A path to translation: How 3D patient tumor avatars enable next generation precision oncology

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9 Citations (Scopus)

Abstract

3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future steps to realize their potential for clinical decision making. 3D-PTAs require standardization criteria and prospective trials to establish clinical benefits. Innovative trial designs that combine omics and 3D-PTA readouts may lead to more accurate clinical predictors, and an integrated platform that combines diagnostic and therapeutic development will accelerate new treatments for patients with refractory disease.

Original languageEnglish
JournalCancer Cell
DOIs
Publication statusE-pub ahead of print - 18 Oct 2022

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