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  • J.H. van Es
2019

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

van Es, J. H., Wiebrands, K., López-Iglesias, C., van de Wetering, M., Zeinstra, L., van den Born, M., Korving, J., Sasaki, N., Peters, P. J., van Oudenaarden, A. & Clevers, H., 16 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

Gehart, H., van Es, J. H., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J. F., Rios, A. & Clevers, H., 21 Feb 2019, In : Cell. 176, 5, p. 1158-1173.e16

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Oral mucosal organoids as a potential platform for personalized cancer therapy

Driehuis, E., Kolders, S., Spelier, S., Lohmussaar, K., Willems, S. M., Devriese, L. A., de Bree, R., de Ruiter, E. J., Korving, J., Begthel, H., Van Es, J. H., Geurts, V., He, G-W., van Jaarsveld, R. H., Oka, R., Muraro, M. J., Vivie, J., Zandvliet, M. M. J. M., Hendrickx, A. P. A., Iakobachvili, N. & 8 others, Sridevi, P., Kranenburg, O., van Boxtel, R., Kops, G. J. P. L., Tuveson, D. A., Peters, P. J., van Oudenaarden, A. & Clevers, H., Jul 2019, In : Cancer Discovery.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

Artegiani, B., van Voorthuijsen, L., Lindeboom, R. G. H., Seinstra, D., Heo, I., Tapia, P., López-Iglesias, C., Postrach, D., Dayton, T., Oka, R., Hu, H., van Boxtel, R., van Es, J. H., Offerhaus, J., Peters, P. J., van Rheenen, J., Vermeulen, M. & Clevers, H., 06 Jun 2019, In : Cell Stem Cell. 24, 6, p. 927-943.e6

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2018

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

Beumer, J., Artegiani, B., Post, Y., Reimann, F., Gribble, F., Nguyen, T. N., Zeng, H., Van den Born, M., Van Es, J. H. & Clevers, H., Aug 2018, In : Nature Cell Biology. 20, 8, p. 909-916 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

Chakrabarti, R., Celià-Terrassa, T., Kumar, S., Hang, X., Wei, Y., Choudhury, A., Hwang, J., Peng, J., Nixon, B., Grady, J. J., DeCoste, C., Gao, J., van Es, J. H., Li, M. O., Aifantis, I., Clevers, H. & Kang, Y., 29 Jun 2018, In : Science. 360, 6396

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Profiling proliferative cells and their progeny in damaged murine hearts

Kretzschmar, K., Post, Y., Bannier-Hélaouët, M., Mattiotti, A., Drost, J., Basak, O., Li, V. S. W., van den Born, M., Gunst, Q. D., Versteeg, D., Kooijman, L., van der Elst, S., van Es, J. H., van Rooij, E., van den Hoff, M. J. B. & Clevers, H., 26 Dec 2018, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., Simons, B. D. & Clevers, H., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E610-E619

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2017

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

Artegiani, B., Lyubimova, A., Muraro, M. J., van Es, J. H., van Oudenaarden, A. & Clevers, H., 12 Dec 2017, In : Cell Reports. 21, 11, p. 3271-3284 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2016

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., He, X., Wang, J., Lu, C., Wu, L. N., Weng, Q., Mao, M., Li, J., van Es, J. H., Xin, M., Parry, L., Goldman, S. A., Clevers, H. & Lu, Q. R., 2016, In : Nature Communications. 7, p. 10883

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

Tetteh, P. W., Kretzschmar, K., Begthel, H., van den Born, M., Korving, J., Morsink, F. H. M., Farin, H., van Es, J. H., Offerhaus, G. J. A. & Clevers, H., 18 Oct 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. 11859-11864 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. & 5 others, Sabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 04 Aug 2016, In : Cell Stem Cell.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon

Sasaki, N., Sachs, N., Wiebrands, K., Ellenbroek, S. I. J., Fumagalli, A., Lyubimova, A., Begthel, H., van den Born, M., van Es, J. H., Karthaus, W. R., Li, V. S. W., López-Iglesias, C., Peters, P. J., van Rheenen, J., van Oudenaarden, A. & Clevers, H., 29 Aug 2016, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

Tetteh, P. W., Basak, O., Farin, H. F., Wiebrands, K., Kretzschmar, K., Begthel, H., van den Born, M., Korving, J., de Sauvage, F., van Es, J. H., van Oudenaarden, A. & Clevers, H., 04 Feb 2016, In : Cell Stem Cell. 18, 2, p. 203-13 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2015

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

Schneeberger, K., Vogel, G. F., Teunissen, H., van Ommen, D. D., Begthel, H., El Bouazzaoui, L., van Vugt, A. H. M., Beekman, J. M., Klumperman, J., Müller, T., Janecke, A., Gerner, P., Huber, L. A., Hess, M. W., Clevers, H., van Es, J. H., Nieuwenhuis, E. E. S. & Middendorp, S., 06 Oct 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 40, p. 12408-13 6 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

Dow, L. E., O'Rourke, K. P., Simon, J., Tschaharganeh, D. F., van Es, J. H., Clevers, H. & Lowe, S. W., 18 Jun 2015, In : Cell. 161, 7, p. 1539-52 14 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations

van Es, J. H. & Clevers, H., 2015, In : Methods in Molecular Biology. 1267, p. 125-44 20 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia

Koo, B-K., van Es, J. H., van den Born, M. & Clevers, H., 28 May 2015, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Targeting development of incretin-producing cells increases insulin secretion

Petersen, N., Reimann, F., van Es, J. H., van den Berg, B. M., Kroone, C., Pais, R., Jansen, E., Clevers, H., Gribble, F. M. & de Koning, E. J. P., Jan 2015, In : Journal of Clinical Investigation. 125, 1, p. 379-85 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
2014

A20 controls intestinal homeostasis through cell-specific activities

Vereecke, L., Vieira-Silva, S., Billiet, T., van Es, J. H., Mc Guire, C., Slowicka, K., Sze, M., van den Born, M., De Hertogh, G., Clevers, H., Raes, J., Rutgeerts, P., Vermeire, S., Beyaert, R. & van Loo, G., 2014, In : Nature Communications. 5, p. 5103

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

Snippert, H. J., Schepers, A. G., van Es, J. H., Simons, B. D. & Clevers, H., Jan 2014, In : EMBO Reports. 15, 1, p. 62-9 8 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

GRASP65 controls the cis Golgi integrity in vivo

Veenendaal, T., Jarvela, T., Grieve, A. G., van Es, J. H., Linstedt, A. D. & Rabouille, C., 2014, In : Biology Open. 3, 6, p. 431-43 13 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition

Bolden, J. E., Tasdemir, N., Dow, L. E., van Es, J. H., Wilkinson, J. E., Zhao, Z., Clevers, H. & Lowe, S. W., 25 Sep 2014, In : Cell Reports. 8, 6, p. 1919-29 11 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele

Basak, O., van de Born, M., Korving, J., Beumer, J., van der Elst, S., van Es, J. H. & Clevers, H., 17 Sep 2014, In : EMBO Journal. 33, 18, p. 2057-68 12 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

Yin, X., Farin, H. F., van Es, J. H., Clevers, H., Langer, R. & Karp, J. M., Jan 2014, In : Nature Methods. 11, 1, p. 106-12 7 p.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Paneth cells

van Es, J. H. & Clevers, H., 16 Jun 2014, In : Current Biology. 24, 12, p. R547-8

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2013

A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta

Lu, J., Zhang, S., Nakano, H., Simmons, D. G., Wang, S., Kong, S., Wang, Q., Shen, L., Tu, Z., Wang, W., Wang, B., Wang, H., Wang, Y., van Es, J. H., Clevers, H., Leone, G. & Cross, J. C., 2013, In : PLoS Biology. 11, 4, p. 1001536

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium

Stange, D. E., Koo, B. K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Koster, J., Geahlen, J. H., Peters, P. J., van Es, J. H., van de Wetering, M., Mills, J. C. & Clevers, H., 2013, In : Cell. 155, 2, p. 357-368

Research output: Contribution to journal/periodicalArticleScientificpeer-review

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

Kaaij, L. T., van de Wetering, M., Fang, F., Decato, B., Molaro, A., van de Werken, H. J., van Es, J. H., Schuijers, J., de Wit, E., de Laat, W., Hannon, G. J., Clevers, H. C., Smith, A. D. & Ketting, R. F., 2013, In : Genome Biology. 14, 5, p. 50

Research output: Contribution to journal/periodicalArticleScientificpeer-review

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G. J., Grompe, M. & Clevers, H., 2013, In : Nature. 494, 7436, p. 247-250

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium

de Groot, R. E., Farin, H. F., Macurkova, M., van Es, J. H., Clevers, H. C. & Korswagen, H. C., 2013, In : PLoS One. 8, 10, p. 76971

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J., van de Wetering, M., Sojoodi, M., Li, V. S., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., van Es, J. H., de Koning, E., Vries, R. G. J., Heimberg, H. & Clevers, H., 2013, In : EMBO Journal. 32, 20, p. 2708-2721

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2012

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal

van Es, J. H., Haegebarth, A., Kujala, P., Itzkovitz, S., Koo, B. K., Boj, S. F., Korving, J., van den Born, M., van Oudenaarden, A., Robine, S. & Clevers, H., 2012, In : Molecular and Cellular Biology. 32, 10, p. 1918-1927

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand

Boj, S. F., van Es, J. H., Huch, M., Li, V. S., Jose, A., Hatzis, P., Mokry, M., Haegebarth, A., van den Born, M., Chambon, P., Voshol, P., Dor, Y., Cuppen, E., Fillat, C. & Clevers, H., 2012, In : Cell. 151, 7, p. 1595-1607

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

van Es, J. H., Sato, T., van de Wetering, M., Lyubimova, A., Nee, A. N., Gregorieff, A., Sasaki, N., Zeinstra, L., van den Born, M., Korving, J., Martens, A. C., Barker, N., van Oudenaarden, A. & Clevers, H., 2012, In : Nature Cell Biology. 14, 10, p. 1099-1104

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development

Barker, N., Rookmaaker, M. B., Kujala, P., Ng, A., Leushacke, M., Snippert, H., van de Wetering, M., Tan, S., van Es, J. H., Huch, M., Poulsom, R., Verhaar, M. C., Peters, P. J. & Clevers, H., 2012, In : Cell Reports. 2, 3, p. 540-552

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

Schepers, A. G., Snippert, H. J. G., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M. & Clevers, H., 2012, In : Science Magazine. 337, 6095, p. 730-735

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Redundant sources of wnt regulate intestinal stem cells and promote formation of paneth cells

Farin, H. F., van Es, J. H. & Clevers, H., 2012, In : Gastroenterology. 143, 6, p. 1517-1518

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Single-molecule transcript counting of stem-cell markers in the mouse intestine

Itzkovitz, S., Lyubimova, A., Blat, I. C., Maynard, M., van Es, J. H., Lees, J., Jacks, T., Clevers, H. & van Oudenaarden, A., 2012, In : Nature Cell Biology. 14, 1, p. 106-114

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

Munoz, J., Stange, D. E., Schepers, A. G., van de Wetering, M., Koo, B. K., Itzkovitz, S., Volckmann, R., Kung, K. S., Koster, J., Radulescu, S., Myant, K., Versteeg, R., Sansom, O. J., van Es, J. H., Barker, N., van Oudenaarden, A., Mohammed, S., Heck, A. J. R. & Clevers, H., 2012, In : EMBO Journal. 31, 14, p. 3079-3091

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Koo, B. K., Spit, M., Jordens, I., Low, T. Y., Stange, D. E., van de Wetering, M., van Es, J. H., Mohammed, S., Heck, A. J. R., Maurice, M. M. & Clevers, H., 2012, In : Nature. 488, 7413, p. 665-669

Research output: Contribution to journal/periodicalArticleScientificpeer-review

2011

CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo

Bos, F. L., Caunt, M., Peterson-Maduro, J., Planas-Paz, L., Kowalski, J., Karpanen, T., van Impel, A., Tong, R., Ernst, J. A., Korving, J., van Es, J. H., Lammert, E., Duckers, H. J. & Schulte-Merker, S., 2011, In : Circulation Research. 109, 5, p. 486-491

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., van Es, J. H. & Clevers, H., 2011, In : Nature Methods. 9, 1, p. 81-83

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

Gerbe, F., van Es, J. H., Makrini, L., Brulin, B., Mellitzer, G., Robine, S., Romagnolo, B., Shroyer, N. F., Bourgaux, J. F., Pignodel, C., Clevers, H. & Jay, P., 2011, In : Journal of Cell Biology. 192, 5, p. 767-780

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

de Lau, W. B. M., Barker, N., Low, T. Y., Koo, B. K., Li, V. S., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P., van de Wetering, M. L., Stange, D. E., van Es, J. H., Guardavaccaro, D., Schasfoort, R. B., Mohri, Y., Nishimori, K., Mohammed, S., Heck, A. & Clevers, H., 2011, In : Nature. 476, 7360, p. 293-297

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium

Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D. & Clevers, H., 2011, In : Gastroenterology. 141, 5, p. 1762-1772

Research output: Contribution to journal/periodicalArticleScientificpeer-review

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis

Sylva, M., Li, V. S., Buffing, A. A., van Es, J. H., van den Born, M. M. W., van der Velden, S., Gunst, Q., Koolstra, J. H., Moorman, A. F., Clevers, H. & van den Hoff, M. J., 2011, In : PLoS One. 6, 8, p. 22616

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Open Access
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