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• 2020

  A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells

  Ormel, P. R., Böttcher, C., Gigase, F. A. J., Missall, R. D., van Zuiden, W., Camila Fernández Zapata, M., Ilhan, D., de Goeij, M., Udine, E., Sommer, I. E. C., Priller, J., Raj, T., Kahn, R. S., Hol, E. M. & de Witte, L. D., 2020, In: Brain, Behavior, and Immunity. 90, p. 196-207

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Microglia
  • Schizophrenia
  • Phenotype
  • RNA Sequence Analysis
  • HLA-DR Antigens

• Cannabinoids and psychotic symptoms: A potential role for a genetic variant in the P2X purinoceptor 7 (P2RX7) gene

  Boks, M. P., He, Y., Schubart, C. D., van Gastel, W., Elkrief, L., Huguet, G., van Eijk, K., Vinkers, C. H., Kahn, R. S., Paus, T., Conrod, P., Hol, E. M. & de Witte, L. D., 2020, In: Brain, Behavior, and Immunity. 88, p. 573-581

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Purinergic P2X Receptors
  • Cannabinoids
  • Cannabis
  • Genes
  • Purinergic P2X7 Receptors

• Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage

  van Dijk, B. J., Meijers, J. C. M., Kloek, A. T., Knaup, V. L., Rinkel, G. J. E., Morgan, B. P., van der Kamp, M. J., Osuka, K., Aronica, E., Ruigrok, Y. M., van de Beek, D., Brouwer, M., Pekna, M., Hol, E. M. & Vergouwen, M. D. I., 2020, In: Translational Stroke Research. 11, p. 678-688

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Complement C5
  • Subarachnoid Hemorrhage
  • Brain Injuries
  • Anaphylatoxin C5a Receptor
  • Complement Activation
  124 Downloads (Pure)

• From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation

  Goulay, R., Mena Romo, L., Hol, E. M. & Dijkhuizen, R. M., 2020, In: Translational Stroke Research. 11, p. 601-614

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Amyloid
  • Dementia
  • Stroke
  • Cerebral Amyloid Angiopathy
  • Glymphatic System
  81 Downloads (Pure)

• Increased number of T-lymphocytes in post-mortem brain tissue of patients with schizophrenia

  Sneeboer, M. A. M., van Mierlo, H. C., Stotijn, E., MacIntyre, D. J., Smith, C., Kahn, R. S., Hol, E. M. & de Witte, L. D., 2020, In: Schizophrenia Research. 216, p. 526-528

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

• Microglial activation in schizophrenia: Is translocator 18 kDa protein (TSPO) the right marker?

  Sneeboer, M. A. M., van der Doef, T., Litjens, M., Psy, N. B. B., Melief, J., Hol, E. M., Kahn, R. S. & de Witte, L. D., 2020, In: Schizophrenia Research. 215, p. 167-172

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Schizophrenia
  • Microglia
  • Proteins
  • Positron-Emission Tomography
  • Brain

• The adult human subventricular zone: partial ependymal coverage and proliferative capacity of cerebrospinal fluid

  de Sonnaville, S. F. A. M., van Strien, M. E., Middeldorp, J., Sluijs, J. A., van den Berge, S. A., Moeton, M., Donega, V., van Berkel, A., Deering, T., De Filippis, L., Vescovi, A. L., Aronica, E., Glass, R., van de Berg, W. D. J., Swaab, D. F., Robe, P. A. & Hol, E. M., 2020, In: Brain communications. 2, 2, p. fcaa150

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Neural Stem Cells
  • Lateral Ventricles
  • Cerebrospinal Fluid
  • Neurogenesis
  • Ependyma
  71 Downloads (Pure)

• The impact of antidiabetic treatment on human hypothalamic infundibular neurons and microglia

  Kalsbeek, M. J., Wolff, S. E., Korpel, N. L., la Fleur, S. E., Romijn, J. A., Fliers, E., Kalsbeek, A., Swaab, D. F., Huitinga, I., Hol, E. M. & Yi, C-X., 2020, In: JCI insight. 5, 16, 133868.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Microglia
  • Hypoglycemic Agents
  • Type 2 Diabetes Mellitus
  • Neurons
  • Neuropeptide Y
  69 Downloads (Pure)
• 2019

  DNA methylation changes related to nutritional deprivation: a genome-wide analysis of population and in vitro data

  He, Y., de Witte, L. D., Houtepen, L. C., Nispeling, D. M., Xu, Z., Yu, Q., Yu, Y., Hol, E. M., Kahn, R. S. & Boks, M. P., Mar 2019, In: Clinical Epigenetics. 11, 1, p. 80

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Starvation
  • DNA Methylation
  • Genome
  • In Vitro Techniques
  • Population
  123 Downloads (Pure)

• Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.

  Böttcher, C., Schlickeiser, S., Sneeboer, M. A. M., Kunkel, D., Knop, A., Paza, E., Fidzinski, P., Kraus, L., Snijders, G. J. L., Kahn, R. S., Schulz, A. R., Mei, H. E., Hol, E. M., Siegmund, B., Glauben, R., Spruth, E. J., de Witte, L. D. & Priller, J., 04 Jan 2019, In: Nature Neuroscience. 22, p. 78-90

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Microglia
  • Phenotype
  • Immunophenotyping
  • Cryopreservation
  • Workflow

• Importance of GFAP isoform-specific analyses in astrocytoma

  van Bodegraven, E. J., van Asperen, J. V., Robe, P. A. J. & Hol, E. M., Jan 2019, In: GLIA. 33, p. 12941-12959

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Glial Fibrillary Acidic Protein
  • Astrocytoma
  • Protein Isoforms
  • Neuroglia
  • Glioma
  174 Downloads (Pure)

• Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function

  He, Y., de Witte, L. D., Schubart, C. D., Van Gastel, W. A., Koeleman, B. P. C., de Jong, S., Ophoff, R. A., Hol, E. M. & Boks, M. P., Jan 2019, In: European Neuropsychopharmacology. 29, p. 643-652

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Cannabis
  • Cannabidiol
  • Gene Expression
  • Dronabinol
  • Monocytes

• Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated

  Sneeboer, M. A. M., Snijders, G. J. L. J., Berdowski, W. M., Fernández-Andreu, A., van Mierlo, H. C., Berdenis van Berlekom, A., Litjens, M., Kahn, R. S., Hol, E. M. & de Witte, L. D., Apr 2019, In: Translational Psychiatry. 9, 1, p. 153

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Microglia
  • Bipolar Disorder
  • Brain
  • Prefrontal Cortex
  • Thalamus
  137 Downloads (Pure)

• Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease

  Donega, V., Burm, S. M., van Strien, M. E., van Bodegraven, E. J., Paliukhovich, I., Geut, H., van de Berg, W. D. J., Li, K. W., Smit, A. B., Basak, O. & Hol, E. M., Apr 2019, In: Acta neuropathologica communications. 7, 1, p. 4

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Neural Stem Cells
  • Lateral Ventricles
  • Proteome
  • Gene Expression Profiling
  • Adapalene
  99 Downloads (Pure)
• 2018

  Cell adhesion and matricellular support by astrocytes of the tripartite synapse

  Hillen, A. E. J., Burbach, J. P. H. & Hol, E. M., 2018, In: Progress in Neurobiology. 165-167, p. 66-86

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Cell Adhesion
  • Astrocytes
  • Synapses
  • Cell Adhesion Molecules
  • Neurons
  258 Downloads (Pure)

• Clinical and immunological characteristics of the spectrum of GFAP autoimmunity: a case series of 22 patients

  Iorio, R., Damato, V., Evoli, A., Gessi, M., Gaudino, S., Di Lazzaro, V., Spagni, G., Sluijs, J. A. & Hol, E. M., 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89, p. 138-146

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Autoimmunity
  • Neuroglia
  • Proteins
  • Autoantibodies
  • Myelitis

• Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

  Oosterhof, N., Kuil, L. E., van der Linde, H. C., Burm, S. M., Berdowski, W., van IJcken, W. F. J., van Swieten, J. C., Hol, E. M., Verheijen, M. H. G. & van Ham, T. J., Jun 2018, In: Cell Reports. 24, 5, p. 1203-1217.e6

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Microglia
  • Colony-Stimulating Factor Receptors
  • Macrophage Colony-Stimulating Factor
  • Neuroglia
  • Zebrafish
  156 Downloads (Pure)

• Microglia innately develop within cerebral organoids

  Ormel, P. R., Vieira de Sá, R., van Bodegraven, E. J., Karst, H., Harschnitz, O., Sneeboer, M. A. M., Johansen, L. E., van Dijk, R. E., Scheefhals, N., Berdenis van Berlekom, A., Ribes Martínez, E., Kling, S., MacGillavry, H. D., van den Berg, L. H., Kahn, R. S., Hol, E. M., de Witte, L. D. & Pasterkamp, R. J., 2018, In: Nature Communications. 9, 1, 4167.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Microglia
  • Organoids
  • brain
  • stem cells
  • Brain
  131 Downloads (Pure)

• Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

  Antonovaite, N., Beekmans, S. V., Hol, E. M., Wadman, W. J. & Iannuzzi, D., 2018, In: Scientific Reports. 8, 1, p. 12517

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Brain
  • Nervous System Diseases
  • Hippocampus
  112 Downloads (Pure)

• Role of von Willebrand Factor and ADAMTS13 in early brain injury after experimental subarachnoid hemorrhage

  Wan, H., Wang, Y., Ai, J., Brathwaite, S., Ni, H., Macdonald, R. L., Hol, E. M., Meijers, J. C. M. & Vergouwen, M. D. I., 2018, In: Journal of Thrombosis and Haemostasis. 16, p. 1413-1422

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • von Willebrand Factor
  • Subarachnoid Hemorrhage
  • Brain Injuries
  • Neurons
  • Platelet Aggregation
  120 Downloads (Pure)
• 2017

  Characterization of macrophages from schizophrenia patients

  Ormel, P. R., van Mierlo, H. C., Litjens, M., Strien, M. E. V., Hol, E. M., Kahn, R. S. & de Witte, L. D., 2017, In: NPJ Schizophrenia. 3, 1, 41.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Schizophrenia
  • Macrophages
  • Myeloid Cells
  • Microglia
  • Synapses
  122 Downloads (Pure)

• Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

  Jansen, A. H. P., van Hal, M., Op den Kelder, I. C., Meier, R. T., de Ruiter, A-A., Schut, M. H., Smith, D. L., Grit, C., Brouwer, N., Kamphuis, W., Boddeke, H. W. G. M., den Dunnen, W. F. A., van Roon, W. M. C., Bates, G. P., Hol, E. M. & Reits, E. A., 02 Jan 2017, In: GLIA. 65, p. 50-61

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Intranuclear Inclusion Bodies
  • Huntingtin Protein
  • Neuroglia
  • Huntington Disease
  • Mutant Proteins
  202 Downloads (Pure)

• Gene Expression Profilling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

  Hendrickx, D. A. E., van Scheppingen, J., van der Poel, M., Bossers, K., Schuurman, K. G., van Eden, C. G., Hol, E. M., Hamann, J. & Huitinga, I., 21 Dec 2017, In: Frontiers in Immunology. 8, 1810.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File
  185 Downloads (Pure)

• GFAPδ/GFAPα ratio directs astrocytoma gene expression towards a more malignant profile

  Stassen, O. M. J. A., van Bodegraven, E. J., Giuliani, F., Moeton, M., Kanski, R., Sluijs, J. A., van Strien, M. E., Kamphuis, W., Robe, P. A. J. & Hol, E. M., Oct 2017, In: Oncotarget. 8, 50, p. 88104-88121 18 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Glial Fibrillary Acidic Protein
  • Astrocytoma
  • Gene Expression
  • human GFAP protein
  • Protein Isoforms
  368 Downloads (Pure)

• Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

  Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., Hol, E. M., Kamphuis, W., Bayer, T. A., De Deyn, P. P. & Boddeke, E., 2017, In: Neurobiology of Aging. 55, p. 115-122

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Microglia
  • Alzheimer Disease
  • HLA-DR alpha-Chains
  • Phenotype
  • Gene Ontology

• Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies

  van Kesteren, C. F. M. G., Gremmels, H., de Witte, L. D., Hol, E. M., Van Gool, A. R., Falkai, P. G., Kahn, R. S. & Sommer, I. E. C., 01 Mar 2017, In: Translational Psychiatry. 7, 3, p. e1075

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Schizophrenia
  • Meta-Analysis
  • Brain
  • Immune System
  • Gene Expression
  201 Downloads (Pure)

• Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin

  Hol, E. M. & Capetanaki, Y., 2017, In: Cold Spring Harbor perspectives in biology. 9, 12, a021642.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Peripherins
  • Desmin
  • Glial Fibrillary Acidic Protein
  • Intermediate Filaments
  • Vimentin
• 2016

  Astrocytes: a central element in neurological diseases

  Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J-M., Parpura, V., Hol, E. M., Sofroniew, M. V. & Verkhratsky, A., Mar 2016, In: Acta Neuropathologica. 131, 3, p. 323-45 23 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Astrocytes
  • Neurodegenerative Diseases
  • Alexander Disease
  • Stroke
  • Spinal Cord Diseases

• Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

  Osborn, L. M., Kamphuis, W., Wadman, W. J. & Hol, E. M., 2016, In: Progress in Neurobiology. 144, p. 121-141

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Astrocytes
  • Alzheimer Disease
  • Dementia
  • Brain
  • Gliosis

• Characterizing primary human microglia: A comparative study with myeloid subsets and culture models

  Melief, J., Sneeboer, M. A. M., Litjens, M., Ormel, P. R., Palmen, S. J. M. C., Huitinga, I., Kahn, R. S., Hol, E. M. & de Witte, L. D., 2016, In: GLIA. 64, p. 1857-1868

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Microglia
  • Poly I-C
  • Corpus Callosum
  • Myeloid Cells
  • Frontal Lobe

• GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions

  Moeton, M., Stassen, O. M. J. A., Sluijs, J. A., van der Meer, V. W. N., Kluivers, L. J., van Hoorn, H., Schmidt, T., Reits, E. A. J., van Strien, M. E. & Hol, E. M., 2016, In: Cellular and Molecular Life Sciences. 73, p. 4101-4120

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Focal Adhesions
  • Glial Fibrillary Acidic Protein
  • Intermediate Filaments
  • Cell Adhesion
  • Protein Isoforms
  180 Downloads (Pure)

• Glial cell response after aneurysmal subarachnoid hemorrhage - Functional consequences and clinical implications

  van Dijk, B. J., Vergouwen, M. D. I., Kelfkens, M. M., Rinkel, G. J. E. & Hol, E. M., Mar 2016, In: Biochimica et Biophysica Acta- Molecular Basis of Disease. 1862, 3, p. 492-505 14 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• The Indispensable Roles of Microglia and Astrocytes during Brain Development

  Reemst, K., Noctor, S. C., Lucassen, P. J. & Hol, E. M., 2016, In: Frontiers in Human Neuroscience. 10, p. 566

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  File

  • Microglia
  • Astrocytes
  • Brain
  • Neuronal Plasticity
  • Neurodevelopmental Disorders
  148 Downloads (Pure)

• Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

  Kamphuis, W., Kooijman, L., Schetters, S., Orre, M. & Hol, E. M., 2016, In: Biochimica et Biophysica Acta- Molecular Basis of Disease. 1862, p. 1847-1860

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Amyloid Plaques
  • Microglia
  • Alzheimer Disease
  • Population
  • Apolipoproteins E