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Research Output

2020

Cerebellar plasticity and associative memories are controlled by perineuronal nets

Carulli, D., Broersen, R., de Winter, F., Muir, E. M., Mešković, M., de Waal, M., de Vries, S., Boele, H-J., Canto, C. B., De Zeeuw, C. I. & Verhaagen, J., 09 Mar 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, p. 6855-6865

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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120 Downloads (Pure)

ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons

Willems, J., de Jong, A. P. H., Scheefhals, N., Mertens, E., Catsburg, L. A. E., Poorthuis, R. B., de Winter, F., Verhaagen, J., Meye, F. J. & MacGillavry, H. D., 13 Jan 2020, In : PLoS Biology. 18, 4, p. e3000665

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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18 Downloads (Pure)

Regeneration of adult rat sensory and motor neuron axons through chimeric peroneal nerve grafts containing donor Schwann cells engineered to express different neurotrophic factors

Godinho, M. J., Staal, J. L., Krishnan, V. S., Hodgetts, S. I., Pollett, M. A., Goodman, D. P., Teh, L., Verhaagen, J., Plant, G. W. & Harvey, A. R., 2020, In : Experimental Neurology. p. 113355

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2019

Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease

Hu, Y-T., Chen, X-L., Huang, S-H., Zhu, Q-B., Yu, S-Y., Shen, Y., Sluiter, A., Verhaagen, J., Zhao, J., Swaab, D. & Bao, A-M., 2019, In : Brain Pathology. 29, p. 502-512

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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45 Downloads (Pure)

Enhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsion

Eggers, R., de Winter, F., Arkenaar, C., Tannemaat, M. R. & Verhaagen, J., 16 May 2019, In : Experimental Neurology. 321, p. 113037

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex

Boggio, E. M., Ehlert, E. M., Lupori, L., Moloney, E. B., De Winter, F., Vander Kooi, C. W., Baroncelli, L., Mecollari, V., Blits, B., Fawcett, J. W., Verhaagen, J. & Pizzorusso, T., Jan 2019, In : Molecular Neurobiology. 56, p. 5987-5997

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Recent advances in the therapeutic uses of chondroitinase ABC

Muir, E., De Winter, F., Verhaagen, J. & Fawcett, J., Jan 2019, In : Experimental Neurology. 321, p. 113032

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Effects of Sindbis Viral Vectors on Neuronal Function

Uyaniker, S., van der Spek, S. J. F., Reinders, N. R., Xiong, H., Li, K. W., Bossers, K., Smit, A. B., Verhaagen, J. & Kessels, H. W., 2019, In : Frontiers in Cellular Neuroscience. 13, p. 362

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.

Eggers, R., De Winter, F., Hoyng, S. A., Hoeben, R. C., Malessy, M. J., Tannemaat, M. & Verhaagen, J., 16 Jan 2019, In : Brain. 142, p. 295-311

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

Melief, J., Orre, M., Bossers, K., van Eden, C. G., Schuurman, K. G., Mason, M. R. J., Verhaagen, J., Hamann, J. & Huitinga, I., 25 Apr 2019, In : Acta neuropathologica communications. 7, 1, 60.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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197 Downloads (Pure)
2018

Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.

Burnside, E. R., De Winter, F., Didangelos, A., James, N. D., Andreica, E. C., Layard-Horsfall, H., Muir, E. M., Verhaagen, J. & Bradbury, E. J., Jul 2018, In : Brain. 141, p. 2362-2381

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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171 Downloads (Pure)

Integrins promote axonal regeneration after injury of the nervous system

Nieuwenhuis, B., Haenzi, B., Andrews, M. R., Verhaagen, J. & Fawcett, J. W., 2018, In : Biological Reviews. 93, p. 1339-1362

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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198 Downloads (Pure)

Intrinsic Determinants of Axon Regeneration

Fawcett, J. W. & Verhaagen, J., Sep 2018, In : Developmental Neurobiology. 78, p. 890-897

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair

Maldonado-Lasunción, I., Verhaagen, J. & Oudega, M., 2018, In : Neurotherapeutics. 15, p. 578-587

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System

Verhaagen, J., Hobo, B., Ehlert, E. M. E., Eggers, R., Korecka, J. A., Hoyng, S. A., Attwell, C. L., Harvey, A. R. & Mason, M. R. J., 03 Jan 2018, In : Methods in Molecular Biology. 1715, p. 3-17 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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The dorsal column lesion model of spinal cord injury and its use in deciphering the neuron-intrinsic injury response

Attwell, C. L., van Zwieten, M., Verhaagen, J. & Mason, M. R. J., 2018, In : Developmental Neurobiology. 78, p. 926-951

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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126 Downloads (Pure)
2017
Open Access
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258 Downloads (Pure)

Repulsive guidance molecule a (RGMa) induces neuropathological and behavioral changes that closely resemble Parkinson's disease

Korecka, J. A., Moloney, E. B., Eggers, R., Hobo, B., Scheffer, S., Ras-Verloop, N., Pasterkamp, R. J., Swaab, D. F., Smit, A. B., van Kesteren, R. E., Bossers, K. & Verhaagen, J., 01 Sep 2017, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, p. 9361-9379

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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140 Downloads (Pure)

Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface

O'Neill, P., Lindsay, S. L., Pantiru, A., Guimond, S. E., Fagoe, N. D., Verhaagen, J., Turnbull, J. E., Riddell, J. S. & Barnett, S. C., 2017, In : GLIA. 65, p. 19-33

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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145 Downloads (Pure)
2016

Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent

Andrews, M. R., Soleman, S., Cheah, M., Tumbarello, D. A., Mason, M. R. J., Moloney, E., Verhaagen, J., Bensadoun, J-C., Schneider, B., Aebischer, P. & Fawcett, J. W., Jul 2016, In : eNeuro. 3, 4, 0029-16.2016.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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481 Downloads (Pure)

Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion

Eggers, R., Tannemaat, M. R., De Winter, F., Malessy, M. J. A. & Verhaagen, J., Feb 2016, In : The European journal of neuroscience. 43, 3, p. 318-35 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Evaluation of Five Tests for Sensitivity to Functional Deficits following Cervical or Thoracic Dorsal Column Transection in the Rat

Fagoe, N. D., Attwell, C. L., Eggers, R., Tuinenbreijer, L., Kouwenhoven, D., Verhaagen, J. & Mason, M. R. J., 2016, In : PLoS One. 11, 3, p. e0150141

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.

Cheah, M., Andrews, M. R., Chew, D. J., Moloney, E., Verhaagen, J., Fässler, R. & Fawcett, J. W., 06 Jul 2016, In : Journal of Neuroscience. 36, 27, p. 7283-97 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D. & Verhaagen, J., 2016, In : Neural Plasticity. 2016, p. 3679545

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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484 Downloads (Pure)
2015

Chondroitinase gene therapy improves upper limb function following cervical contusion injury

James, N. D., Shea, J., Muir, E. M., Verhaagen, J., Schneider, B. L. & Bradbury, E. J., 01 Jun 2015, In : Experimental Neurology. 271, p. 131-135 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9

Riaz, M., Raz, Y., Moloney, E., van Putten, M., Krom, Y. D., van der Maarel, S. M., Verhaagen, J. & Raz, V., 2015, In : Skeletal Muscle. 5, p. 37

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Gene delivery to neurons of the dorsal root ganglia using adeno-associated viral vectors.

Fagoe, N. D., Eggers, R., Verhaagen, J. & Mason, M. R. J., 2015, In : Neuromethods. 98, p. 175-189

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Gene delivery to rat and human Schwann cells and nerve segments: a comparison of AAV 1-9 and lentiviral vectors

Hoyng, S. A., De Winter, F., Gnavi, S., van Egmond, L., Attwell, C. L., Tannemaat, M. R., Verhaagen, J. & Malessy, M. J. A., Oct 2015, In : Gene Therapy. 22, 10, p. 767-80 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Gene therapy and peripheral nerve repair: a perspective

Hoyng, S. A., de Winter, F., Tannemaat, M. R., Blits, B., Malessy, M. J. A. & Verhaagen, J., 2015, In : Frontiers in Molecular Neuroscience. 8, p. 32

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances Axon Growth In Vitro but Not Axonal Repair In Vivo

van der Kallen, L. R., Eggers, R., Ehlert, E. M., Verhaagen, J., Smit, A. B. & van Kesteren, R. E., 2015, In : PLoS One. 10, 5, p. e0127163

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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158 Downloads (Pure)

Human Neuroma-in-Continuity Contains Focal Deficits in Myelination

van Vliet, A. C., Tannemaat, M. R., van Duinen, S. G., Verhaagen, J., Malessy, M. J. A. & De Winter, F., Sep 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 9, p. 901-11 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Overexpression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects

Fagoe, N. D., Attwell, C. L., Kouwenhoven, D., Verhaagen, J. & Mason, M. R. J., 01 Dec 2015, In : Human Molecular Genetics. 24, 23, p. 6788-800 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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2014

AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations

Alves, J. N., Muir, E. M., Andrews, M. R., Ward, A., Michelmore, N., Dasgupta, D., Verhaagen, J., Moloney, E., Keynes, R. J., Fawcett, J. W. & Rogers, J. H., 30 Apr 2014, In : Journal of Neuroscience Methods. 227, p. 107-20 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A compact dual promoter adeno-associated viral vector for efficient delivery of two genes to dorsal root ganglion neurons

Fagoe, N. D., Eggers, R., Verhaagen, J. & Mason, M. R. J., Mar 2014, In : Gene Therapy. 21, 3, p. 242-52 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF

Hoyng, S. A., De Winter, F., Gnavi, S., de Boer, R., Boon, L. I., Korvers, L. M., Tannemaat, M. R., Malessy, M. J. A. & Verhaagen, J., Nov 2014, In : Experimental Neurology. 261, p. 578-93 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

Moloney, E., de Winter, F. & Verhaagen, J., 2014, In : Frontiers in Neuroscience. 8, p. 252

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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A perspective on the role of class III semaphorin signaling in central nervous system trauma

Mecollari, V., Nieuwenhuis, B. & Verhaagen, J., 2014, In : Frontiers in Cellular Neuroscience. 8, p. 328

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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A Role for Neuropilins in the Interaction between Schwann Cells and Meningeal Cells

Roet, K. C. D., Wirz, K. T. S., Franssen, E. H. P. & Verhaagen, J., 2014, In : PLoS One. 9, 10, p. e109401

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A

Giacobini, P., Parkash, J., Campagne, C., Messina, A., Casoni, F., Vanacker, C., Langlet, F., Hobo, B., Cagnoni, G., Gallet, S., Hanchate, N. K., Mazur, D., Taniguchi, M., Mazzone, M., Verhaagen, J., Ciofi, P., Bouret, S. G., Tamagnone, L. & Prevot, V., Mar 2014, In : PLoS Biology. 12, 3, p. e1001808

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve

Hoyng, S. A., Gnavi, S., de Winter, F., Eggers, R., Ozawa, T., Zaldumbide, A., Hoeben, R. C., Malessy, M. J. A. & Verhaagen, J., Jun 2014, In : Gene Therapy. 21, 6, p. 549-57 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Early molecular changes in Alzheimer disease: can we catch the disease in its presymptomatic phase?

Wirz, K. T. S., Keitel, S., Swaab, D. F., Verhaagen, J. & Bossers, K., 2014, In : Journal of Alzheimer's Disease. 38, 4, p. 719-40 22 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury

Bartus, K., James, N. D., Didangelos, A., Bosch, K. D., Verhaagen, J., Yáñez-Muñoz, R. J., Rogers, J. H., Schneider, B. L., Muir, E. M. & Bradbury, E. J., 02 Apr 2014, In : Journal of Neuroscience. 34, 14, p. 4822-36 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Misdirection and guidance of regenerating axons after experimental nerve injury and repair

de Ruiter, G. C. W., Spinner, R. J., Verhaagen, J. & Malessy, M. J. A., Feb 2014, In : Journal of Neurosurgery. 120, 2, p. 493-501 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Schwann cells transduced with a lentiviral vector encoding Fgf-2 promote motor neuron regeneration following sciatic nerve injury

Allodi, I., Mecollari, V., González-Pérez, F., Eggers, R., Hoyng, S., Verhaagen, J., Navarro, X. & Udina, E., Oct 2014, In : GLIA. 62, 10, p. 1736-46 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Spinal cord injury and the neuron-intrinsic regeneration-associated gene program

Fagoe, N. D., van Heest, J. & Verhaagen, J., Dec 2014, In : NeuroMolecular Medicine. 16, 4, p. 799-813 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa

Alves, C. H., Pellissier, L. P., Vos, R. M., Garcia Garrido, M., Sothilingam, V., Seide, C., Beck, S. C., Klooster, J., Furukawa, T., Flannery, J. G., Verhaagen, J., Seeliger, M. W. & Wijnholds, J., 01 Jul 2014, In : Human Molecular Genetics. 23, 13, p. 3384-401 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Understanding the neural repair-promoting properties of olfactory ensheathing cells

Roet, K. C. D. & Verhaagen, J., Nov 2014, In : Experimental Neurology. 261C, p. 594-609 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Wnt signaling through the Ror receptor in the nervous system

Petrova, I. M., Malessy, M. J., Verhaagen, J., Fradkin, L. G. & Noordermeer, J. N., Feb 2014, In : Molecular Neurobiology. 49, 1, p. 303-15 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2013

Alteration of the microRNA network during the progression of Alzheimer's disease.

Lau, P., Bossers, K., Janky, R., Salta, E., Sala Frigerio, C., Barbash, S., Rothman, R., Sierksma, A. S. R., Thathiah, A., Greenberg, D., Papadopoulou, A. S., Achsel, T., Ayoubi, T., Soreq, H., Verhaagen, J., Swaab, D. F., Aerts, S. & De Strooper, B., 2013, In : EMBO Molecular Medicine. 5, p. 1613-1634

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheating cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons.

Roet, K. C. D., Franssen, E. H. P., De Bree, F. M., Essing, A. H. W., Zijlstra, S. J., Fagoe, N. D., Eggink, H. M., Eggers, R., Smit, A. B., Van Kesteren, R. E. & Verhaagen, J., 2013, In : Journal of Neuroscience. 33, p. 11116-11135

Research output: Contribution to journal/periodicalArticleScientificpeer-review