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• 2020

  Cerebellar plasticity and associative memories are controlled by perineuronal nets

  Carulli, D., Broersen, R., de Winter, F., Muir, E. M., Mešković, M., de Waal, M., de Vries, S., Boele, H-J., Canto, C. B., De Zeeuw, C. I. & Verhaagen, J., 09 Mar 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, p. 6855-6865

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Cerebellar Nuclei
  • Memory
  • Conditioning (Psychology)
  • Learning
  • Neurons
  308 Downloads (Pure)

• Combining timed GDNF and ChABC gene therapy to promote long-distance regeneration following ventral root avulsion and repair

  Eggers, R., de Winter, F., Smit, L., Luimens, M., Muir, E. M., Bradbury, E. J., Tannemaat, M. R. & Verhaagen, J., 2020, In: FASEB Journal. 34, p. 10605-10622

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Gene therapy
  • Chondroitin ABC Lyase
  • Glial Cell Line-Derived Neurotrophic Factor
  • Spinal Nerve Roots
  • Genetic Therapy
  187 Downloads (Pure)

• GDNF Gene Therapy to Repair the Injured Peripheral Nerve

  Eggers, R., de Winter, F., Tannemaat, M. R., Malessy, M. J. A. & Verhaagen, J., 2020, In: Frontiers in bioengineering and biotechnology. 8, p. 583184

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Gene therapy
  • Glial Cell Line-Derived Neurotrophic Factor
  • Spinal Nerve Roots
  • Peripheral Nerves
  • Motor Neurons
  73 Downloads (Pure)

• ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons

  Willems, J., de Jong, A. P. H., Scheefhals, N., Mertens, E., Catsburg, L. A. E., Poorthuis, R. B., de Winter, F., Verhaagen, J., Meye, F. J. & MacGillavry, H. D., 13 Jan 2020, In: PLoS Biology. 18, 4, p. e3000665

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • protein tagging
  • gene editing
  • Gene Editing
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Neurons
  148 Downloads (Pure)

• Regeneration of adult rat sensory and motor neuron axons through chimeric peroneal nerve grafts containing donor Schwann cells engineered to express different neurotrophic factors

  Godinho, M. J., Staal, J. L., Krishnan, V. S., Hodgetts, S. I., Pollett, M. A., Goodman, D. P., Teh, L., Verhaagen, J., Plant, G. W. & Harvey, A. R., 2020, In: Experimental Neurology. 330, p. 113355

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Peroneal Nerve
  • Schwann Cells
  • Nerve Growth Factors
  • Sensory Receptor Cells
  • Motor Neurons

• Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries

  Warren, P. M., Andrews, M. R., Smith, M., Bartus, K., Bradbury, E. J., Verhaagen, J., Fawcett, J. W. & Kwok, J. C. F., 09 Mar 2020, In: Scientific Reports. 10, 1, p. 11262

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Chondroitin ABC Lyase
  • Schwann Cells
  • Neuroglia
  • Chondroitin Sulfate Proteoglycans
  • Transplants
  90 Downloads (Pure)
• 2019

  Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease

  Hu, Y-T., Chen, X-L., Huang, S-H., Zhu, Q-B., Yu, S-Y., Shen, Y., Sluiter, A., Verhaagen, J., Zhao, J., Swaab, D. & Bao, A-M., 2019, In: Brain Pathology. 29, p. 502-512

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Acetylcholinesterase
  • Alzheimer Disease
  • Growth
  • Messenger RNA
  • Cholinergic Agents
  135 Downloads (Pure)

• Enhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsion

  Eggers, R., de Winter, F., Arkenaar, C., Tannemaat, M. R. & Verhaagen, J., 16 May 2019, In: Experimental Neurology. 321, p. 113037

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Glial Cell Line-Derived Neurotrophic Factor
  • Spinal Nerve Roots
  • Genetic Therapy
  • Axons
  • Regeneration

• Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex

  Boggio, E. M., Ehlert, E. M., Lupori, L., Moloney, E. B., De Winter, F., Vander Kooi, C. W., Baroncelli, L., Mecollari, V., Blits, B., Fawcett, J. W., Verhaagen, J. & Pizzorusso, T., Jan 2019, In: Molecular Neurobiology. 56, p. 5987-5997

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • ocular Dominance
  • Visual Cortex
  • Critical Period (Psychology)
  • Inhibition (Psychology)
  • Immunoglobulin Fc Fragments

• Recent advances in the therapeutic uses of chondroitinase ABC

  Muir, E., De Winter, F., Verhaagen, J. & Fawcett, J., Jan 2019, In: Experimental Neurology. 321, p. 113032

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Chondroitinases and Chondroitin Lyases
  • Chondroitin ABC Lyase
  • Therapeutic Uses
  • Spinal Cord Injuries
  • Enzymes

• The Effects of Sindbis Viral Vectors on Neuronal Function

  Uyaniker, S., van der Spek, S. J. F., Reinders, N. R., Xiong, H., Li, K. W., Bossers, K., Smit, A. B., Verhaagen, J. & Kessels, H. W., 2019, In: Frontiers in Cellular Neuroscience. 13, p. 362

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Neurons
  • Proteome
  • Transcriptome
  • Proteins
  • Injections
  79 Downloads (Pure)

• Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.

  Eggers, R., De Winter, F., Hoyng, S. A., Hoeben, R. C., Malessy, M. J., Tannemaat, M. & Verhaagen, J., 16 Jan 2019, In: Brain. 142, p. 295-311

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Switch Genes
  • Glial Cell Line-Derived Neurotrophic Factor
  • Genetic Therapy
  • Axons
  • Regeneration

• Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

  Melief, J., Orre, M., Bossers, K., van Eden, C. G., Schuurman, K. G., Mason, M. R. J., Verhaagen, J., Hamann, J. & Huitinga, I., 25 Apr 2019, In: Acta neuropathologica communications. 7, 1, 60.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Gene Expression Profiling
  • Transcriptome
  • White Matter
  • Multiple Sclerosis
  • Hydrocortisone
  277 Downloads (Pure)
• 2018

  Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.

  Burnside, E. R., De Winter, F., Didangelos, A., James, N. D., Andreica, E. C., Layard-Horsfall, H., Muir, E. M., Verhaagen, J. & Bradbury, E. J., Jul 2018, In: Brain. 141, p. 2362-2381

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Chondroitinases and Chondroitin Lyases
  • Switch Genes
  • Spinal Cord Injuries
  • Chondroitin ABC Lyase
  • Genetic Therapy
  244 Downloads (Pure)

• Integrins promote axonal regeneration after injury of the nervous system

  Nieuwenhuis, B., Haenzi, B., Andrews, M. R., Verhaagen, J. & Fawcett, J. W., 2018, In: Biological Reviews. 93, p. 1339-1362

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • integrins
  • Nervous System Trauma
  • Neurology
  • nervous system
  • Integrins
  242 Downloads (Pure)

• Intrinsic Determinants of Axon Regeneration

  Fawcett, J. W. & Verhaagen, J., Sep 2018, In: Developmental Neurobiology. 78, p. 890-897

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Axons
  • Regeneration
  • Axotomy
  • Axonal Transport
  • Neurons

• Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair

  Maldonado-Lasunción, I., Verhaagen, J. & Oudega, M., 2018, In: Neurotherapeutics. 15, p. 578-587

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Spinal Cord Regeneration
  • Mesenchymal Stem Cells
  • Macrophages
  • Spinal Cord Injuries
  • Wounds and Injuries
  149 Downloads (Pure)

• Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System

  Verhaagen, J., Hobo, B., Ehlert, E. M. E., Eggers, R., Korecka, J. A., Hoyng, S. A., Attwell, C. L., Harvey, A. R. & Mason, M. R. J., 03 Jan 2018, In: Methods in Molecular Biology. 1715, p. 3-17 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Viral Genes
  • Nervous System
  • Optogenetics
  • caN protocol
  • Phase II Clinical Trials
  237 Downloads (Pure)

• The dorsal column lesion model of spinal cord injury and its use in deciphering the neuron-intrinsic injury response

  Attwell, C. L., van Zwieten, M., Verhaagen, J. & Mason, M. R. J., 2018, In: Developmental Neurobiology. 78, p. 926-951

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Spinal Cord Injuries
  • Neurons
  • Wounds and Injuries
  • Spinal Ganglia
  • Axotomy
  172 Downloads (Pure)
• 2017

  Expression of a Mutant SEMA3A Protein with Diminished Signalling Capacity Does Not Alter ALS-Related Motor Decline, or Confer Changes in NMJ Plasticity after BotoxA-Induced Paralysis of Male Gastrocnemic Muscle

  Moloney, E., Hobo, B., De Winter, F. & Verhaagen, J., 19 Jan 2017, In: PLoS One. 12, 1, p. e0170314

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • amyotrophic lateral sclerosis
  • Semaphorin-3A
  • paralysis
  • Neuromuscular Junction
  • Amyotrophic Lateral Sclerosis
  306 Downloads (Pure)

• Repulsive guidance molecule a (RGMa) induces neuropathological and behavioral changes that closely resemble Parkinson's disease

  Korecka, J. A., Moloney, E. B., Eggers, R., Hobo, B., Scheffer, S., Ras-Verloop, N., Pasterkamp, R. J., Swaab, D. F., Smit, A. B., van Kesteren, R. E., Bossers, K. & Verhaagen, J., 01 Sep 2017, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, p. 9361-9379

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Dopaminergic Neurons
  • Parkinson Disease
  • Axon Guidance
  • Substantia Nigra
  • Cues
  182 Downloads (Pure)

• Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface

  O'Neill, P., Lindsay, S. L., Pantiru, A., Guimond, S. E., Fagoe, N. D., Verhaagen, J., Turnbull, J. E., Riddell, J. S. & Barnett, S. C., 2017, In: GLIA. 65, p. 19-33

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Sulfatases
  • Schwann Cells
  • Astrocytes
  • Neuroglia
  • Injections
  214 Downloads (Pure)
• 2016

  Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent

  Andrews, M. R., Soleman, S., Cheah, M., Tumbarello, D. A., Mason, M. R. J., Moloney, E., Verhaagen, J., Bensadoun, J-C., Schneider, B., Aebischer, P. & Fawcett, J. W., Jul 2016, In: eNeuro. 3, 4, 0029-16.2016.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Integrins
  • Axons
  • Tn receptor
  • Rhizotomy
  • Red Nucleus
  529 Downloads (Pure)

• Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion

  Eggers, R., Tannemaat, M. R., De Winter, F., Malessy, M. J. A. & Verhaagen, J., Feb 2016, In: The European journal of neuroscience. 43, 3, p. 318-35 18 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Spinal Nerve Roots
  • Regeneration
  • Motor Neurons
  • Replantation
  • Axons

• Evaluation of Five Tests for Sensitivity to Functional Deficits following Cervical or Thoracic Dorsal Column Transection in the Rat

  Fagoe, N. D., Attwell, C. L., Eggers, R., Tuinenbreijer, L., Kouwenhoven, D., Verhaagen, J. & Mason, M. R. J., 2016, In: PLoS One. 11, 3, p. e0150141

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Ladders
  • Rats
  • ladders
  • chest
  • lesions (animal)
  241 Downloads (Pure)

• Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.

  Cheah, M., Andrews, M. R., Chew, D. J., Moloney, E., Verhaagen, J., Fässler, R. & Fawcett, J. W., 06 Jul 2016, In: Journal of Neuroscience. 36, 27, p. 7283-97 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Spinal Cord Regeneration
  • Tenascin
  • Integrins
  • Axons
  • Regeneration
  263 Downloads (Pure)

• The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

  de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D. & Verhaagen, J., 2016, In: Neural Plasticity. 2016, p. 3679545

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Semaphorin-3A
  • Proteins
  • Neuronal Plasticity
  • Brain
  • Semaphorins
  564 Downloads (Pure)