ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

Patricia Regina Manzine; Elena Marcello; Barbara Borroni; W. Kamphuis; E.M. Hol; Alessandro Padovani; Carla Crispim Nascimento; Patricia de Godoy Bueno; Francisco Assis Carvalho Vale; Sofia Cristina Iost Pavarini; Monica Di Luca; Márcia Regina Cominetti

doi:10.3109/1354750X.2015.1062554

ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

Patricia Regina Manzine, Elena Marcello, Barbara Borroni, W. Kamphuis, E.M. Hol, Alessandro Padovani, Carla Crispim Nascimento, Patricia de Godoy Bueno, Francisco Assis Carvalho Vale, Sofia Cristina Iost Pavarini, Monica Di Luca, Márcia Regina Cominetti

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

26 Citations (Scopus)

Abstract

ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.

Original language	English
Pages (from-to)	196-201
Number of pages	6
Journal	Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Volume	20
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2015.1062554
Publication status	Published - May 2015

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Manzine, P. R., Marcello, E., Borroni, B., Kamphuis, W., Hol, E. M., Padovani, A., Nascimento, C. C., de Godoy Bueno, P., Assis Carvalho Vale, F., Iost Pavarini, S. C., Di Luca, M., & Cominetti, M. R. (2015). ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 20(3), 196-201. https://doi.org/10.3109/1354750X.2015.1062554

@article{7695e59218b944e78c671a794f636732,

title = "ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects",

abstract = "ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.",

author = "Manzine, {Patricia Regina} and Elena Marcello and Barbara Borroni and W. Kamphuis and E.M. Hol and Alessandro Padovani and Nascimento, {Carla Crispim} and {de Godoy Bueno}, Patricia and {Assis Carvalho Vale}, Francisco and {Iost Pavarini}, {Sofia Cristina} and {Di Luca}, Monica and Cominetti, {M{\'a}rcia Regina}",

year = "2015",

month = may,

doi = "10.3109/1354750X.2015.1062554",

language = "English",

volume = "20",

pages = "196--201",

journal = "Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals",

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Manzine, PR, Marcello, E, Borroni, B, Kamphuis, W , Hol, EM, Padovani, A, Nascimento, CC, de Godoy Bueno, P, Assis Carvalho Vale, F, Iost Pavarini, SC, Di Luca, M & Cominetti, MR 2015, 'ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects', Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, vol. 20, no. 3, pp. 196-201. https://doi.org/10.3109/1354750X.2015.1062554

ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects. / Manzine, Patricia Regina; Marcello, Elena; Borroni, Barbara et al.
In: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 20, No. 3, 05.2015, p. 196-201.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

TY - JOUR

T1 - ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

AU - Manzine, Patricia Regina

AU - Marcello, Elena

AU - Borroni, Barbara

AU - Kamphuis, W.

AU - Hol, E.M.

AU - Padovani, Alessandro

AU - Nascimento, Carla Crispim

AU - de Godoy Bueno, Patricia

AU - Assis Carvalho Vale, Francisco

AU - Iost Pavarini, Sofia Cristina

AU - Di Luca, Monica

AU - Cominetti, Márcia Regina

PY - 2015/5

Y1 - 2015/5

N2 - ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.

AB - ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.

U2 - 10.3109/1354750X.2015.1062554

DO - 10.3109/1354750X.2015.1062554

M3 - Article

C2 - 26220620

SN - 1354-750X

VL - 20

SP - 196

EP - 201

JO - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

JF - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

IS - 3

ER -

ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

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