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• 2020

  5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

  Cho, Y-H., Ro, E. J., Yoon, J-S., Mizutani, T., Kang, D-W., Park, J-C., Il Kim, T., Clevers, H. & Choi, K-Y., 21 Oct 2020, In: Nature Communications. 11, 1, p. 5321

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Catenins
  • Fluorouracil
  • cancer
  • Chemical activation
  • Colorectal Neoplasms

• A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing

  Saltsman, J. A., Hammond, W. J., Narayan, N. J. C., Requena, D., Gehart, H., Lalazar, G., LaQuaglia, M. P., Clevers, H. & Simon, S., 18 Sep 2020, In: Cancers. 12, 9

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Hepatoblastoma
  • Organoids
  • Drug Design
  • Neoplasms
  • Liver

• An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

  Calandrini, C., Schutgens, F., Oka, R., Margaritis, T., Candelli, T., Mathijsen, L., Ammerlaan, C., van Ineveld, R. L., Derakhshan, S., de Haan, S., Dolman, E., Lijnzaad, P., Custers, L., Begthel, H., Kerstens, H. H. D., Visser, L. L., Rookmaaker, M., Verhaar, M., Tytgat, G. A. M., Kemmeren, P. & 11 others, de Krijger, R. R., Al-Saadi, R., Pritchard-Jones, K., Kool, M., Rios, A. C., van den Heuvel-Eibrink, M. M., Molenaar, J. J., van Boxtel, R., Holstege, F. C. P., Clevers, H. & Drost, J., 11 Mar 2020, In: Nature Communications. 11, 1, p. 1310

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • kidneys
  • Kidney Neoplasms
  • Tumors
  • tumors

• An Organoid-derived Bronchioalveolar Model for SARS-CoV-2 Infection of Human Alveolar-type II-like Cells

  Lamers, M. M., van der Vaart, J., Knoops, K., Riesebosch, S., Breugem, T. I., Mykytyn, A. Z., Beumer, J., Schipper, D., Bezstarosti, K., Koopman, C. D., Groen, N., Ravelli, R. B. G., Duimel, H. Q., Demmers, J. A. A., Verjans, G. M. G. M., Koopmans, M. P. G., Muraro, M. J., Peters, P. J., Clevers, H. & Haagmans, B. L., 06 Dec 2020, In: EMBO Journal. p. e105912

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Coronavirus Infections
  • Organoids
  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Viruses

• Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells

  Murata, K., Jadhav, U., Madha, S., van Es, J., Dean, J., Cavazza, A., Wucherpfennig, K., Michor, F., Clevers, H. & Shivdasani, R. A., 05 Mar 2020, In: Cell Stem Cell. 26, 3, p. 377-390.e6

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Cell Dedifferentiation
  • Regeneration
  • Stem Cells
  • Interleukin-11 Receptors
  • Interleukin-11

• Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

  Lõhmussaar, K., Kopper, O., Korving, J., Begthel, H., Vreuls, C. P. H., van Es, J. H. & Clevers, H., 27 May 2020, In: Nature Communications. 11, 1, p. 2660

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • mice
  • Tumors
  • grade

• Cell fate specification and differentiation in the adult mammalian intestine

  Beumer, J. & Clevers, H., 21 Sep 2020, In: Nature reviews. Molecular cell biology.

  Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

  • Intestines
  • Stem Cells
  • Organoids
  • Cell Plasticity
  • Intestinal Mucosa

• Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

  Dijkstra, K. K., Monkhorst, K., Schipper, L. J., Hartemink, K. J., Smit, E. F., Kaing, S., de Groot, R., Wolkers, M. C., Clevers, H., Cuppen, E. & Voest, E. E., 05 May 2020, In: Cell Reports. 31, 5, p. 107588

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Precision Medicine
  • Tumors
  • Medicine
  • Lung Neoplasms

• Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids

  Wiechmann, S., Maisonneuve, P., Grebbin, B. M., Hoffmeister, M., Kaulich, M., Clevers, H., Rajalingam, K., Kurinov, I., Farin, H. F., Sicheri, F. & Ernst, A., 03 Apr 2020, In: The Journal of biological chemistry. 295, 14, p. 4526-4540 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • ras Proteins
  • Conformations
  • Dependency (Psychology)
  • Mutation

• COVID-19: organoids go viral

  Clevers, H., 01 Jul 2020, In: Nature Reviews Molecular Cell Biology. 21, 7, p. 355-356 2 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

  Geurts, M. H., de Poel, E., Amatngalim, G. D., Oka, R., Meijers, F. M., Kruisselbrink, E., van Mourik, P., Berkers, G., de Winter-de Groot, K. M., Michel, S., Muilwijk, D., Aalbers, B. L., Mullenders, J., Boj, S. F., Suen, S. W. F., Brunsveld, J. E., Janssens, H. M., Mall, M. A., Graeber, S. Y., van Boxtel, R. & 3 others, van der Ent, C. K., Beekman, J. M. & Clevers, H., 02 Apr 2020, In: Cell Stem Cell. 26, 4, p. 503-510.e7

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Adenine
  • Nonsense Codon
  • Cystic Fibrosis

• CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

  Hendriks, D., Clevers, H. & Artegiani, B., 05 Nov 2020, In: Cell Stem Cell. 27, 5, p. 705-731 27 p.

  Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

  • Organoids
  • Genetic Engineering
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Stem Cells
  • CRISPR-Cas Systems

• Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss

  Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, B-K., Dollé, P., Bloch-Zupan, A. & Niederreither, K., 09 Sep 2020, In: Scientific Reports. 10, 1, p. 14817

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • endoplasmic reticulum glycoprotein p72
  • Tooth Injuries
  • Calcium
  • Bone and Bones
  • Tooth

• Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer

  Whittle, J. R., Vaillant, F., Surgenor, E., Policheni, A. N., Giner, G., Capaldo, B. D., Chen, H-R., Liu, H. K., Dekkers, J. F., Sachs, N., Clevers, H., Fellowes, A., Green, T., Xu, H., Fox, S. B., Herold, M. J., Smyth, G. K., Gray, D. H. D., Visvader, J. E. & Lindeman, G. J., 01 Aug 2020, In: Clinical Cancer Research. 26, 15, p. 4120-4134 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Cyclin-Dependent Kinase 6
  • Cyclin-Dependent Kinase 4
  • venetoclax
  • palbociclib
  • Estrogen Receptors

• Enteroendocrine Dynamics - New Tools Reveal Hormonal Plasticity in the Gut

  Beumer, J., Gehart, H. & Clevers, H., 01 Oct 2020, In: Endocrine connections. 41, 5

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Enteroendocrine Cells
  • Organoids
  • Bone Morphogenetic Proteins
  • Endocrine Cells
  • Adult Stem Cells

• Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation

  Wei, G., Gao, N., Chen, J., Fan, L., Zeng, Z., Gao, G., Li, L., Fang, G., Hu, K., Pang, X., Fan, H-Y., Clevers, H., Liu, M., Zhang, X. & Li, D., 02 Sep 2020, In: Development (Cambridge). 147, 17

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • proliferation
  • cell
  • life-span
  • activation
  • death

• Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells

  Pleguezuelos-Manzano, C., Puschhof, J., van den Brink, S., Geurts, V., Beumer, J. & Clevers, H., Sep 2020, In: Current protocols in immunology. 130, 1, p. e106

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Adult Stem Cells
  • Conditioned Culture Medium
  • Small Intestine
  • Colon

• Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver

  Hendriks, D., Artegiani, B., Hu, H., Chuva de Sousa Lopes, S. & Clevers, H., 27 Nov 2020, In: Nature Protocols.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Hepatocytes
  • Organoids
  • Cell culture
  • Gene Knockout Techniques
  • Clustered Regularly Interspaced Short Palindromic Repeats

• Establishment of patient-derived cancer organoids for drug-screening applications

  Driehuis, E., Kretzschmar, K. & Clevers, H., Oct 2020, In: Nature Protocols. 15, 10, p. 3380-3409 30 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Preclinical Drug Evaluations
  • Screening
  • Tissue
  • Epithelial Cells

• Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing

  Artegiani, B., Hendriks, D., Beumer, J., Kok, R., Zheng, X., Joore, I., Chuva de Sousa Lopes, S., van Zon, J., Tans, S. & Clevers, H., Mar 2020, In: Nature Cell Biology. 22, 3, p. 321-331 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Gene Editing
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Gene Transfer Techniques
  • Spindle Apparatus

• Fasting-mimicking diet and hormone therapy induce breast cancer regression

  Caffa, I., Spagnolo, V., Vernieri, C., Valdemarin, F., Becherini, P., Wei, M., Brandhorst, S., Zucal, C., Driehuis, E., Ferrando, L., Piacente, F., Tagliafico, A., Cilli, M., Mastracci, L., Vellone, V. G., Piazza, S., Cremonini, A. L., Gradaschi, R., Mantero, C., Passalacqua, M. & 14 others, Ballestrero, A., Zoppoli, G., Cea, M., Arrighi, A., Odetti, P., Monacelli, F., Salvadori, G., Cortellino, S., Clevers, H., De Braud, F., Sukkar, S. G., Provenzani, A., Longo, V. D. & Nencioni, A., Jul 2020, In: Nature. 583, 7817, p. 620-624 5 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Diet Therapy
  • Fasting
  • Hormones
  • Breast Neoplasms
  • Diet

• Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

  Ringel, T., Frey, N., Ringnalda, F., Janjuha, S., Cherkaoui, S., Butz, S., Srivatsa, S., Pirkl, M., Russo, G., Villiger, L., Rogler, G., Clevers, H., Beerenwinkel, N., Zamboni, N., Baubec, T. & Schwank, G., 05 Mar 2020, In: Cell Stem Cell. 26, 3, p. 431-440.e8

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Genome
  • Genes
  • Chromatin Assembly and Disassembly

• Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance

  Joosten, S. P. J., Spaargaren, M., Clevers, H. & Pals, S. T., Dec 2020, In: Biochimica et biophysica acta. Reviews on cancer. 1874, 2, p. 188437

  Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

  Open Access

  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-met
  • Colorectal Neoplasms
  • Carcinogenesis
  • Stem Cells

• High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

  Beumer, J., Puschhof, J., Bauzá-Martinez, J., Martínez-Silgado, A., Elmentaite, R., James, K. R., Ross, A., Hendriks, D., Artegiani, B., Busslinger, G. A., Ponsioen, B., Andersson-Rolf, A., Saftien, A., Boot, C., Kretzschmar, K., Geurts, M. H., Bar-Ephraim, Y. E., Pleguezuelos-Manzano, C., Post, Y., Begthel, H. & 12 others, van der Linden, F., Lopez-Iglesias, C., van de Wetering, W. J., van der Linden, R., Peters, P. J., Heck, A. J. R., Goedhart, J., Snippert, H., Zilbauer, M., Teichmann, S. A., Wu, W. & Clevers, H., 11 Jun 2020, In: Cell. 181, 6, p. 1291-1306.e19

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Enteroendocrine Cells
  • Atlases
  • Hormones
  • Messenger RNA
  • Organoids

• Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

  Nikolaev, M., Mitrofanova, O., Broguiere, N., Geraldo, S., Dutta, D., Tabata, Y., Elci, B., Brandenberg, N., Kolotuev, I., Gjorevski, N., Clevers, H. & Lutolf, M. P., Sep 2020, In: Nature. 585, 7826, p. 574-578 5 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Morphogenesis
  • Intestines
  • Stem Cells
  • Longevity

• How the COVID-19 pandemic highlights the necessity of animal research

  Genzel, L., Adan, R., Berns, A., van den Beucken, J., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., Dam, A-M. V., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., Fentener van Vlissingen, J. M. & 62 others, la Fleur, S., Fouchier, R., Fitzsimons, C. P., Frieling, W., Haagmans, B., Heesters, B. A., Henckens, M., Herfst, S., Hol, E., van den Hove, D., de Jonge, M. I., Jonkers, J., Joosten, L. A. B., Kalsbeek, A., Kamermans, M., Kampinga, H. H., Kas, M. J., Keijer, J., Kersten, S., Kiliaan, A. J., Kooij, T. W. A., Kooijman, S., Koopman, W. J. H., Korosi, A., Krugers, H. J., Kuiken, T., Kushner, S. A., Langermans, J. A. M., Lesscher, H., Lucassen, P. J., Lutgens, E., Netea, M. G., Noldus, L. P. J. J., van der Meer, J. W. M., Meye, F. J., Mul, J. D., van Oers, K., Olivier, J. D. A., Pasterkamp, R. J., Philippens, I. H. C. H. M., Prickaerts, J., Pullox, B., Rensen, P. C. N., van Rheenen, J., van Rij, R. P., Ritsma, L., Rockx, B. H. G., Roozendaal, B., van Schothorst, E. M., Stittelaar, K., Stockhofe, N., Swaab, D. F., de Swart, R. L., Vanderschuren, L. J. M. J., de Vries, T., de Vrij, F., van Wezel, R., Wierenga, C. J., Wiesmann, M., Willuhn, I., de Zeeuw, C. I. & Homberg, J. R., 10 Aug 2020, In: Current Biology. 30, 18, p. R1014-R1018 5 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • animal research
  • pandemic
  • Pandemics
  • Animals
  • animals
  65 Downloads (Pure)

• Human-Derived Model Systems in Gynecological Cancer Research

  Lõhmussaar, K., Boretto, M. & Clevers, H., Dec 2020, In: Trends in Cancer. 6, 12, p. 1031-1043 13 p.

  Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

  Open Access

  • Vaginal Neoplasms
  • Vulvar Neoplasms
  • Vulva
  • Fallopian Tubes
  • Vagina

• Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

  Verstegen, M. M. A., Roos, F. J. M., Burka, K., Gehart, H., Jager, M., de Wolf, M., Bijvelds, M. J. C., de Jonge, H. R., Ardisasmita, A. I., van Huizen, N. A., Roest, H. P., de Jonge, J., Koch, M., Pampaloni, F., Fuchs, S. A., Schene, I. F., Luider, T. M., van der Doef, H. P. J., Bodewes, F. A. J. A., de Kleine, R. H. J. & 6 others, Spee, B., Kremers, G-J., Clevers, H., IJzermans, J. N. M., Cuppen, E. & van der Laan, L. J. W., 14 Dec 2020, In: Scientific Reports. 10, 1, p. 21900

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Bile Duct Diseases
  • Organoids
  • Cystic Fibrosis
  • Extrahepatic Bile Ducts
  • Intrahepatic Bile Ducts

• Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions

  Boonekamp, K. E., Dayton, T. L. & Clevers, H., 01 Aug 2020, In: Nature Reviews Molecular Cell Biology. 12, 8, p. 562-568 7 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• Intestinal Regeneration: Regulation by the Microenvironment

  Hageman, J. H., Heinz, M. C., Kretzschmar, K., van der Vaart, J., Clevers, H. & Snippert, H. J. G., 24 Aug 2020, In: Developmental Cell. 54, 4, p. 435-446 12 p.

  Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

  • Stem cells
  • Regeneration
  • Stem Cells
  • Stem Cell Niche
  • Mechanical Stress

• Kidney Organoids and Tubuloids

  Yousef Yengej, F. A., Jansen, J., Rookmaaker, M. B., Verhaar, M. C. & Clevers, H., 26 May 2020, In: Cells. 9, 6

  Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

  Open Access

  • Stem cells
  • Organoids
  • Physiology
  • Regenerative Medicine
  • Kidney

• LifeTime and improving European healthcare through cell-based interceptive medicine

  Nov 2020, In: Nature. 587, 7834, p. 377-386 10 p.

  Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

  Open Access

  • Medicine
  • Delivery of Health Care
  • Disease Progression
  • Artificial Intelligence
  • Health

• Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors

  Wang, D., Wang, J., Bai, L., Pan, H., Feng, H., Clevers, H. & Zeng, Y. A., 19 Mar 2020, In: Cell. 180, 6, p. 1198-1211.e19

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Islets of Langerhans
  • Cells
  • Endothelial Protein C Receptor
  • Differentiation Antigens

• Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease

  Kruitwagen, H. S., Oosterhoff, L. A., van Wolferen, M. E., Chen, C., Nantasanti Assawarachan, S., Schneeberger, K., Kummeling, A., van Straten, G., Akkerdaas, I. C., Vinke, C. R., van Steenbeek, F. G., van Bruggen, L. W. L., Wolfswinkel, J., Grinwis, G. C. M., Fuchs, S. A., Gehart, H., Geijsen, N., Vries, R. G., Clevers, H., Rothuizen, J. & 3 others, Schotanus, B. A., Penning, L. C. & Spee, B., 11 Feb 2020, In: Cells. 9, 2

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Liver
  • Metabolic Diseases
  • Hepatocytes
  • Canidae

• Mathematical model of colorectal cancer initiation

  Paterson, C., Clevers, H. & Bozic, I., 25 Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20681-20688 8 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Theoretical Models
  • Colorectal Neoplasms
  • Mutation Rate
  • Oncogenes
  • Tumor Suppressor Genes

• Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

  Pleguezuelos-Manzano, C., Puschhof, J., Rosendahl Huber, A., van Hoeck, A., Wood, H. M., Nomburg, J., Gurjao, C., Manders, F., Dalmasso, G., Stege, P. B., Paganelli, F. L., Geurts, M. H., Beumer, J., Mizutani, T., Miao, Y., van der Linden, R., van der Elst, S., Garcia, K. C., Top, J., Willems, R. J. L. & 7 others, Giannakis, M., Bonnet, R., Quirke, P., Meyerson, M., Cuppen, E., van Boxtel, R. & Clevers, H., Apr 2020, In: Nature. 580, 7802, p. 269-273 5 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Genomic Islands
  • Colorectal Neoplasms
  • Escherichia coli
  • Bacteria

• Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

  Miao, Y., Ha, A., de Lau, W., Yuki, K., Santos, A. J. M., You, C., Geurts, M. H., Puschhof, J., Pleguezuelos-Manzano, C., Peng, W. C., Senlice, R., Piani, C., Buikema, J. W., Gbenedio, O. M., Vallon, M., Yuan, J., de Haan, S., Hemrika, W., Rösch, K., Dang, L. T. & 13 others, Baker, D., Ott, M., Depeille, P., Wu, S. M., Drost, J., Nusse, R., Roose, J. P., Piehler, J., Boj, S. F., Janda, C. Y., Clevers, H., Kuo, C. J. & Garcia, K. C., 05 Nov 2020, In: Cell Stem Cell. 27, 5, p. 840-851.e6

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Growth
  • Frizzled Receptors
  • Stem Cells
  • Regenerative Medicine

• Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

  Rosenbluth, J. M., Schackmann, R. C. J., Gray, G. K., Selfors, L. M., Li, C. M-C., Boedicker, M., Kuiken, H. J., Richardson, A., Brock, J., Garber, J., Dillon, D., Sachs, N., Clevers, H. & Brugge, J. S., 06 Apr 2020, In: Nature Communications. 11, 1, p. 1711

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • breast
  • cancer
  • Tissue
  • Breast

• Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

  Yan, H. H. N., Siu, H. C., Ho, S. L., Yue, S. S. K., Gao, Y., Tsui, W. Y., Chan, D., Chan, A. S., Wong, J. W. H., Man, A. H. Y., Lee, B. C. H., Chan, A. S. Y., Chan, A. K. W., Hui, H. S., Cheung, A. K. L., Law, W. L., Lo, O. S. H., Yuen, S. T., Clevers, H. & Leung, S. Y., Dec 2020, In: Gut. 69, 12, p. 2165-2179 15 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Genetic Profile
  • Colorectal Neoplasms
  • Mutation
  • Colon

• Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

  Yao, Y., Xu, X., Yang, L., Zhu, J., Wan, J., Shen, L., Xia, F., Fu, G., Deng, Y., Pan, M., Guo, Q., Gao, X., Li, Y., Rao, X., Zhou, Y., Liang, L., Wang, Y., Zhang, J., Zhang, H., Li, G. & 8 others, Zhang, L., Peng, J., Cai, S., Hu, C., Gao, J., Clevers, H., Zhang, Z. & Hua, G., 02 Jan 2020, In: Cell Stem Cell. 26, 1, p. 17-26.e6

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Rectal Neoplasms
  • Phase III Clinical Trials
  • Sensitivity and Specificity
  • Clinical Trials

• Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

  de Witte, C. J., Espejo Valle-Inclan, J., Hami, N., Lõhmussaar, K., Kopper, O., Vreuls, C. P. H., Jonges, G. N., van Diest, P., Nguyen, L., Clevers, H., Kloosterman, W. P., Cuppen, E., Snippert, H. J. G., Zweemer, R. P., Witteveen, P. O. & Stelloo, E., 16 Jun 2020, In: Cell Reports. 31, 11, p. 107762

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Ovarian Neoplasms
  • Tumors
  • Pharmaceutical Preparations
  • Chemotherapy

• Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses

  Raimondi, G., Mato-Berciano, A., Pascual-Sabater, S., Rovira-Rigau, M., Cuatrecasas, M., Fondevila, C., Sánchez-Cabús, S., Begthel, H., Boj, S. F., Clevers, H. & Fillat, C., Jun 2020, In: EBioMedicine. 56, p. 102786

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Tumors
  • Chemotherapy
  • Cytotoxicity
  • Adenoviridae

• Primary Intestinal Epithelial Organoid Culture

  Mizutani, T. & Clevers, H., 2020, In: Methods in molecular biology (Clifton, N.J.). 2171, p. 185-200 16 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Stem Cells
  • Intestines
  • Epithelial Cells
  • Stem Cell Research

• SARS-CoV-2 productively infects human gut enterocytes

  Lamers, M. M., Beumer, J., van der Vaart, J., Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Paul van Schayck, J., Mykytyn, A. Z., Duimel, H. Q., van Donselaar, E., Riesebosch, S., Kuijpers, H. J. H., Schipper, D., van de Wetering, W. J., de Graaf, M., Koopmans, M., Cuppen, E., Peters, P. J., Haagmans, B. L. & 1 others, Clevers, H., 03 Jul 2020, In: Science. 369, 6499, p. 50-54 5 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Enterocytes
  • Organoids
  • coronavirus receptor

• Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies

  Battich, N., Beumer, J., de Barbanson, B., Krenning, L., Baron, C. S., Tanenbaum, M. E., Clevers, H. & van Oudenaarden, A., 06 Mar 2020, In: Science. 367, 6482, p. 1151-1156 6 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Messenger RNA
  • Gene Expression
  • Cell Differentiation
  • Population
  • Cell Cycle

• Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

  Demmers, L. C., Kretzschmar, K., Van Hoeck, A., Bar-Epraïm, Y. E., van den Toorn, H. W. P., Koomen, M., van Son, G., van Gorp, J., Pronk, A., Smakman, N., Cuppen, E., Clevers, H., Heck, A. J. R. & Wu, W., 21 Oct 2020, In: Nature Communications. 11, 1, p. 5338

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • leukocytes
  • Organoids
  • antigens
  • peptides
  • Tumors

• Snake Venom Gland Organoids

  Post, Y., Puschhof, J., Beumer, J., Kerkkamp, H. M., de Bakker, M. A. G., Slagboom, J., de Barbanson, B., Wevers, N. R., Spijkers, X. M., Olivier, T., Kazandjian, T. D., Ainsworth, S., Iglesias, C. L., van de Wetering, W. J., Heinz, M. C., van Ineveld, R. L., van Kleef, R. G. D. M., Begthel, H., Korving, J., Bar-Ephraim, Y. E. & 11 others, Getreuer, W., Rios, A. C., Westerink, R. H. S., Snippert, H. J. G., van Oudenaarden, A., Peters, P. J., Vonk, F. J., Kool, J., Richardson, M. K., Casewell, N. R. & Clevers, H., 23 Jan 2020, In: Cell. 180, 2, p. 233-247.e21

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Snake Venoms
  • Venoms
  • Stem cells
  • Tissue

• The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies

  Busslinger, G. A., Lissendorp, F., Franken, I. A., van Hillegersberg, R., Ruurda, J. P., Clevers, H. & de Maat, M. F. G., Apr 2020, In: Open Biology. 10, 4, p. 190274

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Tumors
  • Oncology
  • Biopsy
  • Gastrointestinal Neoplasms

• Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

  Tanaka, N., Kanatani, S., Kaczynska, D., Fukumoto, K., Louhivuori, L., Mizutani, T., Kopper, O., Kronqvist, P., Robertson, S., Lindh, C., Kis, L., Pronk, R., Niwa, N., Matsumoto, K., Oya, M., Miyakawa, A., Falk, A., Hartman, J., Sahlgren, C., Clevers, H. & 1 others, Uhlén, P., Sep 2020, In: Annals of Biomedical Engineering. 4, 9, p. 875-888 14 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Biopsy
  • RNA
  • Tumors
  • Proteins
  • Imaging techniques

• Translation and Replication Dynamics of Single RNA Viruses

  Boersma, S., Rabouw, H. H., Bruurs, L. J. M., Pavlovič, T., van Vliet, A. L. W., Beumer, J., Clevers, H., van Kuppeveld, F. J. M. & Tanenbaum, M. E., 06 Nov 2020, In: Cell.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Viruses
  • RNA Viruses
  • Single Molecule Imaging
  • Virus Diseases
  • RNA