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  • Jeroen Bakkers
2019

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

Smeland, M. F., McClenaghan, C., Roessler, H. I., Savelberg, S., Hansen, G. Å. M., Hjellnes, H., Arntzen, K. A., Müller, K. I., Dybesland, A. R., Harter, T., Sala-Rabanal, M., Emfinger, C. H., Huang, Y., Singareddy, S. S., Gunn, J., Wozniak, D. F., Kovacs, A., Massink, M., Tessadori, F., Kamel, S. M. & 5 others, Bakkers, J., Remedi, M. S., Van Ghelue, M., Nichols, C. G. & van Haaften, G., 01 Oct 2019, In : Nature Communications. 10, 1, p. 4457

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder

Tessadori, F., Rehman, A. U., Giltay, J. C., Xia, F., Streff, H., Duran, K., Bakkers, J., Lalani, S. R. & van Haaften, G., 05 Dec 2019, In : European Journal of Human Genetics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies

Laarman, M. D., Kleinloog, R., Bakker, M. K., Rinkel, G. J. E., Bakkers, J. & Ruigrok, Y. M., Oct 2019, In : Stroke. 50, 10, p. 2933-2936 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes

07 May 2019, In : Journal of the American Heart Association. 8, 9, p. e011201

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Chromatin conformation links putative enhancers in intracranial aneurysm-associated regions to potential candidate genes.

Laarman, M., Geeven, G., Barnett, P., Rinkel, G. J. E., de Laat, W., Ruigrok, Y. M. & Bakkers, J., 2019, In : Journal of the American Heart Association. 8, e011201.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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91 Downloads (Pure)

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program

van Duijvenboden, K., de Bakker, D. E. M., Man, J. C. K., Janssen, R., Günthel, M., Hill, M. C., Hooijkaas, I. B., van der Made, I., van der Kraak, P. H., Vink, A., Creemers, E. E., Martin, J. F., Barnett, P., Bakkers, J. & Christoffels, V. M., 09 Sep 2019, In : Circulation. 140, 10, p. 864-879 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh)

Veerman, C. C., Mengarelli, I., Koopman, C. D., Wilders, R., van Amersfoorth, S. C., Bakker, D., Wolswinkel, R., Hababa, M., de Boer, T. P., Guan, K., Milnes, J., Lodder, E. M., Bakkers, J., Verkerk, A. O. & Bezzina, C. R., 09 Jul 2019, In : Disease Models & Mechanisms. 12, 7

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation

van den Boogaard, M., van Weerd, J. H., Bawazeer, A. C., Hooijkaas, I. B., van de Werken, H. J. G., Tessadori, F., de Laat, W., Barnett, P., Bakkers, J. & Christoffels, V. M., 03 Sep 2019, In : Cell Reports. 28, 10, p. 2704-2714.e5

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Identification of human D lactate dehydrogenase deficiency

Monroe, G. R., van Eerde, A. M., Tessadori, F., Duran, K. J., Savelberg, S. M. C., van Alfen, J. C., Terhal, P. A., van der Crabben, S. N., Lichtenbelt, K. D., Fuchs, S. A., Gerrits, J., van Roosmalen, M. J., van Gassen, K. L., van Aalderen, M., Koot, B. G., Oostendorp, M., Duran, M., Visser, G., de Koning, T. J., Calì, F. & 8 others, Bosco, P., Geleijns, K., de Sain-van der Velden, M. G. M., Knoers, N. V., Bakkers, J., Verhoeven-Duif, N. M., van Haaften, G. & Jans, J. J., 01 Apr 2019, In : Nature Communications. 10, 1, p. 1477

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development

Chrispijn, N. D., Elurbe, D. M., Mickoleit, M., Aben, M., de Bakker, D. E. M., Andralojc, K. M., Huisken, J., Bakkers, J. & Kamminga, L. M., 13 Mar 2019, In : Scientific Reports. 9, 1, p. 4327

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TPF-beta Signaling and Epigenomics

Piche, J., Gosset, N., Legault, L-M., Pacis, A., Oneglia, A., Caron, M., Chetaille, P., Barreiro, L., Liu, D., Qi, X., Nattel, S., Leclerc, S., Breton-Larrivee, M., McGraw, S., Andelfinger, G., Bakkers, J., Loeys, B. & Puceat, M., 2019, In : CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 7, 2, p. 411-431

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations

Ciapaite, J., Albersen, M., Savelberg, S. M. C., Bosma, M., Tessadori, F., Gerrits, J., Lansu, N., Zwakenberg, S., Bakkers, J. P. W., Zwartkruis, F. J. T., van Haaften, G., Jans, J. J. & Verhoeven-Duif, N. M., 21 Nov 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. p. 165607

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Honkoop, H., de Bakker, D. E., Aharonov, A., Kruse, F., Shakked, A., Nguyen, P. D., de Heus, C., Garric, L., Muraro, M. J., Shoffner, A., Tessadori, F., Peterson, J. C., Noort, W., Bertozzi, A., Weidinger, G., Posthuma, G., Grun, D., van der Laarse, W. J., Klumperman, J., Jaspers, R. T. & 4 others, Poss, K. D., van Oudenaarden, A., Tzahor, E. & Bakkers, J., 23 Dec 2019, In : eLife. 8

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2018

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

Tessadori, F., Roessler, H. I., Savelberg, S. M. C., Chocron, S., Kamel, S. M., Duran, K. J., van Haelst, M. M., van Haaften, G. & Bakkers, J., 18 Oct 2018, In : Disease Models & Mechanisms. 11, 10

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

Rumping, L., Tessadori, F., Pouwels, P. J., Vringer, E., Wijnen, J. P., Bhogal, A. A., Savelberg, S. M., Duran, K. J., Bakkers, M. J., Ramos, R. J., Schellekens, P. A., Kroes, H. Y., Klomp, D. W., Black, G. C., Taylor, R. L., Bakkers, J. P., Prinsen, H. C., Knaap, M. S., Dansen, T. B., Rehmann, H. & 6 others, Zwartkruis, F. J., Houwen, R. H., Haaften, G., Verhoeven-Duif, N. M., Jans, J. J. & Hasselt, P. M., 2018, In : Human Molecular Genetics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis

Laarman, M. D., Vermunt, M. W. & Ruigrok, Y. M., Feb 2018, In : Stroke. 49, 2, p. 447-453 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
File
190 Downloads (Pure)

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo

Sala, L., van Meer, B. J., Tertoolen, L. T., Bakkers, J., Bellin, M., Davis, R. P., Denning, C. N., Dieben, M. A., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E., Jongbloed, M. R., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P., Mosqueira, D. & 7 others, Orlova, V. V., Passier, R., Ribeiro, M. C., Saleem, U., Smith, G., Burton, F. L. L. & Mummery, C. L., 02 Feb 2018, In : Circulation Research.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis

van Opbergen, C. J. M., Koopman, C. D., Kok, B. J. M., Knöpfel, T., Renninger, S. L., Orger, M. B., Vos, M. A., van Veen, T. A. B., Bakkers, J. & de Boer, T. P., 2018, In : Theranostics. 8, 17, p. 4750-4764 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Shaping up with morphogen gradients

Garric, L. & Bakkers, J., Sep 2018, In : Nature Cell Biology. 20, 9, p. 998-999 2 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate

Burkhard, S. B. & Bakkers, J., 05 Feb 2018, In : eLife. 7

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome

Kievit, A., Tessadori, F., Douben, H., Jordens, I., Maurice, M., Hoogeboom, J., Hennekam, R., Nampoothiri, S., Kayserili, H., Castori, M., Whiteford, M., Motter, C., Melver, C., Cunningham, M., Hing, A., Kokitsu-Nakata, N. M., Vendramini-Pittoli, S., Richieri-Costa, A., Baas, A. F., Breugem, C. C. & 17 others, Duran, K., Massink, M., Derksen, P. W. B., van IJcken, W. F. J., van Unen, L., Santos-Simarro, F., Lapunzina, P., Gil-da Silva Lopes, V. L., Lustosa-Mendes, E., Krall, M., Slavotinek, A., Martinez-Glez, V., Bakkers, J., van Gassen, K. L. I., de Klein, A., van den Boogaard, M-J. H. & van Haaften, G., Feb 2018, In : European Journal of Human Genetics. 26, 2, p. 210-219 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2017

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control

Tessadori, F., Giltay, J. C., Hurst, J. A., Massink, M. P., Duran, K., Vos, H. R., van Es, R. M., Scott, R. H., van Gassen, K. L. I., Bakkers, J. & van Haaften, G., Nov 2017, In : Nature Genetics. 49, 11, p. 1642-1646 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

On the Evolution of the Cardiac Pacemaker

Burkhard, S., van Eif, V., Garric, L., Christoffels, V. M. & Bakkers, J., 27 Apr 2017, In : Journal of Cardiovascular Development and Disease. 4, 2, p. 4 1 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

De Angelis, J. E., Lagendijk, A. K., Chen, H., Tromp, A., Bower, N. I., Tunny, K. A., Brooks, A. J., Bakkers, J., Francois, M., Yap, A. S., Simons, C., Wicking, C., Hogan, B. M. & Smith, K. A., 23 Jan 2017, In : Developmental Cell. 40, 2, p. 123-136 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

De Angelis, J. E., Lagendijk, A. K., Chen, H., Tromp, A., Bower, N. I., Tunny, K. A., Brooks, A. J., Bakkers, J., Francois, M., Yap, A. S., Simons, C., Wicking, C., Hogan, B. M. & Smith, K. A., 27 Feb 2017, In : Developmental Cell. 40, 4, p. 421

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Twists and turns

Noël, E. S. & Bakkers, J., 28 Nov 2017, In : eLife. 6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2016

A zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals its Specific Role in Laterality Organ Function

Noël, E. S., Momenah, T. S., Al-Dagriri, K., Al-Suwaid, A., Al-Shahrani, S., Jiang, H., Willekers, S., Oostveen, Y. Y., Chocron, S., Postma, A. V., Bhuiyan, Z. A. & Bakkers, J., Feb 2016, In : Human Mutation.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

Lodder, E. M., De Nittis, P., Koopman, C. D., Wiszniewski, W., Moura de Souza, C. F., Lahrouchi, N., Guex, N., Napolioni, V., Tessadori, F., Beekman, L., Nannenberg, E. A., Boualla, L., Blom, N. A., de Graaff, W., Kamermans, M., Cocciadiferro, D., Malerba, N., Mandriani, B., Akdemir, Z. H. C., Fish, R. J. & 13 others, Eldomery, M. K., Ratbi, I., Wilde, A. A. M., de Boer, T., Simonds, W. F., Neerman-Arbez, M., Sutton, V. R., Kok, F., Lupski, J. R., Reymond, A., Bezzina, C. R., Bakkers, J. & Merla, G., 2016, In : American Journal of Human Genetics. 99, p. 704-710

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

Lodder, E. M., De Nittis, P., Koopman, C. D., Wiszniewski, W., Moura de Souza, C. F., Lahrouchi, N., Guex, N., Napolioni, V., Tessadori, F., Beekman, L., Nannenberg, E. A., Boualla, L., Blom, N. A., de Graaff, W., Kamermans, M., Cocciadiferro, D., Malerba, N., Mandriani, B., Coban Akdemir, Z. H., Fish, R. J. & 13 others, Eldomery, M. K., Ratbi, I., Wilde, A. A. M., de Boer, T., Simonds, W. F., Neerman-Arbez, M., Sutton, V. R., Kok, F., Lupski, J. R., Reymond, A., Bezzina, C. R., Bakkers, J. & Merla, G., 01 Sep 2016, In : American Journal of Human Genetics. 99, 3, p. 786

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity

Josifova, D. J., Monroe, G. R., Tessadori, F., de Graaff, E., van der Zwaag, B., Mehta, S. G., Harakalova, M., Duran, K. J., Savelberg, S. M. C., Nijman, I. J., Jungbluth, H., Hoogenraad, C. C., Bakkers, J., Knoers, N. V., Firth, H. V., Beales, P. L., van Haaften, G. & van Haelst, M. M., 22 Mar 2016, In : Human Molecular Genetics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2

San, B., Chrispijn, N. D., Wittkopp, N., van Heeringen, S. J., Lagendijk, A. K., Aben, M., Bakkers, J., Ketting, R. F. & Kamminga, L. M., 2016, In : Scientific Reports. 6, p. 24658

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Rare novel variants in the ZIC3 gene cause X-linked heterotaxy

Paulussen, A. D. C., Steyls, A., Vanoevelen, J., van Tienen, F. H., Krapels, I. P. C., Claes, G. R., Chocron, S., Velter, C., Tan-Sindhunata, G. M., Lundin, C., Valenzuela, I., Nagy, B., Bache, I., Maroun, L. L., Avela, K., Brunner, H. G., Smeets, H. J. M., Bakkers, J. & van den Wijngaard, A., 13 Jul 2016, In : European Journal of Human Genetics.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

Wu, C-C., Kruse, F., Vasudevarao, M. D., Junker, J. P., Zebrowski, D. C., Fischer, K., Noël, E. S., Grün, D., Berezikov, E., Engel, F. B., van Oudenaarden, A., Weidinger, G. & Bakkers, J., 11 Jan 2016, In : Developmental Cell. 36, 1, p. 36-49 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tomo-seq: A method to obtain genome-wide expression data with spatial resolution

Kruse, F., Junker, J. P., van Oudenaarden, A. & Bakkers, J., 2016, In : Methods in Cell Biology. 135, p. 299-307 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish

Han, M. K. L., Hoijman, E., Nöel, E., Garric, L., Bakkers, J. & de Rooij, J., 2016, In : Biology Open. 5, 10, p. 1461-1472 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2015

Animal and in silico models for the study of sarcomeric cardiomyopathies

Duncker, D. J., Bakkers, J., Brundel, B. J., Robbins, J., Tardiff, J. C. & Carrier, L., 01 Apr 2015, In : Cardiovascular Research. 105, 4, p. 439-448 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies

Ramspacher, C., Steed, E., Boselli, F., Ferreira, R., Faggianelli, N., Roth, S., Spiegelhalter, C., Messaddeq, N., Trinh, L., Liebling, M., Chacko, N., Tessadori, F., Bakkers, J., Laporte, J., Hnia, K. & Vermot, J., 16 Jun 2015, In : Cell Reports. 11, 10, p. 1564-76 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish

Jiménez-Amilburu, V., Jong-Raadsen, S., Bakkers, J., Spaink, H. P. & Marín-Juez, R., Jan 2015, In : The Journal of endocrinology. 224, 1, p. 1-15 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling

Strate, I., Tessadori, F. & Bakkers, J., 15 May 2015, In : Development. 142, 10, p. 1767-76 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Nodal signaling range is regulated by proprotein convertase-mediated maturation

Tessadori, F., Noël, E. S., Rens, E. G., Magliozzi, R., Evers-van Gogh, I. J. A., Guardavaccaro, D., Merks, R. M. H. & Bakkers, J., 09 Mar 2015, In : Developmental Cell. 32, 5, p. 631-9 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes

Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A. T., Wolfe, L. A., Tifft, C. J., Zerfas, P. M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M. G. & 27 others, Lee, C-C. R., Ferraz, V., da Silva, E. M., Stevens, C. A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B. P., Maduro, V., Dallapiccola, B., Ramos, F. J., Chung, H-Y. B., Le Caignec, C., Martins, F., Jacyk, W. K., Mazzanti, L., Brunner, H. G., Bakkers, J., Lin, S., Malicdan, M. C. V., Boerkoel, C. F., Gahl, W. A., de Vries, B. B. A., van Haelst, M. M., Zenker, M. & Markello, T. C., 02 Jul 2015, In : American Journal of Human Genetics. 97, 1, p. 99-110 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2014

Genome-wide RNA Tomography in the zebrafish embryo

Junker, J. P., Noël, E. S., Guryev, V., Peterson, K. A., Shah, G., Huisken, J., McMahon, A. P., Berezikov, E., Bakkers, J. & van Oudenaarden, A., 23 Oct 2014, In : Cell. 159, 3, p. 662-75 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

Chetaille, P., Preuss, C., Burkhard, S., Côté, J-M., Houde, C., Castilloux, J., Piché, J., Gosset, N., Leclerc, S., Wünnemann, F., Thibeault, M., Gagnon, C., Galli, A., Tuck, E., Hickson, G. R., El Amine, N., Boufaied, I., Lemyre, E., de Santa Barbara, P., Faure, S. & 13 others, Jonzon, A., Cameron, M., Dietz, H. C., Gallo-McFarlane, E., Benson, D. W., Moreau, C., Labuda, D., Zhan, S. H., Shen, Y., Jomphe, M., Jones, S. J. M., Bakkers, J. & Andelfinger, G., Nov 2014, In : Nature Genetics. 46, 11, p. 1245-9 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

Bonetti, M., Paardekooper Overman, J., Tessadori, F., Noël, E., Bakkers, J. & den Hertog, J., May 2014, In : Development. 141, 9, p. 1961-70 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2013

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

Noel, E. S., Verhoeven, M., Lagendijk, A. K., Tessadori, F., Smith, K., Choorapoikayil, S., den Hertog, J. & Bakkers, J., 2013, In : Nature Communications. 4, p. 2754

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

Lagendijk, A. K., Szabo, A., Merks, R. M. & Bakkers, J., 2013, In : Trends in Cardiovascular Medicine. 23, 5, p. 135-142

Research output: Contribution to journal/periodicalArticleScientificpeer-review

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling

Goudarzi, M., Strate, I., Paksa, A., Lagendijk, A. K., Bakkers, J. & Raz, E., 2013, In : Nature Genetics. 45, 11, p. 1264-1265

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis

Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, L., Murphy, M. P., Medana, C., Stainier, D. Y., Bakkers, J. & Santoro, M. M., 2013, In : Cell. 152, 3, p. 504-518

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2012

Bmp signaling exerts opposite effects on cardiac differentiation

de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., Strate, I., Smith, K., Lagendijk, A. K., Schilling, T. F., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M. & Bakkers, J., 2012, In : Circulation Research. 110, 4, p. 578-587

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

van den Boogaard, M., Wong, L. Y., Tessadori, F., Bakker, M. L., Dreizehnter, L. K., Wakker, V., Bezzina, C. R., 't Hoen, P. A., Bakkers, J., Barnett, P. & Christoffels, V. M., 2012, In : Journal of Clinical Investigation. 122, 7, p. 2519-2530

Research output: Contribution to journal/periodicalArticleScientificpeer-review