Hans Clevers

2021

The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19

Geurts, M. H., van der Vaart, J., Beumer, J. & Clevers, H., 09 Mar 2021, In: Stem Cell Reports. 16, 3, p. 412-418 7 p.

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

Open Access

16 Citations (Scopus)

Tissue regeneration: Reserve or reverse?

Shivdasani, R. A., Clevers, H. & de Sauvage, F. J., 19 Feb 2021, In: Science. 371, 6531, p. 784-786 3 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

39 Citations (Scopus)

Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription

Sun, L., Zhao, X., Liu, X., Zhong, B., Tang, H., Jin, W., Clevers, H., Wang, H., Wang, X. & Dong, C., 01 Jun 2021, In: Cell Reports. 35, 9, p. 109188

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

7 Citations (Scopus)

Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification

Kretzschmar, K., Boonekamp, K. E., Bleijs, M., Asra, P., Koomen, M., Chuva de Sousa Lopes, S. M., Giovannone, B. & Clevers, H., 14 Sept 2021, In: Stem Cell Reports. 16, 9, p. 2379-2394 16 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

3 Citations (Scopus)

2020

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

Cho, Y-H., Ro, E. J., Yoon, J-S., Mizutani, T., Kang, D-W., Park, J-C., Il Kim, T., Clevers, H. & Choi, K-Y., 21 Oct 2020, In: Nature Communications. 11, 1, p. 5321

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

207 Citations (Scopus)

A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing

Saltsman, J. A., Hammond, W. J., Narayan, N. J. C., Requena, D., Gehart, H., Lalazar, G., LaQuaglia, M. P., Clevers, H. & Simon, S., 18 Sept 2020, In: Cancers. 12, 9

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

38 Citations (Scopus)

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Calandrini, C., Schutgens, F., Oka, R., Margaritis, T., Candelli, T., Mathijsen, L., Ammerlaan, C., van Ineveld, R. L., Derakhshan, S., de Haan, S., Dolman, E., Lijnzaad, P., Custers, L., Begthel, H., Kerstens, H. H. D., Visser, L. L., Rookmaaker, M., Verhaar, M., Tytgat, G. A. M., Kemmeren, P., & 11 othersde Krijger, R. R., Al-Saadi, R., Pritchard-Jones, K., Kool, M., Rios, A. C., van den Heuvel-Eibrink, M. M., Molenaar, J. J., van Boxtel, R., Holstege, F. C. P., Clevers, H. & Drost, J., 11 Mar 2020, In: Nature Communications. 11, 1, p. 1310

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

186 Citations (Scopus)

An Organoid-derived Bronchioalveolar Model for SARS-CoV-2 Infection of Human Alveolar-type II-like Cells

Lamers, M. M., van der Vaart, J., Knoops, K., Riesebosch, S., Breugem, T. I., Mykytyn, A. Z., Beumer, J., Schipper, D., Bezstarosti, K., Koopman, C. D., Groen, N., Ravelli, R. B. G., Duimel, H. Q., Demmers, J. A. A., Verjans, G. M. G. M., Koopmans, M. P. G., Muraro, M. J., Peters, P. J., Clevers, H. & Haagmans, B. L., 06 Dec 2020, (E-pub ahead of print) In: EMBO Journal. p. e105912

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

146 Citations (Scopus)

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells

Murata, K., Jadhav, U., Madha, S., van Es, J., Dean, J., Cavazza, A., Wucherpfennig, K., Michor, F., Clevers, H. & Shivdasani, R. A., 05 Mar 2020, In: Cell Stem Cell. 26, 3, p. 377-390.e6

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

140 Citations (Scopus)

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

Lõhmussaar, K., Kopper, O., Korving, J., Begthel, H., Vreuls, C. P. H., van Es, J. H. & Clevers, H., 27 May 2020, In: Nature Communications. 11, 1, p. 2660

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

77 Citations (Scopus)

Cell fate specification and differentiation in the adult mammalian intestine

Beumer, J. & Clevers, H., 21 Sept 2020, (E-pub ahead of print) In: Nature reviews. Molecular cell biology.

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

311 Citations (Scopus)

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Dijkstra, K. K., Monkhorst, K., Schipper, L. J., Hartemink, K. J., Smit, E. F., Kaing, S., de Groot, R., Wolkers, M. C., Clevers, H., Cuppen, E. & Voest, E. E., 05 May 2020, In: Cell Reports. 31, 5, p. 107588

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

143 Citations (Scopus)

Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids

Wiechmann, S., Maisonneuve, P., Grebbin, B. M., Hoffmeister, M., Kaulich, M., Clevers, H., Rajalingam, K., Kurinov, I., Farin, H. F., Sicheri, F. & Ernst, A., 03 Apr 2020, In: The Journal of biological chemistry. 295, 14, p. 4526-4540 15 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

12 Citations (Scopus)

COVID-19: organoids go viral

Clevers, H., 01 Jul 2020, In: Nature Reviews Molecular Cell Biology. 21, 7, p. 355-356 2 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

55 Citations (Scopus)

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Geurts, M. H., de Poel, E., Amatngalim, G. D., Oka, R., Meijers, F. M., Kruisselbrink, E., van Mourik, P., Berkers, G., de Winter-de Groot, K. M., Michel, S., Muilwijk, D., Aalbers, B. L., Mullenders, J., Boj, S. F., Suen, S. W. F., Brunsveld, J. E., Janssens, H. M., Mall, M. A., Graeber, S. Y., van Boxtel, R., & 3 othersvan der Ent, C. K., Beekman, J. M. & Clevers, H., 02 Apr 2020, In: Cell Stem Cell. 26, 4, p. 503-510.e7

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

141 Citations (Scopus)

CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

Hendriks, D., Clevers, H. & Artegiani, B., 05 Nov 2020, In: Cell Stem Cell. 27, 5, p. 705-731 27 p.

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

116 Citations (Scopus)

Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss

Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, B-K., Dollé, P., Bloch-Zupan, A. & Niederreither, K., 09 Sept 2020, In: Scientific Reports. 10, 1, p. 14817

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

16 Citations (Scopus)

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer

Whittle, J. R., Vaillant, F., Surgenor, E., Policheni, A. N., Giner, G., Capaldo, B. D., Chen, H-R., Liu, H. K., Dekkers, J. F., Sachs, N., Clevers, H., Fellowes, A., Green, T., Xu, H., Fox, S. B., Herold, M. J., Smyth, G. K., Gray, D. H. D., Visvader, J. E. & Lindeman, G. J., 01 Aug 2020, In: Clinical Cancer Research. 26, 15, p. 4120-4134 15 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

64 Citations (Scopus)

Enteroendocrine Dynamics - New Tools Reveal Hormonal Plasticity in the Gut

Beumer, J., Gehart, H. & Clevers, H., 01 Oct 2020, In: Endocrine connections. 41, 5

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

29 Citations (Scopus)

Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation

Wei, G., Gao, N., Chen, J., Fan, L., Zeng, Z., Gao, G., Li, L., Fang, G., Hu, K., Pang, X., Fan, H-Y., Clevers, H., Liu, M., Zhang, X. & Li, D., 02 Sept 2020, In: Development (Cambridge). 147, 17

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

22 Citations (Scopus)

Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells

Pleguezuelos-Manzano, C., Puschhof, J., van den Brink, S., Geurts, V., Beumer, J. & Clevers, H., Sept 2020, In: Current protocols in immunology. 130, 1, p. e106

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

106 Citations (Scopus)

Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver

Hendriks, D., Artegiani, B., Hu, H., Chuva de Sousa Lopes, S. & Clevers, H., 27 Nov 2020, (E-pub ahead of print) In: Nature Protocols.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

90 Citations (Scopus)

Establishment of patient-derived cancer organoids for drug-screening applications

Driehuis, E., Kretzschmar, K. & Clevers, H., Oct 2020, In: Nature Protocols. 15, 10, p. 3380-3409 30 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

342 Citations (Scopus)

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing

Artegiani, B., Hendriks, D., Beumer, J., Kok, R., Zheng, X., Joore, I., Chuva de Sousa Lopes, S., van Zon, J., Tans, S. & Clevers, H., Mar 2020, In: Nature Cell Biology. 22, 3, p. 321-331 11 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

168 Citations (Scopus)

Fasting-mimicking diet and hormone therapy induce breast cancer regression

Caffa, I., Spagnolo, V., Vernieri, C., Valdemarin, F., Becherini, P., Wei, M., Brandhorst, S., Zucal, C., Driehuis, E., Ferrando, L., Piacente, F., Tagliafico, A., Cilli, M., Mastracci, L., Vellone, V. G., Piazza, S., Cremonini, A. L., Gradaschi, R., Mantero, C., Passalacqua, M., & 14 othersBallestrero, A., Zoppoli, G., Cea, M., Arrighi, A., Odetti, P., Monacelli, F., Salvadori, G., Cortellino, S., Clevers, H., De Braud, F., Sukkar, S. G., Provenzani, A., Longo, V. D. & Nencioni, A., Jul 2020, In: Nature. 583, 7817, p. 620-624 5 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

219 Citations (Scopus)

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

Ringel, T., Frey, N., Ringnalda, F., Janjuha, S., Cherkaoui, S., Butz, S., Srivatsa, S., Pirkl, M., Russo, G., Villiger, L., Rogler, G., Clevers, H., Beerenwinkel, N., Zamboni, N., Baubec, T. & Schwank, G., 05 Mar 2020, In: Cell Stem Cell. 26, 3, p. 431-440.e8

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

109 Citations (Scopus)

Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance

Joosten, S. P. J., Spaargaren, M., Clevers, H. & Pals, S. T., Dec 2020, In: Biochimica et biophysica acta. Reviews on cancer. 1874, 2, p. 188437

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

Open Access

27 Citations (Scopus)

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

Beumer, J., Puschhof, J., Bauzá-Martinez, J., Martínez-Silgado, A., Elmentaite, R., James, K. R., Ross, A., Hendriks, D., Artegiani, B., Busslinger, G. A., Ponsioen, B., Andersson-Rolf, A., Saftien, A., Boot, C., Kretzschmar, K., Geurts, M. H., Bar-Ephraim, Y. E., Pleguezuelos-Manzano, C., Post, Y., Begthel, H., & 12 othersvan der Linden, F., Lopez-Iglesias, C., van de Wetering, W. J., van der Linden, R., Peters, P. J., Heck, A. J. R., Goedhart, J., Snippert, H., Zilbauer, M., Teichmann, S. A., Wu, W. & Clevers, H., 11 Jun 2020, In: Cell. 181, 6, p. 1291-1306.e19

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

97 Citations (Scopus)

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Nikolaev, M., Mitrofanova, O., Broguiere, N., Geraldo, S., Dutta, D., Tabata, Y., Elci, B., Brandenberg, N., Kolotuev, I., Gjorevski, N., Clevers, H. & Lutolf, M. P., Sept 2020, In: Nature. 585, 7826, p. 574-578 5 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

431 Citations (Scopus)

How the COVID-19 pandemic highlights the necessity of animal research

Genzel, L., Adan, R., Berns, A., van den Beucken, J., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., Dam, A-M. V., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., Fentener van Vlissingen, J. M., & 62 othersla Fleur, S., Fouchier, R., Fitzsimons, C. P., Frieling, W., Haagmans, B., Heesters, B. A., Henckens, M., Herfst, S., Hol, E., van den Hove, D., de Jonge, M. I., Jonkers, J., Joosten, L. A. B., Kalsbeek, A., Kamermans, M., Kampinga, H. H., Kas, M. J., Keijer, J., Kersten, S., Kiliaan, A. J., Kooij, T. W. A., Kooijman, S., Koopman, W. J. H., Korosi, A., Krugers, H. J., Kuiken, T., Kushner, S. A., Langermans, J. A. M., Lesscher, H., Lucassen, P. J., Lutgens, E., Netea, M. G., Noldus, L. P. J. J., van der Meer, J. W. M., Meye, F. J., Mul, J. D., van Oers, K., Olivier, J. D. A., Pasterkamp, R. J., Philippens, I. H. C. H. M., Prickaerts, J., Pullox, B., Rensen, P. C. N., van Rheenen, J., van Rij, R. P., Ritsma, L., Rockx, B. H. G., Roozendaal, B., van Schothorst, E. M., Stittelaar, K., Stockhofe, N., Swaab, D. F., de Swart, R. L., Vanderschuren, L. J. M. J., de Vries, T., de Vrij, F., van Wezel, R., Wierenga, C. J., Wiesmann, M., Willuhn, I., de Zeeuw, C. I. & Homberg, J. R., 10 Aug 2020, In: Current Biology. 30, 18, p. R1014-R1018 5 p.

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Open Access

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27 Citations (Scopus)

174 Downloads (Pure)

Human-Derived Model Systems in Gynecological Cancer Research

Lõhmussaar, K., Boretto, M. & Clevers, H., Dec 2020, In: Trends in Cancer. 6, 12, p. 1031-1043 13 p.

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

Open Access

30 Citations (Scopus)

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen, M. M. A., Roos, F. J. M., Burka, K., Gehart, H., Jager, M., de Wolf, M., Bijvelds, M. J. C., de Jonge, H. R., Ardisasmita, A. I., van Huizen, N. A., Roest, H. P., de Jonge, J., Koch, M., Pampaloni, F., Fuchs, S. A., Schene, I. F., Luider, T. M., van der Doef, H. P. J., Bodewes, F. A. J. A., de Kleine, R. H. J., & 6 othersSpee, B., Kremers, G-J., Clevers, H., IJzermans, J. N. M., Cuppen, E. & van der Laan, L. J. W., 14 Dec 2020, In: Scientific Reports. 10, 1, p. 21900

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Open Access

49 Citations (Scopus)

Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions

Boonekamp, K. E., Dayton, T. L. & Clevers, H., 01 Aug 2020, In: Nature Reviews Molecular Cell Biology. 12, 8, p. 562-568 7 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

36 Citations (Scopus)

Intestinal Regeneration: Regulation by the Microenvironment

Hageman, J. H., Heinz, M. C., Kretzschmar, K., van der Vaart, J., Clevers, H. & Snippert, H. J. G., 24 Aug 2020, In: Developmental Cell. 54, 4, p. 435-446 12 p.

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

101 Citations (Scopus)

Kidney Organoids and Tubuloids

Yousef Yengej, F. A., Jansen, J., Rookmaaker, M. B., Verhaar, M. C. & Clevers, H., 26 May 2020, In: Cells. 9, 6

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

Open Access

55 Citations (Scopus)

LifeTime and improving European healthcare through cell-based interceptive medicine

Nov 2020, In: Nature. 587, 7834, p. 377-386 10 p.

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

Open Access

98 Citations (Scopus)

LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate

Gao, Y., Yan, Y., Tripathi, S., Pentinmikko, N., Amaral, A., Päivinen, P., Domènech-Moreno, E., Andersson, S., Wong, I. P. L., Clevers, H., Katajisto, P. & Mäkelä, T. P., Apr 2020, In: Gastroenterology. 158, 5, p. 1389-1401.e10

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

31 Citations (Scopus)

Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors

Wang, D., Wang, J., Bai, L., Pan, H., Feng, H., Clevers, H. & Zeng, Y. A., 19 Mar 2020, In: Cell. 180, 6, p. 1198-1211.e19

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

130 Citations (Scopus)

Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease

Kruitwagen, H. S., Oosterhoff, L. A., van Wolferen, M. E., Chen, C., Nantasanti Assawarachan, S., Schneeberger, K., Kummeling, A., van Straten, G., Akkerdaas, I. C., Vinke, C. R., van Steenbeek, F. G., van Bruggen, L. W. L., Wolfswinkel, J., Grinwis, G. C. M., Fuchs, S. A., Gehart, H., Geijsen, N., Vries, R. G., Clevers, H., Rothuizen, J., & 3 othersSchotanus, B. A., Penning, L. C. & Spee, B., 11 Feb 2020, In: Cells. 9, 2

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Open Access

36 Citations (Scopus)

Mathematical model of colorectal cancer initiation

Paterson, C., Clevers, H. & Bozic, I., 25 Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20681-20688 8 p.

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Open Access

39 Citations (Scopus)

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Pleguezuelos-Manzano, C., Puschhof, J., Rosendahl Huber, A., van Hoeck, A., Wood, H. M., Nomburg, J., Gurjao, C., Manders, F., Dalmasso, G., Stege, P. B., Paganelli, F. L., Geurts, M. H., Beumer, J., Mizutani, T., Miao, Y., van der Linden, R., van der Elst, S., Garcia, K. C., Top, J., Willems, R. J. L., & 7 othersGiannakis, M., Bonnet, R., Quirke, P., Meyerson, M., Cuppen, E., van Boxtel, R. & Clevers, H., Apr 2020, In: Nature. 580, 7802, p. 269-273 5 p.

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Open Access

619 Citations (Scopus)

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Miao, Y., Ha, A., de Lau, W., Yuki, K., Santos, A. J. M., You, C., Geurts, M. H., Puschhof, J., Pleguezuelos-Manzano, C., Peng, W. C., Senlice, R., Piani, C., Buikema, J. W., Gbenedio, O. M., Vallon, M., Yuan, J., de Haan, S., Hemrika, W., Rösch, K., Dang, L. T., & 13 othersBaker, D., Ott, M., Depeille, P., Wu, S. M., Drost, J., Nusse, R., Roose, J. P., Piehler, J., Boj, S. F., Janda, C. Y., Clevers, H., Kuo, C. J. & Garcia, K. C., 05 Nov 2020, In: Cell Stem Cell. 27, 5, p. 840-851.e6

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81 Citations (Scopus)

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Rosenbluth, J. M., Schackmann, R. C. J., Gray, G. K., Selfors, L. M., Li, C. M-C., Boedicker, M., Kuiken, H. J., Richardson, A., Brock, J., Garber, J., Dillon, D., Sachs, N., Clevers, H. & Brugge, J. S., 06 Apr 2020, In: Nature Communications. 11, 1, p. 1711

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Open Access

130 Citations (Scopus)

Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

Yan, H. H. N., Siu, H. C., Ho, S. L., Yue, S. S. K., Gao, Y., Tsui, W. Y., Chan, D., Chan, A. S., Wong, J. W. H., Man, A. H. Y., Lee, B. C. H., Chan, A. S. Y., Chan, A. K. W., Hui, H. S., Cheung, A. K. L., Law, W. L., Lo, O. S. H., Yuen, S. T., Clevers, H. & Leung, S. Y., Dec 2020, In: Gut. 69, 12, p. 2165-2179 15 p.

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59 Citations (Scopus)

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Yao, Y., Xu, X., Yang, L., Zhu, J., Wan, J., Shen, L., Xia, F., Fu, G., Deng, Y., Pan, M., Guo, Q., Gao, X., Li, Y., Rao, X., Zhou, Y., Liang, L., Wang, Y., Zhang, J., Zhang, H., Li, G., & 8 othersZhang, L., Peng, J., Cai, S., Hu, C., Gao, J., Clevers, H., Zhang, Z. & Hua, G., 02 Jan 2020, In: Cell Stem Cell. 26, 1, p. 17-26.e6

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430 Citations (Scopus)

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte, C. J., Espejo Valle-Inclan, J., Hami, N., Lõhmussaar, K., Kopper, O., Vreuls, C. P. H., Jonges, G. N., van Diest, P., Nguyen, L., Clevers, H., Kloosterman, W. P., Cuppen, E., Snippert, H. J. G., Zweemer, R. P., Witteveen, P. O. & Stelloo, E., 16 Jun 2020, In: Cell Reports. 31, 11, p. 107762

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Open Access

163 Citations (Scopus)

Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses

Raimondi, G., Mato-Berciano, A., Pascual-Sabater, S., Rovira-Rigau, M., Cuatrecasas, M., Fondevila, C., Sánchez-Cabús, S., Begthel, H., Boj, S. F., Clevers, H. & Fillat, C., Jun 2020, In: EBioMedicine. 56, p. 102786

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Open Access

40 Citations (Scopus)

Primary Intestinal Epithelial Organoid Culture

Mizutani, T. & Clevers, H., 2020, In: Methods in molecular biology (Clifton, N.J.). 2171, p. 185-200 16 p.

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23 Citations (Scopus)

SARS-CoV-2 productively infects human gut enterocytes

Lamers, M. M., Beumer, J., van der Vaart, J., Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Paul van Schayck, J., Mykytyn, A. Z., Duimel, H. Q., van Donselaar, E., Riesebosch, S., Kuijpers, H. J. H., Schipper, D., van de Wetering, W. J., de Graaf, M., Koopmans, M., Cuppen, E., Peters, P. J., Haagmans, B. L., & 1 othersClevers, H., 03 Jul 2020, In: Science. 369, 6499, p. 50-54 5 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Open Access

1216 Citations (Scopus)

Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies

Battich, N., Beumer, J., de Barbanson, B., Krenning, L., Baron, C. S., Tanenbaum, M. E., Clevers, H. & van Oudenaarden, A., 06 Mar 2020, In: Science. 367, 6482, p. 1151-1156 6 p.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

98 Citations (Scopus)

Hans Clevers

Research output

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