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2019

Astrocyte changes in the prefrontal cortex from aged non-suicidal depressed patients.

Qi, X-R., Kamphuis, W. & Shan, L., 2019, In : Frontiers in Cellular Neuroscience. 13, 503.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small songbird

Verhagen, I., Laine, V. N., Mateman, A. C., Pijl, A., de Wit, R., van Lith, B., Kamphuis, W., Viitaniemi, H. M., Williams, T. D., Caro, S. P., Meddle, S. L., Gienapp, P., van Oers, K. & Visser, M. E., 2019, In : Journal of Experimental Biology. 222, jeb.202481.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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NMNAT Proteins that Limit Wallerian Degeneration Also Regulate Critical Period Plasticity in the Visual Cortex

van Lier, M., Smit-Rigter, L., Krimpenfort, R., Saiepour, M. H., Ruimschotel, E., Kamphuis, W., Heimel, J. A. & Levelt, C. N., 06 Jan 2019, In : eNeuro. 6, 1, e0277-18.2018.

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2017

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

Jansen, A. H. P., van Hal, M., Op den Kelder, I. C., Meier, R. T., de Ruiter, A-A., Schut, M. H., Smith, D. L., Grit, C., Brouwer, N., Kamphuis, W., Boddeke, H. W. G. M., den Dunnen, W. F. A., van Roon, W. M. C., Bates, G. P., Hol, E. M. & Reits, E. A., 02 Jan 2017, In : GLIA. 65, p. 50-61

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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GFAPδ/GFAPα ratio directs astrocytoma gene expression towards a more malignant profile

Stassen, O. M. J. A., van Bodegraven, E. J., Giuliani, F., Moeton, M., Kanski, R., Sluijs, J. A., van Strien, M. E., Kamphuis, W., Robe, P. A. J. & Hol, E. M., Oct 2017, In : Oncotarget. 8, 50, p. 88104-88121 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., Hol, E. M., Kamphuis, W., Bayer, T. A., De Deyn, P. P. & Boddeke, E., 2017, In : Neurobiology of Aging. 55, p. 115-122

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2016

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

Osborn, L. M., Kamphuis, W., Wadman, W. J. & Hol, E. M., 2016, In : Progress in Neurobiology. 144, p. 121-141

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

Kamphuis, W., Kooijman, L., Schetters, S., Orre, M. & Hol, E. M., 2016, In : Biochimica et Biophysica Acta- Molecular Basis of Disease. 1862, p. 1847-1860

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2015

ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

Manzine, P. R., Marcello, E., Borroni, B., Kamphuis, W., Hol, E. M., Padovani, A., Nascimento, C. C., de Godoy Bueno, P., Assis Carvalho Vale, F., Iost Pavarini, S. C., Di Luca, M. & Cominetti, M. R., May 2015, In : Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 20, 3, p. 196-201 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Different stress-related gene expression in depression and suicide

Zhao, J., Qi, X-R., Gao, S-F., Lu, J., van Wamelen, D. J., Kamphuis, W., Bao, A-M. & Swaab, D. F., Sep 2015, In : Journal of Psychiatric Research. 68, p. 176-85 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

Kamphuis, W., Kooijman, L., Orre, M., Stassen, O., Pekny, M. & Hol, E. M., Jun 2015, In : GLIA. 63, 6, p. 1036-56 21 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2014

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

Orre, M., Kamphuis, W., Osborn, L. M., Melief, J., Kooijman, L., Huitinga, I., Klooster, J., Bossers, K. & Hol, E. M., Jan 2014, In : Neurobiology of Aging. 35, 1, p. 1-14 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Enteric GFAP expression and phosphorylation in Parkinson's disease

Clairembault, T., Kamphuis, W., Leclair-Visonneau, L., Rolli-Derkinderen, M., Coron, E., Neunlist, M., Hol, E. M. & Derkinderen, P., Sep 2014, In : Journal of Neurochemistry. 130, 6, p. 805-15 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

Kamphuis, W., Middeldorp, J., Kooijman, L., Sluijs, J. A., Kooi, E-J., Moeton, M., Freriks, M., Mizee, M. R. & Hol, E. M., Mar 2014, In : Neurobiology of Aging. 35, 3, p. 492-510 19 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer's disease

Végh, M. J., Heldring, C. M., Kamphuis, W., Hijazi, S., Timmerman, A. J., Li, K. W., van Nierop, P., Mansvelder, H. D., Hol, E. M., Smit, A. B. & van Kesteren, R. E., 2014, In : Acta neuropathologica communications. 2, p. 76

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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2013

Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients.

Qi, X. R., Kamphuis, W., Wang, S., Wang, Q., Lucassen, P. J., Zhou, J. N. & Swaab, D. F., 2013, In : Psychoneuroendocrinology. 38, p. 863-870

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model.

Wirz, K. T. S., Bossers, K., Stargardt, A., Kamphuis, W., Swaab, D. F., Hol, E. M. & Verhaagen, J., 2013, In : Neurobiology of Aging. 34, p. 11342-12328

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Reactive glia show increased immunoproteasome activity in Alzheimer's disease.

Orre, M., Kamphuis, W., Dooves, S., Kooijman, L., Chan, E. T., Kirk, C. J., Dimayuga Smith, V., Koot, S., Mamber, C., Jansen, A. H., Ovaa, H. & Hol, E. M., 2013, In : Brain: a journal of neurology. 136, p. 1415-1431

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Reduced amyloid beta degradation in early Alzheimer's diesease but not in the APPswePS1dE9 and 3xTg-AD mouse modles.

Stargardt, A., Gillis, J., Kamphuis, W., Wiemhoefer, A., Kooijman, L., Raspe, M., Benckhuijsen, W., Drijfhout, J. W., Hol, E. M. & Reits, E. A., 2013, In : Aging Cell. 12, p. 499-507

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Shades of grey: the delineation of marker expression within the adult rodent subvenricular zone.

Mamber, C., Kozareva, D. A., Kamphuis, W. & Hol, E. M., 2013, In : Progress in Neurobiology. 111, p. 1-16

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2012

Deep brain stimulation and the role of astrocytes.

Vedam-Mai, V., Van Battum, E. Y., Kamphuis, W., Feenstra, M. G. P., Denys, D., Reynolds, B. A., Okun, M. S. & Hol, E. M., 2012, In : Molecular Psychiatry. 17, p. 124-131

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differential cell proliferation in the cortex of the appseps1de9 Alzheimer's disease mouse model.

Kamphuis, W., Orre, M., Kooijman, L., Dahmen, M. & Hol, E. M., 2012, In : GLIA. 60, p. 615-629

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients.

Zhao, J., Bao, A. M., Qi, X. R., Kamphuis, W., Luchetti, S., Lou, J. S. & Swaab, D. F., 2012, In : Journal of Affective Disorders. 138, p. 494-502

Research output: Contribution to journal/periodicalArticleScientificpeer-review

GFAPdelta expression in glia of the developmental and adolescent mouse brain.

Mamber, C., Kamphuis, W., Haring, N. L., Peprah, N., Middeldorp, J. & Hol, E. M., 2012, In : PLoS One. 7, p. 52659

Research output: Contribution to journal/periodicalArticleScientificpeer-review

GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer's disease.

Kamphuis, W., Mamber, C., Moeton, M., Kooijman, L., Sluijs, J. A., Jansen, A. H., Verveer, M., De Groot, L. R., Smith, V., Rangarajan, S., Rodriguez, J., Orre, M. & Hol, E. M., 2012, In : PLoS One. 7, p. 42823

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Unravelling the actions of deep brain stimulation: potential role for astrocytes.

Vedam-Mai, V., Van Battum, E. Y., Kamphuis, W., Feenstra, M. G. P., Denys, D., Reynolds, B. A., Okun, M. S. & Hol, E. M., 2012, In : Molecular Psychiatry. 17, p. 115

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2011

A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid beta and elicits antibodies against oligomeric and fibrilar amyloid and plaques.

Hoogerhout, P., Kamphuis, W., Brugghe, H. F., Sluijs, J. A., Timmermans, H. A., Westdijk, J., Zomer, G., Boog, C. J., Hol, E. M. & Van den Dobbelsteen, G. P., 2011, In : PLoS One. 6, p. 19110

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.

Van Tijn, P., Kamphuis, W., Marlatt, M. W., Hol, E. M. & Lucassen, P. J., 2011, In : Progress in Neurobiology. 93, p. 149-164

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2010

Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression.

Zhou, T., Wang, S., Ren, H., Qi, X. R., Luchetti, S., Kamphuis, W., Zhou, J. N., Wang, G. & Swaab, D. F., 2010, In : Brain: a journal of neurology. 133, p. 3069-3079

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2009

Diabetes changes the levels of ionotropic glutamate receptors in the rat retina.

Santiago, A. R., Gaspar, J. M., Baptista, F. I., Cristovao, A. J., Santos, P. F., Kamphuis, W. & Ambrosio, A. F., 2009, In : Molecular Vision. 15, p. 1620-1630

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Intermediate filament transcription in astrocytes is repressed by proteasome inhibition.

Middeldorp, J., Kamphuis, W., Sluijs, J. A., Achoui, D., Leenaars, C. H. C., Feenstra, M. G. P., Van Tijn, P., Fischer, D. F., Berkers, C., Ovaa, H., Quinlan, R. A. & Hol, E. M., 2009, In : FASEB Journal. 23, p. 2710-2726

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2008

Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances.

Wang, S. S., Kamphuis, W., Huitinga, I., Zhou, J. N. & Swaab, D. F., 2008, In : Molecular Psychiatry. 13, 8, p. 786-799

Research output: Contribution to journal/periodicalArticleScientificpeer-review

pseudo-immunolabelling with the avidin-biotin-peroxidase complex due to the presence of endogenous biotin in the retina.

Kamphuis, W. & Klooster, J., 2008, In : Methods in Molecular Biology. 418, p. 129-138

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2005

Circadian expression of clock genes and clock-controlled genes in the rat retina.

Kamphuis, W., Cailotto, C., Dijk, F., Bergen, A. & Buijs, R. M., 2005, In : Biochemical and Biophysical Research Communications. 330, p. 18-26

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2002

Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: a comparison with lentiviral vectors

Harvey, A. R., Kamphuis, W., Eggers, R., Symons, N. A., Blits, B., Niclou, S., Boer, G. J. & Verhaagen, J., Sep 2002, In : Molecular and Cellular Neurosciences. 21, 1, p. 141-57 17 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

1987

The development of changes in hippocampal GABA immunoreactivity in the rat kindling model of epilepsy: a light microscopic study with GABA antibodies

Kamphuis, W., Wadman, W. J., Buijs, R. M. & Lopes da Silva, F. H., 1987, In : Neuroscience. 23, p. 433-446

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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1986

Decrease in number of hippocampal acid (GABA) immunoreactive cells in the rat kindling model of epilepsy

Kamphuis, W., Wadman, W. J., Buijs, R. M. & Lopes da Silva, F. H., 1986, In : Experimental Brain Research. 64, p. 491-495

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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1985

Loss of gamma-aminobutyric acid (GABA)-immunoreactivity in a kindling induced focus of epileptic activity

Kamphuis, W., Wadman, W. J., Buijs, R. M. & Lopes da Silva, F. H., 1985, In : Neuroscience Letters. 22

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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