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• 2020

  A High Cell-Bearing Capacity Multibore Hollow Fiber Device for Macroencapsulation of Islets of Langerhans

  Skrzypek, K., Groot Nibbelink, M., Liefers-Visser, J., Smink, A. M., Stoimenou, E., Engelse, M. A., de Koning, E. J. P., Karperien, M., de Vos, P., van Apeldoorn, A. & Stamatialis, D., Aug 2020, In: Macromolecular bioscience. 20, 8, p. e2000021

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Islets of Langerhans
  • Insulin
  • Equipment and Supplies
  • Glucose
  • Graft Survival

• L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

  Lund, M. L., Sorrentino, G., Egerod, K. L., Kroone, C., Mortensen, B., Knop, F. K., Reimann, F., Gribble, F. M., Drucker, D. J., de Koning, E. J. P., Schoonjans, K., Bäckhed, F., Schwartz, T. W. & Petersen, N., Apr 2020, In: Diabetes. 69, 4, p. 614-623 10 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Glucagon-Like Peptide 1
  • Bile Acids and Salts
  • GTP-Binding Proteins
  • Serotonin
  • Cell Differentiation

• Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide-for type 1 diabetes

  Nikolic, T., Zwaginga, J. J., Uitbeijerse, B. S., Woittiez, N. J., de Koning, E. J., Aanstoot, H-J. & Roep, B. O., Jun 2020, In: The Lancet Diabetes & Endocrinology. 8, 6, p. 470-472 3 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Tacrolimus-Induced BMP/SMAD Signaling Associates with Metabolic Stress-Activated FOXO1 to Trigger β-Cell Failure

  Triñanes, J., Dijke, P. T., Groen, N., Hanegraaf, M., Porrini, E., Rodriguez-Rodriguez, A. E., Drachenberg, C., Rabelink, T. J., de Koning, E., Carlotti, F. & de Vries, A. P. J., Feb 2020, In: Diabetes.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Physiological Stress
  • Tacrolimus
  • Transcription Factors
  • Organ Transplantation
  • High Fat Diet

• β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

  Thomaidou, S., Kracht, M. J. L., van der Slik, A., Laban, S., de Koning, E. J., Carlotti, F., Hoeben, R. C., Roep, B. O. & Zaldumbide, A., Apr 2020, In: Diabetes. 69, 4, p. 670-680 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • preproinsulin
  • Aminopeptidases
  • Cell Shape
  • Protein Sorting Signals
  • Endoplasmic Reticulum
• 2019

  Advances in β-cell replacement therapy for the treatment of type 1 diabetes

  Vantyghem, M-C., de Koning, E. J. P., Pattou, F. & Rickels, M. R., 05 Oct 2019, In: The Lancet. 394, 10205, p. 1274-1285 12 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Islets of Langerhans Transplantation
  • Cell- and Tissue-Based Therapy
  • Type 1 Diabetes Mellitus
  • Hypoglycemia
  • Kidney

• Association between person and disease related factors and the planned diabetes care in people who receive person-centered type 2 diabetes care: An implementation study

  van Vugt, H. A., de Koning, E. J. P. & Rutten, G. E. H. M., 2019, In: PLoS One. 14, 7, p. e0219702

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • noninsulin-dependent diabetes mellitus
  • Medical problems
  • diabetes
  • drug therapy
  • Type 2 Diabetes Mellitus

• A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas

  van Gurp, L., Muraro, M. J., Dielen, T., Seneby, L., Dharmadhikari, G., Gradwohl, G., van Oudenaarden, A. & de Koning, E. J. P., 24 Jun 2019, In: Development (Cambridge). 146, 12

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • gene
  • embryonic development
  • reporter
  • proliferation
  • regulation

• Cell Type Purification by Single-Cell Transcriptome-Trained Sorting

  Baron, C. S., Barve, A., Muraro, M. J., van der Linden, R., Dharmadhikari, G., Lyubimova, A., de Koning, E. J. P. & van Oudenaarden, A., 03 Oct 2019, In: Cell. 179, 2, p. 527-542.e19

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Purification
  • Sorting
  • Transcriptome
  • Fluorescence
  • Antibodies

• Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study

  Li-Gao, R., Carlotti, F., de Mutsert, R., van Hylckama Vlieg, A., de Koning, E. J. P., Jukema, J. W., Rosendaal, F. R., Willems van Dijk, K. & Mook-Kanamori, D. O., Dec 2019, In: Diabetes. 68, 12, p. 2327-2336 10 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Genome-Wide Association Study
  • Netherlands
  • Meals
  • Epidemiology
  • Insulin Secretion

• Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium

  van den Berg, B. M., Wang, G., Boels, M. G. S., Avramut, M. C., Jansen, E., Sol, W. M. P. J., Lebrin, F., Jan van Zonneveld, A., de Koning, E. J. P., Vink, H., Gröne, H-J., Carmeliet, P., van der Vlag, J. & Rabelink, T. J., Oct 2019, In: Journal of the American Society of Nephrology : JASN. 30, 10, p. 1886-1897 12 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Hyaluronic Acid
  • Glycocalyx
  • Endothelium
  • Diabetic Nephropathies
  • Hyaluronan Synthases

• Highly efficient ex vivo lentiviral transduction of primary human pancreatic exocrine cells

  Balak, J. R. A., de Graaf, N., Zaldumbide, A., Rabelink, T. J., Hoeben, R. C., de Koning, E. J. P. & Carlotti, F., 01 Nov 2019, In: Scientific Reports. 9, 1, p. 15870

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Genes
  • Cell Plasticity
  • Gene Knockdown Techniques
  • Protamines
  • Ectopic Gene Expression

• Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

  Miguel-Escalada, I., Bonàs-Guarch, S., Cebola, I., Ponsa-Cobas, J., Mendieta-Esteban, J., Atla, G., Javierre, B. M., Rolando, D. M. Y., Farabella, I., Morgan, C. C., García-Hurtado, J., Beucher, A., Morán, I., Pasquali, L., Ramos-Rodríguez, M., Appel, E. V. R., Linneberg, A., Gjesing, A. P., Witte, D. R., Pedersen, O. & 16 others, Grarup, N., Ravassard, P., Torrents, D., Mercader, J. M., Piemonti, L., Berney, T., de Koning, E. J. P., Kerr-Conte, J., Pattou, F., Fedko, I. O., Groop, L., Prokopenko, I., Hansen, T., Marti-Renom, M. A., Fraser, P. & Ferrer, J., Jul 2019, In: Nature Genetics. 51, 7, p. 1137-1148 12 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Islets of Langerhans
  • Chromatin
  • Type 2 Diabetes Mellitus
  • Genome-Wide Association Study
  • Insulin Secretion

• In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion

  Bijkerk, R., Esguerra, J. L. S., Ellenbroek, J. H., Au, Y. W., Hanegraaf, M. A. J., de Koning, E. J., Eliasson, L. & van Zonneveld, A. J., Apr 2019, In: Nucleic Acid Therapeutics. 29, 2, p. 67-72 6 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Antagomirs
  • Insulin Secretion
  • MicroRNAs
  • Blood Glucose
  • Insulin

• Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets

  Hadavi, E., Leijten, J., Engelse, M., de Koning, E., Jonkheijm, P., Karperien, M. & van Apeldoorn, A., Feb 2019, In: Tissue Engineering - Part C: Methods. 25, 2, p. 71-81 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Bioengineering
  • Insulin
  • Collagen
  • Islets of Langerhans Transplantation
  • Scaffolds

• Organoids from the Human Fetal and Adult Pancreas

  Balak, J. R. A., Juksar, J., Carlotti, F., Lo Nigro, A. & de Koning, E. J. P., 11 Dec 2019, In: Current Diabetes Reports. 19, 12, p. 160

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Pancreas
  • Tissue Expansion
  • Culture Techniques
  • Endocrine Cells

• Patient activation in individuals with type 2 diabetes mellitus: associated factors and the role of insulin

  van Vugt, H. A., Boels, A. M., de Weerdt, I., de Koning, E. J. & Rutten, G. E., 2019, In: Patient Preference and Adherence. 13, p. 73-81 9 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Patient Participation
  • chronic illness
  • activation
  • Type 2 Diabetes Mellitus
  • Insulin

• SUGAR-DIP trial: oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial

  de Wit, L., Rademaker, D., Voormolen, D. N., Akerboom, B. M. C., Kiewiet-Kemper, R. M., Soeters, M. R., Verwij-Didden, M. A. L., Assouiki, F., Schippers, D. H., Vermeulen, M. A. R., Kuppens, S. M. I., Oosterwerff, M. M., Zwart, J. J., Diekman, M. J. M., Vogelvang, T. E., Gallas, P. R. J., Galjaard, S., Visser, W., Horree, N., Klooker, T. K. & 46 others, Laan, R., Heijligenberg, R., Huisjes, A. J. M., van Bemmel, T., van Meir, C. A., van den Beld, A. W., Hermes, W., Vidarsdottir, S., Veldhuis-Vlug, A. G., Dullemond, R. C., Jansen, H. J., Sueters, M., de Koning, E. J. P., van Laar, J. O. E. H., Wouters-van Poppel, P., Sanson-van Praag, M. E., van den Akker, E. S., Brouwer, C. B., Hermsen, B. B., Potter van Loon, B. J., van der Heijden, O. W. H., de Galan, B. E., van Leeuwen, M., Wijbenga, J. A. M., de Boer, K., van Bon, A. C., van der Made, F. W., Eskes, S. A., Zandstra, M., van Houtum, W. H., Braams-Lisman, B. A. M., Daemen-Gubbels, C. R. G. M., Wouters, M. G. A. J., IJzerman, R. G., Mensing van Charante, N. A., Zwertbroek, R., Bosmans, J. E., Evers, I. M., Mol, B. W., de Valk, H. W., Groenendaal, F., Naaktgeboren, C. A., Painter, R. C., deVries, J. H., Franx, A. & van Rijn, B. B., 18 Aug 2019, In: BMJ Open. 9, 8, p. e029808

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Pregnancy in Diabetics
  • Non-Randomized Controlled Trials
  • Glyburide
  • Metformin
  • Insulin
• 2018

  Artificial Pancreas or Novel Beta-Cell Replacement Therapies: a Race for Optimal Glycemic Control?

  Nijhoff, M. F. & de Koning, E. J. P., 24 Sep 2018, In: Current Diabetes Reports. 18, 11, p. 110

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Artificial Pancreas
  • Cell- and Tissue-Based Therapy
  • Insulin
  • Cell Transplantation
  • Type 1 Diabetes Mellitus

• Associations of Abdominal Subcutaneous and Visceral Fat with Insulin Resistance and Secretion Differ Between Men and Women: The Netherlands Epidemiology of Obesity Study

  de Mutsert, R., Gast, K., Widya, R., de Koning, E., Jazet, I., Lamb, H., le Cessie, S., de Roos, A., Smit, J., Rosendaal, F. & den Heijer, M., Feb 2018, In: Metabolic Syndrome and Related Disorders. 16, 1, p. 54-63 10 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Abdominal Subcutaneous Fat
  • Intra-Abdominal Fat
  • Insulin Secretion
  • Netherlands
  • Insulin Resistance

• Bioluminescent reporter assay for monitoring ER stress in human beta cells

  Kracht, M. J. L., de Koning, E. J. P., Hoeben, R. C., Roep, B. O. & Zaldumbide, A., 10 Dec 2018, In: Scientific Reports. 8, 1, p. 17738

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Luminescent Measurements
  • Islets of Langerhans
  • Endoplasmic Reticulum
  • Homeostasis
  • Autoimmunity

• Defining outcomes for beta cell replacement therapy: a work in progress

  Piemonti, L., de Koning, E. J. P., Berney, T., Odorico, J. S., Markmann, J. F., Stock, P. G. & Rickels, M. R., Jun 2018, In: Diabetologia. 61, 6, p. 1273-1276 4 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Cell- and Tissue-Based Therapy
  • Pancreas
  • Artificial Pancreas
  • Pancreas Transplantation
  • Islets of Langerhans Transplantation

• Defining outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop

  Rickels, M. R., Stock, P. G., de Koning, E. J. P., Piemonti, L., Pratschke, J., Alejandro, R., Bellin, M. D., Berney, T., Choudhary, P., Johnson, P. R., Kandaswamy, R., Kay, T. W. H., Keymeulen, B., Kudva, Y. C., Latres, E., Langer, R. M., Lehmann, R., Ludwig, B., Markmann, J. F., Marinac, M. & 6 others, Odorico, J. S., Pattou, F., Senior, P. A., Shaw, J. A. M., Vantyghem, M-C. & White, S., Apr 2018, In: Transplant international : official journal of the European Society for Organ Transplantation. 31, 4, p. 343-352 10 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Consensus
  • Cell- and Tissue-Based Therapy
  • C-Peptide
  • Hypoglycemia
  • Education

• Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop

  Rickels, M. R., Stock, P. G., de Koning, E. J. P., Piemonti, L., Pratschke, J., Alejandro, R., Bellin, M. D., Berney, T., Choudhary, P., Johnson, P. R., Kandaswamy, R., Kay, T. W. H., Keymeulen, B., Kudva, Y. C., Latres, E., Langer, R. M., Lehmann, R., Ludwig, B., Markmann, J. F., Marinac, M. & 6 others, Odorico, J. S., Pattou, F., Senior, P. A., Shaw, J. A. M., Vantyghem, M-C. & White, S., Sep 2018, In: Transplantation. 102, 9, p. 1479-1486 8 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Consensus
  • Cell- and Tissue-Based Therapy
  • Hypoglycemia
  • C-Peptide
  • Education

• Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

  Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F. C., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 13 Mar 2018, In: Stem Cell Reports. 10, 3, p. 712-724 13 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Tissue
  • Stem Cells
  • Insulin
  • Aldehyde Dehydrogenase

• Hypothermic Oxygenated Machine Perfusion of the Human Donor Pancreas

  Leemkuil, M., Lier, G., Engelse, M. A., Ploeg, R. J., de Koning, E. J. P., 't Hart, N. A., Krikke, C. & Leuvenink, H. G. D., Oct 2018, In: Transplantation Direct. 4, 10, p. e388

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Pancreas
  • Tissue Donors
  • Perfusion
  • Brain Death
  • Transplantation

• Implementation of a Structured Diabetes Consultation Model to Facilitate a Person-Centered Approach: Results From a Nationwide Dutch Study

  Rutten, G. E. H. M., van Vugt, H. A., de Weerdt, I. & de Koning, E., Apr 2018, In: Diabetes Care. 41, 4, p. 688-695 8 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Referral and Consultation
  • Physicians
  • Nurses
  • General Practice
  • Hospital Outpatient Clinics

• RVCL-S and CADASIL display distinct impaired vascular function

  de Boer, I., Stam, A. H., Buntinx, L., Zielman, R., van der Steen, I., van den Maagdenberg, A. M. J. M., de Koning, E. J. P., Ferrari, M. D., de Hoon, J. N. & Terwindt, G. M., 04 Sep 2018, In: Neurology. 91, 10, p. e956-e963

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • CADASIL
  • Leukoencephalopathies
  • Cerebral Small Vessel Diseases
  • Vascular Smooth Muscle
  • Blood Vessels

• Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation

  Staels, W., Verdonck, Y., Heremans, Y., Leuckx, G., De Groef, S., Heirman, C., de Koning, E., Gysemans, C., Thielemans, K., Baeyens, L., Heimberg, H. & De Leu, N., Aug 2018, In: Diabetologia. 61, 8, p. 1804-1810 7 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Vascular Endothelial Growth Factor A
  • Transfection
  • Transplants
  • Messenger RNA
  • RNA
• 2017

  Association of fasting triglyceride concentration and postprandial triglyceride response with the carotid intima-media thickness in the middle aged: The Netherlands Epidemiology of Obesity study

  Christen, T., de Mutsert, R., Gast, K. B., Rensen, P. C. N., de Koning, E., Rosendaal, F. R., Trompet, S. & Jukema, J. W., 16 May 2017, In: Journal of Clinical Lipidology. 11, 2, p. 377-385.e1

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Carotid Intima-Media Thickness
  • Netherlands
  • Triglycerides
  • Fasting
  • Epidemiology

• Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

  Kracht, M. J. L., van Lummel, M., Nikolic, T., Joosten, A. M., Laban, S., van der Slik, A. R., van Veelen, P. A., Carlotti, F., de Koning, E. J. P., Hoeben, R. C., Zaldumbide, A. & Roep, B. O., Apr 2017, In: Nature Medicine. 23, 4, p. 501-507 7 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • T-cells
  • Medical problems
  • Autoimmunity
  • Genes
  • Type 1 Diabetes Mellitus

• Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

  Busse, N., Paroni, F., Richardson, S. J., Laiho, J. E., Oikarinen, M., Frisk, G., Hyöty, H., de Koning, E., Morgan, N. G. & Maedler, K., 21 Feb 2017, In: Oncotarget. 8, 8, p. 12620-12636 17 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Oligonucleotide Probes
  • RNA Probes
  • Type 1 Diabetes Mellitus
  • Pancreas
  • Virus Diseases

• DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

  Roost, M. S., Slieker, R. C., Bialecka, M., van Iperen, L., Gomes Fernandes, M. M., He, N., Suchiman, H. E. D., Szuhai, K., Carlotti, F., de Koning, E. J. P., Mummery, C. L., Heijmans, B. T. & Chuva de Sousa Lopes, S. M., 13 Oct 2017, In: Nature Communications. 8, 1, p. 908

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • DNA Methylation
  • methylation
  • Stem cells
  • stem cells
  • Pluripotent Stem Cells

• Increased vimentin in human α- and β-cells in type 2 diabetes

  Roefs, M. M., Carlotti, F., Jones, K., Wills, H., Hamilton, A., Verschoor, M., Durkin, J. M. W., Garcia-Perez, L., Brereton, M. F., McCulloch, L., Engelse, M. A., Johnson, P. R. V., Hansen, B. C., Docherty, K., de Koning, E. J. P. & Clark, A., Jun 2017, In: The Journal of endocrinology. 233, 3, p. 217-227 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Vimentin
  • Type 2 Diabetes Mellitus
  • Islets of Langerhans
  • Glucagon
  • Primates

• Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers

  Neiman, D., Moss, J., Hecht, M., Magenheim, J., Piyanzin, S., Shapiro, A. M. J., de Koning, E. J. P., Razin, A., Cedar, H., Shemer, R. & Dor, Y., 19 Dec 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. 13525-13530 6 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Islets of Langerhans
  • Methylation
  • Insulin
  • Glucagon
  • Genes

• Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization

  Marchioli, G., Zellner, L., Oliveira, C., Engelse, M. A., Koning, E. D., Mano, J., Karperien, M., Apeldoorn, A. V. & Moroni, L., 18 Nov 2017, In: Journal of Materials Science: Materials in Medicine. 28, 12, p. 195

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Intercellular Signaling Peptides and Proteins
  • Hydrogels
  • Encapsulation
  • Polyethylene Glycol Dimethacrylate Hydrogel
  • Islets of Langerhans

• Micro-fabricated scaffolds lead to efficient remission of diabetes in mice

  Buitinga, M., Assen, F., Hanegraaf, M., Wieringa, P., Hilderink, J., Moroni, L., Truckenmüller, R., van Blitterswijk, C., Römer, G-W., Carlotti, F., de Koning, E., Karperien, M. & van Apeldoorn, A., Aug 2017, In: Biomaterials. 135, p. 10-22 13 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Scaffolds
  • Medical problems
  • Transplantation
  • Islets of Langerhans
  • Lasers

• MiR-184 expression is regulated by AMPK in pancreatic islets

  Martinez-Sanchez, A., Nguyen-Tu, M-S., Cebola, I., Yavari, A., Marchetti, P., Piemonti, L., de Koning, E., Shapiro, A. M. J., Johnson, P., Sakamoto, K., Smith, D. M., Leclerc, I., Ashrafian, H., Ferrer, J. & Rutter, G. A., 21 Dec 2017, In: FASEB Journal.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Islets of Langerhans
  • MicroRNAs
  • Glucose
  • Medical problems
  • Gene expression

• Pancreas transplantation with grafts from donors deceased after circulatory death (DCD): 5 years single center experience

  Kopp, W. H., Lam, H-D., Schaapherder, A. F. M., Huurman, V. A. L., van der Boog, P., de Koning, E., de Fijter, J. W., Baranski, A. & Braat, A. E., 06 Sep 2017, In: Transplantation.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Pancreas Transplantation
  • Tissue Donors
  • Transplants
  • Brain Death
  • Pancreas

• Pancreatic islet macroencapsulation using microwell porous membranes

  Skrzypek, K., Groot Nibbelink, M., van Lente, J., Buitinga, M., Engelse, M. A., de Koning, E. J. P., Karperien, M., van Apeldoorn, A. & Stamatialis, D., 23 Aug 2017, In: Scientific Reports. 7, 1, p. 9186

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Islets of Langerhans
  • Islets of Langerhans Transplantation
  • Membranes
  • Glucose
  • Equipment and Supplies

• Pancreatic α-cell mass in obesity

  Ellenbroek, J. H., Töns, H. A. M., Hanegraaf, M. A. J., Rabelink, T. J., Engelse, M. A., Carlotti, F. & de Koning, E. J. P., Dec 2017, In: Diabetes, Obesity and Metabolism. 19, 12, p. 1810-1813 4 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Obesity
  • Pancreas
  • Head
  • Body Mass Index
  • Body Regions

• Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

  Dharmadhikari, G., Stolz, K., Hauke, M., Morgan, N. G., Varki, A., de Koning, E., Kelm, S. & Maedler, K., 05 Apr 2017, In: Scientific Reports. 7, p. 45319

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Islets of Langerhans
  • Cell Survival
  • Inflammation
  • human SIGLEC7 protein

• Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia

  Smink, A. M., Li, S., Swart, D. H., Hertsig, D. T., de Haan, B. J., Kamps, J. A. A. M., Schwab, L., van Apeldoorn, A., de Koning, E., Faas, M. M., Lakey, J. R. T. & de Vos, P., Sep 2017, In: Journal of Biomedical Materials Research - Part A. 105, 9, p. 2533-2542 10 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Intercellular Signaling Peptides and Proteins
  • Transplants
  • Fibroblast Growth Factor 1
  • Grafts
  • Scaffolds
• 2016

  A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets

  Smink, A. M., Hertsig, D. T., Schwab, L., van Apeldoorn, A. A., de Koning, E., Faas, M. M., de Haan, B. J. & de Vos, P., 15 Jul 2016, In: Journal of refractive surgery (Thorofare, N.J. : 1995).

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • lactide-caprolactone copolymer
  • Islets of Langerhans Transplantation
  • poly(1,4-butylene terephthalate)
  • terephthalic acid
  • poly(lactide)

• A Single-Cell Transcriptome Atlas of the Human Pancreas

  Muraro, M. J., Dharmadhikari, G., Grün, D., Groen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M. A., Carlotti, F., de Koning, E. J. P. & van Oudenaarden, A., 26 Oct 2016, In: Cell Systems. 3, 4, p. 385-394.e3

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Atlases
  • Transcriptome
  • Pancreas
  • Acinar Cells
  • Robotics

• Coculturing Human Islets with Proangiogenic Support Cells to Improve Islet Revascularization at the Subcutaneous Transplantation Site

  Buitinga, M., Janeczek Portalska, K., Cornelissen, D-J., Plass, J., Hanegraaf, M., Carlotti, F., de Koning, E., Engelse, M., van Blitterswijk, C., Karperien, M., van Apeldoorn, A. & de Boer, J., Feb 2016, In: Tissue engineering. Part A. 22, 3-4, p. 375-85 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Transplantation
  • Mesenchymal Stem Cells
  • Composite materials
  • Endothelial cells
  • Human Umbilical Vein Endothelial Cells

• De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

  Grün, D., Muraro, M. J., Boisset, J-C., Wiebrands, K., Lyubimova, A., Dharmadhikari, G., van den Born, M., van Es, J., Jansen, E., Clevers, H., de Koning, E. J. P. & van Oudenaarden, A., 21 Jun 2016, In: Cell Stem Cell.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Transcriptome
  • Stem Cells
  • Population
  • Adult Stem Cells
  • Hematopoietic Stem Cells

• Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected beta cells

  Schulte, B. M., Kers-Rebel, E. D., Bottino, R., Piganelli, J. D., Galama, J. M., Engelse, M. A., de Koning, E. J. & Adema, G. J., Jun 2016, In: Clinical & Experimental Immunology. 184, 3, p. 293-307 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Cell Communication
  • Dendritic Cells
  • Enterovirus
  • Type 1 Diabetes Mellitus
  • Cytokines

• Human islets and dendritic cells generate post-translationally modified islet auto-antigens

  McLaughlin, R. J., de Haan, A., Zaldumbide, A., de Koning, E. J., de Ru, A. H., van Veelen, P. A., van Lummel, M. & Roep, B. O., 09 Feb 2016, In: Clinical & Experimental Immunology.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Islets of Langerhans
  • Dendritic Cells
  • Antigens
  • Type 1 Diabetes Mellitus
  • transglutaminase 2

• Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans

  Marchioli, G., Luca, A. D., de Koning, E., Engelse, M., Van Blitterswijk, C. A., Karperien, M., Van Apeldoorn, A. A. & Moroni, L., Jul 2016, In: Advanced healthcare materials. 5, 13, p. 1606-16 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Polycaprolactone
  • Intercellular Signaling Peptides and Proteins
  • Alginate
  • polycaprolactone
  • Islets of Langerhans Transplantation