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  • Hans Clevers
2020

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Calandrini, C., Schutgens, F., Oka, R., Margaritis, T., Candelli, T., Mathijsen, L., Ammerlaan, C., van Ineveld, R. L., Derakhshan, S., de Haan, S., Dolman, E., Lijnzaad, P., Custers, L., Begthel, H., Kerstens, H. H. D., Visser, L. L., Rookmaaker, M., Verhaar, M., Tytgat, G. A. M., Kemmeren, P. & 11 others, de Krijger, R. R., Al-Saadi, R., Pritchard-Jones, K., Kool, M., Rios, A. C., van den Heuvel-Eibrink, M. M., Molenaar, J. J., van Boxtel, R., Holstege, F. C. P., Clevers, H. & Drost, J., 11 Mar 2020, In : Nature Communications. 11, 1, p. 1310

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing

Artegiani, B., Hendriks, D., Beumer, J., Kok, R., Zheng, X., Joore, I., Chuva de Sousa Lopes, S., van Zon, J., Tans, S. & Clevers, H., Mar 2020, In : Nature Cell Biology. 22, 3, p. 321-331 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

Ringel, T., Frey, N., Ringnalda, F., Janjuha, S., Cherkaoui, S., Butz, S., Srivatsa, S., Pirkl, M., Russo, G., Villiger, L., Rogler, G., Clevers, H., Beerenwinkel, N., Zamboni, N., Baubec, T. & Schwank, G., 05 Mar 2020, In : Cell Stem Cell. 26, 3, p. 431-440.e8

Research output: Contribution to journal/periodicalArticleScientificpeer-review

How the COVID-19 pandemic highlights the necessity of animal research

Genzel, L., Adan, R., Berns, A., van den Beucken, J., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., Dam, A-M. V., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., Fentener van Vlissingen, J. M. & 62 others, la Fleur, S., Fouchier, R., Fitzsimons, C. P., Frieling, W., Haagmans, B., Heesters, B. A., Henckens, M., Herfst, S., Hol, E., van den Hove, D., de Jonge, M. I., Jonkers, J., Joosten, L. A. B., Kalsbeek, A., Kamermans, M., Kampinga, H. H., Kas, M. J., Keijer, J., Kersten, S., Kiliaan, A. J., Kooij, T. W. A., Kooijman, S., Koopman, W. J. H., Korosi, A., Krugers, H. J., Kuiken, T., Kushner, S. A., Langermans, J. A. M., Lesscher, H., Lucassen, P. J., Lutgens, E., Netea, M. G., Noldus, L. P. J. J., van der Meer, J. W. M., Meye, F. J., Mul, J. D., van Oers, K., Olivier, J. D. A., Pasterkamp, R. J., Philippens, I. H. C. H. M., Prickaerts, J., Pullox, B., Rensen, P. C. N., van Rheenen, J., van Rij, R. P., Ritsma, L., Rockx, B. H. G., Roozendaal, B., van Schothorst, E. M., Stittelaar, K., Stockhofe, N., Swaab, D. F., de Swart, R. L., Vanderschuren, L. J. M. J., de Vries, T., de Vrij, F., van Wezel, R., Wierenga, C. J., Wiesmann, M., Willuhn, I., de Zeeuw, C. I. & Homberg, J. R., 10 Aug 2020, In : Current Biology. 30, 18, p. R1014-R1018 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors

Wang, D., Wang, J., Bai, L., Pan, H., Feng, H., Clevers, H. & Zeng, Y. A., 19 Mar 2020, In : Cell. 180, 6, p. 1198-1211.e19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Rosenbluth, J. M., Schackmann, R. C. J., Gray, G. K., Selfors, L. M., Li, C. M-C., Boedicker, M., Kuiken, H. J., Richardson, A., Brock, J., Garber, J., Dillon, D., Sachs, N., Clevers, H. & Brugge, J. S., 06 Apr 2020, In : Nature Communications. 11, 1, p. 1711

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies

Battich, N., Beumer, J., de Barbanson, B., Krenning, L., Baron, C. S., Tanenbaum, M. E., Clevers, H. & van Oudenaarden, A., 06 Mar 2020, In : Science. 367, 6482, p. 1151-1156 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Snake Venom Gland Organoids

Post, Y., Puschhof, J., Beumer, J., Kerkkamp, H. M., de Bakker, M. A. G., Slagboom, J., de Barbanson, B., Wevers, N. R., Spijkers, X. M., Olivier, T., Kazandjian, T. D., Ainsworth, S., Iglesias, C. L., van de Wetering, W. J., Heinz, M. C., van Ineveld, R. L., van Kleef, R. G. D. M., Begthel, H., Korving, J., Bar-Ephraim, Y. E. & 11 others, Getreuer, W., Rios, A. C., Westerink, R. H. S., Snippert, H. J. G., van Oudenaarden, A., Peters, P. J., Vonk, F. J., Kool, J., Richardson, M. K., Casewell, N. R. & Clevers, H., 23 Jan 2020, In : Cell. 180, 2, p. 233-247.e21

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies

Busslinger, G. A., Lissendorp, F., Franken, I. A., van Hillegersberg, R., Ruurda, J. P., Clevers, H. & de Maat, M. F. G., Apr 2020, In : Open Biology. 10, 4, p. 190274

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2019

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance

Li, N., Babaei-Jadidi, R., Lorenzi, F., Spencer-Dene, B., Clarke, P., Domingo, E., Tulchinsky, E., Vries, R. G. J., Kerr, D., Pan, Y., He, Y., Bates, D. O., Tomlinson, I., Clevers, H. & Nateri, A. S., 19 Feb 2019, In : Oncogenesis. 8, 3, p. 13

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Kopper, O., de Witte, C. J., Lõhmussaar, K., Valle-Inclan, J. E., Hami, N., Kester, L., Balgobind, A. V., Korving, J., Proost, N., Begthel, H., van Wijk, L. M., Revilla, S. A., Theeuwsen, R., van de Ven, M., van Roosmalen, M. J., Ponsioen, B., Ho, V. W. H., Neel, B. G., Bosse, T., Gaarenstroom, K. N. & 11 others, Vrieling, H., Vreeswijk, M. P. G., van Diest, P. J., Witteveen, P. O., Jonges, T., Bos, J. L., van Oudenaarden, A., Zweemer, R. P., Snippert, H. J. G., Kloosterman, W. P. & Clevers, H., May 2019, In : Nature Medicine. 25, 5, p. 838-849 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A rectal cancer organoid platform to study individual responses to chemoradiation

Ganesh, K., Wu, C., O'Rourke, K. P., Szeglin, B. C., Zheng, Y., Sauvé, C-E. G., Adileh, M., Wasserman, I., Marco, M. R., Kim, A. S., Shady, M., Sanchez-Vega, F., Karthaus, W. R., Won, H. H., Choi, S-H., Pelossof, R., Barlas, A., Ntiamoah, P., Pappou, E., Elghouayel, A. & 30 others, Strong, J. S., Chen, C-T., Harris, J. W., Weiser, M. R., Nash, G. M., Guillem, J. G., Wei, I. H., Kolesnick, R. N., Veeraraghavan, H., Ortiz, E. J., Petkovska, I., Cercek, A., Manova-Todorova, K. O., Saltz, L. B., Lavery, J. A., DeMatteo, R. P., Massagué, J., Paty, P. B., Yaeger, R., Chen, X., Patil, S., Clevers, H., Berger, M. F., Lowe, S. W., Shia, J., Romesser, P. B., Dow, L. E., Garcia-Aguilar, J., Sawyers, C. L. & Smith, J. J., Oct 2019, In : Nature Medicine. 25, 10, p. 1607-1614 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues

Klotz, B. J., Oosterhoff, L. A., Utomo, L., Lim, K. S., Vallmajo-Martin, Q., Clevers, H., Woodfield, T. B. F., Rosenberg, A. J. W. P., Malda, J., Ehrbar, M., Spee, B. & Gawlitta, D., Oct 2019, In : Advanced healthcare materials. 8, 19, p. e1900979

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

Basham, K. J., Rodriguez, S., Turcu, A. F., Lerario, A. M., Logan, C. Y., Rysztak, M. R., Gomez-Sanchez, C. E., Breault, D. T., Koo, B-K., Clevers, H., Nusse, R., Val, P. & Hammer, G. D., 01 Feb 2019, In : Genes & Development. 33, 3-4, p. 209-220 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cancer modeling meets human organoid technology

Tuveson, D. & Clevers, H., 07 Jun 2019, In : Science. 364, 6444, p. 952-955 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis

Post, Y. & Clevers, H., 01 Aug 2019, In : Cell Stem Cell. 25, 2, p. 174-183 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells

Han, S., Fink, J., Jörg, D. J., Lee, E., Yum, M. K., Chatzeli, L., Merker, S. R., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, J-H., Sasaki, N., Mort, R. L., Basak, O., Clevers, H., Stange, D. E., Philpott, A. & 3 others, Kim, J. K., Simons, B. D. & Koo, B-K., 05 Sep 2019, In : Cell Stem Cell. 25, 3, p. 342-356.e7

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

van Es, J. H., Wiebrands, K., López-Iglesias, C., van de Wetering, M., Zeinstra, L., van den Born, M., Korving, J., Sasaki, N., Peters, P. J., van Oudenaarden, A. & Clevers, H., 16 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice

Aden, K., Bartsch, K., Dahl, J., Reijns, M. A. M., Esser, D., Sheibani-Tezerji, R., Sinha, A., Wottawa, F., Ito, G., Mishra, N., Knittler, K., Burkholder, A., Welz, L., van Es, J., Tran, F., Lipinski, S., Kakavand, N., Boeger, C., Lucius, R., von Schoenfels, W. & 11 others, Schafmayer, C., Lenk, L., Chalaris, A., Clevers, H., Röcken, C., Kaleta, C., Rose-John, S., Schreiber, S., Kunkel, T., Rabe, B. & Rosenstiel, P., Jan 2019, In : Gastroenterology. 156, 1, p. 145-159.e19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

Giobbe, G. G., Crowley, C., Luni, C., Campinoti, S., Khedr, M., Kretzschmar, K., De Santis, M. M., Zambaiti, E., Michielin, F., Meran, L., Hu, Q., van Son, G., Urbani, L., Manfredi, A., Giomo, M., Eaton, S., Cacchiarelli, D., Li, V. S. W., Clevers, H., Bonfanti, P. & 2 others, Elvassore, N. & De Coppi, P., 11 Dec 2019, In : Nature Communications. 10, 1, p. 5658

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

de Winter-de Groot, K. M., Berkers, G., Marck-van der Wilt, R. E. P., van der Meer, R., Vonk, A., Dekkers, J. F., Geerdink, M., Michel, S., Kruisselbrink, E., Vries, R., Clevers, H., Vleggaar, F. P., Elias, S. G., Heijerman, H. G. M., van der Ent, C. K. & Beekman, J. M., 14 Nov 2019, In : Journal of Cystic Fibrosis.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Frizzled-7 is required for Wnt signaling in gastric tumors with and without Apc mutations

Flanagan, D., Barker, N., Di Costanzo, N. S., Mason, E. A., Gurney, A., Meniel, V. S., Koushyar, S., Austin, C. R., Pearson, H. B., Boussioutas, A., Clevers, H., Phesse, T. J. & Vincan, E., Mar 2019, In : Cancer Research.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

High-resolution 3D imaging of fixed and cleared organoids

Dekkers, J. F., Alieva, M., Wellens, L. M., Ariese, H. C. R., Jamieson, P. R., Vonk, A. M., Amatngalim, G. D., Hu, H., Oost, K. C., Snippert, H. J. G., Beekman, J. M., Wehrens, E. J., Visvader, J. E., Clevers, H. & Rios, A. C., Jun 2019, In : Nature Protocols. 14, 6, p. 1756-1771 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Human Organoids: Tools for Understanding Biology and Treating Diseases

Schutgens, F. & Clevers, H., 24 Sep 2019, In : Annual review of pathology.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

Gehart, H., van Es, J. H., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J. F., Rios, A. & Clevers, H., 21 Feb 2019, In : Cell. 176, 5, p. 1158-1173.e16

Research output: Contribution to journal/periodicalArticleScientificpeer-review

IFN-γ: The T cell's license to kill stem cells in the inflamed intestine

Kretzschmar, K. & Clevers, H., 06 Dec 2019, In : Science immunology. 4, 42

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer

Wang, H., Xiang, D., Liu, B., He, A., Randle, H. J., Zhang, K. X., Dongre, A., Sachs, N., Clark, A. P., Tao, L., Chen, Q., Botchkarev, V. V., Xie, Y., Dai, N., Clevers, H., Li, Z. & Livingston, D. M., 27 Jun 2019, In : Cell. 178, 1, p. 135-151.e19

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

Crosby, P., Hamnett, R., Putker, M., Hoyle, N. P., Reed, M., Karam, C. J., Maywood, E. S., Stangherlin, A., Chesham, J. E., Hayter, E. A., Rosenbrier-Ribeiro, L., Newham, P., Clevers, H., Bechtold, D. A. & O'Neill, J. S., 02 May 2019, In : Cell. 177, 4, p. 896-909.e20

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

Lehle, A. S., Farin, H. F., Marquardt, B., Michels, B. E., Magg, T., Li, Y., Liu, Y., Ghalandary, M., Lammens, K., Hollizeck, S., Rohlfs, M., Hauck, F., Conca, R., Walz, C., Weiss, B., Lev, A., Simon, A. J., Groß, O., Gaidt, M. M., Hornung, V. & 12 others, Clevers, H., Yazbeck, N., Hanna-Wakim, R., Shouval, D. S., Warner, N., Somech, R., Muise, A. M., Snapper, S. B., Bufler, P., Koletzko, S., Klein, C. & Kotlarz, D., Jan 2019, In : Gastroenterology. 156, 1, p. 275-278 4 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells

Schneeberger, K., Sánchez-Romero, N., Ye, S., van Steenbeek, F. G., Oosterhoff, L. A., Pla Palacin, I., Chen, C., van Wolferen, M. E., van Tienderen, G., Lieshout, R., Colemonts-Vroninks, H., Schene, I., Hoekstra, R., Verstegen, M. M. A., van der Laan, L. J. W., Penning, L. C., Fuchs, S. A., Clevers, H., De Kock, J., Baptista, P. M. & 1 others, Spee, B., 12 Nov 2019, In : Hepatology.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Long-term expanding human airway organoids for disease modeling

Sachs, N., Papaspyropoulos, A., Zomer-van Ommen, D. D., Heo, I., Böttinger, L., Klay, D., Weeber, F., Huelsz-Prince, G., Iakobachvili, N., Amatngalim, G. D., de Ligt, J., van Hoeck, A., Proost, N., Viveen, M. C., Lyubimova, A., Teeven, L., Derakhshan, S., Korving, J., Begthel, H., Dekkers, J. F. & 28 others, Kumawat, K., Ramos, E., van Oosterhout, M. F., Offerhaus, G. J., Wiener, D. J., Olimpio, E. P., Dijkstra, K. K., Smit, E. F., van der Linden, M., Jaksani, S., van de Ven, M., Jonkers, J., Rios, A. C., Voest, E. E., van Moorsel, C. H., van der Ent, C. K., Cuppen, E., van Oudenaarden, A., Coenjaerts, F. E., Meyaard, L., Bont, L. J., Peters, P. J., Tans, S. J., van Zon, J. S., Boj, S. F., Vries, R. G., Beekman, J. M. & Clevers, H., 15 Feb 2019, In : EMBO Journal. 38, 4

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures

Boonekamp, K. E., Kretzschmar, K., Wiener, D. J., Asra, P., Derakhshan, S., Puschhof, J., López-Iglesias, C., Peters, P. J., Basak, O. & Clevers, H., 16 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 29, p. 14630-14638 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance

Joosten, S. P. J., Mizutani, T., Spaargaren, M., Clevers, H. & Pals, S. T., Oct 2019, In : Gastroenterology. 157, 4, p. 1153-1155.e1

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids

Dekkers, J. F., Whittle, J. R., Vaillant, F., Chen, H-R., Dawson, C., Liu, K., Geurts, M., Herold, M. J., Clevers, H., Lindeman, G. J. & Visvader, J. E., 07 Oct 2019, In : Journal of the National Cancer Institute.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mouse and human urothelial cancer organoids: A tool for bladder cancer research

Mullenders, J., de Jongh, E., Brousali, A., Roosen, M., Blom, J. P. A., Begthel, H., Korving, J., Jonges, T., Kranenburg, O., Meijer, R. & Clevers, H. C., 05 Mar 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4567-4574 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

Fakhiri, J., Schneider, M. A., Puschhof, J., Stanifer, M., Schildgen, V., Holderbach, S., Voss, Y., El Andari, J., Schildgen, O., Boulant, S., Meister, M., Clevers, H., Yan, Z., Qiu, J. & Grimm, D., 15 Mar 2019, In : Molecular therapy. Methods & clinical development. 12, p. 202-222 21 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Bolhaqueiro, A. C. F., Ponsioen, B., Bakker, B., Klaasen, S. J., Kucukkose, E., van Jaarsveld, R. H., Vivié, J., Verlaan-Klink, I., Hami, N., Spierings, D. C. J., Sasaki, N., Dutta, D., Boj, S. F., Vries, R. G. J., Lansdorp, P. M., van de Wetering, M., van Oudenaarden, A., Clevers, H., Kranenburg, O., Foijer, F. & 2 others, Snippert, H. J. G. & Kops, G. J. P. L., May 2019, In : Nature Genetics. 51, 5, p. 824-834 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Oral mucosal organoids as a potential platform for personalized cancer therapy

Driehuis, E., Kolders, S., Spelier, S., Lohmussaar, K., Willems, S. M., Devriese, L. A., de Bree, R., de Ruiter, E. J., Korving, J., Begthel, H., Van Es, J. H., Geurts, V., He, G-W., van Jaarsveld, R. H., Oka, R., Muraro, M. J., Vivie, J., Zandvliet, M. M. J. M., Hendrickx, A. P. A., Iakobachvili, N. & 8 others, Sridevi, P., Kranenburg, O., van Boxtel, R., Kops, G. J. P. L., Tuveson, D. A., Peters, P. J., van Oudenaarden, A. & Clevers, H., Jul 2019, In : Cancer Discovery.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Organoids in immunological research

Bar-Ephraim, Y. E., Kretzschmar, K. & Clevers, H., 18 Dec 2019, In : Nature Reviews Immunology.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Driehuis, E., van Hoeck, A., Moore, K., Kolders, S., Francies, H. E., Gulersonmez, M. C., Stigter, E. C. A., Burgering, B., Geurts, V., Gracanin, A., Bounova, G., Morsink, F. H., Vries, R., Boj, S., van Es, J., Offerhaus, G. J. A., Kranenburg, O., Garnett, M. J., Wessels, L., Cuppen, E. & 2 others, Brosens, L. A. A. & Clevers, H., 09 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy

Driehuis, E., Spelier, S., Beltrán Hernández, I., de Bree, R., M Willems, S., Clevers, H. & Oliveira, S., 05 Nov 2019, In : Computational Linguistics in the Netherlands Journal. 8, 11

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

Ooft, S. N., Weeber, F., Dijkstra, K. K., McLean, C. M., Kaing, S., van Werkhoven, E., Schipper, L., Hoes, L., Vis, D. J., van de Haar, J., Prevoo, W., Snaebjornsson, P., van der Velden, D., Klein, M., Chalabi, M., Boot, H., van Leerdam, M., Bloemendal, H. J., Beerepoot, L. V., Wessels, L. & 3 others, Cuppen, E., Clevers, H. & Voest, E. E., 09 Oct 2019, In : Science Translational Medicine. 11, 513

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

Artegiani, B., van Voorthuijsen, L., Lindeboom, R. G. H., Seinstra, D., Heo, I., Tapia, P., López-Iglesias, C., Postrach, D., Dayton, T., Oka, R., Hu, H., van Boxtel, R., van Es, J. H., Offerhaus, J., Peters, P. J., van Rheenen, J., Vermeulen, M. & Clevers, H., 06 Jun 2019, In : Cell Stem Cell. 24, 6, p. 927-943.e6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers, G., van Mourik, P., Vonk, A. M., Kruisselbrink, E., Dekkers, J. F., de Winter-de Groot, K. M., Arets, H. G. M., Marck-van der Wilt, R. E. P., Dijkema, J. S., Vanderschuren, M. M., Houwen, R. H. J., Heijerman, H. G. M., van de Graaf, E. A., Elias, S. G., Majoor, C. J., Koppelman, G. H., Roukema, J., Bakker, M., Janssens, H. M., van der Meer, R. & 5 others, Vries, R. G. J., Clevers, H. C., de Jonge, H. R., Beekman, J. M. & van der Ent, C. K., 12 Feb 2019, In : Cell Reports. 26, 7, p. 1701-1708.e3

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Tales from the crypt: new insights into intestinal stem cells

Gehart, H. & Clevers, H., Jan 2019, In : Nature Reviews Gastroenterology and Hepatology. 16, 1, p. 19-34 16 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

Fu, Y-Y., Egorova, A., Sobieski, C., Kuttiyara, J., Calafiore, M., Takashima, S., Clevers, H. & Hanash, A. M., 16 Jul 2019, In : Immunity. 51, 1, p. 90-103.e3

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

Cabeza-Cabrerizo, M., van Blijswijk, J., Wienert, S., Heim, D., Jenkins, R. P., Chakravarty, P., Rogers, N., Frederico, B., Acton, S., Beerling, E., van Rheenen, J., Clevers, H., Schraml, B. U., Bajénoff, M., Gerner, M., Germain, R. N., Sahai, E., Klauschen, F. & Reis E Sousa, C., 01 Mar 2019, In : Science immunology. 4, 33

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tissue-Engineering the Intestine: The Trials before the Trials

Clevers, H., Conder, R. K., Li, V. S. W., Lutolf, M. P., Vallier, L., Chan, S., Grikscheit, T. C., Jensen, K. B. & De Coppi, P., 06 Jun 2019, In : Cell Stem Cell. 24, 6, p. 855-859 5 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Schutgens, F., Rookmaaker, M. B., Margaritis, T., Rios, A., Ammerlaan, C., Jansen, J., Gijzen, L., Vormann, M., Vonk, A., Viveen, M., Yengej, F. Y., Derakhshan, S., de Winter-de Groot, K. M., Artegiani, B., van Boxtel, R., Cuppen, E., Hendrickx, A. P. A., van den Heuvel-Eibrink, M. M., Heitzer, E., Lanz, H. & 7 others, Beekman, J., Murk, J-L., Masereeuw, R., Holstege, F., Drost, J., Verhaar, M. C. & Clevers, H., Mar 2019, In : Nature Biotechnology. 37, 3, p. 303-313 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

Ouahed, J., Spencer, E., Kotlarz, D., Shouval, D. S., Kowalik, M., Peng, K., Field, M., Grushkin-Lerner, L., Pai, S-Y., Bousvaros, A., Cho, J., Argmann, C., Schadt, E., Mcgovern, D. P. B., Mokry, M., Nieuwenhuis, E., Clevers, H., Powrie, F., Uhlig, H., Klein, C. & 3 others, Muise, A., Dubinsky, M. & Snapper, S. B., 03 Dec 2019, In : Inflammatory Bowel Diseases.

Research output: Contribution to journal/periodicalArticleScientificpeer-review