Research output per year
Research output per year
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Dive into the research topics where Wouter de Laat is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands
Rouillon, C., Eckhardt, B. V., Kollenstart, L., Gruss, F., Verkennis, A. E. E., Rondeel, I., Krijger, P. H. L., Ricci, G., Biran, A., van Laar, T., Delvaux de Fenffe, C. M., Luppens, G., Albanese, P., Sato, K., Scheltema, R. A., de Laat, W., Knipscheer, P., Dekker, N. H., Groth, A. & Mattiroli, F., 08 May 2023, In: Nucleic Acids Research. 51, 8, p. 3770-3792 23 p.Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access15 Citations (Scopus) -
Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia
Smits, W. K., Vermeulen, C., Hagelaar, R., Kimura, S., Vroegindeweij, E. M., Buijs-Gladdines, J. G. C. A. M., van de Geer, E., Verstegen, M. J. A. M., Splinter, E., van Reijmersdal, S. V., Buijs, A., Galjart, N., van Eyndhoven, W., van Min, M., Kuiper, R., Kemmeren, P., Mullighan, C. G., de Laat, W. & Meijerink, J. P. P., 25 Apr 2023, In: Cell Reports. 42, 4, p. 112373Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access3 Citations (Scopus) -
Formalin-Fixed, Paraffin-Embedded-Targeted Locus Capture: A Next-Generation Sequencing Technology for Accurate DNA-Based Gene Fusion Detection in Bone and Soft Tissue Tumors
Stelloo, E., Meijers, R. W. J., Swennenhuis, J. F., Allahyar, A., Hajo, K., Cangiano, M., de Leng, W. W. J., van Helvert, S., Van der Meulen, J., Creytens, D., van Kempen, L. C., Cleton-Jansen, A-M., Bovee, J. V. M. G., de Laat, W., Splinter, E. & Feitsma, H., Oct 2023, In: The Journal of molecular diagnostics : JMD. 25, 10, p. 758-770 13 p.Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access3 Citations (Scopus) -
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes
Rinzema, N. J., Sofiadis, K., Tjalsma, S. J. D., Verstegen, M. J. A. M., Oz, Y., Valdes-Quezada, C., Felder, A-K., Filipovska, T., van der Elst, S., de Andrade Dos Ramos, Z., Han, R., Krijger, P. H. L. & de Laat, W., Jun 2022, In: Nature Structural & Molecular Biology. 29, 6, p. 563-574 12 p.Research output: Contribution to journal/periodical › Article › Scientific › peer-review
Open Access45 Citations (Scopus) -
Current challenges in understanding the role of enhancers in disease
Zaugg, J. B., Sahlén, P., Andersson, R., Alberich-Jorda, M., de Laat, W., Deplancke, B., Ferrer, J., Mandrup, S., Natoli, G., Plewczynski, D., Rada-Iglesias, A. & Spicuglia, S., 08 Dec 2022, (E-pub ahead of print) In: Nature Structural & Molecular Biology.Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific
Open Access28 Citations (Scopus)
Activities
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Dark Genome Symposium 2023
Wouter de Laat (Contributor)
13 Nov 2023Activity: Participating in or organising an event › Conference › Academic
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Forced linear enhancer recruitment reactivates genes and assigns function to intervening non-functional DNA sequences
Wouter de Laat (Invited speaker)
13 Nov 2023Activity: Talk or presentation › Academic
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CRISPR-Cas gen reparaties: nieuwe therapieën voor ernstig genetische ziektes
Wouter de Laat (Invited speaker)
26 Oct 2023Activity: Talk or presentation › Societal
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Long-range enhancer action: cohesin and distance matters
Wouter de Laat (Invited speaker)
19 Oct 2023Activity: Talk or presentation › Academic