., Rutter, J., Edgar, B. A. & Summers, S. A., Nov 2023, In: Gastroenterology. 165, 5, p. 1136-1150 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Sphingolipids 100%
  • Ceramides 96%
  • Fatty Acids 69%
  • Serine C-Palmitoyltransferase 59%
  • Stem Cells 34%
  13 Citations (Scopus)

• Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures

  Yang, A. S. P., Dutta, D., Kretzschmar, K., Hendriks, D., Puschhof, J., Hu, H., Boonekamp, K. E., van Waardenburg, Y., Chuva de Sousa Lopes, S. M., van Gemert, G-J., de Wilt, J. H. W., Bousema, T., Clevers, H. & Sauerwein, R. W., 02 Aug 2023, In: Nature Communications. 14, 1, p. 4631

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • RNA Sequencing 100%
  • parasites 86%
  • Organoids 79%
  • liver 66%
  • Plasmodium falciparum 63%
  7 Citations (Scopus)

• Directed Differentiation of Murine and Human Small Intestinal Organoids Toward All Mature Lineages

  Martinez-Silgado, A., Beumer, J. & Clevers, H., 2023, In: Methods in molecular biology (Clifton, N.J.). 2650, p. 107-122 16 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids 100%
  • Adult Stem Cells 22%
  2 Citations (Scopus)

• DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

  Juan, L. S., Freije, A., Sanz-Gómez, N., Jiménez-Matías, B., Pleguezuelos-Manzano, C., Sanz, J. R., de Diego, E., Naranjo, S., Clevers, H. & Gandarillas, A., 21 Jan 2023, In: Cell death discovery. 9, 1, p. 21

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • M Phase Cell Cycle Checkpoints 100%
  • Metaplasia 80%
  • DNA Damage 64%
  • Breast 56%
  • Human Mammary Glands 40%
  6 Citations (Scopus)

• Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites

  Dayton, T. L., Alcala, N., Moonen, L., den Hartigh, L., Geurts, V., Mangiante, L., Lap, L., Dost, A. F. M., Beumer, J., Levy, S., van Leeuwaarde, R. S., Hackeng, W. M., Samsom, K., Voegele, C., Sexton-Oates, A., Begthel, H., Korving, J., Hillen, L., Brosens, L. A. A., Lantuejoul, S., & 16 othersJaksani, S., Kok, N. F. M., Hartemink, K. J., Klomp, H. M., Borel Rinkes, I. H. M., Dingemans, A-M., Valk, G. D., Vriens, M. R., Buikhuisen, W., van den Berg, J., Tesselaar, M., Derks, J., Speel, E. J., Foll, M., Fernández-Cuesta, L. & Clevers, H., 11 Dec 2023, In: Cancer Cell. 41, 12, p. 2083-2099.e9

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids 100%
  • Neuroendocrine Tumors 53%
  • Neuroendocrine Carcinoma 49%
  • Growth 38%
  • Large Cell Carcinoma 25%
  16 Citations (Scopus)

• Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

  Leon-Icaza, S. A., Bagayoko, S., Vergé, R., Iakobachvili, N., Ferrand, C., Aydogan, T., Bernard, C., Sanchez Dafun, A., Murris-Espin, M., Mazières, J., Bordignon, P. J., Mazères, S., Bernes-Lasserre, P., Ramé, V., Lagarde, J-M., Marcoux, J., Bousquet, M-P., Chalut, C., Guilhot, C., Clevers, H., & 7 othersPeters, P. J., Molle, V., Lugo-Villarino, G., Cam, K., Berry, L., Meunier, E. & Cougoule, C., Aug 2023, In: PLoS Pathogens. 19, 8, p. e1011559

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Mycobacterium abscessus 100%
  • cystic fibrosis 82%
  • Organoids 79%
  • Cystic Fibrosis 58%
  • Oxidation-Reduction 57%
  4 Citations (Scopus)

• Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

  Mertens, S., Huismans, M. A., Verissimo, C. S., Ponsioen, B., Overmeer, R., Proost, N., van Tellingen, O., van de Ven, M., Begthel, H., Boj, S. F., Clevers, H., Roodhart, J. M. L., Bos, J. L. & Snippert, H. J. G., 25 Apr 2023, In: Cell Reports. 42, 4, p. 112324

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Vinorelbine 100%
  • Drug Repositioning 79%
  • Organoids 75%
  • Colonic Neoplasms 52%
  • Vinca Alkaloid 44%
  27 Citations (Scopus)

• Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

  Hendriks, D., Brouwers, J. F., Hamer, K., Geurts, M. H., Luciana, L., Massalini, S., López-Iglesias, C., Peters, P. J., Rodríguez-Colman, M. J., Chuva de Sousa Lopes, S., Artegiani, B. & Clevers, H., Nov 2023, In: Nature Biotechnology. 41, 11, p. 1567-1581 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Hepatocytes 100%
  • Lipogenesis 88%
  • Organoids 78%
  • Fatty acids 73%
  • Liver 71%
  70 Citations (Scopus)

• Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids

  Bannier-Hélaouët, M., Geurts, M. H., Korving, J., Begthel, H. & Clevers, H., 03 Feb 2023, In: Journal of Visualized Experiments. 192

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids 100%
  • Ocular 97%
  • Physiology 92%
  • Lacrimal Apparatus 92%
  • Neurotransmitter 84%
  2 Citations (Scopus)

• Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

  Visser, L. L., Bleijs, M., Margaritis, T., van de Wetering, M., Holstege, F. C. P. & Clevers, H., 24 Oct 2023, In: Cancer research communications. 3, 10, p. 2158-2169 12 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Single-Cell Analysis 100%
  • Ewing's Sarcoma 90%
  • Antigen-Presenting Cells 78%
  • Gene Expression Profiling 76%
  • RNA Sequence Analysis 9%
  3 Citations (Scopus)

• Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

  Plattner, C., Lamberti, G., Blattmann, P., Kirchmair, A., Rieder, D., Loncova, Z., Sturm, G., Scheidl, S., Ijsselsteijn, M., Fotakis, G., Noureen, A., Lisandrelli, R., Böck, N., Nemati, N., Krogsdam, A., Daum, S., Finotello, F., Somarakis, A., Schäfer, A., Wilflingseder, D., & 10 othersGonzalez Acera, M., Öfner, D., Huber, L. A., Clevers, H., Becker, C., Farin, H. F., Greten, F. R., Aebersold, R., de Miranda, N. F. C. C. & Trajanoski, Z., 15 Dec 2023, In: iScience. 26, 12, p. 108399

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Proteomics 100%
  • Colorectal Neoplasms 86%
  • Organoids 47%
  • Phosphotransferases 42%
  • Tumor Microenvironment 37%
  6 Citations (Scopus)

• Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants

  Li, C., Huang, J., Yu, Y., Wan, Z., Chiu, M. C., Liu, X., Zhang, S., Cai, J-P., Chu, H., Li, G., Chan, J. F-W., To, K. K-W., Yang, Z., Jiang, S., Yuen, K-Y., Clevers, H. & Zhou, J., 25 Apr 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 17, p. e2300376120

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • SARS Virus 100%
  • Organoids 89%
  • Nose 54%
  • Giant Cells 31%
  • Immune Evasion 12%
  32 Citations (Scopus)

• Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures

  Urciuolo, A., Giobbe, G. G., Dong, Y., Michielin, F., Brandolino, L., Magnussen, M., Gagliano, O., Selmin, G., Scattolini, V., Raffa, P., Caccin, P., Shibuya, S., Scaglioni, D., Wang, X., Qu, J., Nikolic, M., Montagner, M., Galea, G. L., Clevers, H., Giomo, M., & 2 othersDe Coppi, P. & Elvassore, N., 30 May 2023, In: Nature Communications. 14, 1, p. 3128

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids 100%
  • Hydrogels 81%
  • Hydrogel 60%
  • organs 52%
  • spinal cord 36%
  38 Citations (Scopus)

• Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation

  Lucas, C., Sauter, K-S., Steigert, M., Mallet, D., Wilmouth, J., Olabe, J., Plotton, I., Morel, Y., Aeberli, D., Wagner, F., Clevers, H., Pandey, A. V., Val, P., Roucher-Boulez, F. & Flück, C. E., 15 Feb 2023, In: The journal of clinical investigation. 133, 4

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Zona Glomerulosa 100%
  • Salts 62%
  • Hypoaldosteronism 57%
  • Catenins 44%
  • Adrenal Cortex 42%
  6 Citations (Scopus)

• Nanoblades allow high-level genome editing in murine and human organoids

  Tiroille, V., Krug, A., Bokobza, E., Kahi, M., Bulcaen, M., Ensinck, M. M., Geurts, M. H., Hendriks, D., Vermeulen, F., Larbret, F., Gutierrez-Guerrero, A., Chen, Y., Van Zundert, I., Rocha, S., Rios, A. C., Medaer, L., Gijsbers, R., Mangeot, P. E., Clevers, H., Carlon, M. S., & 2 othersBost, F. & Verhoeyen, E., 12 Sept 2023, In: Molecular therapy. Nucleic acids. 33, p. 57-74 18 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids 100%
  • Gene Editing 93%
  • Guide RNA 35%
  • Clustered Regularly Interspaced Short Palindromic Repeats 29%
  • Gene Knockout Techniques 20%
  8 Citations (Scopus)

• Oncogenic signaling is coupled to colorectal cancer cell differentiation state

  Sell, T., Klotz, C., Fischer, M. M., Astaburuaga-García, R., Krug, S., Drost, J., Clevers, H., Sers, C., Morkel, M. & Blüthgen, N., 05 Jun 2023, In: Journal of Cell Biology. 222, 6

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Cell Differentiation 100%
  • Colorectal Neoplasms 97%
  • Organoids 53%
  • Mutation 45%
  • Neoplasms 39%
  2 Citations (Scopus)

• One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

  Geurts, M. H., Gandhi, S., Boretto, M. G., Akkerman, N., Derks, L. L. M., van Son, G., Celotti, M., Harshuk-Shabso, S., Peci, F., Begthel, H., Hendriks, D., Schürmann, P., Andersson-Rolf, A., Chuva de Sousa Lopes, S. M., van Es, J. H., van Boxtel, R. & Clevers, H., 17 Aug 2023, In: Nature Communications. 14, 1, p. 4998

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • stem cells 100%
  • Organoids 95%
  • mutations 84%
  • Adult Stem Cells 84%
  • multiplexing 69%
  16 Citations (Scopus)

• Organoid cell fate dynamics in space and time

  Zheng, X., Betjes, M. A., Ender, P., Goos, Y. J., Huelsz-Prince, G., Clevers, H., van Zon, J. S. & Tans, S. J., 18 Aug 2023, In: Science advances. 9, 33, p. eadd6480

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids 100%
  • Cell Tracking 15%
  • Cell Lineage 11%
  • Back 10%
  • Stem Cells 8%
  5 Citations (Scopus)

• Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss

  Rüland, L., Andreatta, F., Massalini, S., Chuva de Sousa Lopes, S., Clevers, H., Hendriks, D. & Artegiani, B., 03 May 2023, In: Nature Communications. 14, 1, p. 2377

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids 100%
  • mutations 88%
  • cancer 71%
  • Mutation 64%
  • Hepatocytes 63%
  14 Citations (Scopus)

• Paecilomycone Inhibits Quorum Sensing in Gram-Negative Bacteria

  Beenker, W. A. G., Hoeksma, J., Bannier-Hélaouët, M., Clevers, H. & den Hertog, J., 15 Mar 2023, (E-pub ahead of print) In: Microbiology spectrum. 11, 2, p. e0509722

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • virulence 100%
  • Quorum Sensing 94%
  • quorum sensing 90%
  • Gram-Negative Bacteria 75%
  • Pseudomonas aeruginosa 73%
  4 Citations (Scopus)

• Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

  Millen, R., De Kort, W. W. B., Koomen, M., van Son, G. J. F., Gobits, R., Penning de Vries, B., Begthel, H., Zandvliet, M., Doornaert, P., Raaijmakers, C. P. J., Geurts, M. H., Elias, S. G., van Es, R. J. J., de Bree, R., Devriese, L. A., Willems, S. M., Kranenburg, O., Driehuis, E. & Clevers, H., 12 May 2023, In: Med (New York, N.Y.). 4, 5, p. 290-310.e12

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids 100%
  • Head and Neck Neoplasms 76%
  • Biomarkers 49%
  • Therapeutics 12%
  • Radiotherapy 12%
  31 Citations (Scopus)

• Patient-derived tumor organoids predict responses to irinotecan-based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

  Lv, T., Shen, L., Xu, X., Yao, Y., Mu, P., Zhang, H., Wan, J., Wang, Y., Guan, R., Li, X., Fu, G., Zhang, L., Wang, Y., Xia, F., Hu, C., Clevers, H., Zhang, Z. & Hua, G., 01 Feb 2023, In: International Journal of Cancer. 152, 3, p. 524-535 12 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids 100%
  • Irinotecan 89%
  • Chemoradiotherapy 81%
  • Rectal Neoplasms 78%
  • Area Under Curve 24%
  17 Citations (Scopus)

• PGE2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate

  Sporrij, A., Choudhuri, A., Prasad, M., Muhire, B., Fast, E. M., Manning, M. E., Weiss, J. D., Koh, M., Yang, S., Kingston, R. E., Tolstorukov, M. Y., Clevers, H. & Zon, L. I., 09 May 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 19, p. e2220613120

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Nucleosomes 100%
  • Hematopoietic Stem Cells 84%
  • Dinoprostone 82%
  • Chromatin 75%
  • Histones 39%
  1 Citation (Scopus)