#3 A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior.

M Ahmadlou, J.H.W. Houba, J.F.M. Van Vierbergen, M. Giannouli, G.A. Gimenez, C. Van Weeghel, M. Darbanfouladi, M.Y. Shirazi, J. Dziubek, M. Kacem, Fred De Winter, J.A. Heimel

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Exploring the physical and social environment is essential for understanding the surrounding world. We do not know how novelty-seeking motivation initiates the complex sequence of actions that make up investigatory behavior. We found in mice that inhibitory neurons in the medial zona incerta (ZIm), a subthalamic brain region, are essential for the decision to investigate an object or a conspecific. These neurons receive excitatory input from the prelimbic cortex to signal the initiation of exploration. This signal is modulated in the ZIm by the level of investigatory motivation. Increased activity in the ZIm instigates deep investigative action by inhibiting the periaqueductal gray region. A subpopulation of inhibitory ZIm neurons expressing tachykinin 1 (TAC1) modulates the investigatory behavior.
Original languageEnglish
Article numbereabe9681
JournalScience
Volume372
Publication statusPublished - 14 May 2021

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