20122019

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2012

Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex

Li, V. S., Ng, S. S., Boersema, P. J., Low, T. Y., Karthaus, W. R., Gerlach, J. P., Mohammed, S., Heck, A. J. R., Maurice, M. M., Mahmoudi, T. & Clevers, H., 2012, In : Cell. 149, 6, p. 1245-1256

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2014

Identification of multipotent luminal progenitor cells in human prostate organoid cultures

Karthaus, W. R., Iaquinta, P. J., Drost, J., Gracanin, A., van Boxtel, R., Wongvipat, J., Dowling, C. M., Gao, D., Begthel, H., Sachs, N., Vries, R. G. J., Cuppen, E., Chen, Y., Sawyers, C. L. & Clevers, H. C., 25 Sep 2014, In : Cell. 159, 1, p. 163-75 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Organoid cultures derived from patients with advanced prostate cancer

Gao, D., Vela, I., Sboner, A., Iaquinta, P. J., Karthaus, W. R., Gopalan, A., Dowling, C., Wanjala, J. N., Undvall, E. A., Arora, V. K., Wongvipat, J., Kossai, M., Ramazanoglu, S., Barboza, L. P., Di, W., Cao, Z., Zhang, Q. F., Sirota, I., Ran, L., MacDonald, T. Y. & 19 others, Beltran, H., Mosquera, J-M., Touijer, K. A., Scardino, P. T., Laudone, V. P., Curtis, K. R., Rathkopf, D. E., Morris, M. J., Danila, D. C., Slovin, S. F., Solomon, S. B., Eastham, J. A., Chi, P., Carver, B., Rubin, M. A., Scher, H. I., Clevers, H., Sawyers, C. L. & Chen, Y., 25 Sep 2014, In : Cell. 159, 1, p. 176-87 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ

Farin, H. F., Karthaus, W. R., Kujala, P., Rakhshandehroo, M., Schwank, G., Vries, R. G. J., Kalkhoven, E., Nieuwenhuis, E. E. S. & Clevers, H., 30 Jun 2014, In : Journal of Experimental Medicine. 211, 7, p. 1393-405 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2015

Efficient intracellular delivery of native proteins

D'Astolfo, D. S., Pagliero, R. J., Pras, A., Karthaus, W. R., Clevers, H., Prasad, V., Lebbink, R. J., Rehmann, H. & Geijsen, N., 23 Apr 2015, In : Cell. 161, 3, p. 674-90 17 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors

Agarwal, S., Hynes, P. G., Tillman, H. S., Lake, R., Abou-Kheir, W. G., Fang, L., Casey, O. M., Ameri, A. H., Martin, P. L., Yin, J. J., Iaquinta, P. J., Karthaus, W. R., Clevers, H. C., Sawyers, C. L. & Kelly, K., 15 Dec 2015, In : Cell Reports. 13, 10, p. 2147-58 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2016

Organoid culture systems for prostate epithelial and cancer tissue

Drost, J., Karthaus, W. R., Gao, D., Driehuis, E., Sawyers, C. L., Chen, Y. & Clevers, H., Feb 2016, In : Nature Protocols. 11, 2, p. 347-58 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon

Sasaki, N., Sachs, N., Wiebrands, K., Ellenbroek, S. I. J., Fumagalli, A., Lyubimova, A., Begthel, H., van den Born, M., van Es, J. H., Karthaus, W. R., Li, V. S. W., López-Iglesias, C., Peters, P. J., van Rheenen, J., van Oudenaarden, A. & Clevers, H., 29 Aug 2016, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2019

A rectal cancer organoid platform to study individual responses to chemoradiation

Ganesh, K., Wu, C., O'Rourke, K. P., Szeglin, B. C., Zheng, Y., Sauvé, C-E. G., Adileh, M., Wasserman, I., Marco, M. R., Kim, A. S., Shady, M., Sanchez-Vega, F., Karthaus, W. R., Won, H. H., Choi, S-H., Pelossof, R., Barlas, A., Ntiamoah, P., Pappou, E., Elghouayel, A. & 30 others, Strong, J. S., Chen, C-T., Harris, J. W., Weiser, M. R., Nash, G. M., Guillem, J. G., Wei, I. H., Kolesnick, R. N., Veeraraghavan, H., Ortiz, E. J., Petkovska, I., Cercek, A., Manova-Todorova, K. O., Saltz, L. B., Lavery, J. A., DeMatteo, R. P., Massagué, J., Paty, P. B., Yaeger, R., Chen, X., Patil, S., Clevers, H., Berger, M. F., Lowe, S. W., Shia, J., Romesser, P. B., Dow, L. E., Garcia-Aguilar, J., Sawyers, C. L. & Smith, J. J., Oct 2019, In : Nature Medicine. 25, 10, p. 1607-1614 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review