TY - JOUR
T1 - A genomic journey in the secondary metabolite diversity of fungal plant and insect pathogens
T2 - from functional to population genomics
AU - Kuhnert, Eric
AU - Collemare, Jérôme
N1 - Funding Information:
The German Research Foundation (DFG) provided support to E.K. (grant numbers: CO1328/10-1 , CO1328/4-2 ).
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/10
Y1 - 2022/10
N2 - Fungal pathogens produce a broad array of secondary metabolites (SMs), which allow the fungus to thrive in its natural habitat and gain competitive advantage. Analysis of the genetically encoded blueprints for SM assembly highlighted that only a small portion of the SMs these fungi are capable of producing are known, and even fewer have been investigated for their natural function. Using molecular tools, a lot of progress has been made recently in identifying the blueprint products and linking them to their ecological purpose such as the peptide virulence factor fusaoctaxin A released by Fusarium graminearum during infection of wheat or the F. oxysporum polyketide bikaverin that provides competitive advantage against bacteria in tomato. In addition, population genomics have given particularly important insights into the species-specific plasticity of the SM blueprint arsenal, showcasing the ongoing evolution and adaptation of fungal pathogens. This approach holds promise in inferring roles in pathogenicity of many more fungal SMs.
AB - Fungal pathogens produce a broad array of secondary metabolites (SMs), which allow the fungus to thrive in its natural habitat and gain competitive advantage. Analysis of the genetically encoded blueprints for SM assembly highlighted that only a small portion of the SMs these fungi are capable of producing are known, and even fewer have been investigated for their natural function. Using molecular tools, a lot of progress has been made recently in identifying the blueprint products and linking them to their ecological purpose such as the peptide virulence factor fusaoctaxin A released by Fusarium graminearum during infection of wheat or the F. oxysporum polyketide bikaverin that provides competitive advantage against bacteria in tomato. In addition, population genomics have given particularly important insights into the species-specific plasticity of the SM blueprint arsenal, showcasing the ongoing evolution and adaptation of fungal pathogens. This approach holds promise in inferring roles in pathogenicity of many more fungal SMs.
UR - http://www.scopus.com/inward/record.url?scp=85134833189&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2022.102178
DO - 10.1016/j.mib.2022.102178
M3 - Book/Film/Article review
C2 - 35870224
AN - SCOPUS:85134833189
SN - 1369-5274
VL - 69
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
M1 - 102178
ER -