Research output per year
Research output per year
- 500 - 550 out of 772 results
Search results
-
2010
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue
Quyn, A. J., Appleton, P. L., Carey, F. A., Steele, R. J., Barker, N., Clevers, H., Ridgway, R. A., Sansom, O. J. & Nathke, I. S., 2010, In: Cell Stem Cell. 6, 2, p. 175-181Research output: Contribution to journal/periodical › Article › Scientific › peer-review
204 Citations (Scopus) -
Stem cells and cancer of the stomach and intestine
Vries, R. G. J., Huch, M. & Clevers, H., 2010, In: Molecular Oncology. 4, 5, p. 373-384Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access101 Citations (Scopus) -
Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice
Demarque, M. D., Nacerddine, K., Neyret-Kahn, H., Andrieux, A., Danenberg, E. M., Jouvion, G., Bomme, P., Hamard, G., Romagnolo, B., Terris, B., Cumano, A., Barker, N., Clevers, H. & Dejean, A., 2010, In: Gastroenterology. 140, 1, p. 286-296Research output: Contribution to journal/periodical › Article › Scientific › peer-review
51 Citations (Scopus) -
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions
Verzi, M. P., Hatzis, P., Sulahian, R., Philips, J., Schuijers, J., Shin, H. D., Freed, E., Lynch, J. P., Dang, D. T., Brown, M., Clevers, H., Liu, X. S. & Shivdasani, R. A., 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 34, p. 15157-15162Research output: Contribution to journal/periodical › Article › Scientific › peer-review
72 Citations (Scopus) -
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice
Bongers, G., Maussang, D., Muniz, L. R., Noriega, V. M., Fraile-Ramos, A., Barker, N., Marchesi, F., Thirunarayanan, N., Vischer, H. F., Qin, L., Mayer, L., Harpaz, N., Leurs, R., Furtado, G. C., Clevers, H., Tortorella, D., Smit, M. J. & Lira, S. A., 2010, In: Journal of Clinical Investigation. 120, 11, p. 3969-3978Research output: Contribution to journal/periodical › Article › Scientific › peer-review
95 Citations (Scopus) -
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis
Mahmoudi, T., Boj, S. F., Hatzis, P., Li, V. S., Taouatas, N., Vries, R. G. J., Teunissen, H., Begthel, H. L., Korving, J., Mohammed, S., Heck, A. & Clevers, H., 2010, In: PLoS Biology. 8, 11, p. 1000539Research output: Contribution to journal/periodical › Article › Scientific › peer-review
81 Citations (Scopus) -
The next step in tissue culture
Clevers, H., 2010, In: Utrecht Medical Sciences.Research output: Contribution to journal/periodical › Article › Scientific
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Tissue-resident adult stem cell populations of rapidly self-renewing organs
Barker, N., Bartfeld, S. & Clevers, H., 2010, In: Cell Stem Cell. 7, 6, p. 656-670Research output: Contribution to journal/periodical › Article › Scientific › peer-review
292 Citations (Scopus) -
Transplantatie van gekweekte darmpjes moet baby redden
Clevers, H., 2010, In: Trouw.Research output: Contribution to journal/periodical › Article › Popularizing
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Wnts as self-renewal factors: mammary stem cells and beyond
Verheyen, E. M. & Clevers, H., 2010, In: Cell Stem Cell. 6, 6, p. 494-495Research output: Contribution to journal/periodical › Article › Scientific › peer-review
1 Citation (Scopus) -
2009
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development
Fu, H., Cai, J., Clevers, H., Fast, E., Gray, S., Greenberg, R., Jain, M. K., Ma, Q., Qiu, M., Rowitch, D. H., Taylor, C. & Stiles, C. D., 2009, In: Journal of Neuroscience. 29, 36, p. 11399-11408Research output: Contribution to journal/periodical › Article › Scientific › peer-review
109 Citations (Scopus) -
Biochemicus Hans Clevers loopt voorop in de strijd tegen kanker
Clevers, H., 2009, In: Het Financieele Dagblad.Research output: Contribution to journal/periodical › Article › Professional
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Crypt stem cells as the cells-of-origin of intestinal cancer.
Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M. L., Begthel, H. L., van den Born, M. M. W., Danenberg, E. M., Clarke, A. R., Sansom, O. J. & Clevers, H., 2009, In: Nature. 457, 7229, p. 608-611Research output: Contribution to journal/periodical › Article › Scientific › peer-review
1759 Citations (Scopus) -
"De keuze van Hans Clevers"
Clevers, H., 2009, In: Academische Boekengids.Research output: Contribution to journal/periodical › Article › Popularizing
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De man die een darm kweekte
Clevers, H., 2009, In: De Volkskrant.Research output: Contribution to journal/periodical › Article › Popularizing
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Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines
Hollestelle, A., Nagel, J. H., Smid, M., Lam, S., Elstrodt, F., Wasielewski, M., Ng, S. S., French, P. J., Peeters, J. K., Rozendaal, M. J., Riaz, M., Koopman, D. G., Ten Hagen, T. L., De Leeuw, B. H., Zwarthoff, E. C., Teunisse, A., Van der Spek, P. J., Klijn, J. G., Dinjens, W. N., Ethier, S. P., & 6 others, 2009, In: Breast Cancer Research and Treatment.Research output: Contribution to journal/periodical › Article › Scientific › peer-review
232 Citations (Scopus) -
Eyeing up new Wnt pathway players.
Clevers, H., 2009, In: Cell. 139, 2, p. 227-229Research output: Contribution to journal/periodical › Article › Scientific › peer-review
23 Citations (Scopus) -
Fishing for Intestinal Cancer Models: Unraveling Gastrointestinal Homeostasis and Tumorigenesis in Zebrafish
Faro, A., Boj, S. F. & Clevers, H., 2009, In: Zebrafish.Research output: Contribution to journal/periodical › Article › Scientific › peer-review
21 Citations (Scopus) -
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction
Ye, F., Chen, Y., Hoang, T., Montgomery, R. L., Zhao, X. H., Bu, H., Hu, T., Taketo, M. M., van Es, J. H., Clevers, H., Hsieh, J., Bassel-Duby, R., Olson, E. N. & Lu, Q. R., 2009, In: Nature Neuroscience. 12, 7, p. 829-838Research output: Contribution to journal/periodical › Article › Scientific › peer-review
488 Citations (Scopus) -
Identification of primary MAFB target genes in multiple myeloma
Stralen, E., van de Wetering, M. L., Agnelli, L., Neri, A., Clevers, H. & Bast, B., 2009, In: Experimental Hematology. 37, 1, p. 78-86Research output: Contribution to journal/periodical › Article › Scientific › peer-review
45 Citations (Scopus) -
Inflammatory bowel disease, stress, and the endoplasmic reticulum.
Clevers, H., 2009, In: New England Journal of Medicine. 360, 7, p. 726-727Research output: Contribution to journal/periodical › Article › Scientific › peer-review
16 Citations (Scopus) -
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.
Jansen, M., ten Klooster, J. P., Offerhaus, G. J. A. & Clevers, H., 2009, In: Physiological Reviews. 89, 3, p. 777-798Research output: Contribution to journal/periodical › Article › Scientific › peer-review
192 Citations (Scopus) -
MafB oncoprotein detected by immunohistochemistry as a highly sensitive and specific marker for the prognostic unfavorable t(14;20) (q32;q12) in multiple myeloma patients
Stralen, E., Leguit, R. J., Begthel, H. L., Michaux, L., Buijs, A., Lemmens, H., Scheiff, J. M., Doyen, C., Pierre, P., Forget, F., Clevers, H. & Bast, B., 2009, In: Leukemia. 23, 4, p. 801-803Research output: Contribution to journal/periodical › Article › Scientific › peer-review
12 Citations (Scopus) -
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
ten Klooster, J. P., Jansen, M., Yuan, J., Oorschot, V., Begthel, H. L., di Giacomo, V., Colland, F., de Koning, J., Maurice, M. M., Hornbeck, P. & Clevers, H., 2009, In: Developmental Cell. 16, 4, p. 551-562Research output: Contribution to journal/periodical › Article › Scientific › peer-review
132 Citations (Scopus) -
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.
van der Flier, L. G., Haegebarth, A., Stange, D. E., van de Wetering, M. L. & Clevers, H., 2009, In: Gastroenterology. 137, 1, p. 15-17Research output: Contribution to journal/periodical › Article › Scientific › peer-review
417 Citations (Scopus) -
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
Begus-Nahrmann, Y., Lechel, A., Obenauf, A. C., Nalapareddy, K., Peit, E., Hoffmann, E., Schlaudraff, F., Liss, B., Schirmacher, P., Kestler, H., Danenberg, E. M., Barker, N., Clevers, H., Speicher, M. R. & Rudolph, K. L., 2009, In: Nature Genetics. 41, 10, p. 1138-1143Research output: Contribution to journal/periodical › Article › Scientific › peer-review
91 Citations (Scopus) -
Phosphatidylinositol 3-kinase (PI3K) signaling does not activate the Wnt cascade
Ng, S. S., Mahmoudi, T., Danenberg, E. M., Bejaoui, I., de Lau, W. B. M., Korswagen, H. C., Schutte, M. & Clevers, H., 2009, In: Journal of Biological Chemistry. 284, 51, p. 35308-35313Research output: Contribution to journal/periodical › Article › Scientific › peer-review
123 Citations (Scopus) -
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.
Snippert, H. J. G., van Es, J. H., van den Born, M. M. W., Begthel, H. L., Stange, D. E., Barker, N. & Clevers, H., 2009, In: Gastroenterology. 136, 7, p. 2181-2187Research output: Contribution to journal/periodical › Article › Scientific › peer-review
191 Citations (Scopus) -
Searching for adult stem cells in the intestine
Clevers, H., 2009, In: EMBO Molecular Medicine. 1, 5, p. 255-259Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access21 Citations (Scopus) -
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Sato, T., Vries, R. G. J., Snippert, H. J. G., van de Wetering, M. L., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J. & Clevers, H., 2009, In: Nature. 459, 7244, p. 262-265Research output: Contribution to journal/periodical › Article › Scientific › peer-review
5109 Citations (Scopus) -
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
Chen, G., Korfhagen, T. R., Xu, Y., Kitzmiller, J., Wert, S. E., Maeda, Y., Gregorieff, A., Clevers, H. & Whitsett, J. A., 2009, In: Journal of Clinical Investigation. 119, 10, p. 2914-2924Research output: Contribution to journal/periodical › Article › Scientific › peer-review
325 Citations (Scopus) -
Stem cells, self-renewal, and differentiation in the intestinal epithelium.
van der Flier, L. G. & Clevers, H., 2009, In: Annual Review of Physiology. 71, p. 241-260Research output: Contribution to journal/periodical › Article › Scientific › peer-review
1393 Citations (Scopus) -
T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis.
Faro, A., Boj, S. F., Ambrosio, R., van den Broek, O., Korving, J. & Clevers, H., 2009, In: Zebrafish. 6, 1, p. 59-68Research output: Contribution to journal/periodical › Article › Scientific › peer-review
18 Citations (Scopus) -
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.
Gregorieff, A., Stange, D. E., Kujala, P., Begthel, H. L., van den Born, M. M. W., Korving, J., Peters, P. J. & Clevers, H., 2009, In: Gastroenterology. 137, 4, p. 1333-1333Research output: Contribution to journal/periodical › Article › Scientific › peer-review
189 Citations (Scopus) -
The kinase TNIK is an essential activator of Wnt target genes.
Mahmoudi, T., Li, V. S., Ng, S. S., Taouatas, N., Vries, R. G. J., Mohammed, S., Heck, A. J. R. & Clevers, H., 2009, In: EMBO Journal. 28, 21, p. 3329-3340Research output: Contribution to journal/periodical › Article › Scientific › peer-review
163 Citations (Scopus) -
The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors)
Lips, D. J., Barker, N., Clevers, H. & Hennipman, A., 2009, In: European Journal of Surgical Oncology. 35, 1, p. 3-10Research output: Contribution to journal/periodical › Article › Scientific › peer-review
115 Citations (Scopus) -
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer
Medina, P. P., Castillo, S. D., Blanco, S., Sanz-Garcia, M., Largo, C., Alvarez, S., Yokota, J., Gonzalez-Neira, A., Benitez, J., Clevers, H., Cigudosa, J. C., Lazo, P. A. & Sanchez-Cespedes, M., 2009, In: Human Molecular Genetics. 18, 7, p. 1343-1352Research output: Contribution to journal/periodical › Article › Scientific › peer-review
101 Citations (Scopus) -
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
van der Flier, L. G., van Gijn, M. E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D. E., Begthel, H. L., van den Born, M. M. W., Guryev, V., Oving, I. M., van Es, J. H., Barker, N., Peters, P. J., van de Wetering, M. L. & Clevers, H., 2009, In: Cell. 136, 5, p. 903-912Research output: Contribution to journal/periodical › Article › Scientific › peer-review
589 Citations (Scopus) -
Wnt signaling, lgr5, and stem cells in the intestine and skin.
Haegebarth, A. & Clevers, H., 2009, In: American Journal of Pathology. 174, 3, p. 715-721Research output: Contribution to journal/periodical › Article › Scientific › peer-review
287 Citations (Scopus) -
2008
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.
Goessling, W., North, T. E., Lord, A. M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A. P., Puder, M., Clevers, H., Moon, R. T. & Zon, L. I., 2008, In: Developmental Biology. 320, 1, p. 161-174Research output: Contribution to journal/periodical › Article › Scientific › peer-review
165 Citations (Scopus) -
A transgenic mouse model for "lipid hang-up", or why pathologists need to be involved in genetically engineered mouse modelling
Offerhaus, G. J. A., Milne, A. N. A., Oving, I. M., van Gijn, M. E., Hruban, R. H. & Clevers, H., 2008, In: Gut. 57, p. 1739-1740 1739 p.Research output: Contribution to journal/periodical › Article › Scientific › peer-review
1 Citation (Scopus) -
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.
Hatzis, P., van der Flier, L. G., van Driel, M. A., Guryev, V., Nielsen, F., Denissov, S., Nijman, I. J., Koster, J., Santo, E. E., Welboren, W., Versteeg, R., van de Wetering, M. L., Clevers, H. & Stunnenberg, H. G., 2008, In: Molecular and Cellular Biology. 28, 8, p. 2732-2744Research output: Contribution to journal/periodical › Article › Scientific › peer-review
199 Citations (Scopus) -
Investigation of Frizzled-5 during embryonic neural development in mouse.
Burns, C. J., Zhang, J., Brown, E. C., van Bibber, A. M., van Es, J. H., Clevers, H., Ishikawa, T. O., Taketo, M. M., Vetter, M. L. & Fuhrmann, S., 2008, In: Developmental Dynamics. 237, 6, p. 1614-1626Research output: Contribution to journal/periodical › Article › Scientific › peer-review
49 Citations (Scopus) -
Lgr5 marks cycling, yet long-lived, hair follicle stem cells.
Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J. G., Clevers, H. & Toftgard, R., 2008, In: Nature Genetics. 40, 11, p. 1291-1299Research output: Contribution to journal/periodical › Article › Scientific › peer-review
794 Citations (Scopus) -
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
Riccio, O., van Gijn, M. E., Bezdek, A. C., Pellegrinet, L., van Es, J. H., Zimber-Strobl, U., Strobl, L. J., Honjo, T., Clevers, H. & Radtke, F., 2008, In: EMBO Reports. 9, 4, p. 377-383Research output: Contribution to journal/periodical › Article › Scientific › peer-review
331 Citations (Scopus) -
The intestinal stem cell.
Barker, N., van de Wetering, M. L. & Clevers, H., 2008, In: Genes & Development. 22, 14, p. 1856-1864Research output: Contribution to journal/periodical › Article › Scientific › peer-review
519 Citations (Scopus) -
2007
APCmin tumors need a SPARC
Gregorrieff, A. & Clevers, J. C., 2007, In: Gut. 56Research output: Contribution to journal/periodical › Article › Scientific › peer-review
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c-Myb is required for progenitor cell homeostasis in colonic crypts
Malaterre, J., Carpinelli, M., Ernst, M., Alexander, W., Cooke, M., Sutton, S., Dworkin, S., Heakth, J. K., Frampton, J., McArthur, G., Clevers, J. C., Hilton, D., Mantamadiotis, T. & Ramsay, R. G., 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, p. 3829-3834Research output: Contribution to journal/periodical › Article › Scientific › peer-review
92 Citations (Scopus) -
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., Van Es, J. H., Kuipers, J., Kujala, P., Van Den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J. & Clevers, H., 25 Oct 2007, In: Nature. 449, 7165, p. 1003-1007 5 p.Research output: Contribution to journal/periodical › Article › Scientific › peer-review
4421 Citations (Scopus) -
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.
Vooijs, M., Ong, C. T., Hadland, B., Huppert, S., Liu, Z., Korving, J., Born, M. V. D., Stappenbeck, T., Wu, Y., Clevers, J. C. & Kopan, R., 2007, In: Development. 134, p. 535-544Research output: Contribution to journal/periodical › Article › Scientific › peer-review
123 Citations (Scopus)