Jeroen Bakkers

Research output

Research output per year 2002 2011 2016 2018 2019 2021 2022 2022

• 106 Article
• 1 Contribution to conference proceedings
• 1 Book/Film/Article review

Research output per year

Research output per year

Search results

• 2016

  A zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals its Specific Role in Laterality Organ Function

  Noël, E. S., Momenah, T. S., Al-Dagriri, K., Al-Suwaid, A., Al-Shahrani, S., Jiang, H., Willekers, S., Oostveen, Y. Y., Chocron, S., Postma, A. V., Bhuiyan, Z. A. & Bakkers, J., Feb 2016, In: Human Mutation.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Dextrocardia 100%
  • Zebrafish 66%
  • Cilia 50%
  • Mutation 36%
  • Gene Editing 26%
  21 Citations (Scopus)

• GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

  Lodder, E. M., De Nittis, P., Koopman, C. D., Wiszniewski, W., Moura de Souza, C. F., Lahrouchi, N., Guex, N., Napolioni, V., Tessadori, F., Beekman, L., Nannenberg, E. A., Boualla, L., Blom, N. A., de Graaff, W., Kamermans, M., Cocciadiferro, D., Malerba, N., Mandriani, B., Akdemir, Z. H. C., Fish, R. J., & 13 othersEldomery, M. K., Ratbi, I., Wilde, A. A. M., de Boer, T., Simonds, W. F., Neerman-Arbez, M., Sutton, V. R., Kok, F., Lupski, J. R., Reymond, A., Bezzina, C. R., Bakkers, J. & Merla, G., 2016, In: American Journal of Human Genetics. 99, 3, p. 704-710

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Muscle Hypotonia 100%
  • Bradycardia 86%
  • GTP-Binding Proteins 55%
  • Mutation 46%
  • Heart Rate 40%
  42 Citations (Scopus)

• Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity

  Josifova, D. J., Monroe, G. R., Tessadori, F., de Graaff, E., van der Zwaag, B., Mehta, S. G., Harakalova, M., Duran, K. J., Savelberg, S. M. C., Nijman, I. J., Jungbluth, H., Hoogenraad, C. C., Bakkers, J., Knoers, N. V., Firth, H. V., Beales, P. L., van Haaften, G. & van Haelst, M. M., 22 Mar 2016, In: Human Molecular Genetics.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Paraplegia 100%
  • Intellectual Disability 81%
  • Exons 71%
  • Neurites 63%
  • Obesity 60%
  26 Citations (Scopus)

• Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2

  San, B., Chrispijn, N. D., Wittkopp, N., van Heeringen, S. J., Lagendijk, A. K., Aben, M., Bakkers, J., Ketting, R. F. & Kamminga, L. M., 2016, In: Scientific Reports. 6, p. 24658

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Enhancer of Zeste Homolog 2 Protein 100%
  • Polycomb-Group Proteins 64%
  • Vertebrates 58%
  • Maintenance 45%
  • Stored Messenger RNA 33%
  22 Citations (Scopus)

• Rare novel variants in the ZIC3 gene cause X-linked heterotaxy

  Paulussen, A. D. C., Steyls, A., Vanoevelen, J., van Tienen, F. H., Krapels, I. P. C., Claes, G. R., Chocron, S., Velter, C., Tan-Sindhunata, G. M., Lundin, C., Valenzuela, I., Nagy, B., Bache, I., Maroun, L. L., Avela, K., Brunner, H. G., Smeets, H. J. M., Bakkers, J. & van den Wijngaard, A., 13 Jul 2016, In: European Journal of Human Genetics.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • X-Linked Genes 100%
  • Zinc Fingers 44%
  • Zebrafish Proteins 33%
  • Human Genetics 23%
  • Genes 23%
  14 Citations (Scopus)

• Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

  Wu, C-C., Kruse, F., Vasudevarao, M. D., Junker, J. P., Zebrowski, D. C., Fischer, K., Noël, E. S., Grün, D., Berezikov, E., Engel, F. B., van Oudenaarden, A., Weidinger, G. & Bakkers, J., 11 Jan 2016, In: Developmental Cell. 36, 1, p. 36-49 14 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Bone Morphogenetic Proteins 100%
  • Zebrafish 83%
  • Cardiac Myocytes 76%
  • Regeneration 69%
  • Genome 55%
  111 Citations (Scopus)

• Tomo-seq: A method to obtain genome-wide expression data with spatial resolution

  Kruse, F., Junker, J. P., van Oudenaarden, A. & Bakkers, J., 2016, In: Methods in Cell Biology. 135, p. 299-307 9 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Genome 100%
  • Zebrafish 99%
  • Cryoultramicrotomy 83%
  • Embryonic Structures 80%
  • Heart Injuries 69%
  31 Citations (Scopus)

• αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish

  Han, M. K. L., Hoijman, E., Nöel, E., Garric, L., Bakkers, J. & de Rooij, J., 2016, In: Biology Open. 5, 10, p. 1461-1472 12 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • catenins 100%
  • mechanotransduction 91%
  • cadherins 80%
  • Catenins 75%
  • Danio rerio 61%
  20 Citations (Scopus)
• 2015

  Animal and in silico models for the study of sarcomeric cardiomyopathies

  Duncker, D. J., Bakkers, J., Brundel, B. J., Robbins, J., Tardiff, J. C. & Carrier, L., 01 Apr 2015, In: Cardiovascular Research. 105, 4, p. 439-448 10 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Cardiomyopathies 100%
  • Computer Simulation 96%
  • Animals 51%
  • Zebrafish 41%
  • Animal Models 29%
  35 Citations (Scopus)

• Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies

  Ramspacher, C., Steed, E., Boselli, F., Ferreira, R., Faggianelli, N., Roth, S., Spiegelhalter, C., Messaddeq, N., Trinh, L., Liebling, M., Chacko, N., Tessadori, F., Bakkers, J., Laporte, J., Hnia, K. & Vermot, J., 16 Jun 2015, In: Cell Reports. 11, 10, p. 1564-76 13 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Ryanodine 100%
  • Developmental 81%
  • Desmin 80%
  • Biomechanical Phenomena 64%
  • Disorder 57%
  32 Citations (Scopus)

• GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish

  Jiménez-Amilburu, V., Jong-Raadsen, S., Bakkers, J., Spaink, H. P. & Marín-Juez, R., Jan 2015, In: The Journal of endocrinology. 224, 1, p. 1-15 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Facilitative Glucose Transport Proteins 100%
  • Zebrafish 87%
  • Larva 68%
  • Heart Failure 63%
  • Insulin 58%
  25 Citations (Scopus)

• Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling

  Strate, I., Tessadori, F. & Bakkers, J., 15 May 2015, In: Development. 142, 10, p. 1767-76 10 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Embryo 100%
  • embryo 94%
  • Defects 79%
  • defect 70%
  • mutant 68%
  25 Citations (Scopus)

• Nodal signaling range is regulated by proprotein convertase-mediated maturation

  Tessadori, F., Noël, E. S., Rens, E. G., Magliozzi, R., Evers-van Gogh, I. J. A., Guardavaccaro, D., Merks, R. M. H. & Bakkers, J., 09 Mar 2015, In: Developmental Cell. 32, 5, p. 631-9 9 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Proprotein Convertases 100%
  • Growth Factor 79%
  • Cleavage 46%
  • Zebrafish 34%
  • Computer Simulation 31%
  11 Citations (Scopus)

• Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes

  Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A. T., Wolfe, L. A., Tifft, C. J., Zerfas, P. M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M. G., & 27 othersLee, C-C. R., Ferraz, V., da Silva, E. M., Stevens, C. A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B. P., Maduro, V., Dallapiccola, B., Ramos, F. J., Chung, H-Y. B., Le Caignec, C., Martins, F., Jacyk, W. K., Mazzanti, L., Brunner, H. G., Bakkers, J., Lin, S., Malicdan, M. C. V., Boerkoel, C. F., Gahl, W. A., de Vries, B. B. A., van Haelst, M. M., Zenker, M. & Markello, T. C., 02 Jul 2015, In: American Journal of Human Genetics. 97, 1, p. 99-110 12 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Barber Say syndrome 100%
  • Ablepharon macrostomia syndrome 98%
  • Macrostomia 84%
  • Mutation 26%
  • Ectodermal Dysplasia 13%
  41 Citations (Scopus)
• 2014

  Genome-wide RNA Tomography in the zebrafish embryo

  Junker, J. P., Noël, E. S., Guryev, V., Peterson, K. A., Shah, G., Huisken, J., McMahon, A. P., Berezikov, E., Bakkers, J. & van Oudenaarden, A., 23 Oct 2014, In: Cell. 159, 3, p. 662-75 14 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • RNA Sequencing 100%
  • Zebrafish 61%
  • Embryonic Structures 49%
  • RNA Sequence Analysis 45%
  • RNA 41%
  166 Citations (Scopus)

• Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

  Chetaille, P., Preuss, C., Burkhard, S., Côté, J-M., Houde, C., Castilloux, J., Piché, J., Gosset, N., Leclerc, S., Wünnemann, F., Thibeault, M., Gagnon, C., Galli, A., Tuck, E., Hickson, G. R., El Amine, N., Boufaied, I., Lemyre, E., de Santa Barbara, P., Faure, S., & 13 othersJonzon, A., Cameron, M., Dietz, H. C., Gallo-McFarlane, E., Benson, D. W., Moreau, C., Labuda, D., Zhan, S. H., Shen, Y., Jomphe, M., Jones, S. J. M., Bakkers, J. & Andelfinger, G., Nov 2014, In: Nature Genetics. 46, 11, p. 1245-9 5 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Heart 100%
  • cohesins 88%
  • Mutation 86%
  • Railroads 48%
  • Enteric Nervous System 40%
  79 Citations (Scopus)

• Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

  Bonetti, M., Paardekooper Overman, J., Tessadori, F., Noël, E., Bakkers, J. & den Hertog, J., May 2014, In: Development. 141, 9, p. 1961-70 10 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Embryo 100%
  • embryo 94%
  • Defects 79%
  • defect 70%
  • mutation 60%
  40 Citations (Scopus)
• 2013

  A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

  Noel, E. S., Verhoeven, M., Lagendijk, A. K., Tessadori, F., Smith, K., Choorapoikayil, S., den Hertog, J. & Bakkers, J., 2013, In: Nature Communications. 4, p. 2754

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • chirality 100%
  • Asymmetry 99%
  • Chirality 88%
  • organs 64%
  • Heart 61%
  81 Citations (Scopus)

• Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

  Lagendijk, A. K., Szabo, A., Merks, R. M. & Bakkers, J., 2013, In: Trends in Cardiovascular Medicine. 23, 5, p. 135-142

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Heart Valves 100%
  • Hyaluronic Acid 93%
  • Endocardial Cushions 83%
  • Extracellular Matrix 32%
  • MicroRNAs 21%
  28 Citations (Scopus)

• On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling

  Goudarzi, M., Strate, I., Paksa, A., Lagendijk, A. K., Bakkers, J. & Raz, E., 2013, In: Nature Genetics. 45, 11, p. 1264-1265

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review
  5 Citations (Scopus)

• Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis

  Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, L., Murphy, M. P., Medana, C., Stainier, D. Y., Bakkers, J. & Santoro, M. M., 2013, In: Cell. 152, 3, p. 504-518

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • coenzyme Q10 100%
  • Antioxidant Agent 58%
  • Antioxidants 56%
  • Reactive Oxygen Species 45%
  • Enzymes 41%
  154 Citations (Scopus)
• 2012

  Bmp signaling exerts opposite effects on cardiac differentiation

  de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., Strate, I., Smith, K., Lagendijk, A. K., Schilling, T. F., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M. & Bakkers, J., 2012, In: Circulation Research. 110, 4, p. 578-587

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Embryonic Structures 100%
  • Mesoderm 65%
  • Embryonic Stem Cells 64%
  • Zebrafish 62%
  • Cardiac Myocytes 56%
  58 Citations (Scopus)

• Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

  van den Boogaard, M., Wong, L. Y., Tessadori, F., Bakker, M. L., Dreizehnter, L. K., Wakker, V., Bezzina, C. R., 't Hoen, P. A., Bakkers, J., Barnett, P. & Christoffels, V. M., 2012, In: Journal of Clinical Investigation. 122, 7, p. 2519-2530

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Genetic Variation 100%
  • Cardiac Arrhythmias 87%
  • Transcription Factors 77%
  • Genome 70%
  • Heart 67%
  147 Citations (Scopus)

• Identification and functional characterization of cardiac pacemaker cells in zebrafish

  Tessadori, F., van Weerd, J. H., Burkhard, S. B., Verkerk, A. O., de Pater, E., Boukens, B. J., Vink, A., Christoffels, V. M. & Bakkers, J., 2012, In: PLoS One. 7, 10, p. 47644

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Zebrafish 100%
  • Sinoatrial Node 40%
  • Vertebrates 29%
  • Heart Conduction System 27%
  • Cell Surface Extensions 25%
  122 Citations (Scopus)

• Identification and regulation of a molecular module for bleb-based cell motility

  Goudarzi, M., Banisch, T. U., Mobin, M. B., Maghelli, N., Tarbashevich, K., Strate, I., ter Berg, J., Blaser, H., Bandemer, S., Paluch, E., Bakkers, J., Tolic-Norrelykke, I. M. & Raz, E., 2012, In: Developmental Cell. 23, 1, p. 210-218

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • MicroRNA 100%
  • Blister 86%
  • Cell Movement 66%
  • Environment 46%
  • Germ Cells 40%
  49 Citations (Scopus)

• Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues

  Lagendijk, A. K., Moulton, J. D. & Bakkers, J., 2012, In: Biology Open. 1, 6, p. 566-569

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • MicroRNA 100%
  • Danio rerio 83%
  • Zebrafish 82%
  • microRNA 82%
  • in situ hybridization 75%
  22 Citations (Scopus)

• UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly

  Hyde, A. S., Farmer, E. L., Easley, K. E., van Lammeren, K., Christoffels, V. M., Barycki, J. J., Bakkers, J. & Simpson, M. A., 2012, In: Journal of Biological Chemistry. 287, 39, p. 32708-32716

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Uridine Diphosphate Glucose Dehydrogenase 100%
  • Enzyme Stability 82%
  • Congenital Heart Defects 65%
  • Heart Valves 62%
  • Valve 59%
  17 Citations (Scopus)
• 2011

  ALK2 mutation in a patient with Down's syndrome and a congenital heart defect

  Joziasse, I. C., Smith, K., Chocron, S., van Dinther, M., Guryev, V., van der Smagt, J. J., Cuppen, E., ten Dijke, P., Mulder, B. J. M., Maslen, C. L., Reshey, B., Doevendans, P. A. & Bakkers, J., 2011, In: European Journal of Human Genetics. 19, 4, p. 389-393

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Congenital Heart Defects 100%
  • Mutation 47%
  • Chromosomes, Human, Pair 21 44%
  • Bone Morphogenetic Proteins 41%
  • Partial atrioventricular canal 29%
  29 Citations (Scopus)

• Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish

  Smith, K., Noel, E., Thurlings, I., Rehmann, H., Chocron, S. & Bakkers, J., 2011, In: PLoS Genetics. 7, 9, p. 1002289

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Danio rerio 100%
  • Zebrafish 99%
  • mutation 96%
  • Embryonic Structures 59%
  • embryo 59%
  36 Citations (Scopus)

  570 Downloads (Pure)

• Macrophage development from HSCs requires PU.1-coordinated microRNA expression

  Ghani, S., Riemke, P., Schonheit, J., Lenze, D., Stumm, J., Hoogenkamp, M., Lagendijk, A. K., Heinz, S. K., Bonifer, C., Bakkers, J., Abdelilah-Seyfried, S., Hummel, M. & Rosenbauer, F., 2011, In: Blood. 118, 8, p. 2275-2284

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • MicroRNA 100%
  • MicroRNAs 68%
  • Macrophages 57%
  • Antagonist 50%
  • Pharmacological Metabolism 41%
  98 Citations (Scopus)

  757 Downloads (Pure)

• MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production

  Lagendijk, A. K., Goumans, M. J., Burkhard, S. B. & Bakkers, J., 2011, In: Circulation Research. 109, 6, p. 649-657

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Endocardial Cushions 100%
  • Heart Valves 68%
  • Hyaluronic Acid 63%
  • MicroRNAs 51%
  • Zebrafish 20%
  94 Citations (Scopus)

  790 Downloads (Pure)

• Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43

  Boogerd, C. J., Wong, L. Y., van den Boogaard, M., Bakker, M. A. J., Tessadori, F., Bakkers, J., 't Hoen, P. A. C., Moorman, A. F., Christoffels, V. M. & Barnett, P., 2011, In: Cellular and Molecular Life Sciences. 68, 23, p. 3949-3961

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Connexins 100%
  • Connexin 43 98%
  • T-Box Domain Proteins 62%
  • Zebrafish 54%
  • Heart 52%
  18 Citations (Scopus)

  209 Downloads (Pure)

• Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development

  Smith, K., Lagendijk, A. K., Courtney, A. D., Chen, H., Paterson, S., Hogan, B. M., Wicking, C. & Bakkers, J., 2011, In: Development. 138, 19, p. 4193-4198

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Canals 100%
  • canal 91%
  • Protein 88%
  • protein 71%
  • mutant 52%
  45 Citations (Scopus)

  300 Downloads (Pure)

• Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

  Verhoeven, M. C., Haase, C., Christoffels, V. M., Weidinger, G. & Bakkers, J., 2011, In: Birth Defects Research Part A: Clinical and Molecular Teratology. 91, 6, p. 435-440

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • beta Catenin 100%
  • Congenital Heart Defects 57%
  • Heart Valves 55%
  • Zebrafish 50%
  • Myocardium 40%
  50 Citations (Scopus)

• Zebrafish as a model to study cardiac development and human cardiac disease

  Bakkers, J., 2011, In: Cardiovascular Research. 91, 2, p. 279-288

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Human Development 100%
  • Zebrafish 94%
  • Heart Diseases 75%
  • Embryology 51%
  • Developmental Gene Expression Regulation 24%
  432 Citations (Scopus)

  437 Downloads (Pure)
• 2010

  CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

  Beqqali, A., Monshouwer-Kloots, J., Monteiro, R., Welling, M., Bakkers, J., Ehler, E., Verkleij, A. J., Mummery, C. L. & Passier, R., 2010, In: Journal of Cell Science. 123, Pt 7, p. 1141-1150

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Actins 100%
  • Myocardium 98%
  • Skeletal Muscle 93%
  • Heart 76%
  • Proteins 43%
  44 Citations (Scopus)
• 2009

  Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart.

  de Pater, E. M., Clijsters, L., Marques, S. R., Lin, Y. F., Garavito-Aguilar, Z. V., Yelon, D. & Bakkers, J., 2009, In: Development. 136, 10, p. 1633-1641

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • vertebrate 100%
  • animal 88%
  • Embryo 84%
  • regulation 76%
  • Animals 69%
  191 Citations (Scopus)

• Dominant-negative ALK2 allele associates with congenital heart defects.

  Smith, K., Joziasse, I. C., Chocron, S., van Dinther, M., Guryev, V., Verhoeven, M. C., Rehmann, H., van der Smagt, J. J., Doevendans, P. A., Cuppen, E., Mulder, B. J. M., ten Dijke, P. & Bakkers, J., 2009, In: Circulation. 119, 24, p. 3062-3069

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Congenital Heart Defects 100%
  • Single Nucleotide Polymorphism 71%
  • Bone Morphogenetic Protein Receptors 62%
  • Alleles 62%
  • Bone Morphogenetic Proteins 52%
  75 Citations (Scopus)

• Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

  Marques, I. J., Weiss, F. U., Vlecken, D. H., Nitsche, C., Bakkers, J., Lagendijk, A. K., Partecke, L. I., Heidecke, C. D., Lerch, M. M. & Bagowski, C. P., 2009, In: BMC Cancer. 9

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Heterologous Transplantation 100%
  • Zebrafish 79%
  • Neoplasm Micrometastasis 29%
  • Embryonic Structures 25%
  • Neoplasms 25%
  181 Citations (Scopus)

• Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis.

  Bakkers, J., Verhoeven, M. C. & Abdelilah-Seyfried, S., 2009, In: Developmental Biology. 330, 2, p. 213-220

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Zebrafish 100%
  • Morphogenesis 98%
  • Vertebrates 88%
  • Epithelium 75%
  • Heart 63%
  48 Citations (Scopus)
• 2008

  Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

  Krens, S. F. G., He, S., Lamers, G. E. M., Meijer, A. H., Bakkers, J., Schmidt, T., Spaink, H. P. & Snaar-Jagalska, B. E., 2008, In: Developmental Biology. 319, 2, p. 370-383

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Gastrulation 100%
  • Zebrafish 78%
  • Embryonic Development 70%
  • Cell Movement 63%
  • Messenger RNA 44%
  53 Citations (Scopus)

• Genes in congenital heart disease: atrioventricular valve formation.

  Joziasse, I. C., van de Smagt, J. J., Smith, K., Bakkers, J., Sieswerda, G. J., Mulder, B. J. M. & Doevendans, P. A., 2008, In: Basic Research in Cardiology. 103, 3, p. 216-227

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Heart Valve Diseases 100%
  • Genes 32%
  • Uridine Diphosphate Glucose Dehydrogenase 23%
  • Mutation 22%
  • Heart Diseases 21%
  43 Citations (Scopus)

• Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells.

  Smith, K., Chocron, S., von der Hardt, S., de Pater, E. M., Soufan, A., Bussmann, J., Schulte-Merker, S., Hammerschmidt, M. & Bakkers, J., 2008, In: Developmental Cell. 14, 2, p. 287-297

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Zebrafish 100%
  • Displacement 79%
  • Plate Like Crystal 76%
  • Stem Cells 72%
  • Heart 63%
  99 Citations (Scopus)

• Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish.

  Monteiro, R., van Dinther, M., Bakkers, J., Wilkinson, R., Patient, R., ten Dijke, P. & Mummery, C. L., 2008, In: Developmental Biology. 315, 1, p. 55-71

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Type II Bone Morphogenetic Protein Receptors 100%
  • Bone Morphogenetic Proteins 75%
  • Zebrafish 63%
  • Mesoderm 44%
  • Morpholinos 27%
  45 Citations (Scopus)

• Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex.

  Postel, R., Vakeel, P., Topczewski, J., Knoll, R. & Bakkers, J., 2008, In: Developmental Biology. 318, 1, p. 92-101

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • zebrafish ILK protein 100%
  • Laminin 43%
  • Integrins 37%
  • Skeletal Muscle 31%
  • Muscular Dystrophies 31%
  82 Citations (Scopus)
• 2006

  Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.

  Thijssen, V. L., Postel, R., Brandwijk, R. J., Dings, R. P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L. G., Bakkers, J., Mayo, K. H., Poirier, F. & Griffioen, A. W., 2006, Proceedings of the National Academy of Sciences of the United States of America. p. 15975-15980

  Research output: Chapter in book/volume › Contribution to conference proceedings › Scientific

  397 Citations (Scopus)

• Inter-laboratory comparison of three different real-time PCR assays for the detection of Pneumocystis jiroveci in bronchoalveolar lavage fluid samples.

  Linssen, C. F., Jacobs, J. A., Beckers, P., Templeton, K. E., Bakkers, J., Kuijper, E. J., Melchers, W. J., Drent, M. & Vink, C., 2006, In: Journal of Medical Microbiology. 55, Pt 9, p. 1229-1235

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Pneumocystis carinii 100%
  • Bronchoalveolar Lavage Fluid 81%
  • Real-Time Polymerase Chain Reaction 59%
  • Pneumocystis Pneumonia 47%
  • Microscopy 41%
  55 Citations (Scopus)

• Serotypes, genotypes, and antibiotic susceptibility profiles of group B streptococci causing neonatal sepsis and meningitis before and after introduction of antibiotic prophylaxis.

  Trijbels-Smeulders, M. A., Kimpen, J. L., Kollee, L. A., Bakkers, J., Melchers, W. J., Spanjaard, L., Wannet, W. J. & Hoogkamp-Korstanje, M. A., 2006, In: Pediatric Infectious Disease Journal. 25, 10, p. 945-948

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Infant, Newborn, Diseases 100%
  • Neonatal Sepsis 93%
  • Streptococcus agalactiae 86%
  • Antibiotic Prophylaxis 83%
  • Penicillins 71%
  15 Citations (Scopus)

• Zebrafish cypher is important for somite formation and heart development.

  van der Meer, D. L., Marques, I. J., Leito, J. T., Besser, J., Bakkers, J., Schoonheere, E. & Bagowski, C. P., 2006, In: Developmental Biology. 299, 2, p. 356-372

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Somites 100%
  • Zebrafish 77%
  • Heart 49%
  • PDZ Domains 35%
  • Embryonic Structures 20%
  46 Citations (Scopus)
• 2005

  Chlamydia trachomatis and genital human papillomavirus infections in female university students in Honduras.

  Tabora, N., Zelaya, A., Bakkers, J., Melchers, W. J. & Ferrera, A., 2005, In: The American Journal of Tropical Medicine and Hygiene. 73, 1, p. 50-53

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Honduras 100%
  • Papillomaviridae 89%
  • Chlamydia trachomatis 87%
  • Papillomavirus Infections 71%
  • college students 69%
  14 Citations (Scopus)