A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli

Wouter van Elzelingen; Jessica Goedhoop; Pascal Warnaar; Damiaan Denys; Tara Arbab; Ingo Willuhn

doi:10.1073/pnas.2117270119

A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli

Wouter van Elzelingen, Jessica Goedhoop, Pascal Warnaar, Damiaan Denys, Tara Arbab, Ingo Willuhn

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

SignificanceAlthough it is undisputed that striatal dopamine plays a prominent role in motivated behavior and learning, the precise information conveyed by dopamine signals as such is under active debate. For a long time, the idea dominated that dopamine encodes a reward prediction error and that this signal is broadcast uniformly throughout the brain. However, here, we capture dopamine dynamics across many striatal regions and demonstrate that dopamine release is, regionally, extremely heterogeneous and that a reward prediction error-like signal is predominantly found in the relatively small limbic domain of the striatum. Another striking organizing principle is that stimulus valence directs dopamine concentration homogeneously across all regions (i.e., appetitive stimuli increase dopamine and aversive stimuli decrease dopamine).

Original language	English
Pages (from-to)	e2117270119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	21
DOIs	https://doi.org/10.1073/pnas.2117270119
Publication status	Published - 24 May 2022

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title = "A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli",

abstract = "SignificanceAlthough it is undisputed that striatal dopamine plays a prominent role in motivated behavior and learning, the precise information conveyed by dopamine signals as such is under active debate. For a long time, the idea dominated that dopamine encodes a reward prediction error and that this signal is broadcast uniformly throughout the brain. However, here, we capture dopamine dynamics across many striatal regions and demonstrate that dopamine release is, regionally, extremely heterogeneous and that a reward prediction error-like signal is predominantly found in the relatively small limbic domain of the striatum. Another striking organizing principle is that stimulus valence directs dopamine concentration homogeneously across all regions (i.e., appetitive stimuli increase dopamine and aversive stimuli decrease dopamine).",

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A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli. / van Elzelingen, Wouter; Goedhoop, Jessica; Warnaar, Pascal et al.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 21, 24.05.2022, p. e2117270119.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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AU - van Elzelingen, Wouter

AU - Goedhoop, Jessica

AU - Warnaar, Pascal

AU - Denys, Damiaan

AU - Arbab, Tara

AU - Willuhn, Ingo

PY - 2022/5/24

Y1 - 2022/5/24

N2 - SignificanceAlthough it is undisputed that striatal dopamine plays a prominent role in motivated behavior and learning, the precise information conveyed by dopamine signals as such is under active debate. For a long time, the idea dominated that dopamine encodes a reward prediction error and that this signal is broadcast uniformly throughout the brain. However, here, we capture dopamine dynamics across many striatal regions and demonstrate that dopamine release is, regionally, extremely heterogeneous and that a reward prediction error-like signal is predominantly found in the relatively small limbic domain of the striatum. Another striking organizing principle is that stimulus valence directs dopamine concentration homogeneously across all regions (i.e., appetitive stimuli increase dopamine and aversive stimuli decrease dopamine).

AB - SignificanceAlthough it is undisputed that striatal dopamine plays a prominent role in motivated behavior and learning, the precise information conveyed by dopamine signals as such is under active debate. For a long time, the idea dominated that dopamine encodes a reward prediction error and that this signal is broadcast uniformly throughout the brain. However, here, we capture dopamine dynamics across many striatal regions and demonstrate that dopamine release is, regionally, extremely heterogeneous and that a reward prediction error-like signal is predominantly found in the relatively small limbic domain of the striatum. Another striking organizing principle is that stimulus valence directs dopamine concentration homogeneously across all regions (i.e., appetitive stimuli increase dopamine and aversive stimuli decrease dopamine).

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JF - Proceedings of the National Academy of Sciences of the United States of America

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A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli

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