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2020

Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation

Korotkov, A., Puhakka, N., Gupta, S. D., Vuokila, N., Broekaart, D. W. M., Anink, J. J., Heiskanen, M., Karttunen, J., van Scheppingen, J., Huitinga, I., Mills, J. D., van Vliet, E. A., Pitkänen, A. & Aronica, E., 2020, In : Brain Pathology.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Lesion stage-dependent causes for impaired remyelination in MS

Heß, K., Starost, L., Kieran, N. W., Thomas, C., Vincenten, M. C. J., Antel, J., Martino, G., Huitinga, I., Healy, L. & Kuhlmann, T., 2020, In : Acta Neuropathologica.

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Levels of Retinal Amyloid-β Correlate with Levels of Retinal IAPP and Hippocampal Amyloid-β in Neuropathologically Evaluated Individuals

Schultz, N., Byman, E. & Wennström, M., 2020, In : Journal of Alzheimer's Disease. 73, p. 1201-1209

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Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series

Geut, H., Hepp, D. H., Foncke, E., Berendse, H. W., Rozemuller, J. M., Huitinga, I. & van de Berg, W. D. J., Jan 2020, In : Acta neuropathologica communications. 8, 1, p. 39

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Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis

Smolders, J., Fransen, N. L., Hsiao, C-C., Hamann, J. & Huitinga, I., 2020, In : Expert Review of Neurotherapeutics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Post-mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms

Fransen, N., Crusius, J. B. A., Smolders, J., Mizee, M. R., van Eden, C. G., Luchetti, S., Remmerswaal, E. B. M., Hamann, J., Mason, M. R. J. & Huitinga, I., 02 Jan 2020, In : Brain Pathology. 30, p. 106-119

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Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide

Zhang, L., Verwer, R. W. H., Lucassen, P. J., Huitinga, I. & Swaab, D. F., 2020, In : Journal of Psychiatric Research. 121, p. 31-38 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease

Chen, W-T., Lu, A., Craessaerts, K., Pavie, B., Sala Frigerio, C., Corthout, N., Qian, X., Laláková, J., Kühnemund, M., Voytyuk, I., Wolfs, L., Mancuso, R., Salta, E., Balusu, S., Snellinx, A., Munck, S., Jurek, A., Fernandez Navarro, J., Saido, T. C., Huitinga, I. & 3 others, Lundeberg, J., Fiers, M. & De Strooper, B., 2020, In : Cell.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

Fransen, N. L., Hsiao, C-C., van der Poel, M., Engelenburg, H. J., Verdaasdonk, K., Vincenten, M. C. J., Remmerswaal, E. B. M., Kuhlmann, T., Mason, M. R. J., Hamann, J., Smolders, J. & Huitinga, I., 13 May 2020, In : Brain. 143, p. 1714-1730

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2019

A Potential Role for α-Amylase in Amyloid-β-Induced Astrocytic Glycogenolysis and Activation

Byman, E., Schultz, N., Blom, A. M. & Wennström, M., Jan 2019, In : Journal of Alzheimer's Disease. 68, p. 205-217

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Chromatin conformation links putative enhancers in intracranial aneurysm-associated regions to potential candidate genes.

Laarman, M., Geeven, G., Barnett, P., Rinkel, G. J. E., de Laat, W., Ruigrok, Y. M. & Bakkers, J., 2019, In : Journal of the American Heart Association. 8, e011201.

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Hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates Alzheimer's disease pathways and genes

van Rooij, J. G. J., Meeter, L. H. H., Melhem, S., Nijholt, D. A. T., Wong, T. H., Rozemuller, A., Uitterlinden, A. G., van Meurs, J. G. & van Swieten, J. C., 2019, In : Neurobiology of Aging. 74, p. 225-233 9 p.

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Legal and Ethical Issues in Brain Banking

Huitinga, I., de Goeij, M. & Klioueva, N., 2019, In : Neuroscience Bulletin. 35, p. 267-269

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Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes.

van der Poel, M., Ulas, T., Mizee, M. R., Hsiao, C. C., Miedema, S. S. M., Adelia, Schuurman, K., Helder, B., Tas, S. W., Schultze, J. L., Hamann, J. & Huitinga, I., 13 Mar 2019, In : Nature Communications. 10, 1139.

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Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

Melief, J., Orre, M., Bossers, K., van Eden, C. G., Schuurman, K. G., Mason, M. R. J., Verhaagen, J., Hamann, J. & Huitinga, I., 25 Apr 2019, In : Acta neuropathologica communications. 7, 1, 60.

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2018

Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro

Schultz, N., Brännström, K., Byman, E., Moussaud, S., Nielsen, H. M., Olofsson, A. & Wennström, M., 2018, In : Aging Cell. 17, e12728.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Brain alpha-amylase - a novel energy regulator important in Alzheimer disease?

Byman, E., Schultz, N., Fex, M. & Wennström, M., 2018, In : Brain Pathology. 28, p. 920-932

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Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis

Laarman, M. D., Vermunt, M. W. & Ruigrok, Y. M., Feb 2018, In : Stroke. 49, 2, p. 447-453 7 p.

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Levels of retinal IAPP are altered in Alzheimer's disease patients and correlate with vascular changes and hippocampal IAPP levels

Schultz, N., Byman, E. & Wennström, M., May 2018, In : Neurobiology of Aging. 69, p. 94-101 8 p.

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Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coil

Hoogland, I. C. M., Westhoff, D., Engelen-Lee, J-Y., Melief, J., Seron, M. V., Houben-Weerts, J. H. M. P., Huitinga, I., van Westerloo, D. J., van der Poll, T., van Gool, W. A. & van de Beek, D., Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 110.

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Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease

Dekker, A. D., Vermeiren, Y., Carmona-Iragui, M., Benejam, B., Videla, L., Gelpi, E., Aerts, T., Van Dam, D., Fernández, S., Lleó, A., Videla, S., Sieben, A., Martin, J-J., Blesa, R., Fortea, J. & De Deyn, P. P., May 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 99-111 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Progressive Multiple Sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis.

Luchetti, S., Fransen, N. L., van Eden, C. G., Ramaglia, V., Mason, M. & Huitinga, I., 2018, In : Acta Neuropathologica. 135, p. 511-528

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Stress-Axis Regulation by Vitamin D-3 in Multiple Sclerosis

Rolf, L., Damoiseaux, J., Huitinga, I., Kimenai, D., van den Ouweland, J., Hupperts, R. & Smolders, J., Apr 2018, In : Frontiers in Neurology. 9, 263.

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Three VCP mutations in patients with frontotemporal dementia.

Wong, T. H., Pottier, C., Hondius, D., Meeter, L. H. H., van Rooij, J. G. J., Melhem, S., van Minkelen, R., Van Duijn, C. M., J M Rozemuller, A., Seelaar, H., Rademakers, R. & Van Swieten, J. C., 2018, In : Journal of Alzheimer's Disease. 65, p. 1139-1146

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue-resident memory T cells populate the human brain.

Smolders, J., Heutinck, K. M., Fransen, N. L., Remmerswaal, E. B. M., Hombrink, P., Ten Berge, I. J. M., Van Lier, R. A. W., Huitinga, I. & Hamann, J., 02 Nov 2018, In : Nature Communications. 9, 4593.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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2017

Banking brain tissue for research

Klioueva, N., Bovenberg, J. & Huitinga, I., 2017, In : Handbook of Clinical Neurology. 145, p. 9-12 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Gene Expression Profilling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

Hendrickx, D. A. E., van Scheppingen, J., van der Poel, M., Bossers, K., Schuurman, K. G., van Eden, C. G., Hol, E. M., Hamann, J. & Huitinga, I., 21 Dec 2017, In : Frontiers in Immunology. 8, 1810.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

Mizee, M. R., Miedema, S. S. M., van der Poel, M., Adelia, Schuurman, K. G., van Strien, M. E., Melief, J., Smolders, J., Hendrickx, D. A., Heutinck, K. M., Hamann, J. & Huitinga, I., 07 Feb 2017, In : Acta neuropathologica communications. 5, 1, p. 16

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Staining of HLA-DR, lba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology.

Hendrickx, D. A., van Eden, C. G., Schuurman, K. G., Hamann, J. & Huitinga, I., 02 May 2017, In : Journal of Neuroimmunology. 309, p. 12-22

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2016

Characterizing primary human microglia: A comparative study with myeloid subsets and culture models

Melief, J., Sneeboer, M. A. M., Litjens, M., Ormel, P. R., Palmen, S. J. M. C., Huitinga, I., Kahn, R. S., Hol, E. M. & de Witte, L. D., 2016, In : GLIA. 64, p. 1857-1868

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Glucocorticoid receptor haplotypes conferring increased sensitivity (Bcll and N363S) are associated with faster progression of multiple sclerosis.

Melief, J., Koper, J. W., Endert, E., Moller, H., Hamann, J., Uitdehaag, B. M. & Huitinga, I., 01 Oct 2016, In : Journal of Neuroimmunology. 299, p. 84-89

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Network of nuclear receptor ligands in multiple sclerosis: Common pathways and interactions of sex-steroids, corticosteroids and vitamin D3-derived molecules

Rolf, L., Damoiseaux, J., Hupperts, R., Huitinga, I. & Smolders, J., 06 Jul 2016, In : Autoimmunity Reviews. 15, p. 900-910

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2015

BrainNet Europe's Code of Conduct for brain banking

Klioueva, N. M., Rademaker, M. C., Dexter, D. T., Al-Sarraj, S., Seilhean, D., Streichenberger, N., Schmitz, P., Bell, J. E., Ironside, J. W., Arzberger, T. & Huitinga, I., Jul 2015, In : Journal of Neural Transmission. 122, 7, p. 937-40 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Brain region-specific gene expression profiles in freshly isolated rat microglia

Doorn, K. J., Brevé, J. J. P., Drukarch, B., Boddeke, H. W., Huitinga, I., Lucassen, P. J. & van Dam, A-M., 2015, In : Frontiers in Cellular Neuroscience. 9, p. 84

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

Michailidou, I., Willems, J. G. P., Kooi, E-J., van Eden, C., Gold, S. M., Geurts, J. J. G., Baas, F., Huitinga, I. & Ramaglia, V., Jun 2015, In : Annals of Neurology. 77, 6, p. 1007-26 20 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2014

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

Orre, M., Kamphuis, W., Osborn, L. M., Melief, J., Kooijman, L., Huitinga, I., Klooster, J., Bossers, K. & Hol, E. M., Jan 2014, In : Neurobiology of Aging. 35, 1, p. 1-14 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Enhanced uptake of multiple sclerosis-derived myelin by THP-1 macrophages and primary human microglia

Hendrickx, D. A. E., Schuurman, K. G., van Draanen, M., Hamann, J. & Huitinga, I., 2014, In : Journal of Neuroinflammation. 11, p. 64

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Mutant COQ2 in multiple-system atrophy

Schottlaender, L. V., Houlden, H. & Huitinga, I., 03 Jul 2014, In : The New England Journal of Medicine. 371, 1, p. 81

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Saffold cardiovirus and multiple sclerosis: no evidence for an association

Galama, J. M. D., Zoll, J. G., Lanke, K. H., de Jong, A. S., Melief, J., Huitinga, I., Verbeek, M. M. & van Kuppeveld, F. J. M., Aug 2014, In : Annals of Clinical and Translational Neurology. 1, 8, p. 618-21 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination

Mohan, H., Friese, A., Albrecht, S., Krumbholz, M., Elliott, C. L., Arthur, A., Menon, R., Farina, C., Junker, A., Stadelmann, C., Barnett, S. C., Huitinga, I., Wekerle, H., Hohlfeld, R., Lassmann, H., Kuhlmann, T., Linington, C. & Meinl, E., 11 Dec 2014, In : Acta neuropathologica communications. 2, 1, p. 178

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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2013

Accumulation of differentiated CD8+ and CD4+ T cells in the human brain.

Smolders, J., Remmerswaal, E. B. M., Schuurman, K. G., Melief, J., Van Eden, C. G., Van Lier, R. A. W., Huitinga, I. & Hamann, J., 2013, In : Acta Neuropathologica. 126, p. 525-535

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Brain banking for neurological disorders.

Samarasekera, N., Salman, R. A., Huitinga, I., Klioueva, N. M., McLean, C. A., Kretzschmar, H., Smith, C. & Ironside, J. W., 2013, In : Lancet Neurology. 12, p. 1096-1105

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue.

Smolders, J., Schuurman, K. G., van Strien, M. E., Melief, J., Hendrickx, D. A., Hol, E. M., Van Eden, C. G., Luchetti, S. & Huitinga, I., 2013, In : Journal of Neuropathology and Experimental Neurology. 72, p. 91-105

Research output: Contribution to journal/periodicalArticleScientificpeer-review

HPA-Axis activity in multiple sclerosis correlates with disease severity, lesion type and gene expression in normal-appearing white matter.

Melief, J., De Wit, S., Van Eden, C. G., Teunissen, C., Hamann, J., Uitdehaag, B. M. J., Swaab, D. F. & Huitinga, I., 2013, In : Acta Neuropathologica. 126, p. 237-249

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed.

Melief, J., Schuurman, K. G., Van de Garde, M. D., Smolders, J., Van Eijk, M., Hamann, J. & Huitinga, I., 2013, In : GLIA. 61, p. 1848-1861

Research output: Contribution to journal/periodicalArticleScientificpeer-review

NG2 cells, a new trail for Alzheimer's disease mechanisms?

Nielsen, H. M., Ek, D., Avdic, U., Orbjorn, C., Hansson, O., Huitinga, I., Veerhuis, R., Rozemuller, A. J. M., Brun, A., Minthon, L. & Wennstrom, M., 2013, In : Acta neuropathologica communications. 1, p. 7

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis.

Hendrickx, D. A., Koning, N., Schuurman, K. G., van Strien, M. E., Van Eden, C. G., Hamann, J. & Huitinga, I., 2013, In : Journal of Neuropathology and Experimental Neurology. 72, p. 106-118

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2012

C3-dependent mechanism of microglial priming relevant to multiple sclerosis.

Ramaglia, V., Hughes, T. R., Donev, R. M., Ruseva, M. M., Wu, X., Huitinga, I., Baas, F., Neal, J. W. & Morgan, B. P., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, p. 965-970

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Phenotyping primary human microglia: Tight regulation of LPS responsiveness.

Melief, J., Koning, N., Schuurman, K. G., Van de Garde, M. D., Smolders, J., Hoek, R. M., Van Eijk, M., Hamann, J. & Huitinga, I., 2012, In : GLIA. 60, p. 1506-1517

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2011

Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with depressive disorder.

Klok, M. D., Alt, S. R., Irurzun Lafitte, A. J. M., Turner, J. D., Lakke, E. A. J. F., Huitinga, I., Muller, C. P., Zitman, F. G., De Kloet, E. R. & De Rijk, R. H., 2011, In : Journal of Psychiatric Research. 45, p. 871-878

Research output: Contribution to journal/periodicalArticleScientificpeer-review