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  • E.M. Hol
2020

A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells

Ormel, P. R., Böttcher, C., Gigase, F. A. J., Missall, R. D., van Zuiden, W., Camila Fernández Zapata, M., Ilhan, D., de Goeij, M., Udine, E., Sommer, I. E. C., Priller, J., Raj, T., Kahn, R. S., Hol, E. M. & de Witte, L. D., 2020, In : Brain, Behavior, and Immunity. 90, p. 196-207

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Cannabinoids and psychotic symptoms: A potential role for a genetic variant in the P2X purinoceptor 7 (P2RX7) gene

Boks, M. P., He, Y., Schubart, C. D., van Gastel, W., Elkrief, L., Huguet, G., van Eijk, K., Vinkers, C. H., Kahn, R. S., Paus, T., Conrod, P., Hol, E. M. & de Witte, L. D., 2020, In : Brain, Behavior, and Immunity. 88, p. 573-581

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage

van Dijk, B. J., Meijers, J. C. M., Kloek, A. T., Knaup, V. L., Rinkel, G. J. E., Morgan, B. P., van der Kamp, M. J., Osuka, K., Aronica, E., Ruigrok, Y. M., van de Beek, D., Brouwer, M., Pekna, M., Hol, E. M. & Vergouwen, M. D. I., 2020, In : Translational Stroke Research. 11, p. 678-688

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Distinct non-inflammatory signature of microglia in post-mortem brain tissue of patients with major depressive disorder

Snijders, G. J. L. J., Sneeboer, M. A. M., Fernández-Andreu, A., Udine, E., Boks, M. P., Ormel, P. R., van Berlekom, A. B., van Mierlo, H. C., Bӧttcher, C., Priller, J., Raj, T., Hol, E. M., Kahn, R. S. & de Witte, L. D., 28 Jun 2020, In : Molecular Psychiatry.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation

Goulay, R., Mena Romo, L., Hol, E. M. & Dijkhuizen, R. M., 2020, In : Translational Stroke Research. 11, p. 601-614

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Increased number of T-lymphocytes in post-mortem brain tissue of patients with schizophrenia

Sneeboer, M. A. M., van Mierlo, H. C., Stotijn, E., MacIntyre, D. J., Smith, C., Kahn, R. S., Hol, E. M. & de Witte, L. D., 2020, In : Schizophrenia Research. 216, p. 526-528

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Microglial activation in schizophrenia: Is translocator 18 kDa protein (TSPO) the right marker?

Sneeboer, M. A. M., van der Doef, T., Litjens, M., Psy, N. B. B., Melief, J., Hol, E. M., Kahn, R. S. & de Witte, L. D., 2020, In : Schizophrenia Research. 215, p. 167-172

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The impact of antidiabetic treatment on human hypothalamic infundibular neurons and microglia

Kalsbeek, M. J., Wolff, S. E., Korpel, N. L., la Fleur, S. E., Romijn, J. A., Fliers, E., Kalsbeek, A., Swaab, D. F., Huitinga, I., Hol, E. M. & Yi, C-X., 2020, In : JCI insight. 5, 16, 133868.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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2019

DNA methylation changes related to nutritional deprivation: a genome-wide analysis of population and in vitro data

He, Y., de Witte, L. D., Houtepen, L. C., Nispeling, D. M., Xu, Z., Yu, Q., Yu, Y., Hol, E. M., Kahn, R. S. & Boks, M. P., Mar 2019, In : Clinical Epigenetics. 11, 1, p. 80

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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108 Downloads (Pure)

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.

Böttcher, C., Schlickeiser, S., Sneeboer, M. A. M., Kunkel, D., Knop, A., Paza, E., Fidzinski, P., Kraus, L., Snijders, G. J. L., Kahn, R. S., Schulz, A. R., Mei, H. E., Hol, E. M., Siegmund, B., Glauben, R., Spruth, E. J., de Witte, L. D. & Priller, J., 04 Jan 2019, In : Nature Neuroscience. 22, p. 78-90

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Importance of GFAP isoform-specific analyses in astrocytoma

van Bodegraven, E. J., van Asperen, J. V., Robe, P. A. J. & Hol, E. M., Jan 2019, In : GLIA. 33, p. 12941-12959

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function

He, Y., de Witte, L. D., Schubart, C. D., Van Gastel, W. A., Koeleman, B. P. C., de Jong, S., Ophoff, R. A., Hol, E. M. & Boks, M. P., Jan 2019, In : European Neuropsychopharmacology. 29, p. 643-652

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated

Sneeboer, M. A. M., Snijders, G. J. L. J., Berdowski, W. M., Fernández-Andreu, A., van Mierlo, H. C., Berdenis van Berlekom, A., Litjens, M., Kahn, R. S., Hol, E. M. & de Witte, L. D., Apr 2019, In : Translational Psychiatry. 9, 1, p. 153

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease

Donega, V., Burm, S. M., van Strien, M. E., van Bodegraven, E. J., Paliukhovich, I., Geut, H., van de Berg, W. D. J., Li, K. W., Smit, A. B., Basak, O. & Hol, E. M., Apr 2019, In : Acta neuropathologica communications. 7, 1, p. 4

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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80 Downloads (Pure)
2018

Cell adhesion and matricellular support by astrocytes of the tripartite synapse

Hillen, A. E. J., Burbach, J. P. H. & Hol, E. M., 2018, In : Progress in Neurobiology. 165-167, p. 66-86

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Clinical and immunological characteristics of the spectrum of GFAP autoimmunity: a case series of 22 patients

Iorio, R., Damato, V., Evoli, A., Gessi, M., Gaudino, S., Di Lazzaro, V., Spagni, G., Sluijs, J. A. & Hol, E. M., 2018, In : Journal of Neurology, Neurosurgery and Psychiatry. 89, p. 138-146

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

Oosterhof, N., Kuil, L. E., van der Linde, H. C., Burm, S. M., Berdowski, W., van IJcken, W. F. J., van Swieten, J. C., Hol, E. M., Verheijen, M. H. G. & van Ham, T. J., Jun 2018, In : Cell Reports. 24, 5, p. 1203-1217.e6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Microglia innately develop within cerebral organoids

Ormel, P. R., Vieira de Sá, R., van Bodegraven, E. J., Karst, H., Harschnitz, O., Sneeboer, M. A. M., Johansen, L. E., van Dijk, R. E., Scheefhals, N., Berdenis van Berlekom, A., Ribes Martínez, E., Kling, S., MacGillavry, H. D., van den Berg, L. H., Kahn, R. S., Hol, E. M., de Witte, L. D. & Pasterkamp, R. J., 2018, In : Nature Communications. 9, 1, 4167.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Antonovaite, N., Beekmans, S. V., Hol, E. M., Wadman, W. J. & Iannuzzi, D., 2018, In : Scientific Reports. 8, 1, p. 12517

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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107 Downloads (Pure)

Role of von Willebrand Factor and ADAMTS13 in early brain injury after experimental subarachnoid hemorrhage

Wan, H., Wang, Y., Ai, J., Brathwaite, S., Ni, H., Macdonald, R. L., Hol, E. M., Meijers, J. C. M. & Vergouwen, M. D. I., 2018, In : Journal of Thrombosis and Haemostasis. 16, p. 1413-1422

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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106 Downloads (Pure)
2017

Characterization of macrophages from schizophrenia patients

Ormel, P. R., van Mierlo, H. C., Litjens, M., Strien, M. E. V., Hol, E. M., Kahn, R. S. & de Witte, L. D., 2017, In : NPJ Schizophrenia. 3, 1, 41.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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116 Downloads (Pure)

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

Jansen, A. H. P., van Hal, M., Op den Kelder, I. C., Meier, R. T., de Ruiter, A-A., Schut, M. H., Smith, D. L., Grit, C., Brouwer, N., Kamphuis, W., Boddeke, H. W. G. M., den Dunnen, W. F. A., van Roon, W. M. C., Bates, G. P., Hol, E. M. & Reits, E. A., 02 Jan 2017, In : GLIA. 65, p. 50-61

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Gene Expression Profilling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

Hendrickx, D. A. E., van Scheppingen, J., van der Poel, M., Bossers, K., Schuurman, K. G., van Eden, C. G., Hol, E. M., Hamann, J. & Huitinga, I., 21 Dec 2017, In : Frontiers in Immunology. 8, 1810.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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GFAPδ/GFAPα ratio directs astrocytoma gene expression towards a more malignant profile

Stassen, O. M. J. A., van Bodegraven, E. J., Giuliani, F., Moeton, M., Kanski, R., Sluijs, J. A., van Strien, M. E., Kamphuis, W., Robe, P. A. J. & Hol, E. M., Oct 2017, In : Oncotarget. 8, 50, p. 88104-88121 18 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., Hol, E. M., Kamphuis, W., Bayer, T. A., De Deyn, P. P. & Boddeke, E., 2017, In : Neurobiology of Aging. 55, p. 115-122

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies

van Kesteren, C. F. M. G., Gremmels, H., de Witte, L. D., Hol, E. M., Van Gool, A. R., Falkai, P. G., Kahn, R. S. & Sommer, I. E. C., 01 Mar 2017, In : Translational Psychiatry. 7, 3, p. e1075

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin

Hol, E. M. & Capetanaki, Y., 2017, In : Cold Spring Harbor perspectives in biology. 9, 12, a021642.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2016

Astrocytes: a central element in neurological diseases

Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J-M., Parpura, V., Hol, E. M., Sofroniew, M. V. & Verkhratsky, A., Mar 2016, In : Acta Neuropathologica. 131, 3, p. 323-45 23 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

Osborn, L. M., Kamphuis, W., Wadman, W. J. & Hol, E. M., 2016, In : Progress in Neurobiology. 144, p. 121-141

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Characterizing primary human microglia: A comparative study with myeloid subsets and culture models

Melief, J., Sneeboer, M. A. M., Litjens, M., Ormel, P. R., Palmen, S. J. M. C., Huitinga, I., Kahn, R. S., Hol, E. M. & de Witte, L. D., 2016, In : GLIA. 64, p. 1857-1868

Research output: Contribution to journal/periodicalArticleScientificpeer-review

GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions

Moeton, M., Stassen, O. M. J. A., Sluijs, J. A., van der Meer, V. W. N., Kluivers, L. J., van Hoorn, H., Schmidt, T., Reits, E. A. J., van Strien, M. E. & Hol, E. M., 2016, In : Cellular and Molecular Life Sciences. 73, p. 4101-4120

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Glial cell response after aneurysmal subarachnoid hemorrhage - Functional consequences and clinical implications

van Dijk, B. J., Vergouwen, M. D. I., Kelfkens, M. M., Rinkel, G. J. E. & Hol, E. M., Mar 2016, In : Biochimica et Biophysica Acta- Molecular Basis of Disease. 1862, 3, p. 492-505 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

The Indispensable Roles of Microglia and Astrocytes during Brain Development

Reemst, K., Noctor, S. C., Lucassen, P. J. & Hol, E. M., 2016, In : Frontiers in Human Neuroscience. 10, p. 566

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

Kamphuis, W., Kooijman, L., Schetters, S., Orre, M. & Hol, E. M., 2016, In : Biochimica et Biophysica Acta- Molecular Basis of Disease. 1862, p. 1847-1860

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2015

Activation of endogenous neural stem cells for multiple sclerosis therapy

Michailidou, I., de Vries, H. E., Hol, E. M. & van Strien, M. E., 2015, In : Frontiers in Neuroscience. 8, p. 454

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

Manzine, P. R., Marcello, E., Borroni, B., Kamphuis, W., Hol, E. M., Padovani, A., Nascimento, C. C., de Godoy Bueno, P., Assis Carvalho Vale, F., Iost Pavarini, S. C., Di Luca, M. & Cominetti, M. R., May 2015, In : Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 20, 3, p. 196-201 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Aicardi-Goutières syndrome harbours abundant systemic and brain-reactive autoantibodies

Cuadrado, E., Vanderver, A., Brown, K. J., Sandza, A., Takanohashi, A., Jansen, M. H., Anink, J., Herron, B., Orcesi, S., Olivieri, I., Rice, G. I., Aronica, E., Lebon, P., Crow, Y. J., Hol, E. M. & Kuijpers, T. W., Oct 2015, In : Annals of the Rheumatic Diseases. 74, 10, p. 1931-9 9 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Editorial overview: cell architecture: intermediate filaments - from molecules to patients

Hol, E. M. & Etienne-Manneville, S., Feb 2015, In : Current Opinion in Cell Biology. 32, p. v-vi

Research output: Contribution to journal/periodicalArticleScientificpeer-review

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

Kamphuis, W., Kooijman, L., Orre, M., Stassen, O., Pekny, M. & Hol, E. M., Jun 2015, In : GLIA. 63, 6, p. 1036-56 21 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

Hol, E. M. & Pekny, M., Feb 2015, In : Current Opinion in Cell Biology. 32, p. 121-30 10 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells

de Vrij, J., Maas, S. L. N., Kwappenberg, K. M. C., Schnoor, R., Kleijn, A., Dekker, L., Luider, T. M., de Witte, L. D., Litjens, M., van Strien, M. E., Hol, E. M., Kroonen, J., Robe, P. A., Lamfers, M. L., Schilham, M. W. & Broekman, M. L. D., 01 Oct 2015, In : International Journal of Cancer. 137, 7, p. 1630-42 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

Holtman, I. R., Raj, D. D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., Hol, E. M., Boddeke, E. W. G. M. & Eggen, B. J. L., 2015, In : Acta neuropathologica communications. 3, p. 31

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Phenotypic Variation in Aicardi-Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release

Cuadrado, E., Michailidou, I., van Bodegraven, E. J., Jansen, M. H., Sluijs, J. A., Geerts, D., Couraud, P-O., De Filippis, L., Vescovi, A. L., Kuijpers, T. W. & Hol, E. M., 15 Apr 2015, In : Journal of Immunology. 194, 8, p. 3623-33 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

Herrera Moro Chao, D., Kallemeijn, W. W., Marques, A. R. A., Orre, M., Ottenhoff, R., van Roomen, C., Foppen, E., Renner, M. C., Moeton, M., van Eijk, M., Boot, R. G., Kamphuis, W., Hol, E. M., Aten, J., Overkleeft, H. S., Kalsbeek, A. & Aerts, J. M. F. G., 2015, In : PLoS One. 10, 9, p. e0138107

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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2014

Abundant kif21b is associated with accelerated progression in neurodegenerative diseases

Kreft, K. L., van Meurs, M., Wierenga-Wolf, A. F., Melief, M-J., van Strien, M. E., Hol, E. M., Oostra, B. A., Laman, J. D. & Hintzen, R. Q., 03 Oct 2014, In : Acta neuropathologica communications. 2, 1, p. 144

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

Orre, M., Kamphuis, W., Osborn, L. M., Melief, J., Kooijman, L., Huitinga, I., Klooster, J., Bossers, K. & Hol, E. M., Jan 2014, In : Neurobiology of Aging. 35, 1, p. 1-14 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

A star is born: new insights into the mechanism of astrogenesis

Kanski, R., van Strien, M. E., van Tijn, P. & Hol, E. M., Feb 2014, In : Cellular and Molecular Life Sciences. 71, 3, p. 433-47 15 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Enteric GFAP expression and phosphorylation in Parkinson's disease

Clairembault, T., Kamphuis, W., Leclair-Visonneau, L., Rolli-Derkinderen, M., Coron, E., Neunlist, M., Hol, E. M. & Derkinderen, P., Sep 2014, In : Journal of Neurochemistry. 130, 6, p. 805-15 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

Kamphuis, W., Middeldorp, J., Kooijman, L., Sluijs, J. A., Kooi, E-J., Moeton, M., Freriks, M., Mizee, M. R. & Hol, E. M., Mar 2014, In : Neurobiology of Aging. 35, 3, p. 492-510 19 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network

Kanski, R., Sneeboer, M. A. M., van Bodegraven, E. J., Sluijs, J. A., Kropff, W., Vermunt, M. W., Creyghton, M. P., De Filippis, L., Vescovi, A., Aronica, E., van Tijn, P., van Strien, M. E. & Hol, E. M., 15 Oct 2014, In : Journal of Cell Science. 127, Pt 20, p. 4368-80 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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