1. 2019
  2. Enhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsion

    Eggers, R., de Winter, F., Arkenaar, C., Tannemaat, M. R. & Verhaagen, J., 16 May 2019, In : Experimental Neurology. p. 113037

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  3. Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

    Melief, J., Orre, M., Bossers, K., van Eden, C. G., Schuurman, K. G., Mason, M. R. J., Verhaagen, J., Hamann, J. & Huitinga, I., 25 Apr 2019, In : Acta neuropathologica communications. 7, 1, 60.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  4. Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.

    Eggers, R., De Winter, F., Hoyng, S. A., Hoeben, R. C., Malessy, M. J., Tannemaat, M. & Verhaagen, J., 16 Jan 2019, In : Brain. 142, p. 295-311

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  5. Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex

    Boggio, E. M., Ehlert, E. M., Lupori, L., Moloney, E. B., De Winter, F., Vander Kooi, C. W., Baroncelli, L., Mecollari, V., Blits, B., Fawcett, J. W., Verhaagen, J. & Pizzorusso, T., Jan 2019, In : Molecular Neurobiology.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  6. Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease

    Hu, Y-T., Chen, X-L., Huang, S-H., Zhu, Q-B., Yu, S-Y., Shen, Y., Sluiter, A., Verhaagen, J., Zhao, J., Swaab, D. & Bao, A-M., 2019, In : Brain Pathology.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  7. 2018
  8. Intrinsic Determinants of Axon Regeneration

    Fawcett, J. W. & Verhaagen, J., Sep 2018, In : Developmental Neurobiology. 78, p. 890-897

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  9. Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.

    Burnside, E. R., De Winter, F., Didangelos, A., James, N. D., Andreica, E. C., Layard-Horsfall, H., Muir, E. M., Verhaagen, J. & Bradbury, E. J., Jul 2018, In : Brain. 141, p. 2362-2381

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  10. Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System

    Verhaagen, J., Hobo, B., Ehlert, E. M. E., Eggers, R., Korecka, J. A., Hoyng, S. A., Attwell, C. L., Harvey, A. R. & Mason, M. R. J., 03 Jan 2018, In : Methods in Molecular Biology. 1715, p. 3-17 15 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  11. Integrins promote axonal regeneration after injury of the nervous system

    Nieuwenhuis, B., Haenzi, B., Andrews, M. R., Verhaagen, J. & Fawcett, J. W., 2018, In : Biological Reviews. 93, p. 1339-1362

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  12. Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair

    Maldonado-Lasunción, I., Verhaagen, J. & Oudega, M., 2018, In : Neurotherapeutics. 15, p. 578-587

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  13. The dorsal column lesion model of spinal cord injury and its use in deciphering the neuron-intrinsic injury response

    Attwell, C. L., van Zwieten, M., Verhaagen, J. & Mason, M. R. J., 2018, In : Developmental Neurobiology. 78, p. 926-951

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  14. 2017
  15. Repulsive guidance molecule a (RGMa) induces neuropathological and behavioral changes that closely resemble Parkinson's disease

    Korecka, J. A., Moloney, E. B., Eggers, R., Hobo, B., Scheffer, S., Ras-Verloop, N., Pasterkamp, R. J., Swaab, D. F., Smit, A. B., van Kesteren, R. E., Bossers, K. & Verhaagen, J., 01 Sep 2017, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, p. 9361-9379

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  16. Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface

    O'Neill, P., Lindsay, S. L., Pantiru, A., Guimond, S. E., Fagoe, N. D., Verhaagen, J., Turnbull, J. E., Riddell, J. S. & Barnett, S. C., 2017, In : GLIA. 65, p. 19-33

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  17. 2016
  18. Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.

    Cheah, M., Andrews, M. R., Chew, D. J., Moloney, E., Verhaagen, J., Fässler, R. & Fawcett, J. W., 06 Jul 2016, In : Journal of Neuroscience. 36, 27, p. 7283-97 15 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  19. Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent

    Andrews, M. R., Soleman, S., Cheah, M., Tumbarello, D. A., Mason, M. R. J., Moloney, E., Verhaagen, J., Bensadoun, J-C., Schneider, B., Aebischer, P. & Fawcett, J. W., Jul 2016, In : eNeuro. 3, 4, 0029-16.2016.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  20. Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion

    Eggers, R., Tannemaat, M. R., De Winter, F., Malessy, M. J. A. & Verhaagen, J., Feb 2016, In : The European journal of neuroscience. 43, 3, p. 318-35 18 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  21. Evaluation of Five Tests for Sensitivity to Functional Deficits following Cervical or Thoracic Dorsal Column Transection in the Rat

    Fagoe, N. D., Attwell, C. L., Eggers, R., Tuinenbreijer, L., Kouwenhoven, D., Verhaagen, J. & Mason, M. R. J., 2016, In : PLoS One. 11, 3, p. e0150141

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  22. The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

    de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D. & Verhaagen, J., 2016, In : Neural Plasticity. 2016, p. 3679545

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  23. 2015
  24. Overexpression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects

    Fagoe, N. D., Attwell, C. L., Kouwenhoven, D., Verhaagen, J. & Mason, M. R. J., 01 Dec 2015, In : Human Molecular Genetics. 24, 23, p. 6788-800 13 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  25. Gene delivery to rat and human Schwann cells and nerve segments: a comparison of AAV 1-9 and lentiviral vectors

    Hoyng, S. A., De Winter, F., Gnavi, S., van Egmond, L., Attwell, C. L., Tannemaat, M. R., Verhaagen, J. & Malessy, M. J. A., Oct 2015, In : Gene Therapy. 22, 10, p. 767-80 14 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  26. Human Neuroma-in-Continuity Contains Focal Deficits in Myelination

    van Vliet, A. C., Tannemaat, M. R., van Duinen, S. G., Verhaagen, J., Malessy, M. J. A. & De Winter, F., Sep 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 9, p. 901-11 11 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  27. Chondroitinase gene therapy improves upper limb function following cervical contusion injury

    James, N. D., Shea, J., Muir, E. M., Verhaagen, J., Schneider, B. L. & Bradbury, E. J., 01 Jun 2015, In : Experimental Neurology. 271, p. 131-135 5 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  28. Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9

    Riaz, M., Raz, Y., Moloney, E., van Putten, M., Krom, Y. D., van der Maarel, S. M., Verhaagen, J. & Raz, V., 2015, In : Skeletal Muscle. 5, p. 37

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  29. Gene delivery to neurons of the dorsal root ganglia using adeno-associated viral vectors.

    Fagoe, N. D., Eggers, R., Verhaagen, J. & Mason, M. R. J., 2015, In : Neuromethods. 98, p. 175-189

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  30. Gene therapy and peripheral nerve repair: a perspective

    Hoyng, S. A., de Winter, F., Tannemaat, M. R., Blits, B., Malessy, M. J. A. & Verhaagen, J., 2015, In : Frontiers in Molecular Neuroscience. 8, p. 32

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  31. Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances Axon Growth In Vitro but Not Axonal Repair In Vivo

    van der Kallen, L. R., Eggers, R., Ehlert, E. M., Verhaagen, J., Smit, A. B. & van Kesteren, R. E., 2015, In : PLoS One. 10, 5, p. e0127163

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  32. 2014
  33. Spinal cord injury and the neuron-intrinsic regeneration-associated gene program

    Fagoe, N. D., van Heest, J. & Verhaagen, J., Dec 2014, In : NeuroMolecular Medicine. 16, 4, p. 799-813 15 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  34. A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF

    Hoyng, S. A., De Winter, F., Gnavi, S., de Boer, R., Boon, L. I., Korvers, L. M., Tannemaat, M. R., Malessy, M. J. A. & Verhaagen, J., Nov 2014, In : Experimental Neurology. 261, p. 578-93 16 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  35. Understanding the neural repair-promoting properties of olfactory ensheathing cells

    Roet, K. C. D. & Verhaagen, J., Nov 2014, In : Experimental Neurology. 261C, p. 594-609 16 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  36. Schwann cells transduced with a lentiviral vector encoding Fgf-2 promote motor neuron regeneration following sciatic nerve injury

    Allodi, I., Mecollari, V., González-Pérez, F., Eggers, R., Hoyng, S., Verhaagen, J., Navarro, X. & Udina, E., Oct 2014, In : GLIA. 62, 10, p. 1736-46 11 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  37. Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa

    Alves, C. H., Pellissier, L. P., Vos, R. M., Garcia Garrido, M., Sothilingam, V., Seide, C., Beck, S. C., Klooster, J., Furukawa, T., Flannery, J. G., Verhaagen, J., Seeliger, M. W. & Wijnholds, J., 01 Jul 2014, In : Human Molecular Genetics. 23, 13, p. 3384-401 18 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  38. Developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve

    Hoyng, S. A., Gnavi, S., de Winter, F., Eggers, R., Ozawa, T., Zaldumbide, A., Hoeben, R. C., Malessy, M. J. A. & Verhaagen, J., Jun 2014, In : Gene Therapy. 21, 6, p. 549-57 9 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  39. AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations

    Alves, J. N., Muir, E. M., Andrews, M. R., Ward, A., Michelmore, N., Dasgupta, D., Verhaagen, J., Moloney, E., Keynes, R. J., Fawcett, J. W. & Rogers, J. H., 30 Apr 2014, In : Journal of Neuroscience Methods. 227, p. 107-20 14 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  40. Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury

    Bartus, K., James, N. D., Didangelos, A., Bosch, K. D., Verhaagen, J., Yáñez-Muñoz, R. J., Rogers, J. H., Schneider, B. L., Muir, E. M. & Bradbury, E. J., 02 Apr 2014, In : Journal of Neuroscience. 34, 14, p. 4822-36 15 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  41. A compact dual promoter adeno-associated viral vector for efficient delivery of two genes to dorsal root ganglion neurons

    Fagoe, N. D., Eggers, R., Verhaagen, J. & Mason, M. R. J., Mar 2014, In : Gene Therapy. 21, 3, p. 242-52 11 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  42. Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A

    Giacobini, P., Parkash, J., Campagne, C., Messina, A., Casoni, F., Vanacker, C., Langlet, F., Hobo, B., Cagnoni, G., Gallet, S., Hanchate, N. K., Mazur, D., Taniguchi, M., Mazzone, M., Verhaagen, J., Ciofi, P., Bouret, S. G., Tamagnone, L. & Prevot, V., Mar 2014, In : PLoS Biology. 12, 3, p. e1001808

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  43. Misdirection and guidance of regenerating axons after experimental nerve injury and repair

    de Ruiter, G. C. W., Spinner, R. J., Verhaagen, J. & Malessy, M. J. A., Feb 2014, In : Journal of Neurosurgery. 120, 2, p. 493-501 9 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  44. Wnt signaling through the Ror receptor in the nervous system

    Petrova, I. M., Malessy, M. J., Verhaagen, J., Fradkin, L. G. & Noordermeer, J. N., Feb 2014, In : Molecular Neurobiology. 49, 1, p. 303-15 13 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  45. ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

    Moloney, E., de Winter, F. & Verhaagen, J., 2014, In : Frontiers in Neuroscience. 8, p. 252

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  46. A perspective on the role of class III semaphorin signaling in central nervous system trauma

    Mecollari, V., Nieuwenhuis, B. & Verhaagen, J., 2014, In : Frontiers in Cellular Neuroscience. 8, p. 328

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  47. A Role for Neuropilins in the Interaction between Schwann Cells and Meningeal Cells

    Roet, K. C. D., Wirz, K. T. S., Franssen, E. H. P. & Verhaagen, J., 2014, In : PLoS One. 9, 10, p. e109401

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  48. Early molecular changes in Alzheimer disease: can we catch the disease in its presymptomatic phase?

    Wirz, K. T. S., Keitel, S., Swaab, D. F., Verhaagen, J. & Bossers, K., 2014, In : Journal of Alzheimer's Disease. 38, 4, p. 719-40 22 p.

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  49. 2013
  50. Alteration of the microRNA network during the progression of Alzheimer's disease.

    Lau, P., Bossers, K., Janky, R., Salta, E., Sala Frigerio, C., Barbash, S., Rothman, R., Sierksma, A. S. R., Thathiah, A., Greenberg, D., Papadopoulou, A. S., Achsel, T., Ayoubi, T., Soreq, H., Verhaagen, J., Swaab, D. F., Aerts, S. & De Strooper, B., 2013, In : EMBO Molecular Medicine. 5, p. 1613-1634

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  51. A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheating cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons.

    Roet, K. C. D., Franssen, E. H. P., De Bree, F. M., Essing, A. H. W., Zijlstra, S. J., Fagoe, N. D., Eggink, H. M., Eggers, R., Smit, A. B., Van Kesteren, R. E. & Verhaagen, J., 2013, In : Journal of Neuroscience. 33, p. 11116-11135

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  52. Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model.

    Wirz, K. T. S., Bossers, K., Stargardt, A., Kamphuis, W., Swaab, D. F., Hol, E. M. & Verhaagen, J., 2013, In : Neurobiology of Aging. 34, p. 11342-12328

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  53. Gene therapy approaches to enhance regeneration of the injured peripheral nerve.

    De Winter, F., Hoyng, S., Tannemaat, M., Eggers, R., Mason, M., Malessy, M. & Verhaagen, J., 2013, In : European Journal of Pharmacology. 719, p. 145-152

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  54. Homodimerization of the Wnt receptor derailed recruits the Src family kinase SRC64B.

    Petrova, I. M., Lahaye, L. L., Martianez, T., De Jong, A. W., Malessy, M. J., Verhaagen, J., Noordermeer, J. N. & Fradkin, L. G., 2013, In : Molecular and Cellular Biology. 33, p. 4116-4127

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  55. Immunohistochemical, ultrastructural and functional analysis of axonal regeneration through peripheral nerve grafts containing Schwann cells expressing BDNF, CNTF or NT3.

    Godinho, M. J., The, L., Pollett, M. A., Goodman, D., Hodgetts, S. I., Sweetman, I., Walters, M., Verhaagen, J., Plant, G. W. & Harvey, A. R., 2013, In : PLoS One. 8, p. 69987

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

  56. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior.

    Fitzsimons, C. P., Van Hooijdonk, L. W. A., Schouten, M., Zalachoras, I., Brinks, V., Zheng, T., Schouten, T. G., Saaltink, D. J., Dijkmans, T., Steindler, D. A., Verhaagen, J., Verbeek, F. J., Lucassen, P. J., De Kloet, E. R., Meijer, O. C., Karst, H., Joels, M., Oitzl, M. S. & Vreugdenhil, E., 2013, In : Molecular Psychiatry. 18, p. 993-1005

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

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