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• 2020

  Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

  Lõhmussaar, K., Kopper, O., Korving, J., Begthel, H., Vreuls, C. P. H., van Es, J. H. & Clevers, H., 27 May 2020, In: Nature Communications. 11, 1, p. 2660

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Organoids
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • mice
  • Tumors
  • grade

• Correction: The function of GORASPs in Golgi apparatus organization in vivo

  Grond, R., Veenendaal, T., Duran, J. M., Raote, I., van Es, J. H., Corstjens, S., Delfgou, L., El Haddouti, B., Malhotra, V. & Rabouille, C., 07 Sep 2020, In: Journal of Cell Biology. 219, 9

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

• The function of GORASPs in Golgi apparatus organization in vivo

  Grond, R., Veenendaal, T., Duran, J. M., Raote, I., van Es, J. H., Corstjens, S., Delfgou, L., El Haddouti, B., Malhotra, V. & Rabouille, C., 07 Sep 2020, In: Journal of Cell Biology. 219, 9

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Coat Protein Complex I
  • Golgi Apparatus
  • In Vitro Techniques
  • Proteins
• 2019

  Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

  van Es, J. H., Wiebrands, K., López-Iglesias, C., van de Wetering, M., Zeinstra, L., van den Born, M., Korving, J., Sasaki, N., Peters, P. J., van Oudenaarden, A. & Clevers, H., 16 Dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Paneth Cells
  • Enteroendocrine Cells
  • Stem Cells
  • Heparin-binding EGF-like Growth Factor
  • Maintenance

• Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

  Gehart, H., van Es, J. H., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J. F., Rios, A. & Clevers, H., 21 Feb 2019, In: Cell. 176, 5, p. 1158-1173.e16

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Cell Differentiation
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Plasticity
  • Genes
  • Specifications

• Oral mucosal organoids as a potential platform for personalized cancer therapy

  Driehuis, E., Kolders, S., Spelier, S., Lohmussaar, K., Willems, S. M., Devriese, L. A., de Bree, R., de Ruiter, E. J., Korving, J., Begthel, H., Van Es, J. H., Geurts, V., He, G-W., van Jaarsveld, R. H., Oka, R., Muraro, M. J., Vivie, J., Zandvliet, M. M. J. M., Hendrickx, A. P. A., Iakobachvili, N. & 8 others, Sridevi, P., Kranenburg, O., van Boxtel, R., Kops, G. J. P. L., Tuveson, D. A., Peters, P. J., van Oudenaarden, A. & Clevers, H., Jul 2019, In: Cancer Discovery.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Squamous Cell Carcinoma of Head and Neck
  • Pharmaceutical Preparations
  • Neoplasms
  • Heterologous Transplantation

• Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

  Artegiani, B., van Voorthuijsen, L., Lindeboom, R. G. H., Seinstra, D., Heo, I., Tapia, P., López-Iglesias, C., Postrach, D., Dayton, T., Oka, R., Hu, H., van Boxtel, R., van Es, J. H., Offerhaus, J., Peters, P. J., van Rheenen, J., Vermeulen, M. & Clevers, H., 06 Jun 2019, In: Cell Stem Cell. 24, 6, p. 927-943.e6

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Organoids
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Cholangiocarcinoma
  • Chromatin
  • Liver
• 2018

  Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

  Beumer, J., Artegiani, B., Post, Y., Reimann, F., Gribble, F., Nguyen, T. N., Zeng, H., Van den Born, M., Van Es, J. H. & Clevers, H., Aug 2018, In: Nature Cell Biology. 20, 8, p. 909-916 8 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Enteroendocrine Cells
  • Hormones
  • Organoids
  • Secretin
  • Cell Lineage

• Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

  Chakrabarti, R., Celià-Terrassa, T., Kumar, S., Hang, X., Wei, Y., Choudhury, A., Hwang, J., Peng, J., Nixon, B., Grady, J. J., DeCoste, C., Gao, J., van Es, J. H., Li, M. O., Aifantis, I., Clevers, H. & Kang, Y., 29 Jun 2018, In: Science. 360, 6396

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Stem Cell Niche
  • Human Mammary Glands
  • Breast
  • Stem Cells
  • Ligands

• Profiling proliferative cells and their progeny in damaged murine hearts

  Kretzschmar, K., Post, Y., Bannier-Hélaouët, M., Mattiotti, A., Drost, J., Basak, O., Li, V. S. W., van den Born, M., Gunst, Q. D., Versteeg, D., Kooijman, L., van der Elst, S., van Es, J. H., van Rooij, E., van den Hoff, M. J. B. & Clevers, H., 26 Dec 2018, In: Proceedings of the National Academy of Sciences of the United States of America.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Heart
  • Cardiac Myocytes
  • Stem Cells
  • Fibroblasts
  • Follistatin-Related Proteins

• Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

  Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., Simons, B. D. & Clevers, H., 23 Jan 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E610-E619

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Neural Stem Cells
  • Brain Stem
  • Cell Cycle
  • Stem Cells
  • Cell Count
• 2017

  A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

  Artegiani, B., Lyubimova, A., Muraro, M. J., van Es, J. H., van Oudenaarden, A. & Clevers, H., 12 Dec 2017, In: Cell Reports. 21, 11, p. 3271-3284 14 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Microglia
  • Stem cells
  • RNA Sequence Analysis
  • Molecular Dynamics Simulation
  • Molecular dynamics
• 2016

  Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

  Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., He, X., Wang, J., Lu, C., Wu, L. N., Weng, Q., Mao, M., Li, J., van Es, J. H., Xin, M., Parry, L., Goldman, S. A., Clevers, H. & Lu, Q. R., 2016, In: Nature Communications. 7, p. 10883

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Catenins
  • Oligodendroglia
  • switches
  • Biosynthesis
  • cholesterol

• Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

  Tetteh, P. W., Kretzschmar, K., Begthel, H., van den Born, M., Korving, J., Morsink, F. H. M., Farin, H., van Es, J. H., Offerhaus, G. J. A. & Clevers, H., 18 Oct 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. 11859-11864 6 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  • Colonic Neoplasms
  • Colon
  • Cecum
  • Enzymes
  • Mutation

• Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

  Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. & 5 others, Sabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 04 Aug 2016, In: Cell Stem Cell.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Stem Cell Niche
  • Equidae
  • Wnt Signaling Pathway
  • Colorectal Neoplasms
  • Stem Cells

• Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon

  Sasaki, N., Sachs, N., Wiebrands, K., Ellenbroek, S. I. J., Fumagalli, A., Lyubimova, A., Begthel, H., van den Born, M., van Es, J. H., Karthaus, W. R., Li, V. S. W., López-Iglesias, C., Peters, P. J., van Rheenen, J., van Oudenaarden, A. & Clevers, H., 29 Aug 2016, In: Proceedings of the National Academy of Sciences of the United States of America.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Stem Cell Niche
  • Colon
  • Stem Cells
  • Paneth Cells
  • Organoids

• Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

  Tetteh, P. W., Basak, O., Farin, H. F., Wiebrands, K., Kretzschmar, K., Begthel, H., van den Born, M., Korving, J., de Sauvage, F., van Es, J. H., van Oudenaarden, A. & Clevers, H., 04 Feb 2016, In: Cell Stem Cell. 18, 2, p. 203-13 11 p.

  Research output: Contribution to journal/periodical › Article › Scientific › peer-review

  Open Access

  • Cell Plasticity
  • Enterocytes
  • Stem Cells
  • Phosphates
  • Regeneration